杏林大学医学部 衛生学公衆衛生学教室

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業績(2009年以降)

原著論文

  • Swann JB, Weyn A, Nagakubo D, Bleul CC, Toyoda A, Happe C, Netuschil N, Hess I, Haas-Assenbaum A, Taniguchi Y, Schorpp M, Boehm T. Conversion of the thymus into a bipotent lymphoid organ by replacement of FOXN1 with its paralog, FOXN4. Cell Rep. 8:1184-1197, 2014
  • Nagao Y, Suzuki T, Shimizu A, Kimura T, Seki R, Adachi T, Inoue C, Kamei Y, Hara I, Taniguchi Y, Naruse K, Wakamatsu Y, Kelsh RN, Hibi M, Hashimoto H. Sox5 functions as a fate switch in medaka pigment cell development. PLoS Genetics, 10:e1004246, 2014
  • Okuyama T, Yokoi S, Abe H, Isoe Y, Suehiro Y, Imada H, Tanaka M, Kawasaki T, Yuba S, Taniguchi Y, Kamei Y, Okubo K, Shimada A, Naruse K, Takeda H, Oka Y, Kubo T, Takeuchi H. A neural mechanism underlying mating preferences for familiar individuals in medaka fish. Science., 343:91-94, 2014
  • Chisada S, Kurokawa T, Murashita K, Rønnestad I, Taniguchi Y, Toyoda A, Sakaki Y, Takeda S, Yoshiura Y. Leptin receptor-deficient (knockout) medaka, Oryzias latipes, show chronical up-regulated levels of orexigenic neuropeptides, elevated food intake and stage specific effects on growth and fat allocation. Gen Comp Endocrinol., 195:9-20, 2013
  • Kikuchi K, Narita T, Pham VT, Iijima J, Hirota K, Keka IS, Mohiuddin M, Okawa K, Hori T, Fukagawa T, Essers J, Kanaar R, Whitby MC, Sugasawa K, Taniguchi Y, Kitagawa K, Takeda S. Structure-specific endonucleases Xpf and Mus81 play overlapping but essential roles in DNA repair by homologous recombination. Cancer Res., 73:4362-4371, 2013
  • Matsui H, Sato F, Sato S, Koike M, Taruno Y, Saiki S, Funayama M, Ito H, Taniguchi Y, Uemura N, Toyoda A, Sakaki Y, Takeda S, Uchiyama Y, Hattori N, Takahashi R. ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons. FEBS Lett. 587:1316-25, 2013
  • Matsui H, Gavinio R, Asano T, Uemura N, Ito H, Taniguchi Y, Kobayashi Y, Maki T, Shen J, Takeda S, Uemura K, Yamakado H, Takahashi R. PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. Hum Mol Genet. 22:2423-2434, 2013
  • Ishikawa T, Okada T, Ishikawa-Fujiwara T, Todo T, Kamei Y, Shigenobu S, Tanaka M, Saito TL, Yoshimura J, Morishita S, Toyoda A, Sakaki Y, Taniguchi Y, Takeda S, Mori K. ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish. Mol Biol Cell. 24:1387-1395, 2013
  • Morita A, Nakahira K, Hasegawa T, Uchida K, Taniguchi Y, Takeda S, Toyoda A, Sakaki Y, Shimada A, Takeda H, Yanagihara I. Establishment and characterization of Roberts syndrome and SC phocomelia model medaka (Oryzias latipes). Dev Growth Differ. 54:588-604, 2012
  • Isoe Y, Okuyama T, Taniguchi Y, Kubo T, Takeuchi H. p53 Mutation suppresses adult neurogenesis in medaka fish (Oryzias latipes). Biochem Biophys Res Commun. 423:627-631, 2012
  • Nakamura S, Watakabe I, Nishimura T, Picard JY, Toyoda A, Taniguchi Y, di Clemente N, Tanaka M. Hyperproliferation of mitotically active germ cells due to defective anti-Müllerian hormone signaling mediates sex reversal in medaka. Development. 139:2283-2287, 2012
  • Nakamura S, Watakabe I, Nishimura T, Toyoda A, Taniguchi Y, Tanaka M. Analysis of medaka sox9 orthologue reveals a conserved role in germ cell maintenance. PLoS One. 7:e29982, 2012
  • Ishikawa T, Taniguchi Y, Okada T, Takeda S, Mori K. Vertebrate Unfolded Protein Response: Mammalian Signaling Pathways Are Conserved in Medaka Fish. Cell Struct Funct. 36:247-259, 2011
  • Chisada S, Okamoto H, Taniguchi Y, Kimori Y, Toyoda A, Sakaki Y, Takeda S, Yoshiura Y. Myostatin-deficient medaka exhibit a double-muscling phenotype with hyperplasia and hypertrophy, which occur sequentially during post-hatch development. Dev Biol. 359:82-94, 2011
  • Matsui H, Ito H, Taniguchi Y, Takeda S, Takahashi R. Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson’s disease-like phenotypes in medaka fish. J Neurochem. 115:1150-1160, 2010
  • Jurado S, Smyth I, van Denderen B, Tenis N, Hammet A, Hewitt K, Ng JL, McNees CJ, Kozlov SV, Oka H, Kobayashi M, Conlan LA, Cole TJ, Yamamoto K, Taniguchi Y, Takeda S, Lavin MF, Heierhorst J. Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis. PLoS Genet. 6:e1001170, 2010
  • Iijima J, Zeng Z, Takeda S, Taniguchi Y. RAP80 acts independently of BRCA1 in repair of topoisomerase II poison-induced DNA damage. Cancer Res. 70:8467-8474, 2010
  • Matsui H, Ito H, Taniguchi Y, Inoue H, Takeda S, Takahashi R. Proteasome inhibition in medaka brain induces the features of Parkinson disease. J Neurochem. 115:178-187, 2010
  • Nakamura K, Kogame T, Oshiumi H, Shinohara A, Sumitomo Y, Agama K, Pommier Y, Tsutsui KM, Tsutsui K, Hartsuiker E, Ogi T, Takeda S, Taniguchi Y. Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair. PLoS Genet. 6:e1000828, 2010
  • Matsui H, Taniguchi Y, Inoue H, Kobayashi Y, Sakaki Y, Toyoda A, Uemura K, Kobayashi D, Takeda S, Takahashi R. Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement. Neurosci Res. 66:151-61, 2010
  • Schartl M, Wilde B, Laisney J, Taniguchi Y, Takeda S, Meierjohann S. A mutated EGFR is sufficient to induce malignant melanoma with genetic background dependent histopathologies. J Invest Dermatol., 130:249-58, 2010
  • Ji K, Kogame T, Choi K, Wang X, Lee J, Taniguchi Y, Takeda S. A novel approach using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants. Environ Health Perspect. 117:1737-44, 2009
  • Kawasaki T, Saito K, Mitsui K, Ikawa M, Yamashita M, Taniguchi Y, Takeda S, Mitani K, Sakai N. Introduction of a foreign gene into zebrafish and medaka cells using adenoviral vectors. Zebrafish 6:253-8, 2009
  • Matsui H, Taniguchi Y, Inoue H, Uemura K, Takeda S, Takahashi R. A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish. Neurosci Res. 65:263-71, 2009
  • Kikuchi K, Abdel-Aziz HI, Taniguchi Y, Yamazoe M, Takeda S, Hirota K. Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences. J Biol Chem. 284:26360-7, 2009
  • Nakahara M, Sonoda E, Nojima K, Sale JE, Takenaka K, Kikuchi K, Taniguchi Y, Nakamura K, Sumitomo Y, Bree RT, Lowndes NF, Takeda S. Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig V in chicken B lymphocytes. PLoS Genetics. 5:e1000356, 2009

総説

  • 谷口善仁、大北倫
    遺伝子改変小型実験魚が拓く新たな挑戦・メダカで大魚は釣れるか 
    実験医学、羊土社、29:1449-1454, 2011
  • 山本君代、河野公一、谷口善仁
    遺伝薬理学的手法を利用した化学物質の変異原性と抗癌剤シーズのハイスループットスクリーニング法
    細胞工学 29:67-72, 2010
  • 谷口善
    化学物質対策に関する法律
    Modern Physician 30:1346-1348, 2010
  • 谷口善仁, 武田俊一
    魚類を利用した創薬
    実験医学 27:805-810, 2009

著書

  • 谷口善仁
    化審法と化管法
    医療従事者のためのこれだけは知っておきたい61の法律、金芳堂、368-373、2011
  • Y. Taniguchi
    p53-deficient medaka created by TILLING
    Medaka: Model for Organogenesis, Human Diseases and Evolution. Springer, 157-172, 2011