大学ホーム医学部教員紹介大崎 敬子

教員紹介:大崎 敬子

氏名
 
大崎 敬子
オオサキ タカコ OSAKI, Takako
職位 教授
学内の役職・委員等 学生主任
所属教室 感染症学(微生物学)
専攻・専門分野
 (大学院)
病理系専攻 感染症・熱帯病学分野
担当科目(学部) 感染症・免疫学
担当科目(大学院) 医科学研究特論(医学研究科)
基礎医学特論(国際協力研究科)
専門分野 微生物学、感染症学
研究テーマ 家族間感染したヘリコバクター・ピロリの遺伝子解析と家族内感染の現状
ヘリコバクター・ピロリ感染者のマイクロビオータの解析
略歴 日本女子大学卒業
東海大学医学部生体防御機構系にて博士号(医学)取得
所有する学位 博士(医学)
論文・著書等を含む主要研究業績 1.Mishima Y, Osaki T, Shimada A, Kamiya S, Hasegawa-Ishii S: Sex‑dependent differences in the gut microbiota following chronic nasal inflammation in adult mice. Sci Rep 11(1).4640. 2021. 10.1038/s41598-021-83896-5
2.Rimbara E, Suzuki M, Matsui H, Nakamura M, Morimoto M, Sasakawa C, Masuda H5,6, Nomura S, Osaki T, Nagata N, Shibayama K, Tokunaga K: Isolation and characterization of Helicobacter suis from human stomach. Proc Natl Acad Sci USA. 118(13). 2021. 10.1073/pnas.2026337118.
3.Hojo F, Osaki T, Yonezawa H, Hanawa T, Kurata S, Kamiya S. Acanthamoeba castellanii supports extracellular survival of Helicobacter pylori in co-culture. J Infect Chemother. 2020;26(9):946-954. doi:10.1016/j.jiac.2020.04.016
4.Lin Y, Nakatochi M, Hosono Y, et al. Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. Nat Commun. 2020;11(1):3175. doi:10.1038/s41467-020-16711-w
5.Okuda M, Lin Y, Mabe K, Kato M, Osaki T, Miyamoto R, Okumura A, Kamiya S, Kikuchi S :Serum pepsinogen values in Japanese junior high school students and Helicobacter pylori infection. J Epidemiol. 30(1). 30-36. 2020. doi: 10.2188/jea.JE20180119.
6.Zaman C, Osaki T, Furuta Y, Hojo F, Yonezawa H, Konno M, Kurata S, Hanawa T, Kamiya S:Enhanced infectivity of strains of Helicobacter pyloriisolated from children compared with parental strains. J Med Microbiol 68(4):633-641, 2019 doi:10.1099/jmm.0.000918
7.Yonezawa H, Osaki T, Hojo F, Kamiya S: Effect of Helicobacter pyloribiofilm formation on susceptibility to amoxicillin, metronidazole and clarithromycin. Microb Pathog 132:100-108. doi:10.1016/j.micpath., 2019
8.Matsumoto H, Kuroki Y, Higashi S, Goda K, Fukushima S, Katsumoto R, Oosawa M, Murao T, Ishii M, Oka K, Takahashi M, Osaki T, Kamiya S, Shiotani A: Analysis of the colonic mucosa associated microbiota (MAM) using brushing samples during colonic endoscopic procedures. J Clin Biochem Nutr 65(2):132-137, 2019, doi:10.3164/jcbn.19-3.
9.Kamiya S, Yonezawa H, Osaki T: Role of probiotics in eradication therapy for Helicobacter pylori infection. Adv Exp Med Biol 369, 243-255, 2019. DOI: 10.1007/5584_2019_369.
10.Osaki T, Zaman C, Yonezawa H, Lin Y, Okuda M, Nozaki E, Hojo F, Kurata S, Hanawa T, Kikuchi S, Kamiya S. Influence of Intestinal Indigenous Microbiota on Intrafamilial Infection by Helicobacter pylori in Japan. Front Immunol, 21;9:287. doi: 10.3389/fimmu.2018.00287, 2018.
11.Oka K, Osaki T, Hanawa T, Kurata S, Sugiyama E, Takahashi M, Tanaka M, Taguchi H, Kamiya: Establishment of an Endogenous Clostridium difficile Rat Infection Model and Evaluation of the Effects of Clostridium butyricum MIYAIRI 588 Probiotic Strain. Front Microbiol. 9:1264. 2018. DOI: 10.3389/fmicb.2018.01264.
12.Osaki T, Mabe K, Zaman C, Yonezawa H, Okuda M, Amagai K, Fujieda S, Goto M, Shibata W, Kato M, Kamiya S : Usefulness of detection of clarithromycin-resistant Helicobacter pylori from fecal specimens for young adults treated with eradication therapy. Helicobacter 22(5), 2017. DOI: 10.1111/hel.12396. Epub 2017 May 22.
13.Kato S, Osaki T, Kamiya S, Zhang XS, Blaser MJ :  Helicobacter pylori sabA gene is associated with iron deficiency anemia in childhood and adolescence. PLoS One 12(8):e0184046, 2017. DOI: 10.1371/journal.pone.0184046.
14. Osaki T, Konno M, Yonezawa H, Hojo F, Takahashi M, Fujiwara S, Zaman C, Kamiya S. Analysis of intra-familial transmission of  Helicobacter pylori in Japanese families. J Med Microbiol. doi: 10.1099/jmm.0.080507-0. 2014
15. Osaki T, Okuda M, Ueda J, Konno M, Yonezawa H, Hojo F, Yagyu K, Lin Y, Fukuda Y, Kikuchi S, Kamiya S. Multi locus sequence typing for the analysis of intra-familial transmission of  Helicobacter pylori by using feacal specimens. Journal Med Microbiol. 62, 761-765. 2013
16. Osaki T, Matsuki T, Asahara T, Zaman C, Hanawa T, Yonezawa H, Kurata S, Woo T D.H, Nomoto K, Kamiya S. Comparative analysis of gastric bacterial microbiota in Mongolian gerbils after long-term infection with Helicobacter pylori. Microbial Pathogenesis,53:12-18. 2012.
17. Osaki T, Mabe K, Hanawa T and Kamiya S. Urease-positive bacteria in stomach induce false positive reaction on urea breath test for diagnosis of Helicobacter pylori. J Med Microbiol. 57:814-819. 2008.
所属学会 日本細菌学会(評議員、監事) 日本ヘリコバクター学会(理事) 日本無菌生物ノートバイオロジー学会(常任理事)腸内細菌学会(理事)臨床腸内細菌学会(評議員) 日本臨牀微生物学会 日本感染症学会 
学外活動 都立府中看護専門学校 非常勤講師
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