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大学ホーム保健学部 教員紹介

教員紹介

項 目 内 容
教員名 大迫 俊二
フリガナ オオサコシュンジ
NAME Ohsako Shunji
職 位 教授
研究テーマ・分野 脳神経系の発生・分化および可塑性に関する研究
略 歴 名古屋大学理学部生物学科卒業
名古屋大学理学系大学院生物学専攻修士課程修了
名古屋大学理学系大学院生物学専攻博士課程中途退学
名古屋大学理学系大学院生物学専攻学位取得(理学博士)
(財)東京都神経科学総合研究所・研究員
アメリカ・コーネル大学医学部・博士研究員
(財)東京都神経科学総合研究所・主任研究員
(財)東京都医学総合研究所・主任研究員
平成24年1月より現職
所有する学位 理学博士(名古屋大学)
主要研究業績 原著論文

Horiguchi, K,, Fujiwara, K., Tsukada, T., Yoshida, S., Higuchi, M., Tateno, K., Hasegawa, R., Takigami, S., Ohsako, S., Yashiro, T., Kato, T., Kato, Y. (2016) CXCL10/CXCR3 signaling mediates inhibitory action by interferon-gamma on CRF-stimulated adenocorticotropic hormone (ACTH) release.
Cell Tissue Res. 364, 395-404.

Horiguchi, K., Fujiwara, K., Tsukada, T., Yako, H., Tateno, K., Hasegawa, R., Takigami, S., Ohsako, S., Yashiro, T., Kato, T., Kato, Y. (2016) Expression of Slug in S100β-protein-positive cells of postnatal developing rat anterior pituitary gland.
Cell Tissue Res. 363, 513-24.

Horiguchi, K., Higuchi, M., Yoshida, S., Nakakura, T., Tateno, K., Hasegawa, R., Takigami ,S., Ohsako, S., Kato, T., Kato, Y. (2014) Proton receptor GPR68 expression in dendritic-cell-like S100β-positive cells of rat anterior pituitary gland: GPR68 induces interleukin-6 gene expression in extracellular acidification. Cell Tissue Res. 358, 515-25.

Horiguchi, K., Fujiwara, K,. Higuchi, M., Yoshida, S., Tsukada, T,, Ueharu, H., Chen, M., Hasegawa, R., Takigami, S., Ohsako, S., Yashiro, T., Kato, T., Kato ,Y. (2014) Expression of chemokine CXCL10 in dendritic-cell-like S100β-positive cells in rat anterior pituitary gland. Cell Tissue Res. 357, 757-65.

Horiguchi, K., Fujiwara, K., Yoshida, S,. Higuchi, M., Tsukada ,T., Kanno, N., Yashiro, T., Tateno, K., Osako, S., Kato, T., Kato, Y. (2014) Isolation of dendritic-cell-like S100β-positive cells in rat anterior pituitary gland. Cell Tissue Res. 357, 301-8.

Hiraoka, M., Inoue, K., Ohtaka-Maruyama, C., Ohsako, S., Kojima, N., Senoo, H., Takada, M. (2010) Intracapsular organization of ciliary zonules in monkey eyes. Anat Rec (Hoboken) 293, 1797-804.

Huang, L., Ohsako, S., and Tanda, S. (2005) The lesswright mutation activates rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster. Dev Biol. 280, 407-420.

Takigami, S., Wakabayashi, Y., Ohsako, S. et. al (2004) Fetal development of the vomeronasal organ in the goat. Dev. Brain Res. 149, 113-121.

Takamatsu, Y., Kishimoto, Y., and Ohsako, S. (2003) Immunohistochemical study of Ca2+/calmodulin-dependent protein kinase II in the Drosophila brain using a specific monoclonal antibody. Brain Res. 974, 99-116.

Takamatsu, Y., Nakagoshi, H., Rachidi, M., Lopes, C., Nishida, Y., and Ohsako, S. (2002) Characterization of the dCaMKII-GAL4 driver line whose expression is controlled by the Drosophila Ca2+/calmodulin-dependent protein kinase II promoter. Cell Tissue Res. 310, 237-252.

Rachidi, M., Lopes, C., Takamatsu, Y., Ohsako, S., Benichou, J. C., and Delabar, J. M. (1999) Dynamic expression pattern of Ca2+/calmodulin-dependent protein kinase gene in the central nervous system of Drosophila throughout development. Biochem. Biophys. Res. Commun. 290, 707-711.

Ohsako, S., and Takamatsu, Y. (1999) Identification and characterization of a Drosophila homologue of the yeast UBC9 and hus5 genes. J. Biochem. 125, 230-235.

Fisher, A. L., Ohsako, S., and Caudy, M. (1996) The WRPW motif of the Hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino acid transcription repression and protein-protein interaction domain. Mol. Cell. Biol. 16, 2670-2677.

Ohsako, S., Hyer, J., Panganiban, G., Oliver, I., and Caudy, M. (1994) hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation. Genes & Dev. 8, 2743-2755.

Takamatsu, Y., Ohsako, S., Nishida, Y., and Yamauchi, T. (1994) Identification of an alternative form of the Drosophila Ca2+/calmodulin-dependent protein kinase II that is maternally derived. Biochim. Biophys. Acta 1220, 188-192.

Ohsako, S., Nishida, Y., Ryo, H., and Yamauchi, T. (1993) Molecular characterization and expression of the Drosophila Ca2+/calmodulin-dependent protein kinase II gene: Identification of four forms of the enzyme generated from a single gene by alternative splicing. J. Biol. Chem. 268, 2052-2062.

Goshima, Y., Ohsako, S., and Yamauchi, T. (1993) Overexpression of Ca2+/calmodulin-dependent protein kinase II in Neuro2a and NG108-15 neuroblastoma cell lines promotes neurite outgrowth and growth cone motility. J. Neurosci. 13, 559-567.

Ichikawa, T., Sekihara, S., Ohsako, S., Hirata, Y., and Yamauchi, T. (1992) Ca2+/calmodulin-dependent protein kinase II in the cerebellum; An immunohistochemical study with monoclonal antibodies specific to either α or β subunit. J. Chem. Neuroanat. 5, 383-390.

Ichikawa, T., Ohsako, S., and Deguchi, T. (1991) Production of an antiserum using a fusion protein produced by a cDNA for rat choline acetyltransferase. Neurosci. Lett., 131, 213-216.

Hagiwara, T., Ohsako, S., and Yamauchi, T. (1991) Studies on the regulatory domain of Ca2+/calmodulin-dependent protein kinase II by expression of mutated cDNAs in Escherichia coli. J. Biol. Chem. 266, 16401-16408.

Sasaki, Y., Ohsako, S., and Deguchi, T. (1991) Molecular and genetic analyses of arylamine N-acetyltransferase polymorphism of rabbit liver. J. Biol. Chem. 266, 13243-13250.

Yamauchi, T., Sekihara, S., and Ohsako, S. (1991) Characterization of Ca2+/calmodulin-dependent protein kinase II isoforms from forebrain and cerebellum. Brain Res. 541, 198-205.

Ohsako, S., Nakazawa, H., Sekihara, S., Ikai, A., and Yamauchi, T. (1991) Role of threonine-286 as autophosphorylation site for appearance of Ca2+-independent activity of calmodulin-dependent protein kinase II α subunit. J. Biochem. 109, 137-143.

Ohsako, S., Watanabe, A., Sekihara, S., Ikai, A., and Yamauchi, T. (1990) Expression of a catalytically active polypeptide of calmodulin-dependent protein kinase II α subunit in Escherichia coli. Biochem. Biophys. Res. Commun. 170, 705-712.

Yamauchi, T., Sekihara, S., and Ohsako, S. (1990) Subcellular distribution of α and β subunit proteins of Ca2+/calmodulin-dependent protein kinase II by expressed in Chinese hamster ovary cells. FEBS Lett. 266, 55-58.

Ohsako, S., and Deguchi, T. (1990) Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-actyltransferases from human liver. J. Biol. Chem. 265, 4630-4634.

Yamauchi, T., Ohsako, S., and Deguchi, T. (1989) Expression and characterization of calmodulin-dependent protein kinase II from cloned cDNAs in Chinese hamster ovary cells. J. Biol. Chem. 264, 19108-19116.

Kawai, N., Saito, M., and Ohsako, S. (1988) Differential expression of glutamate receptors in Xenopus oocytes injected with messenger RNA from lobster muscle. Neurosci. Lett. 95, 203-207.

Ichikawa, T., Ishida, I., Ohsako, S., and Deguchi, T. (1988) In situ hybridization demonstrating coexpression of urotensin I, II-α, and II-γ in the caudal neurosecretory neurons of the carp, Cyprinus carpio. Gen. Comp. Endocrimol. 71, 493-503.

Ohsako, S., Ohtomi, M., Sakamoto, Y., Uyemura, K., and Deguchi, T. (1988) Arylamine N-acetyltransferase from chicken liver. II. Cloning of cDNA and expression in Chinese hamster ovary cells. J. Biol. Chem. 263, 7534-7538

Saito, M., Ohsako, S., Deguchi, T., and Kawai, N. (1987) Glutamate receptors expressed in Xenopus oocytes by messenger RNA from invertebrate muscle. Mol. Brain Res. 3, 83-87.

Ishida, I., Ohsako, S., Nakane, M., and Deguchi, T. (1987) Expression and characterization of hydroxyindole O-methyltransferase from a cloned cDNA in Chinese hamster ovary cells. Mol. Brain Res. 2, 185-189.

Ohsako, S., Ishida, I., Ichikawa, T., and Deguchi, T. (1986) Cloning and sequence analysis of cDNAs encoding precursors of urotensin II-α and -γ. J. Neurosci. 6, 2730-2735.

Ohsako, S., and Deguchi, T. (1984) Receptor-mediated regulation of calcium mobilization and cyclic GMP synthesis in neuroblastoma cells. Biochem. Biophys. Res. Commun. 122, 333-339.

Ohsako, S., and Deguchi, T. (1983) Phosphatidic acid mimics the muscarinic action of acetylcholine in bovine cultured chromaffin cells. FEBS Lett. 152, 62-66.

Ohsako, S., and Deguchi, T. (1981) Stimulation by phosphatidic acid of calcium influx and cyclic GMP synthesis in neuroblastoma cells. J. Biol. Chem. 256, 10945-10948.

著書、総説等

ガートナー/ハイヤット組織学第3版 アトラスとテキスト (監訳)川上速人・松村讓兒 (第6, 7章) MEDSiメディカル・インターナショナル・サイエンス (2014) 

Takamatsu, Y., Nakagoshi, H., Nishida, Y., Yamauchi, T., and Ohsako, S. (1997) Transcriptional regulation of the Ca2+/calmodulin-dependent protein kinase II gene in Drosophila. In: Kinases and phosphatases in lymphocyte and neuronal signaling, pp297-298. Berlin: Springer Press.

山内卓、大迫俊二、萩原民雄「セリン/スレオニンキナーゼとその調節」代謝Vol.28臨時増刊号「シグナル伝達とクロストーク」p181-187. (1991)

山内卓、大迫俊二 Ca2+-カルモデュリン依存性プロテインキナーゼII 生化学 第62巻、38-44. (1990)

Ichikawa, T., Ishida, I., Ohsako, S., and Deguchi, T. (1988) Precursors of uroteinsins and their co-expression in the caudal neurosecretory system. In: Neurosecretion (Proceeding of the Tenth International Symposium on Neurosecretion), pp35-41. New York: Plenum Press.

Deguchi, T., Ohsako, S., Nakane, M., Ichikawa, M., and Yoshioka, M. (1983) Cellular mechanism involved in the synthesis of cyclic GMP in nervous tissues. J. Neural Transmission, Suppl. 18, 369-378.

Deguchi, T., Ohsako, S., Nakane, M, and Amano-Yokoyama, E. (1982) Role of phospholipid in the transmitter-induced synthesis of cyclic GMP in nervous tissue. Adv. in Pharmacol. and Therapeutics II 69-78.
所属学会 日本神経化学会、日本分子生物学会、Society for Neuroscience
居室・研究室 B棟416室、426室
オフィスアワー 水曜日午後5〜6時 B416
更新年月 2016年8月24日
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