大学ホーム医学部教員紹介渡邊 卓

教員紹介:渡邊 卓

氏名 渡邊 卓
フリガナ ワタナベ タカシ
職位 教授
学内の役職・委員等 学部長 (医学部)、医学研究科長
所属教室 臨床検査医学
専攻・専門分野
 (大学院)
病理系専攻 臨床検査医学分野
担当科目(学部) 検査医学総論、免疫検査、臨床免疫学(神経と免疫)など
担当科目(大学院) 基礎臨床共通講義「腫瘍と免疫」
専門分野 神経発生学、臨床免疫学、神経免疫学
研究テーマ 神経発生学(網膜の発生に関する研究)、安全な採血法に関する研究
略歴 1978年 3月 東京大学医学部医学科卒業
1978年6月~1986年6月 東大病院、日本赤十字医療センター、国立がんセンター中央病院、都立荏原病院脳神経外科にて脳神経外科臨床に従事
1986年 7月 東京大学医学部脳神経外科助手
1987年 7月 University College London (Department of Zoology)客員研究員
1991年 9月 杏林大学医学部臨床病理学講師
1994年 8月 同助教授
2001年 4月 杏林大学医学部臨床検査医学教授、同付属病院臨床検査部長
2014年 4月 杏林大学医学部長、医学研究科長
現在に至る。
所有する学位 博士(医学)
指導医・専門医・認定医、その他の資格等 日本脳神経外科専門医(昭和59年取得)
日本臨床検査医学会認定臨床検査専門医(平成11年取得)
論文・著書等を含む主要研究業績 1. Watanabe K, Kishino T, Sano J, Ariga T, Okuyama S, Mori H, Matsushima S, Ohtsuka K, Ohnishi H, Watanabe T : Relationship between epicardial adipose tissue thickness and early impairment of left ventricular systolic function in patients with preserved ejection fraction. Heart Vessels 31:1010-1015(2016)

2. Ida Y, Ohnishi H, Araki K, Saito R, Kawai S, Watanabe T : Efficient management and maintenance of ultrasonic nebulizers to prevent microbial contamination. World Methodol 6:126-132(2016)

3. Kobayashi T, Masaki T, Nozaki E, Sugiyama M, Nagashima F, Furuse J, Onishi H, Watanabe T, Ohkura Y : Microarray analysis of gene Expression at the tumor front of colon cancer. Anticancer Res 35:6577-6582(2015)

4. Ohtsuka K, Ohnishi H, Nozaki E, Ramos JP, Tortoli E, Yonetani S, Matsushima S, Tateishi Y, Matsumoto S, Watanabe T : Whole-genome sequence of Mycobacterium kyorinense. Genome Announcements 2:e01062 (2014)

5. Yonetani S, Ohnishi H, Araki K, Hiroi M, Takagi Y, Ichimura S, Watanabe T: A psoas abscess caused by Propionibacterium propionicum. J Infect Chemother 20:650-652(2014)

6. Matsushima S, Ohtsuka K, Ohnishi H, Fujiwara M, Nakamura H, Morii T, Kishino T, Goto H, Watanabe T : V843I, a lung cancer predisposing EGFR mutation, is responsible for resistnace to EGFR tyrosine kinase inhibitors. J Thorac Oncol 9:1377-1384(2014)

7. Ohnishi H, Tortoli E, Ramos JP, Kazumi Y, Yonetani S, Matsushima S, Ohtuska K, Watanabe T: Proposal of reclassification of Mycobacteruim celatum type2 as Mycobacterium kyorinense. Ann Microbiol 64:1879-1882 (2014)

8. Kishiki T, Ohnishi H, Masaki T, Ohtsuka K, Ohkura Y, Furuse J, Sugiyama M , Watanabe T : Impact of genetic profiles on the efficacy of anti-EGFR antibodies in metastatic colorectal cancer with KRAS mutation. Oncol Rep 32:57-64 (2014)

9. Inoue S-I, Niikura M, Inoue M, Mineo S, Kawakami Y, Uchida A, Ohnishi H, Kamiya S, Watanabe T, Kobayashi F : The protective effect of CD40 ligand-CD40 signalling is limited during the early phase of Plasmodium infection. FEBS Letters 588:2147-2153 (2014)

10. Kishiki T, Ohnishi H, Masaki T, Ohtsuka K, Ohkura Y, Furuse J, Watanabe T, Sugiyama M: Overexpression of MET is a new predictive marker for anti-EGFR therapy in metastatic colorectal cancer with wild-type KRAS. Cancer Chemother Pharmacol 73:749-757(2014)

11. Ohnishi H, Yonetani S, Matsushima S, Wada H, Takeshita K, Kuramochi D, Caldas PC, Campos CE , Costa BP, Ramos JP, Mikura S, Narisawa E, Fujita A, Funayama Y, Kobashi Y, Sakakibara Y, Ishiyama Y, Takakura S, Goto H, Watanabe T: Mycobacterium kyorinense infection. Emerg Infect Dis 19:508-510(2013)

12. Campos CE , Caldas PC, Ohnishi H, Watanabe T, Ohtsuka K, Matsushima S, Ferreira NV, da Silva MV, Redner P, de Carvalho LD, Medeiros RF, Abbud Filho JA , Montes FC, Galvão TC, Ramos JP: First isolation of Mycobacterium kyorinense from clinical specimens in Brazil. J Clin Microbiol 50:2477-2478(2012)

13. Yonetani S, Okazaki M, Araki K, Makino H, Fukugawa Y, Okuyama T, Ohnishi H, Watanabe T: Direct inoculation method using BacT/ALERT 3D and BD Phoenix System allows rapid and accurate identification and susceptibility testing for both Gram-positive cocci and Gram-negative rods in aerobic blood cultures. Diagn Micr Infec Dis 73:129-134(2012)

14. Fukugawa Y, Ohnishi H, Ishii T, Tanouchi A, Sano J, Miyawaki H, Kishino T, Ohtsuka K, Yoshino H, Watanabe T: Effect of carryover of clot activators on coagulation tests during phlebotomy. Am J Clin Pathol 137:900-903(2012)

15. Ohnishi H, Watanabe M, Watanabe T: Butterfly needles reduce the incidence of nerve injury during phlebotomy. Arch Pathol Lab Med 136:352(2012)

16. Oka K, Osaki T, Hanawa T, Kurata S, Okazaki M, Manzoku T, Takahashi M, Tanaka M, Taguchi H, Watanabe T, Inamatsu T, Kamiya S: Molecular and microbiological characterization of Clostridium difficile isolates from single, relapse, and reinfection cases. J Clin Microbiol 50:915-921(2012)

17. Mikura S, Wada H, Okazaki M, Nakamura M, Honda K, Yasutake T, Higaki M, Ishii H, Watanabe T, Tsunoda T, Goto H: Risk factors for bacteraemia attributable to Pseudomonas aeruginosa resistant to imipenem, levofloxacin. or gentamicin. J Hosp Infect 79:267-268(2011)

18. Kishino T, Ohnishi H, Ohtsuka K, Matsushima S, Watanebe K, Urata T, Honda Y, Matsumoto M, Mine Y, Nishikawa K, Mori H, Takahashi S, Ishida H, Watanabe T: Subcutaneous rather than visceral adipose tissue thickness of the abdomen correlates with alterations in serum fatty acid profile in Japanese women. Clin Chim Acta 412:1893-1894(2011)

19. Ohtsuka K, Ohnishi H, Morii T, Fujiwara M, Kishino T, Ogura W, Chiba M, Matsushima S, Goya T, Watanabe T: Down-regulated ABCG2 enhances sensitivity to topoisomerase I inhibitor in epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI)-resistant non-small cell lung cancer(NSCLC).J Thorac Oncol 5:1726-1733(2011)

20. Ohtsuka K, Ohnishi H, Kurai D, Matsushima S, Morishita Y, Shinonaga M, Goto H, Watanabe T: Familial lung adenocarcinoma caused by the EGFR V843I germ-line mutation. J Clin Oncol 29: e191-e192(2011)

21. Kishino T, Ohnishi H, Ohtsuka K, Matsushima S, Urata T, Watanebe K, Honda Y, Mine Y, Matsumoto M, Nishikawa K, Mori H, Takahashi S, Ishida H, Watanabe T: Low concentrations of serum n-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease patients with liver injury. Clin Chem Lab Med 49: 159-162(2011)

22. Wu J, Kubota J, Hirayama J, Nagai Y, Nishina S, Yokoi T, Asaoka Y, Seo J, Shimizu N, Kajiho H, Watanabe T, Azuma N, Katada T, Nishina H: p38 Mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription. Stem Cells Dev 19: 1723-1734(2010)

23. Nakazawa H, Ohnishi H, Okazaki H, Hashimoto S, Hotta H, Watanabe T, Ohkawa R, Yatomi Y, Nakajima K, Iwao Y, Takamoto S, Shimizu M, Iijima T: Impact of fresh frozen plasma from male-only donors versus mixed gender donors on postoperative respiratory function in surgical patients: a prospective case-controlled study. Transfusion 49: 2434-2441(2009)

24. Okazaki M, Ohkusu K, Hata H, Ohnishi H, Sugahara K, Kawamura C, Fujiwara N, Matsumoto S, Nishiuchi Y, Toyoda K, Saito H, Yonetani S, Fukugawa Y, Yamamoto M, Wada H, Sejimo A, Ebina A, Goto H, Ezaki T, Watanabe T: Mycobacterium kyorinense sp. nov., a novel slowly growing Mycobacterium sp. related to Mycobacterium celatum isolated from human clinical specimens. Int J Syst Evol Microbiol 59: 1336-1341(2009)

25. Ohnishi H, Urata T, Takano M, Kishino T, Watanabe T: A novel maneuver to prevent median nerve injury in phlebotomy. Ann Intern Med 151: 290-291(2009)

26. Shimizu N, Watanabe H, Kubota J, Wu J, Saito R, Yokoi T, Era T, Iwatsubo T, Watanabe T, Nishina S, Azuma N, Katada T, Nishina H: Pax6-5a promotes neuronal differentiation of murine embryonic stem cells. Biol Pharm Bull 32: 999-1003(2009)

27. Wada H, Yamamoto M, Okazaki M, Watanabe T, Goto H: Isolation of Mycobacterium kyorinense in a patient with respiratory failure.Ann Intern Med 150: 568-570(2009)

28. Ohnishi H, Hosoi K, Yoshino H, Sugiura M, Matsushima S, Watanabe T, Bessho F: A novel JAK2 splicing mutation in neonatal myeloproliferative disorder accompanying congenital anomalies. Br J Haematol 145: 676-678(2009)

29. Kishino T, Morii T, Mochizuki K, Sudo E, Hirano K, Okazaki M, Ohtuska K, Ohnishi H, Kurihara S, Tsuneyoshi M, Fujioka Y, Watanabe T: Unusual sonographic appearance of synovial sarcoma arising from the anterior abdominal wall. J Clin Ultrasound 37: 233-235(2009)

30. Ohnishi H, Taki T, Yoshino H, Takita J, Ida K, Ishii M, Nishida K, Hayashi Y, Taniwaki M, Bessho F, Watanabe T. A complex t(1;22;11)(q44;q13;q23) translocation causing
MLL-p300 fusion gene in therapy-related acute myeloid leukemia. Eur J Haematol 81:475-80 (2008)

31. Kishino T, Watanabe K, Urata T, Takano M, Uemura T, Nishikawa K, Mine Y, Matsumoto M, Ohtsuka K, Ohnishi H, Mori H, Takahashi S, Ishida H, Watanabe T: Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition. Clin Chim Acta 398:57-62 (2008)

32. Ohara-Imaizumi M, Fujiwara T, Nakamichi Y, Okamura T, Akimoto Y, Kawai J, Mtsushima S, Kawakami H, Watanabe T, Akagawa K, Nagamatsu S: Imaging analysis reveals mechanistic differences between first-and second-phase insulin exocytosis. J Cell Biol 177:695-705 (2007)

33. Ohnishi H, Kaniyu K, Iwasahita M, Tanaka A, Watanabe T: Fibrin monomer complex in normal pregnant women: a potential thrombotic marker in pregnancy. Ann Clin Biochem
44:449-454 (2007)

34. Ohtsuka K, Ohnishi H, Fujiwara M, Kishino T, Matsushima S, Furuyashiki G, Takei H, Koshiishi Y, Goya T, Watanabe T: Abnormalities of epidermal growth factor receptor in lung
squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas: tyrosine kinase domain mutations are not rare in tumors with an adenocarcinoma component. Cancer 109:741-750 (2007)

35. Ohnishi H, Kandabashi K, Maeda Y, Kawamura M, Watanabe T: Chronic eosinophilic leukaemia with FIP1L1-PDGFRA fusion and T6741 mutation that evolved from Langerhans cell histiocytosis with eosinophilia after chemotherapy. Br J Haematol 134:547-549 (2006)

36. Ohnishi H, Ohtsuka K, Ooide A, Matsushima S, Goya T, Watanabe T: A simple and sensitive method for detecting major mutations within the tyrosine kinase domain of the epidermal growth factor receptor gene in non-small-cell lung carcinoma. Diagn Mol Pathol 15:101-108 (2006)
所属学会 日本臨床検査医学会(評議員)
日本臨床化学会(評議員)
日本臨床検査自動化学会(評議員)
日本脳神経外科学会(評議員)
公的な委員会等の役員・委員歴 大学評価・学位授与機構(学位審査会専門委員)
学外活動 東京大学医学部講師
ひとことメッセージ 「臨床検査」を通じて人類の健康と福祉に貢献することを目標としています。
付属病院ホームページ ドクター紹介(2010年05月21日公開)
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