大学ホーム医学部教員紹介大塚 弘毅

教員紹介:大塚 弘毅

氏名 大塚 弘毅
フリガナ オオツカ コウキ
職位 講師
学内の役職・委員等 杏林大学医学部附属病院病院CPC運営委員会委員
所属教室 臨床検査医学
専攻・専門分野
 (大学院)
病理系専攻 臨床検査医学分野
担当科目(学部) がん分子診断
担当科目(大学院) がん分子診断
専門分野 がん分子診断
研究テーマ がん分子診断、発がんメカニズム解明、がん予防および早期発見、進行がん診療のバイオマーカー探索
略歴 1994年 鹿児島大学医学部卒業
1994年 杏林大学医学部第2外科入局
1996年 茨城県立地域がんセンター外科
1998年 国立がんセンター中央病院外科
2001年 杏林大学医学部第2外科助手
2001年 新潟県厚生連長岡中央綜合病院呼吸器外科医長
2006年 杏林大学医学部外科大学院医学博士課程修了
2006年 杏林大学臨床検査医学助教
2016年 杏林大学臨床検査医学講師、現在に至る
所有する学位 博士(医学)
指導医・専門医・認定医、その他の資格等 日本臨床検査医学会専門医、日本外科学会認定登録医、日本呼吸器外科学会認定登録医、日本胸部外科学会認定医
論文・著書等を含む主要研究業績 26: Yokoyama M, Ohnishi H, Ohtsuka K, Matsushima S, Ohkura Y, Furuse J, Watanabe T, Mori T, Sugiyama M. KRAS Mutation as a Potential Prognostic Biomarker of Biliary Tract Cancers. Jpn Clin Med. 2016;7:33-39.

25: Yoshiyama A, Morii T, Ohtsuka K, Ohnishi H, Tajima T, Aoyagi T, Mochizuki K, Satomi K, Ichimura S. Development of Stemness in Cancer Cell Lines Resistant to the Anticancer Effects of Zoledronic Acid. Anticancer Res. 2016; 36(2): 625-31.

24: Watanabe K, Kishino T, Sano J, Ariga T, Okuyama S, Mori H, Matsushima S, Ohtsuka K, Ohnishi H, Watanabe T. Relationship between epicardial adipose tissue thickness and early impairment of left ventricular systolic function in patients with preserved ejection fraction. Heart Vessels. 2016;31(6):1010-5.

23: Tomonori Kishino, Toshiyuki Mori, Shiho Kawai, Hideaki Mori, Kaori Nishikawa, Kazuhiko Hirano, Satsuki Matsushima, Kouki Ohtsuka, Hiroaki Ohnishi, Takashi Watanabe. Carcinosarcoma, an atypical subset of gallbladder malignancies. Journal of Medical Ultrasonics. 2014; 41(4): 487-490.

22: Hiroaki Ohnishi, Enrico Tortoli, Jesus Pais Ramos, Yuko Kazumi, Shota Yonetani, Satsuki Matsushima, Kouki Ohtsuka, Takashi Watanabe. Proposal of reclassification of Mycobacterium celatum type 2 as Mycobacterium kyorinense. Annals of Microbiology. 2014; 64:1879-82.

21: Morii T, Ohtsuka K, Ohnishi H, Mochizuki K, Yoshiyama A, Aoyagi T, Hornicek FJ, Ichimura S. BH3 Mimetics Inhibit Growth of Chondrosarcoma―A Novel Targeted Therapy for Candidate Models. Anticancer Res. 2014; 34(11):6423-30.

20: Ohtsuka K, Ohnishi H, Nozaki E, Pais Ramos J, Tortoli E, Yonetani S, Matsushima S, Tateishi Y, Matsumoto S, Watanabe T. Whole-Genome Sequence of Mycobacterium kyorinense. Genome Announc. 2014; 2(5). pii: e01062-14.

19: Matsushima S, Ohtsuka K, Ohnishi H, Fujiwara M, Nakamura H, Morii T, Kishino T, Goto H, Watanabe T. V843I, a lung cancer predisposing EGFR mutation, is responsible for resistance to EGFR tyrosine kinase inhibitors. J Thorac Oncol. 2014 ;9(9):1377-84.

18: Kishiki T, Ohnishi H, Masaki T, Ohtsuka K, Ohkura Y, Furuse J, Sugiyama M, Watanabe T. Impact of genetic profiles on the efficacy of anti-EGFR antibodies in metastatic colorectal cancer with KRAS mutation. Oncol Rep.
2014;32(1):57-64.

17: Kishiki T, Ohnishi H, Masaki T, Ohtsuka K, Ohkura Y, Furuse J, Watanabe T,Sugiyama M. Overexpression of MET is a new predictive marker for anti-EGFR therapy in metastatic colorectal cancer with wild-type KRAS. Cancer Chemother Pharmacol. 2014;73(4):749-57.

16: Aoyagi T, Morii T, Ohtsuka K, Ohnishi H, Tajima T, Yoshiyama A, Mochizuki K,Satomi K, Ichimura S. Lung cancer cell line sensitivity to Zoledronic acid is BAX-dependent. Anticancer Res. 2013;33(12):5357-63.

15: Fukugawa Y, Ohnishi H, Ishii T, Tanouchi A, Sano J, Miyawaki H, Kishino T, Ohtsuka K, Yoshino H, Watanabe T. Effect of carryover of clot activators on coagulation tests during phlebotomy. Am J Clin Pathol. 2012;137(6):900-3.

14: Campos CE, Caldas PC, Ohnishi H, Watanabe T, Ohtsuka K, Matsushima S, Ferreira NV, da Silva MV, Redner P, de Carvalho LD, Medeiros RF, Abbud Filho JA, Montes FC, Galvao TC, Ramos JP. First isolation of Mycobacterium kyorinense from clinical specimens in Brazil. J Clin Microbiol.2012;50(7):2477-8.

13: Kishino T, Ohnishi H, Ohtsuka K, Matsushima S, Watanebe K, Urata T, Honda Y, Matsumoto M, Mine Y, Nishikawa K, Mori H, Takahashi S, Ishida H, Watanabe T. Subcutaneous rather than visceral adipose tissue thickness of the abdomen correlates with alterations in serum fatty acid profile in Japanese women. Clin Chim Acta. 2011;412(19-20):1893-4.

12: Kita H, Shiraishi Y, Watanabe K, Suda K, Ohtsuka K, Koshiishi Y, Goya T. Does postoperative serum interleukin-6 influence early recurrence after curative pulmonary resection of lung cancer?. Ann Thorac Cardiovasc Surg.2011;17(5):454-60.

11: Ohtsuka K, Ohnishi H, Kurai D, Matsushima S, Morishita Y, Shinonaga M, Goto H, Watanabe T. Familial lung adenocarcinoma caused by the EGFR V843I germ-line mutation. J Clin Oncol. 2011;29(8):e191-2.

10: Sakata S, Fujiwara M, Ohtsuka K, Kamma H, Nagane M, Sakamoto A, Fujioka Y. ATP-binding cassette transporters in primary central nervous system lymphoma: decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells. Oncol Rep. 2011;25(2):333-9.

9: Kishino T, Ohnishi H, Ohtsuka K, Matsushima S, Urata T, Watanebe K, Honda Y, Mine Y, Matsumoto M, Nishikawa K, Mori H, Takahashi S, Ishida H, Watanabe T. Low concentrations of serum n-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease patients with liver injury. Clin Chem Lab Med. 2011;49(1):159-62.

8: Ohtsuka K, Ohnishi H, Morii T, Fujiwara M, Kishino T, Ogura W, Chiba M, Matsushima S, Goya T, Watanabe T. Downregulated ABCG2 enhances sensitivity to topoisomerase I inhibitor in epidermal growth factor receptor tyrosine kinase inhibitor-resistant non-small cell lung cancer. J Thorac Oncol. 2010;5(11):1726-33.

7: Morii T, Ohtsuka K, Ohnishi H, Mochizuki K, Satomi K. Inhibition of heat-shock protein 27 expression eliminates drug resistance of osteosarcoma to zoledronic acid. Anticancer Res. 2010;30(9):3565-71.

6: Kishino T, Morii T, Mochizuki K, Sudo E, Hirano K, Okazaki M, Ohtsuka K, Ohnishi H, Kurihara S, Tsuneyoshi M, Fujioka Y, Watanabe T. Unusual sonographic appearance of synovial sarcoma of the anterior abdominal wall. J Clin Ultrasound. 2009;37(4):233-5.

5: Kishino T, Watanabe K, Urata T, Takano M, Uemura T, Nishikawa K, Mine Y, Matsumoto M, Ohtsuka K, Ohnishi H, Mori H, Takahashi S, Ishida H, Watanabe T. Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition. Clin Chim Acta. 2008;398(1-2):57-62.

4: Ohtsuka K, Ohnishi H, Furuyashiki G, Nogami H, Koshiishi Y, Ooide A, Matsushima S, Watanabe T, Goya T. Clinico-pathological and biological significance of tyrosine kinase domain gene mutations and overexpression of epidermal growth factor receptor for lung adenocarcinoma. J Thorac Oncol. 2006;1(8):787-95.

3: Ohtsuka K, Ohnishi H, Fujiwara M, Kishino T, Matsushima S, Furuyashiki G, Takei H, Koshiishi Y, Goya T, Watanabe T. Abnormalities of epidermal growth factor receptor in lung squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas: tyrosine kinase domain mutations are not rare in tumors with an adenocarcinoma component. Cancer. 2007;109(4):741-50.

2: Ohnishi H, Ohtsuka K, Ooide A, Matsushima S, Goya T, Watanabe T. A simple and sensitive method for detecting major mutations within the tyrosine kinase domain of the epidermal growth factor receptor gene in non-small-cell lung carcinoma. Diagn Mol Pathol. 2006;15(2):101-8.

1: Hirayama K, Hanatsuka K, Ikeuchi T, Shida D, Ohtsuka K, Yoshimi F, Hori M, Itabashi M, Koyama A. Famotidine-induced acute interstitial nephritis. Nephrol Dial Transplant.1998;13(10):2636-8.
所属学会 日本臨床検査医学会、日本肺癌学会、日本外科学会、日本呼吸器外科学会
学外活動 1.Eminent Scientist of the Year 2008 International Award
2.World Journal of Respirology editorial board
3.Journal of Translational Internal Medicine editorial board
ひとことメッセージ がん分子診断を通してがん診療に貢献したいと思います。
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