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大学ホーム保健学研究科教員一覧・オフィスアワー

教員詳細

項 目 内 容
教員名 渡部 和彦
フリガナ ワタベ カズヒコ
NAME Kazuhiko Watabe
職 位 教授
役職・委員(大学) 井の頭キャンパス 校医
研究テーマ・分野 1)運動ニューロンとグリア細胞の分子神経病理学,2)組換えウイルスベクターを用いた神経変性疾患の実験研究,3)神経幹細胞の発生生物学と体細胞リプログラミング,4)新しい神経系培養細胞株の樹立とミエリン形成
担当科目(学部) 神経内科学
担当科目(大学院) 神経病理学
略 歴 1981年 新潟大学医学部医学科卒業
1985年 新潟大学大学院医学研究科(脳研究所・実験神経病理学部門)修了
1985年 新潟大学脳研究所実験神経病理学部門・医員
1986年 British Columbia大学医学部神経内科・博士研究員
1989年 東京慈恵会医科大学第2内科学講座・助手
1991年 東京慈恵会医科大学神経科学研究部神経病理研究室・講師,第2内科学講座兼務
1997年 財団法人東京都神経科学総合研究所分子神経病理研究部門・副参事研究員,部門長,プロジェクトリーダー
2011年 公益財団法人東京都医学総合研究所神経変性病理・プロジェクトリーダー
2016年 杏林大学保健学部教授

1997年〜 新潟大学脳研究所病理学分野非常勤講師
1999年〜 岐阜大学医学部神経老年学分野非常勤講師
2014年〜 信州大学医学部神経難病学講座非常勤講師
2015年〜 東京女子医科大学病理学第一講座客員教授
2016年〜 公益財団法人東京都医学総合研究所ウイルス感染プロジェクト客員研究員
所有する学位等 医学博士(新潟大学)
所有する資格 医師免許,死体解剖資格
主要研究業績 <主要論文>
・Ishii T, Kawakami E, Endo K, Misawa H, Watabe K. Myelinating coculture of rodent stem cell line-derived neurons and immortalized Schwann cells. Neuropathology 2017;37:475-481.
・Ishii T, Kawakami E, Endo K, Misawa H, Watabe K. Formation and spreading of TDP-43 aggregates in cultured neuronal and glial cells demonstrated by time-lapse imaging. PLoS One 2017;12(6):e0179375.
・Hayashi K, Mochizuki Y, Takeuchi R, Shimizu T, Nagao M, Watabe K, Arai N, Oyanagi K, Onodera O, Hayashi M, Takahashi H, Kakita A, Isozaki E. Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V). Acta Neuropathol Commun 2016;4:107.
・Bokuda K, Shimizu T, Kimura H, Yamazaki T, Kamiyama T, Watabe K, Kawata A, Hayashi M, Isozaki E. Quantitative analysis of the features of fasciculation potentials and their relation with muscle strength in amyotrophic lateral sclerosis. Neurol Sci. 2016 Dec;37(12):1939-1945.
・Niimi N, Yako H, Tsukamoto M, Takaku S, Yamauchi J, Kawakami E, Yanagisawa H, Watabe K, Utsunomiya K, Sango K. Involvement of oxidative stress and impaired lysosomal degradation in amiodarone-induced schwannopathy. Eur J Neurosci 2016;44(1):1723-1733.
・Bokuda K, Shimizu T, Imamura K, Kawata A, Watabe K, Hayashi M, Nakayama Y, Isozaki E, Nakano I. Predictive factors for prognosis following unsedated percutaneous endoscopic gastrostomy in ALS patients. Muscle Nerve. 2016;54(2):277-283.
・Nakayama Y, Shimizu T, Hayashi K, Mochizuki Y, Nagao M, Watabe K, Kawata A, Nakano I, Oyanagi K. Predictors of impaired communication in amyotrophic lateral sclerosis patients with tracheostomy invasive ventilation. Amyotroph Lateral Scler Frontotemporal Degener 2015;17(1-2):38-46.
・Murakami T, Sango K, Watabe K, Niimi N, Takaku S, Li Z, Yamamura K, Sunada Y. Schwann cells contribute to neurodegeneration of transthyretin amyloidosis. J Neurochem 2015;134:66-74.
・Tsukamoto M, Sango K, Niimi N, Yanagisawa H, Watabe K, Utsunomiya K. Upregulation of galectin-3 in immortalized Schwann cells IFRS1 under diabetic conditions. Neurosci Res 2015;92:80-85.
・渡部和彦.筋萎縮性側索硬化症とニューロパチーの病態解明をめざして;運動ニューロン・シュワン細胞病変モデルの構築と解析.九州薬学会会報 2015;69:1-5.
・Watabe K, Akiyama K, Kawakami E, Ishii T, Endo K, Yanagisawa H, Sango K, Tsukamoto M. Adenoviral expression of TDP-43 and FUS genes and shRNAs for protein degradation pathways in rodent motoneurons in vitro and in vivo. Neuropathology 2014;34:83-98.
・渡部和彦.株化シュワン細胞を用いた末梢神経変性・再生機構の解析.末梢神経 2014;25:214-218.
・Sango K, Kawakami E, Yanagisawa H, Takaku S, Tsukamoto M, Utsunomiya K, Watabe K. Myelination in coculture of established neuronal and Schwann cell lines. Histochem Cell Biol 2012;137:829-839.
・Hashimoto K, Hayashi Y, Watabe K, Inuzuka T, Hozumi I. Metallothionein-III prevents neuronal death and prolongs life span in amyotrophic lateral sclerosis model mice. Neuroscience 2011;189:293-298.
・Sango K, Kawakami E, Yanagisawa H, Takaku S, Ajiki K, Endo K, Watabe K. Spontaneously immortalized adult rat Schwann cells IFRS1 as a vulnerable tool for exploring neuron-Schwann cell interactions. J Neurosci Res 2011;89:898-908.
・Fujita Y, Watabe K, Ikeda K, Mizuno Y, Okamoto K. Morphological changes of Golgi apparatus in rats after facial nerve injuries. Neuropathology 2011;31:42-47.
・渡部和彦,三五一憲.Schwann 細胞培養による病態解明.日本臨床,2010;68 増刊号9:637-640.
・Wada H, Yasuda T, Miura I, Watabe K, Sawa C, Kamijuku H, Kojo S, Taniguchi M, Nishino I, Wakana S, Yoshida H, Seino K. Establishment of an improved mouse model for infantile neuroaxonal dystrophy that shows early disease onset and bears a point mutation in Pla2g6. Am J Pathol 2009;175:2257-2263.
・Wang W, Itoh S, Konno K, Kikkawa T, Ichinose S, Sakai K, Ohkuma T, Watabe K. Effects of Schwann cell alignment along the oriented electrospun chitosan nanofibers on nerve regeneration. J Biomed Mater Res A 2009;91:994-1005.
・Hashimoto M, Ishii K, Nakamura Y, Watabe K, Kohsaka S, Akazawa C. Neuroprotective effect of Sonic hedgehog up-regulated in Schwann cells following sciatic nerve injury. J Neurochem 2008;107:918-927.
・Nagasao J, Hayashi Y, Kawazoe Y, Kawakami E, Watabe K, Oyanagi K. Relationship between ribosomal RNA gene transcription activity and motoneuron death: observations of avulsion and axotomy of the facial nerve in rats. J Neurosci Res 2008;86:435-442.
・Kawashima I, Watabe K, Tajima Y, Fukushige T, Kanzaki T, Kanekura T, Sugawara K, Ohyanagi N, Suzuki T, Togawa T, Sakuraba H. Establishment of immortalized Schwann cells from Fabry mice and their low uptake of recombinant α-galactosidase. J Hum Genet 2007;52:1018-1025.
・Mori Y, Shiotani A, Saito K, Araki K, Ikeda K, Nakagawa M, Watabe K, Ogawa K. A novel drug therapy for recurrent laryngeal nerve injury using T-588. Laryngoscope 2007;117:1313-1318.
・渡部和彦.近位軸索損傷モデルにおける運動神経細胞変性と治療.「ALS:研究と診療の進歩」,神経進歩 2007;59:1179-1186.
・Marubuchi S, Okuda T, Tagawa K, Enokido Y, Horiuchi D, Shimokawa R, Tamura T, Qi M-L, Eishi Y, Watabe K, Shibata M, Nakagawa M, Okazawa H. Hepatoma-derived growth factor, a new trophic factor for motor neurons, is up-regulated in the spinal cord of PQBP-1 transgenic mice before onset of degeneration. J Neurochem 2006;99:70-83.
・Hayashi Y, Kawazoe Y, Sakamoto T, Ojima M, Wang W, Takazawa T, Miyazawa D, Ohya W, Funakoshi H, Nakamura T, Watabe K. Adenoviral gene transfer of hepatocyte growth factor prevents death of injured adult motoneurons after peripheral nerve avulsion. Brain Res 2006;1111:187-195.
S・ango K, Suzuki T, Yanagisawa H, Takaku S, Hirooka H, Tamura M, Watabe K.. High glucose-induced activation of the polyol pathway and changes of gene expression profiles in immortalized adult mouse Schwann cells IMS32. J Neurochem 2006;98:446-458.
・Ito Y, Wiese S, Funk N, Chittka A, Rossoll W, Boemmel H, Watabe K, Wegner M, Sendtner M. Sox10 regulates ciliary neurotrophic factor (Cntf) gene expression in Schwann cells. Proc Natl Acad Sci USA 2006;103:7871-7876.
・Moro K, Shiotani A, Watabe K, Takeda Y, Saito K, Mori Y, Ogawa K. Adenoviral gene transfer of BDNF and GDNF synergistically prevent motoneuron loss in the nucleus ambiguus. Brain Res 2006;1076:1-8.
・Hozumi I, Uchida Y, Watabe K, Sakamoto T, Inuzuka T. Growth inhibitory factor (GIF) can protect brain damage after stab wounds in rat brain. Neurosci Lett 2006;395:220-223.
・Araki K, Shiotani A, Watabe K, Saito K, Moro K, Ogawa K. Adenoviral GDNF gene transfer enhances neurofunctional recovery after recurrent laryngeal nerve crush injury. Gene Ther 2006;13:296-303.
・Ohsawa M, Kotani M, Tajima Y, Tsuji D, Ishibashi Y, Kuroki A, Itoh K, Watabe K, Sango K, Yamanaka S, Sakuraba H. Establishment of immortalized Schwann cells from Sandhoff mice and corrective effect of recombinant human β-hexosaminidase A on the accumulated GM2 ganglioside. J Hum Genet 2005;50:460-467.
・Ikeda K, Aoki M, Kawazoe Y, Sakamoto Y, Hayashi Y, Ishigaki A, Nagai M, Kamii R, Kato S, Itoyama Y, Watabe K. Motoneuron degeneration after facial nerve avulsion is exacerbated in pre-symptomatic transgenic rats expressing human mutant Cu/Zn superoxide dismutase. J Neurosci Res 2005;82:63-70.
・Watabe K, Hayashi Y, Kawazoe Y. Peripheral nerve avulsion injuries as experimental models for adult motoneuron degeneration. Neuropathology 2005;25:371-380.
・Sango K, Tokashiki A, Ajiki K, Horie M, Kawano H, Watabe K, Horie H, Kadoya T. Synthesis, localization and externalization of galectin-1 in mature dorsal root ganglion neurons and Schwann cells. Eur J Neurosci 2004;19:55-64.
・Sakamoto T, Kawazoe Y, Uchida Y, Hozumi I, Inuzuka T, Watabe K. Growth inhibitory factor prevents degeneration of injured adult rat motoneurons. NeuroReport 2003;14:2147-2151.
・Ikeda K, Sakamoto T, Kawazoe Y, Marubuchi S, Nakagawa M, Ono S, Terashima N, Kinoshita M, Iwasaki Y, Watabe K. Oral administration of a neuroprotective compound T-588 prevents motoneuron degeneration after facial nerve avulsion in adult rats. Amyotroph Lateral Scler Other Motor Neuron Disord 2003;4:74-80.
・Sakamoto T, Kawazoe Y, Shen J-S, Takeda Y, Arakawa Y, Ogawa J, Oyanagi K, Ohashi T, Watanabe K, Inoue K, Eto Y, Watabe K. Adenoviral gene transfer of GDNF, BDNF and TGFβ2, but not CNTF, cardiotrophin-1 or IGF1, protects injured adult motoneurons after facial nerve avulsion. J Neurosci Res 2003;72:54-64.
・Watabe K, Sakamoto T, Kawazoe Y, Michikawa M, Miyamoto K, Yamamura T, Saya H, Araki N. Tissue culture methods to study neurological disorders: Establishment of immortalized Schwann cells from murine disease models. Neuropathology 2003;23:64-74.
・Saito K, Shiotani A, Watabe K, Moro K, Fukuda H, Ogawa K. Adenoviral GDNF gene transfer prevents motoneuron loss in the nucleus ambiguus. Brain Res 2003;962:61-67.
・Shen J-S, Watabe K, Meng XL, Ida H, Ohashi T, Eto Y. Establishment and characterization of spontaneously immortalized Schwann cells from murine model of globoid cell leukodystrophy (Twitcher). J Neurosci Res 2002;68:588-594.
・Shen JS, Watabe K, Ohashi T, Eto Y. Intraventricular administration of recombinant adenovirus to neonatal twitcher mouse leads to clinicopathological improvements. Gene Ther 2001;8:1081-1087.
・Watabe K, Ida H, Uehara K, Oyanagi K, Sakamoto T, Tanaka J, Garver WS, Miyawaki S, Ohno K, Eto Y. Establishment and characterization of immortalized Schwann cells from murine model of Niemann-Pick disease type C (spm/spm). J Peripher Nerv Syst 2001;6:85-94.
・Watabe K, Sakamoto T, Ohashi T, Kawazoe Y, Oyanagi K, Takeshima T, Inoue K, Eto Y, Kim SU. Adenoviral gene transfer of glial cell line-derived neurotrophic factor to injured adult motoneurons. Hum Cell 2001;14:7-15.
・Sakamoto T, Watabe K, Ohashi T, Kawazoe Y, Oyanagi K, Inoue K, Eto Y. Adenoviral vector-mediated GDNF gene transfer prevents death of adult facial motoneurons. NeuroReport 2000;11:1857-1860.
・Watabe K, Ohashi T, Sakamoto T, Kawazoe Y, Takeshima T, Oyanagi K, Inoue K, Eto Y, Kim SU. Rescue of lesioned adult rat spinal motoneurons by adenoviral gene transfer of glial cell line-derived neurotrophic factor. J Neurosci Res 2000;60:511-519.
・渡部和彦.Schwann細胞.生田房弘編,Glia細胞.クバプロ, 1999;p317-336.
・Ohashi T, Watabe K, Uehara K, Sly WS, Vogler C, Eto Y. Adenoviral-mediated gene transfer and expression of human β-glucuronidase gene in the liver, spleen, and central nervous system in MPS VII mice. Proc Natl Acad Sci USA 1997;94:1287-1292.
・Ohashi T, Watabe K, Sato Y, Saito I, Berranger JA, Eto Y. Successful transduction of oligodendrocytes and restoration of arylsulfatase A deficiency in metachromatic leukodystrophy fibroblasts using an adenovirus vector. Gene Ther 1995;2:443-449.
・Watabe K, Fukuda T, Tanaka J, Honda H, Toyohara K, Sakai O. Spontaneously immortalized adult mouse Schwann cells secrete autocrine and paracrine growth-promoting activities. J Neurosci Res 1995;41:279-290.
・Watabe K, Fukuda T, Tanaka J, Toyohara K, Sakai O. Mitogenic effects of platelet-derived growth factor, fibroblast growth factor, transforming growth factor-β, and heparin-binding serum factor for adult mouse Schwann cells. J Neurosci Res 1994;39:525-534.
・Yamada M., Watabe K, Saida T, Kim SU. Increased susceptibility of human fetal astrocytes to human T-lymphotropic virus type I in culture. J Neuropathol Exp Neurol 1991;50:97-107.
・Watabe K, Yamada M, Kawamura T, Kim SU. Transfection and stable transformation of adult mouse Schwann cells with SV-40 large T antigen gene. J Neuropathol Exp Neurol 1990;49:455-467.
・Kim SU, Yong VW, Watabe K, Shin DH. Human fetal Schwann cells in culture: phenotypic expressions and proliferative capability. J Neurosci Res 1989;22:50-59.
・Watabe K, Saida T, Kim SU. Human and simian glial cells infected by human T- lymphotropic virus type I in culture. J Neuropathol Exp Neurol 1989;48:610-619.
・Watabe K, Osborne D, Kim SU. Phagocytic activity of human adult astrocytes and oligodendrocytes in culture. J Neuropathol Exp Neurol 1989;48:499-506.
・Matsumoto Y, Watabe K, Ikuta F. Immunohistochemical study on neuroglia identified by the monoclonal antibody against a macrophage differentiation antigen (Mac-1). J Neuroimmunol 1985;9:379-389.
・Yoshida Y, Ikuta F, Watabe K, Nagata T. Developmental microvascular architecture of the rat cerebellar cortex. Anat Embryol 1985;171:129-138.
・Kumanishi T, Watabe K, Washiyama K. An immunohistochemical study of aldolase C in normal and neoplastic nervous tissues. Acta Neuropathol 1985;67:309-314.
・Kumanishi T, Washiyama K, Watabe K, Sekiguchi K. Glial fibrillary acidic protein in medulloblastomas. Acta Neuropathol (Berl) 1985;67:1-5.
・Kumanishi T, Watabe K, Washiyama K. A mouse hybridoma cell line producing a monoclonal antibody specific for the S-100α subunit: Reactivity of the antibody with brains of various animal species. Biomed Res 1984;5:335-346.
・Watabe K, Kumanishi T, Ikuta F, Oyake Y. Tactile-like corpuscles in neurofibromas: Immunohistochemical demonstration of S-100 protein. Acta Neuropathol (Berl) 1983;61:173-177.
<産業財産権>
・大熊恒雄,石川和裕,境勝義,渡部和彦,伊藤聰一郎.「細胞培養基材,及び細胞培養基材の製造方法」特許第5124125号(2012年11月2日,国内).
http://astamuse.com/ja/published/JP/No/2008113580
・渡部和彦.「神経幹細胞の製造方法」特許第4792290号(2011年7月29日,国内).
http://astamuse.com/ja/published/JP/No/2007174954
所属学会 日本神経病理学会(理事),日本神経化学会(評議員),日本神経学会,日本神経科学学会,日本ライソゾーム病研究会(幹事),神経組織培養研究会(事務局長),神経代謝病研究会(幹事),American Association of Neuropathologists (Active), Society for Neuroscience
公的な委員会等の役員・委員歴 2007年〜 国立研究開発法人物質・材料研究機構 遺伝子組換え実験委員会外部委員
2009年〜 Research Grant Council of Hong Kong; External Reviewer
2012年〜 医療法人社団杉浦医院治験審査委員会委員長
居室・研究室 井の頭キャンパス B棟 506室,426室
メールアドレス watabe@ks.kyorin-u.ac.jp
オフィスアワー 月曜日の12時から 13時まで B506室
関連サイト https://www.researchgate.net/profile/Kazuhiko_Watabe

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