{"id":107,"date":"2022-02-15T15:14:07","date_gmt":"2022-02-15T06:14:07","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/_manage\/?page_id=107"},"modified":"2025-06-24T17:14:06","modified_gmt":"2025-06-24T08:14:06","slug":"infection","status":"publish","type":"page","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/infection\/","title":{"rendered":"\u611f\u67d3\u75c7\u5b66\u6559\u5ba4"},"content":{"rendered":"<section class=\"BlkAnchorArea\"><div class=\"BlkAnchorArea__inner\"><ul class=\"anchorMenu\"><li><a class=\"p-anchor\" href=\"#teacher\"><span>\u6559\u54e1<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#summary\"><span>\u6982\u8981<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#study\"><span>\u7814\u7a76<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#achieve\"><span>\u696d\u7e3e<\/span><\/a><\/li><\/ul><\/div><\/section> <a id=\"teacher\" name=\"teacher\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u6559\u5ba4\u5c02\u4efb\u6559\u54e1<\/h2>\r\n  \n<!-- staffdb 2023.08.15 -->\n<div><table class=\"BlkArticle__tableNormal BlkArticle__tableNormal--topLeft\" width=\"100%\" data-update=\"2023.08.15\"><tbody><tr><th>\u6559\u6388<\/th><td><ul class=\"list-on-td\"><li data-sort=\"50000\uff0f53006\"><a href=\"\/univ\/faculty\/medicine\/education\/staffnew\/detail\/?id=med53006\" class=\"arrow\">\u4e09\u6238\u90e8\u3000\u6cbb\u90ce<\/a><\/li><\/ul><\/td><\/tr><tr><th>\u51c6\u6559\u6388<\/th><td><ul class=\"list-on-td\"><li data-sort=\"0\uff0f53008\"><a href=\"\/univ\/faculty\/medicine\/education\/staffnew\/detail\/?id=med53008\" class=\"arrow\">\u68ee\u7530\u3000\u9244\u5175<\/a><\/li><\/ul><\/td><\/tr><tr><th>\u8b1b\u5e2b<\/th><td><ul class=\"list-on-td\"><li data-sort=\"0\uff0f53007\"><a href=\"\/univ\/faculty\/medicine\/education\/staffnew\/detail\/?id=med53007\" class=\"arrow\">\u9808\u85e4\u3000\u76f4\u6a39<\/a><\/li><\/ul><\/td><\/tr><\/tbody><\/table><\/div> <\/section>\r\n<a id=\"summary\" name=\"summary\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u6559\u5ba4\u6982\u8981<\/h2>\r\n  <p>\u5fae\u751f\u7269\u5b66\u5206\u91ce\u3067\u306f\u4e3b\u306b\u6d88\u5316\u5668\u306e\u7d30\u83cc\u611f\u67d3\u75c7\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u5ba4\u306e\u65b9\u91dd\u3068\u3057\u3066\u57fa\u790e\u7814\u7a76\u3092\u901a\u3057\u3066\u611f\u67d3\u75c7\u306e\u8a3a\u65ad\u3001\u75c5\u614b\u89e3\u660e\u3001\u6cbb\u7642\u306a\u3069\u81e8\u5e8a\u533b\u5b66\u3068\u306e\u9023\u643a\u3092\u5fd7\u5411\u3057\u305f\u611f\u67d3\u75c7\u5b66\u306e\u63a2\u6c42\u3092\u884c\u3046\u3053\u3068\u3092\u76ee\u6a19\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u4ed6\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\u3082\u7a4d\u6975\u7684\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\r\n  <p>\u307e\u305f\u81e8\u5e8a\u90e8\u9580\u304b\u3089\u306e\u5bc4\u751f\u866b\u611f\u67d3\u75c7\u5168\u822c\u306e\u30b3\u30f3\u30b5\u30eb\u30c6\u30fc\u30b7\u30e7\u30f3\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<section class=\"BlkArticle__Contents\">\r\n  <h2>\u6559\u80b2\u306e\u7279\u8272<\/h2>\r\n  <p>\u4e8c\u5e74\u9593\u306b\u308f\u305f\u308a\u6388\u696d\u3092\u62c5\u5f53\u3059\u308b\u6559\u5ba4\u3067\u3059\u3002\u5c02\u9580\u6027\u306e\u9ad8\u3044\u75c5\u539f\u4f53\u306f\u56fd\u7acb\u5065\u5eb7\u5371\u6a5f\u7ba1\u7406\u7814\u7a76\u6a5f\u69cb\uff08\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\uff09\u7b49\u306e\u5916\u90e8\u306e\u5c02\u9580\u5bb6\u3092\u62db\u8058\u3057\u3001\u30a2\u30c3\u30d7\u30c7\u30fc\u30c8\u306a\u6388\u696d\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <p>\u533b\u5b66\u90e8\uff12\u5e74\u751f\u300c\u71b1\u5e2f\u75c5\u30fb\u5bc4\u751f\u866b\u5b66\u300d\u300c\u57fa\u790e\u611f\u67d3\u75c7\u5b66\u300d<\/p>\r\n  <p>\u533b\u5b66\u90e83\u5e74\u751f\u300c\u514d\u75ab\u5b66\u300d<\/p>\r\n  <p>\u71b1\u5e2f\u75c5\u30fb\u5bc4\u751f\u866b\u5b66\uff1a\u533b\u5b66\u90e8\uff12\u5e74\u751f\uff08M2\uff09\u524d\u671f\u306b\u96c6\u4e2d\u3057\u3066\u884c\u308f\u308c\u307e\u3059\u3002\u4e16\u754c\u4e2d\u3067\u554f\u984c\u306b\u306a\u3063\u3066\u3044\u308b\u71b1\u5e2f\u75c5\u3001\u885b\u751f\u52d5\u7269\u306e\u7bc4\u56f2\u306a\u3069\u3092\u5b66\u3073\u307e\u3059\u30026\uff5e7\u6708\u306b\u304b\u3051\u3066\u884c\u308f\u308c\u308b\u5b9f\u7fd2\u3067\u306f\u3001\u8d64\u75e2\u30a2\u30e1\u30fc\u30d0\u3084\u30e9\u30f3\u30d6\u30eb\u97ad\u6bdb\u866b\u306e\u751f\u9bae\u6a19\u672c\u89b3\u5bdf\u3001\u751f\u9bae\u9b5a\u985e\u304b\u3089\u306e\u30a2\u30cb\u30b5\u30ad\u30b9\u691c\u51fa\u306a\u3069\u3092\u884c\u3044\u3001\u5b9f\u969b\u306b\u751f\u304d\u3066\u3044\u308b\u5bc4\u751f\u866b\u3092\u89b3\u5bdf\u3059\u308b\u3053\u3068\u3067\u3001\u5bc4\u751f\u866b\u75c7\u306e\u75c5\u614b\u3001\u691c\u67fb\u3001\u6cbb\u7642\u3001\u4e88\u9632\u3078\u306e\u7406\u89e3\u3092\u6df1\u3081\u307e\u3059\u3002<\/p>\r\n  <p>\u57fa\u790e\u611f\u67d3\u75c7\u5b66\uff1a M2\u5f8c\u671f\u306b\u7d30\u83cc\u5b66\u30fb\u30a6\u30a4\u30eb\u30b9\u5b66\u30fb\u771f\u83cc\u5b66\u306b\u95a2\u3059\u308b\u8b1b\u7fa9\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u300210\u6708\u306b\u884c\u308f\u308c\u308b\u5b9f\u7fd2\u3067\u306f\uff11\u9031\u9593\u304b\u3051\u3066\u30b0\u30e9\u30e0\u67d3\u8272\u624b\u6280\u306b\u719f\u9054\u3057\u3001\u75c5\u539f\u7d30\u83cc\u306e\u5206\u96e2\u3001\u540c\u5b9a\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u691c\u51fa\u3001\u81e8\u5e8a\u691c\u67fb\u306b\u6b20\u304b\u305b\u306a\u3044\u6297\u4f53\u6e2c\u5b9a\u6cd5\u306b\u3064\u3044\u3066\u7406\u89e3\u3092\u6df1\u3081\u307e\u3059\u3002<\/p>\r\n  <p>\u514d\u75ab\u5b66\uff1a\u4ee4\u548c\uff16\u5e74\u5ea6\u3088\u308a\u3001\u57fa\u790e\u611f\u67d3\u75c7\u5b66\u304b\u3089\u300c\u514d\u75ab\u5b66\u300d\u304c\u533b\u5b66\u90e83\u5e74\u751f\uff08M3\uff09\u306b\u79fb\u884c\u3057\u307e\u3057\u305f\u3002\u524d\u534a\u306b\u57fa\u790e\u3092\u5b66\u3073\u3001\u5f8c\u534a\u306f\u6d88\u5316\u5668\u5185\u79d1\u5b66\u3001\u81e8\u5e8a\u611f\u67d3\u75c7\u5b66\u3001\u814e\u81d3\u30fb\u30ea\u30a6\u30de\u30c1\u81a0\u539f\u75c5\u5185\u79d1\u5b66\u3001\u5c0f\u5150\u79d1\u5b66\u3001\u816b\u760d\u5185\u79d1\u5b66\u3001\u76ae\u819a\u79d1\u5b66\u3001\u547c\u5438\u5668\u5185\u79d1\u5b66\u3001\u8133\u795e\u7d4c\u5185\u79d1\u5b66\u3001\u8840\u6db2\u5185\u79d1\u5b66\u3001\u7523\u5a66\u4eba\u79d1\u5b66\u306e\u5354\u529b\u3092\u5f97\u3066\u3001\u767a\u5c55\u304c\u8457\u3057\u3044\u514d\u75ab\u5b66\u306e\u5206\u91ce\u3092\u5404\u8a3a\u7642\u79d1\u306e\u30a2\u30c3\u30d7\u30c7\u30fc\u30c8\u306a\u514d\u75ab\u6cbb\u7642\u30fb\u7406\u8ad6\u3092\u30aa\u30e0\u30cb\u30d0\u30b9\u5f62\u5f0f\u3067\u4e00\u671b\u3067\u304d\u308b\u6a5f\u4f1a\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u533b\u5b66\u90e86\u5e74\u751f\uff08M6\uff09\u306e\u81e8\u5e8a\u7dcf\u5408\u6f14\u7fd2\u300c\u6d88\u5316\u5668\u611f\u67d3\u75c7\u300d\u3067\u306f\u56fd\u5bb6\u8a66\u9a13\u554f\u984c\u306e\u6f14\u7fd2\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u793e\u4f1a\u7684\u6d3b\u52d5<\/h2>\r\n  <p>\u65e5\u672c\u7121\u83cc\u751f\u7269\u30ce\u30fc\u30c8\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u5b66\u4f1a<\/p>\r\n    <p>\u65e5\u672c\u7d30\u83cc\u5b66\u4f1a<\/p>\r\n    <p>\u5927\u8178\u83cc\u7814\u7a76\u4f1a<\/p>\r\n    <p>\u7d4c\u6e08\u7523\u696d\u7701\u30fb\u7523\u696d\u69cb\u9020\u5be9\u8b70\u4f1a\u81e8\u6642\u59d4\u54e1<\/p>\r\n    <p>\u65e5\u7c73\u533b\u5b66\u5354\u529b\u7814\u7a76\u4f1a\u30b3\u30ec\u30e9\u30fb\u7d30\u83cc\u6027\u8178\u7ba1\u611f\u67d3\u75c7\u5c02\u9580\u90e8\u4f1a\u3000\u30d1\u30cd\u30eb\u30e1\u30f3\u30d0\u30fc<\/p>\r\n    <p>\u65e5\u672c\u5bc4\u751f\u866b\u5b66\u4f1a\u30fb\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u306a\u3069\u306b\u6240\u5c5e\u3057\u6d3b\u767a\u306b\u6d3b\u52d5\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <!--ul class=\"BlkArticle__listCircle\">\r\n    <li>\u65e5\u672c\u7121\u83cc\u751f\u7269\u30ce\u30fc\u30c8\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u5b66\u4f1a<\/li>\r\n    <li>\u65e5\u672c\u7d30\u83cc\u5b66\u4f1a<\/li>\r\n    <li>\u5927\u8178\u83cc\u7814\u7a76\u4f1a<\/li>\r\n    <li>\u7d4c\u6e08\u7523\u696d\u7701\u30fb\u7523\u696d\u69cb\u9020\u5be9\u8b70\u4f1a\u81e8\u6642\u59d4\u54e1<\/li>\r\n    <li>\u65e5\u7c73\u533b\u5b66\u5354\u529b\u7814\u7a76\u4f1a\u30b3\u30ec\u30e9\u30fb\u7d30\u83cc\u6027\u8178\u7ba1\u611f\u67d3\u75c7\u5c02\u9580\u90e8\u4f1a\u3000\u30d1\u30cd\u30eb\u30e1\u30f3\u30d0\u30fc<\/li>\r\n    <li>\u65e5\u672c\u5bc4\u751f\u866b\u5b66\u4f1a\u30fb\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u306a\u3069\u306b\u6240\u5c5e\u3057\u6d3b\u767a\u306b\u6d3b\u52d5\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\r\n  <\/ul--> \r\n<\/section>\r\n<a id=\"study\" name=\"study\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u7814\u7a76\u30c6\u30fc\u30de<\/h2>\r\n  <p>\u611f\u67d3\u75c7\u5b66\u6559\u5ba4\u306e\u7814\u7a76\u5bfe\u8c61\u306f\u7d30\u83cc\u30fb\u30a6\u30a4\u30eb\u30b9\u30fb\u771f\u83cc\u30fb\u5bc4\u751f\u866b\u3068\u5e45\u5e83\u3044\u3067\u3059\u304c\u3001\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u7279\u306b\u7d30\u83cc\u611f\u67d3\u75c7\u306e\u75c5\u614b\u89e3\u6790\u3084\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3059\u308b\u7814\u7a76\u3068\u30b2\u30ce\u30e0\u89e3\u6790\u306b\u3088\u308b\u611f\u67d3\u7d4c\u8def\u3084\u5b9a\u7740\u306b\u304a\u3051\u308b\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30bf\u306e\u5f79\u5272\u306e\u89e3\u660e\u3092\u4e3b\u4f53\u3068\u3057\u3066\u6307\u5c0e\u3057\u3066\u304a\u308a\u3001\u4ee5\u4e0b\u306b\u6319\u3052\u308b\u8af8\u70b9\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u73fe\u5728\u9032\u884c\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <h3>\u8d64\u75e2\u83cc\u306e\u75c5\u539f\u6027\u767a\u73fe\u6a5f\u69cb\u306e\u89e3\u6790\u3068\u30ef\u30af\u30c1\u30f3\u958b\u767a<\/h3>\r\n  <p>\u8d64\u75e2\u83cc\u306b\u306f\u6709\u52b9\u306a\u30ef\u30af\u30c1\u30f3\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u8d64\u75e2\u83cc\u306e\u75c5\u539f\u56e0\u5b50\u3067\u3042\u308b\uff13\u578b\u5206\u6ccc\u88c5\u7f6e\u306f\u3001RNA\u7d50\u5408\u86cb\u767dHfq\u304c\u6b20\u640d\u3059\u308b\u3068\u6291\u5236\u304c\u5931\u308f\u308c\u3001\u767a\u73fe\u304c\u5897\u3048\u308b\u3053\u3068\u304b\u3089\u8ee2\u5199\u3067\u306f\u306a\u304fmRNA\u30ec\u30d9\u30eb\u3067\u8abf\u7bc0\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u822c\u306bHfq\u304c\u6b20\u640d\u3057\u305f\u75c5\u539f\u83cc\u306f\u5f31\u75c5\u539f\u5316\u3059\u308b\u305f\u3081\u3001\u3053\u306e\u682a\u306f\u30ef\u30af\u30c1\u30f3\u5019\u88dc\u3068\u3057\u3066\u5229\u7528\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u901a\u5e38\u3001\u7d30\u83cc\u306e\u30ef\u30af\u30c1\u30f3\u306f\u8840\u6e05\u578b\u306b\u4f9d\u5b58\u3059\u308b\u3082\u306e\u304c\u591a\u6570\u3067\u3059\u304c\u3001\u3053\u306e\u682a\u306f\u8907\u6570\u306e\u8840\u6e05\u578b\u306e\u8d64\u75e2\u83cc\u306b\u5bfe\u3057\u3066\u52d5\u7269\u5b9f\u9a13\u30ec\u30d9\u30eb\u3067\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u3001\u56fd\u7acb\u5065\u5eb7\u5371\u6a5f\u7ba1\u7406\u7814\u7a76\u6a5f\u69cb\uff08\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\uff09\u3001\u30a4\u30f3\u30c9\u56fd\u7acb\u7d30\u83cc\u611f\u67d3\u75c7\u7814\u7a76\u6240(NIRBI)\u3068\u6539\u826f\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <div class=\"BlkArticle__figureList\">\r\n    <figure><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/2024\/07\/image1.png\" width=\"465\" alt=\"\">\r\n      <figcaption>\u30a4\u30f3\u30c9NIRBI\u3067\u5b9f\u9a13\u4e2d<\/figcaption>\r\n    <\/figure>\r\n  <\/div>\r\n  <h3>\u687f\u83cc\u306e\u5f62\u614b\u5f62\u6210\u306b\u95a2\u308f\u308bRodZ\u86cb\u767d\u306e\u7814\u7a76<\/h3>\r\n  <p>Hfq\u3068\u540c\u69d8\u306b\u3001\u6b20\u640d\u3055\u305b\u308b\u3068\u8d64\u75e2\u83cc\u306e\u75c5\u539f\u56e0\u5b50\u306e\u6291\u5236\u304c\u306a\u304f\u306a\u308b\u5225\u306eRNA\u7d50\u5408\u86cb\u767d\u3092\u540c\u5b9a\u3057\u305f\u3068\u3053\u308d\u3001\u610f\u5916\u306a\u3053\u3068\u306b\u687f\u83cc\u306e\u687f\u72b6\u306e\u5f62\u614b\u3092\u7dad\u6301\u3059\u308bRodZ\u3068\u3044\u3046\u819c\u86cb\u767d\u3068\u540c\u3058\u3082\u306e\u3067\u3057\u305f\u3002\u7cbe\u88fd\u3057\u305fRodZ\u306f\u6eb6\u89e3\u6027\u304c\u826f\u3044\u9ad8\u5206\u5b50\u91cf\u306e\u584a\u3092\u5f62\u6210\u3059\u308b\u305f\u3081\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\uff16\u91cf\u4f53\u306e\u57fa\u672c\u69cb\u9020\u304c\u591a\u6570\u96c6\u5408\u3057\u305f\u300c\u8d85\u69cb\u9020\u300d\u3092\u3068\u308b\u3053\u3068\u3067RNA\u7d50\u5408\u6d3b\u6027\u3092\u6301\u3061\u3001\u751f\u304d\u3066\u3044\u308b\u83cc\u306b\u3082\u8d85\u69cb\u9020\u304c\u542b\u307e\u308c\u308b\u3053\u3068\u3001\u8d85\u89e3\u50cf\u5ea6\u9855\u5fae\u93e1\u306e\u89b3\u5bdf\uff08\u5199\u771f\uff09\u3067RodZ\u306e\u8d85\u69cb\u9020\u306b\u76f8\u5f53\u3059\u308b\u584a\u304c\u87ba\u65cb\u306e\u3088\u3046\u306a\u5c40\u5728\u3092\u3068\u308b\u3053\u3068\u3092\u8a3c\u660e\u3057\u307e\u3057\u305f\u3002\u3053\u3046\u3057\u305f\u7d30\u83cc\u306b\u3068\u3063\u3066\u30d5\u30a1\u30f3\u30c0\u30e1\u30f3\u30bf\u30eb\u306a\u56e0\u5b50\u3068\u3044\u3048\u308bRodZ\u304c\u75c5\u539f\u6027\u4ee5\u5916\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u3082\u4f5c\u7528\u3059\u308b\u304b\u8abf\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  \u3000\r\n  <div class=\"BlkArticle__figureList\">\r\n    <figure><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/2024\/07\/image2.png\" width=\"465\" alt=\"\">\r\n      <figcaption>\u8d64\u75e2\u83cc\u306e\u83cc\u4f53\u5185\u90e8\u306b\u5206\u5e03\u3059\u308bRodZ\u86cb\u767d\u306e\u6297\u4f53\u67d3\u8272\u50cf<br>\r\n        \uff1c\u8d85\u89e3\u50cf\u5ea6\u9855\u5fae\u93e1\u89b3\u5bdf \u5354\u529b\uff1a\u30cb\u30b3\u30f3\u682a\u5f0f\u4f1a\u793e\uff1e<\/figcaption>\r\n    <\/figure>\r\n  <\/div>\r\n  <h3>\u30d8\u30ea\u30b3\u30d0\u30af\u30bf\u30fc\u30fb\u30d4\u30ed\u30ea\u611f\u67d3\u3068\u80c3\u5185\u304a\u3088\u3073\u53e3\u8154\u5185\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30bf\u3068\u306e\u95a2\u9023\u6027\u306b\u3064\u3044\u3066\u306e\u7814\u7a76<\/h3>\r\n  <p>\u80c3\u708e\u3001\u80c3\u5341\u4e8c\u6307\u8178\u6f70\u760d\u304a\u3088\u3073\u80c3\u764c\u306e\u539f\u56e0\u3068\u60f3\u5b9a\u3055\u308c\u3066\u3044\u308b\u30d8\u30ea\u30b3\u30d0\u30af\u30bf\u30fc\u30fb\u30d4\u30ed\u30ea\u306f\u500b\u4f53\u306b\u3088\u3063\u3066\u611f\u67d3\u306e\u5f62\u614b\u304a\u3088\u3073\u7d4c\u904e\u306b\u9055\u3044\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3053\u3067\u3001\u672c\u83cc\u611f\u67d3\u306b\u304a\u3044\u3066\u30d2\u30c8\u306e\u53e3\u8154\u5185\u304a\u3088\u3073\u6d88\u5316\u7ba1\u306b\u5b58\u5728\u3057\u3066\u3044\u308b\u6b63\u5e38\u7d30\u83cc\u53e2\u304c\u5927\u304d\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u4eee\u8aac\u306e\u3082\u3068\u306b\u5b9f\u9a13\u52d5\u7269\u3092\u4f7f\u3063\u305f\u611f\u67d3\u5b9f\u9a13\u7b49\u306b\u3088\u308a\u89e3\u6790\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u3053\u306e\u3088\u3046\u306a\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306b\u3088\u308b\u6cbb\u7642\u52b9\u679c\u306b\u3064\u3044\u3066\u691c\u8a0e\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <h3>\u30ab\u30f3\u30d4\u30ed\u30d0\u30af\u30bf\u30fc\u306e\u75c5\u539f\u6027\u306e\u89e3\u6790<\/h3>\r\n  <p>\u30ab\u30f3\u30d4\u30ed\u30d0\u30af\u30bf\u30fc\u306f\u98df\u4e2d\u6bd2\u306e\u539f\u56e0\u3068\u3057\u3066\u3001\u591a\u6570\u3092\u5360\u3081\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u8a73\u3057\u3044\u75c5\u539f\u6027\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u56fd\u7acb\u5065\u5eb7\u5371\u6a5f\u7ba1\u7406\u7814\u7a76\u6a5f\u69cb\uff08\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\uff09\u7d30\u83cc\u7b2c\u4e00\u90e8\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001\u30ab\u30f3\u30d4\u30ed\u30d0\u30af\u30bf\u30fc\u306e\u52d5\u7269\u5b9f\u9a13\u30e2\u30c7\u30eb\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308bIL-10\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3092\u7e41\u6b96\u3057\u3001\u4f9b\u7d66\u3055\u308c\u305f\u83cc\u682a\u306b\u3064\u3044\u3066\u89e3\u6790\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <h3>\u8178\u7ba1\u51fa\u8840\u6027\u5927\u8178\u83cc\u306b\u304a\u3051\u308bRNA\u306b\u3088\u308b\u75c5\u539f\u6027\u767a\u73fe\u5236\u5fa1\u6a5f\u69cb<\/h3>\r\n  <p>\u8178\u7ba1\u51fa\u8840\u6027\u5927\u8178\u83cc\uff08Enterohaemorrhagic Escherichia coli : EHEC\uff09\u306f\u56fd\u5185\u3067\u5e74\u95933000\u4eba\u4ee5\u4e0a\u306e\u611f\u67d3\u8005\u3092\u51fa\u3057\u3001\u305d\u306e\u3046\u3061\u7d0420-30%\u304c\u91cd\u75c7\u4f8b\uff08\u8840\u4fbf\u30fb\u6eb6\u8840\u6027\u5c3f\u6bd2\u75c7\u75c7\u5019\u7fa4\u30fb\u8133\u75c7\u30fb\u6b7b\u4ea1\uff09\u3092\u4f34\u3046\u611f\u67d3\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3001\u81e8\u5e8a\u4e0a\u91cd\u8981\u306a\u75c5\u539f\u7d30\u83cc\u3067\u3059\u3002EHEC\u306e\u591a\u304f\u306f\u75c5\u539f\u56e0\u5b50\u3068\u3057\u3066\u5fd7\u8cc0\u6bd2\u7d20\u30843\u578b\u5206\u6ccc\u88c5\u7f6e\u3068\u547c\u3070\u308c\u308b\u63a5\u7740\u56e0\u5b50\u3092\u4fdd\u6301\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u75c5\u539f\u6027\u56e0\u5b50\u306e\u767a\u73fe\u306f\u3001\u7d30\u83cc\u3092\u53d6\u308a\u5dfb\u304f\u5916\u74b0\u5883\u306e\u5909\u5316\u306b\u5fdc\u3058\u3066\u7d30\u83cc\u5185\u306e\u591a\u304f\u306e\u56e0\u5b50\u304c\u95a2\u4e0e\u3057\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6211\u3005\u306f\u305d\u306e\u56e0\u5b50\u306e\u4e00\u3064\u3068\u3057\u3066\u7ffb\u8a33\u5236\u5fa1\u56e0\u5b50small RNA\u306b\u7740\u76ee\u3057\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002EHEC\u306e\u75c5\u539f\u6027\u767a\u73fe\u306b\u304a\u3051\u308bsmall RNA\u5236\u5fa1\u306e\u5168\u4f53\u50cf\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u3001\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b5\u30fc\u3092\u7528\u3044\u305f\u7db2\u7f85\u7684\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\u3084\u5206\u5b50\u751f\u7269\u5b66\u7684\u624b\u6cd5\u3001\u751f\u5316\u5b66\u7684\u624b\u6cd5\u3092\u7528\u3044\u305f\u89e3\u6790\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  \u3000\r\n  <div class=\"BlkArticle__figureList\">\r\n    <figure><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/2024\/07\/ehec.jpg\" width=\"465\" alt=\"\">\r\n      <figcaption>\u8178\u7ba1\u51fa\u8840\u6027\u5927\u8178\u83cc\u304c\u57f9\u990a\u7d30\u80de\u306b\u63a5\u7740\u3057\u3066\u3044\u308b\u69d8\u5b50<br>\r\n        (A) \u91ce\u751f\u682a<br>\r\n        (B) small RNA Esr41\u306e\u904e\u5270\u7523\u751f\u682a<\/figcaption>\r\n    <\/figure>\r\n  <\/div>\r\n  <h3>\u5fae\u751f\u7269\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u306e\u6a5f\u69cb\u89e3\u660e\u3068\u7d30\u83cc\u5236\u5fa1\u6cd5\u306e\u78ba\u7acb<\/h3>\r\n  <p>\u5fae\u751f\u7269\u306f\u3001\u81ea\u7136\u3084\u52d5\u7269\u4f53\u5185\u306a\u3069\u591a\u69d8\u306a\u74b0\u5883\u306b\u751f\u606f\u3057\u3066\u304a\u308a\u3001\u74b0\u5883\u5909\u5316\u306b\u5bfe\u5fdc\u3059\u308b\u305f\u3081\u306b\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5404\u53cd\u5fdc\u6bb5\u968e\u3067\u5236\u5fa1\u3057\u307e\u3059\u3002\u3053\u306e\u4e2d\u306b\u306f\u3001\u8ee2\u5199\u7d42\u7d50\u3084mRNA\u306e\u7ffb\u8a33\u3001\u5b89\u5b9a\u6027\u3068\u3044\u3063\u305fRNA\u30ec\u30d9\u30eb\u3067\u306e\u5236\u5fa1\u304c\u898b\u3064\u304b\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u304c\u3001\u5236\u5fa1\u56e0\u5b50\u3084\u5206\u5b50\u6a5f\u69cb\u306b\u306f\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6211\u3005\u306f\u3001\u751f\u5316\u5b66\u7684\u89e3\u6790\u3092\u4e3b\u8ef8\u3068\u3057\u3066\u3001\u7d30\u83cc\u304c\u6301\u3064\u5236\u5fa1\u56e0\u5b50\u3068\u3057\u3066\u306esmall RNA\u3084RNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5bfe\u8c61\u306b\u3057\u305f\u7814\u7a76\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u5206\u5b50\u7cfb\u7d71\u89e3\u6790\u3084\u30aa\u30df\u30af\u30b9\u89e3\u6790\u3092\u53d6\u308a\u5165\u308c\u3001\u75c5\u539f\u6027\u7d30\u83cc\u3078\u3068\u89e3\u6790\u898f\u6a21\u3092\u5e83\u3052\u308b\u3068\u5171\u306b\u3001\u7d30\u83cc\u5236\u5fa1\u3092\u53ef\u80fd\u3068\u3059\u308bRNA\u6280\u8853\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<a id=\"achieve\" name=\"achieve\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u8fd1\u5e74\u306e\u4e3b\u306a\u696d\u7e3e<\/h2>\r\n  <ol class=\"BlkArticle__listNumber\">\r\n    <li>Banerjee S<sup>1<\/sup>, Halder P<sup>1<\/sup>, Das S<sup>1<\/sup>, Maiti S<sup>2<\/sup>, Withey J<sup>3<\/sup>, Mitobe J, Chowdhury G<sup>1<\/sup>, Kitahara K<sup>4<\/sup>, Miyoshi S<sup>4<\/sup>, Mukhopadhyay A. K<sup>1<\/sup>, Dutta S<sup>1<\/sup>, Koley H<sup>1<\/sup>(<sup>1<\/sup> ICMR-National Institute of Cholera and Enteric Diseases, <sup>2<\/sup>University of Missouri, Columbia, <sup>3<\/sup>Wayne State University School of Medicine, <sup>4<\/sup>Okayama University): Trivalent outer membrane vesicles-based combination vaccine candidate induces protective immunity against Campylobacter and invasive non-typhoidal Salmonella in adult mice. Med Microbiol. Immunol. 2024\uff1b vol.213 : 21.<\/li>\r\n    <li>Vale FF<sup>1<\/sup>, Roberts RJ<sup>1<\/sup>, HpGP Research Network(including Osaki T)<sup>2<\/sup>, Kobayashi I<sup>3,4<\/sup>, Camargo MC<sup>5<\/sup>, Rabkin CS<sup>6<\/sup>: (<sup>1<\/sup>Universidade de Lisboa, <sup>2<\/sup>New England Biolabs,<sup>3<\/sup>Hosei University,<sup>4<\/sup>University of Tokyo, <sup>5<\/sup>National Institute for Basic Biology, <sup>6<\/sup>National Cancer Institute):Gene content, phage cycle regulation model and prophage inactivation disclosed by prophage genomics in the <i>Helicobacter pylori <\/i>Genome Project\uff0eGut Microbes\uff0e2024 ; 16(1)\uff0edoi\uff1a10.1080\/19490976.2379440.<\/li>\r\n    <li>Oguri N<sup>1<\/sup>, Miyoshi J<sup>1<\/sup>, Nishinarita Y<sup>1<\/sup>, Wada H<sup>1<\/sup>, Nemoto N<sup>1<\/sup>, Hibi N<sup>1<\/sup>, Kawamura N<sup>1<\/sup>, Miyoshi S<sup>2<\/sup>, Lee TMS<sup>3<\/sup>, Matsuura M<sup>1<\/sup>, Osaki T, Hisamatsu T<sup>1<\/sup>. (<sup>1<\/sup>Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, <sup>2<\/sup>Department of Preventive Medicine, Kyorin University School of Medicine,<sup>3<\/sup>Kansas State University): <i>Akkermansia muciniphila<\/i> in the smallintestine improves liver fibrosis in a murine liver cirrhosis model. NPJ Biofilms Microbiomes16. 2024 ; 10 (1) : 81.<\/li>\r\n    <li>Hasegawa-Ishii S<sup>1<\/sup>, Komaki S<sup>1<\/sup>, Asano H<sup>1<\/sup>, Imai R<sup>1<\/sup>, Osaki T (<sup>1<\/sup>Pathology Research Team, Faculty of Health Sciences, Kyorin University: Chronic nasal inflammation early in life induces transient and long-term dysbiosis of gut microbiota in mice. Brain Behav Immun Health. 2024; 41: 100848. Published 2024 August 29. doi :10.1016\/j.bbih. 100848.<\/li>\r\n    <li>\u5fb3\u6c38 \u5065\u543e<sup>1<\/sup>\uff0c\u4e95\u7530 \u967d\u4ecb<sup>1<\/sup>\uff0c\u4e09\u597d \u4f50\u548c\u5b50<sup>1<\/sup>\uff0c\u6797\u539f \u7d75\u7f8e\u5b50<sup>\uff12<\/sup>\uff0c\u677e\u4e95 \u82f1\u5247<sup>\uff12<\/sup>\uff0c\u9234\u6728 \u4ec1\u4eba<sup>\uff12<\/sup>\uff0c\u67f4\u5c71 \u6075\u543e<sup>\uff13<\/sup>\uff0c\u5927\u5d0e \u656c\u5b50\uff0c\u5927\u91ce \u4e9c\u5e0c\u5b50<sup>4<\/sup>\uff0c\u4e45\u677e \u7406\u4e00<sup>4<\/sup>\uff08<sup>1<\/sup>\u674f\u6797\u5927\u5b66\u533b\u5b66\u90e8\u7dcf\u5408\u533b\u7642\u5b66\u6559\u5ba4\uff0c<sup>\uff12<\/sup>\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\uff0c<sup>3<\/sup>\u540d\u53e4\u5c4b\u5927\u5b66\uff0c<sup>4<\/sup>\u674f\u6797\u5927\u5b66\u533b\u5b66\u90e8\u6d88\u5316\u5668\u5185\u79d1\u5b66\uff09\uff1aNHPH\u306e\u6700\u65b0\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u306e\u554f\u984c\u70b9 \u6771\u4eac\u90fd\u5185\u306e\u691c\u8a3a\u53d7\u8a3a\u8005\u306b\u304a\u3051\u308bNon-<i>Helicobacter pylori<\/i> <i>Helicobacter <\/i>species\u611f\u67d3\u306e\u5b9f\u614b\u8abf\u67fb\uff0e\u65e5\u672c\u6d88\u5316\u7ba1\u5b66\u4f1a\u96d1\u8a8c\uff0e8(Suppl.) 233-233\uff0e2024.<\/li>\r\n    <li>Okimoto T<sup>1-3<\/sup>, Ando T<sup>1, 4<\/sup>, Sasaki M<sup>1, 5<\/sup>, Ono S<sup>1, 6<\/sup>, Kobayashi I<sup>1, 7<\/sup>, Shibayama K<sup>1, 8<\/sup>, Chinda D<sup>1, 9<\/sup>, Tokunaga K<sup>1, 10<\/sup>, Nakajima S<sup>1, 11<\/sup>, Osaki T<sup>1<\/sup>, Sugiyama T<sup>12<\/sup>, Kato M<sup>13<\/sup>, Murakami K<sup>1, 3<\/sup> (<sup>1<\/sup>Committee on Surveillance of Antimicrobial-resistant <i>Helicobacter pylori<\/i> Strains, The Japanese Society for <i>Helicobacter<\/i> Research, <sup>2<\/sup>Oita Prefectural Hospital, <sup>3<\/sup>Oita University, <sup>4<\/sup>Ando Clinic, <sup>5<\/sup>Aichi Medical University School of Medicine, <sup>6<\/sup>Hokkaido University Hospital, <sup>7<\/sup>Toho University, <sup>8<\/sup>Nagoya University Graduate School of Medicine, <sup>9<\/sup>Hirosaki University Hospital, <sup>10<\/sup>Department of General Medicine, Kyorin University School of Medicine, <sup>11<\/sup>Japan Community Healthcare Organization Shiga Hospital, <sup>12<\/sup>Health Sciences University of Hokkaido, <sup>13<\/sup>Hokkaido Cancer Society): Antimicrobial-resistant <i>Helicobacter pylori<\/i> in Japan: Report of nationwide surveillance for 2018-2020. Helicobacter. 29(1) 2024.<\/li>\r\n    <li>Yamaguchi H<sup>1<\/sup>, Okubo T<sup>1<\/sup>, Nozaki E<sup>2<\/sup>, Osaki T (<sup>1<\/sup>Hokkaido University, <sup>2<\/sup> Core Laboratory for Proteomics and Genomics, Kyorin University School of Medicine): Differential impact of environmental factors on airborne live bacteria and inorganic particles in an underground walkway. PLoS One. 19(3). 2024.<\/li>\r\n    <li>Niikura M, Fukutomi T<sup>1<\/sup>, Mitobe J, Kobayashi F<sup>2 <\/sup>(<sup>1<\/sup>Department of Pharmacology and Toxicology, Kyorin University School of Medicine, <sup>2<\/sup>Azabu University): Characterization of a nuclear transport factor 2-like domain-containing protein in <i>Plasmodium berghei<\/i>. Malar J. 23(1):13. 2024.<\/li>\r\n    <li>\u5fb3\u6c38 \u5065\u543e<sup>1<\/sup>\uff0c\u4e95\u7530 \u967d\u4ecb<sup>1<\/sup>\uff0c\u4e09\u597d \u4f50\u548c\u5b50<sup>1<\/sup>\uff0c\u5927\u91ce \u4e9c\u5e0c\u5b50<sup>\uff12<\/sup>\uff0c\u4e45\u677e \u7406\u4e00<sup>\uff12<\/sup>\uff0c\u6797\u539f \u7d75\u7f8e\u5b50<sup>\uff13<\/sup>\uff0c\u677e\u4e95 \u82f1\u5247<sup>\uff13<\/sup>\uff0c\u9234\u6728 \u4ec1\u4eba<sup>\uff13<\/sup>\uff0c\u67f4\u5c71 \u6075\u543e<sup>\uff14<\/sup>\uff0c\u5927\u5d0e \u656c\u5b50\uff08<sup>1<\/sup>\u674f\u6797\u5927\u5b66\u533b\u5b66\u90e8\u7dcf\u5408\u533b\u7642\u5b66\uff0c<sup>\uff12<\/sup>\u674f\u6797\u5927\u5b66\u533b\u5b66\u90e8\u6d88\u5316\u5668\u5185\u79d1\u5b66\uff0c<sup>\uff13<\/sup>\u56fd\u7acb\u611f\u67d3\u75c7\u7814\u7a76\u6240\uff0c<sup>4<\/sup>\u540d\u53e4\u5c4b\u5927\u5b66\uff09\uff1a\u3010\u4e0a\u90e8\u6d88\u5316\u7ba1\u75be\u60a3\u306e\u6b8b\u3055\u308c\u305f\u8ab2\u984c\u3011NHPH\u306b\u3088\u308b\u80c3\u75be\u60a3\u306e\u75ab\u5b66\u3068\u75c5\u614b\uff0eProgress in Medicine. 43(9) 813-815\uff0e2023.<\/li>\r\n    <li>\u5927\ufa11\u656c\u5b50\uff0c\u5fb3\u6c38\u5065\u543e<sup>1<\/sup>\uff08<sup>1<\/sup>\u674f\u6797\u5927\u5b66\u533b\u5b66\u90e8\u7dcf\u5408\u533b\u7642\u5b66\uff09\uff1a<i>Helicobacter pylori<\/i>\u9664\u83cc\u5f8c\u306e\u81ea\u5df1\u514d\u75ab\u6027\u80c3\u708e\u306b\u304a\u3051\u308b\u80c3\u5185\u7d30\u83cc\u53e2\u306e\u7279\u5fb4\uff0eHelicobacter Research 27(2) 173-176\uff0e2023.<\/li>\r\n    <li>Asahi H<sup>1<\/sup>, Niikura M, Inoue SI<sup>2<\/sup>, Sendo F<sup>3<\/sup>, Kobayashi F<sup>4<\/sup>, Wada A<sup>1<\/sup> (<sup>1<\/sup>RIKEN Center for Biosystems Dynamics Research, <sup>2<\/sup>Nagasaki University, <sup>3<\/sup>Kojunosato, <sup>4<\/sup>Azabu University): Dihydroartemisinin Disrupts Zinc Homeostasis in <i>Plasmodium falciparum<\/i> To Potentiate Its Antimalarial Action via Pyknosis. ACS Infect Dis. 9(7):1303-1309. 2023.<\/li>\r\n    <li>\u77f3\u4e95\u3055\u306a\u3048<sup>1<\/sup>\uff0c\u4e09\u5cf6\u7950\u5b50<sup>1<\/sup>\uff0c\u6d45\u91ce\u5983\u5357<sup>2<\/sup>\uff0c\u5927\ufa11\u656c\u5b50\uff08<sup>1<\/sup>\u674f\u6797\u5927\u5b66\u4fdd\u5065\u5b66\u90e8\uff0c<sup>2<\/sup>\u674f\u6797\u5927\u5b66\u5927\u5b66\u9662\uff09\uff1a\u65b0\u751f\u4ed4\u306e\u9f3b\u8154\u708e\u75c7\u306b\u8d77\u56e0\u3059\u308b\u8178\u5185\u7d30\u83cc\u53e2\u306e\u5909\u52d5\u3068\u8133\u7d44\u7e54\u640d\u50b7\uff0e\u7121\u83cc\u751f\u7269\uff0e52(2)\uff0e30-31\uff0e2022.<\/li>\r\n    <li>\u5927\ufa11\u656c\u5b50\uff0c\u6a2a\u7530\u61b2\u6cbb<sup>1<\/sup>\uff0c\u6797\u4fca\u6cbb<sup>2<\/sup>\uff0c\u6a2a\u7530\u4f38\u4e00<sup>3<\/sup>\uff0c\u7af9\u5185\u5553\u6643<sup>4<\/sup>\uff0c\u67f4\u5c71\u6075\u543e<sup>5<\/sup>\uff0c\u6751\u4e0a\u548c\u6210<sup>6<\/sup>\uff0c\u52a0\u85e4\u5143\u55e3<sup>7<\/sup>\uff0c\u6749\u5c71\u654f\u90ce<sup>8<\/sup>\uff08<sup>1<\/sup>\u5ca1\u5c71\u5927\u5b66\u5927\u5b66\u9662\uff0c<sup>2<\/sup>\u5317\u91cc\u5927\u5b66\uff0c<sup>3<\/sup>\u672d\u5e4c\u533b\u79d1\u5927\u5b66\uff0c<sup>4<\/sup>\u56fd\u969b\u533b\u7642\u798f\u7949\u5927\u5b66\u5927\u5b66\u9662\uff0c<sup>5<\/sup>\u540d\u53e4\u5c4b\u5927\u5b66\u5927\u5b66\u9662\uff0c<sup>6<\/sup>\u5927\u5206\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662\uff0c<sup>7<\/sup>\u51fd\u9928\u75c5\u9662\uff0c<sup>8<\/sup>\u5317\u6d77\u9053\u5927\u5b66\u75c5\u9662\uff09\uff1a<i>Helicobacter pylori<\/i>\u85ac\u5264\u611f\u53d7\u6027\u8a66\u9a13\u306e\u56fd\u5185\u6a19\u6e96\u5316\u306b\u3080\u3051\u3066\uff0d\u8010\u6027\u83cc\u57fa\u6e96\u30d1\u30cd\u30eb\u306e\u4f5c\u6210\uff0d\uff0e\u65e5\u672c\u30d8\u30ea\u30b3\u30d0\u30af\u30bf\u30fc\u5b66\u4f1a\u8a8c\uff0e24(1)\uff0e44-48\uff0e2022.<\/li>\r\n    <li>\u672c\u5e84\u552f\u610f<sup>1<\/sup>\uff0c\u5e73\u5d0e\u80fd\u90ce<sup>1<\/sup>\uff0c\u7cf8\u5c71\u980c\u7406<sup>1<\/sup>\uff0c\u65b0\u5009\u4fdd\uff0c\u6797\u6681\u971e<sup>1<\/sup>\uff0c\u5742\u672c\u5bdb\u548c<sup>1<\/sup>\uff0c\u91ce\u5442\u702c\u4e00\u7f8e<sup>1<\/sup>\uff0c\u751f\u6c34\u771f\u7d00\u592b<sup>1<\/sup>\uff0c\u5f66\u5742\u5065\u5150<sup>1<\/sup>\uff08<sup>1<\/sup>\u5343\u8449\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u9662\uff09\uff1a\u65e2\u5b58\u85ac\u5264\u306b\u8010\u6027\u3092\u793a\u3059\u815f\u30c8\u30ea\u30b3\u30e2\u30ca\u30b9\u306b\u5bfe\u3059\u308b7\u7a2e\u306e\u751f\u85ac\u306e\u52b9\u679c\uff0e\u81e8\u5e8a\u5bc4\u751f\u866b\u5b66\u4f1a\u8a8c\uff0e33(1)\uff0e55-58\uff0e2022.<\/li>\r\n    <li>Howlader DR<sup>1<\/sup>, Bhaumik U<sup>1<\/sup>, Halder P<sup>1<\/sup>, Satpathy A<sup>1<\/sup>, Sarkar S<sup>1<\/sup>, Ghoshal M<sup>1<\/sup>, Maiti S<sup>1<\/sup>, Withey JH<sup>2<\/sup>, Mitobe J, Dutta S<sup>1<\/sup>, Koley H<sup>1<\/sup> (<sup>1<\/sup> ICMR-National Institute of Cholera and Enteric Diseases, <sup>2 <\/sup>Wayne State University School of Medicine): An Experimental Adult Zebrafish Model for <i>Shigella<\/i> Pathogenesis, Transmission, and Vaccine Efficacy Studies. Microbiol Spectr. 10(3). e0034722. 2022.<\/li>\r\n    <li>Cho N<sup>1<\/sup>, Kikuzato K<sup>1<\/sup>, Futamura Y<sup>1<\/sup>, Shimizu T<sup>1<\/sup>, Hayase H<sup>1<\/sup>, Kamisaka K<sup>2<\/sup>, Takaya D<sup>2<\/sup>, Yuki H<sup>2<\/sup>, Honma T<sup>2<\/sup>, Niikura M, Kobayashi F<sup>3<\/sup>, Watanabe N<sup>1<\/sup>, Osada H<sup>1<\/sup>, Koyama H<sup>1 <\/sup>(<sup>1<\/sup>RIKEN Center for Sustainable Resource Science, <sup>2<\/sup>RIKEN Center for Biosystems Dynamic Research, <sup>3<\/sup>Azabu University): New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-\u03b2-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety. Bioorg Med Chem. 66. 116830. 2022.<\/li>\r\n    <li>Hoshino Y<sup>1<\/sup>\uff0cSakamoto T<sup>1<\/sup>\uff0cSudo N\uff0cIto M<sup>1<\/sup>\uff0cHaneda T<sup>1<\/sup>\uff0cOkada N<sup>1<\/sup>\uff0cMiki T<sup>1<\/sup>(<sup>1<\/sup>Kitasato University ): Fatty Acid Homeostasis Tunes Flagellar Motility by Activating Phase 2 Flagellin Expression, Contributing to Salmonella Gut Colonization. Infection and Immunity. 90(7). e00184-22. 2022.<\/li>\r\n    <li>Fujiki J<sup>1<\/sup>, Nakamura T<sup>1,2,3<\/sup>, Nakamura K<sup>1<\/sup>, Nishida K<sup>1<\/sup>, Amano Y<sup>1<\/sup>, Watanabe Y<sup>1<\/sup>, Gondaira S<sup>1<\/sup>, Usui M<sup>1<\/sup>, Shimizu M<sup>4<\/sup>, Miyanaga K<sup>5<\/sup>, Watanabe S<sup>5<\/sup>, Iwasaki T<sup>1<\/sup>, Kiga K<sup>3,5<\/sup>, Hanawa T, Higuchi H<sup>1<\/sup>, Sawa T<sup>4<\/sup>, Tanji Y<sup>2<\/sup>, Tamura Y<sup>1<\/sup>, Cui L<sup>5<\/sup>, Iwano H<sup>1<\/sup>(<sup>1<\/sup>Rakuno Gakuen University, <sup>2<\/sup>Waseda University, <sup>3<\/sup>National Institute of Infectious Diseases, <sup>4<\/sup> Kyoto Prefectural University of Medicine, <sup>5<\/sup>Jichi Medical University): Biological properties of <i>Staphylococcus <\/i>virus \u03a6SA012 for phage therapy. Sci Rep. 12(1). 21297. 2022.<\/li>\r\n    <li>Suda T<sup>1<\/sup>, Hanawa T, Tanaka M, Tanji Y<sup>2<\/sup>, Miyanaga K<sup>2,3<\/sup>, Hasegawa-Ishii S<sup>4<\/sup>, Shirato K<sup>5<\/sup>, Kizaki T<sup>5<\/sup>, Matsuda T<sup>1,6<\/sup> (<sup>1<\/sup>Department of General Medicine, Kyorin University School of Medicine, <sup>2 <\/sup>Tokyo Institute of Technology, <sup>3<\/sup> Jichi Medical University, <sup>4<\/sup> Pathology Research Team, Faculty of Health Sciences, Kyorin University, <sup>5<\/sup> Department of Molecular Predictive Medicine and Sport Science, Kyorin University School of Medicine, <sup>6<\/sup> Department of Traumatology and Critical Care Medicine, Kyorin University School of Medicine): Modification of the immune response by bacteriophages alters methicillin-resistant <i>Staphylococcus aureus<\/i> infection. Sci Rep. 12(1). 15656. 2022.<\/li>\r\n    <li>Goto M<sup>1<\/sup>, Abe A<sup>1<\/sup>, Hanawa T, Suzuki M<sup>2<\/sup>, Kuwae A<sup>1<\/sup>(<sup>1<\/sup>Kitasato University, <sup>2<\/sup> National Institute of Infectious Diseases): Bcr4 Is a Chaperone for the Inner Rod Protein in the <i>Bordetella<\/i> Type III Secretion System. Microbiol Spectr. 10(5). e0144322. 2022.<\/li>\r\n    <li>Osaki T, Lin, Y<sup>\uff11<\/sup>, Sasahira N<sup>2<\/sup>, Ueno M<sup>3<\/sup>, Yonezawa H, Hojo F<sup>4<\/sup>, Okuda M<sup> 5<\/sup>, Matsuyama M<sup>2<\/sup>, Sasaki T<sup>2<\/sup>, Kobayashi S<sup> 3<\/sup>, Tezuka S<sup>3<\/sup>, Tanaka K<sup>6<\/sup>, Dan N<sup>6<\/sup>, Kuruma S<sup>7<\/sup>, Egawa N<sup>8<\/sup>, Kamiya S &amp; Kikuchi S<sup>\uff11<\/sup>\uff08<sup>\uff11<\/sup>Aichi Medical University School of Medicine, <sup>2<\/sup>Cancer Institute Hospital of Japanese Foundation for Cancer Research, <sup>3<\/sup>Kanagawa Cancer Center, <sup>4<\/sup>Institute of Laboratory Animals, Graduate School of Medicine, Kyorin University, <sup>5<\/sup>Hyogo College of Medicine, <sup>6<\/sup>Tokyo Metropolitan Ohtsuka Hospital, <sup>7<\/sup>Tokyo Metropolitan Komagome Hospital, <sup>8<\/sup>Tokyo Metropolitan Matsuzawa Hospital\uff09 Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers. Helicobacter. 27(1). e12866. 2022.<\/li>\r\n    <li>Yokota, K<sup>\uff11<\/sup>, Osaki T, Hayashi S<sup>2<\/sup>, Yokota SI<sup> 3<\/sup>, Takeuchi H<sup>4<\/sup>, Rimbara E<sup>5<\/sup>, Ojima H<sup>1<\/sup>, Sato T<sup>3<\/sup>, Yonezawa H, Shibayama K<sup>6<\/sup>, Tokunaga K<sup>7<\/sup>, Kamiya S, Murakami K<sup>8<\/sup>, Kato M<sup>9<\/sup>, &amp; Sugiyama T<sup>10<\/sup>(<sup>\uff11<\/sup>Okayama University, <sup>2<\/sup>Kitasato University, <sup>3<\/sup>Sapporo Medical University, <sup>4<\/sup>International University of Health and Welfare, <sup>5<\/sup>National Institute of Infectious Diseases, <sup>6<\/sup>Nagoya University, <sup>7<\/sup>Department of General Medicine, <sup>8<\/sup>Oita University, <sup>9<\/sup>National Hospital Organization National Hakodate Hospital, <sup>10<\/sup>Hokkaido University Hospital\uff09: Establishment of a reference panel of <i>Helicobacter pylori<\/i> strains for antimicrobial susceptibility testing. Helicobacter. 27(3). e12874. 2022.<\/li>\r\n    <li>\u5927\ufa11\u656c\u5b50\uff0c\u83c5\u539f\u5927\u8f14<sup>1<\/sup>\uff0c\u5927\u91ce\u4e9c\u5e0c\u5b50<sup>2<\/sup>\uff0c\u6960\u539f\u5149\u8b39<sup>2<\/sup>\uff0c\u8535\u7530\u8a13<sup>3<\/sup>\uff0c\u7c73\u6fa4\u82f1\u96c4\uff0c\u5fb3\u6c38\u5065\u543e<sup>4<\/sup>\uff08<sup>1<\/sup>\u674f\u6797\u5927\u5b66\u533b\u5b66\u90e8\u9855\u5fae\u89e3\u5256\u5b66\uff0c<sup>2<\/sup>\u674f\u6797\u5927\u5b66\u533b\u5b66\u90e8\u6d88\u5316\u5668\u5185\u79d1\u5b66\uff0c<sup>3<\/sup>\u674f\u6797\u5927\u5b66\u4fdd\u5065\u5b66\u90e8\u81e8\u5e8a\u691c\u67fb\u6280\u8853\u5b66\u79d1\uff0c<sup>4<\/sup>\u674f\u6797\u5927\u5b66\u533b\u5b66\u90e8\u7dcf\u5408\u533b\u7642\u5b66\uff09\uff1a\u80c3\u764c\u4e88\u9632\u3092\u3081\u3056\u3057\u305f\u80c3\u5185\u7d30\u83cc\u53e2\u306e\u7814\u7a76\uff0e\u674f\u6797\u533b\u5b66\u4f1a\u96d1\u8a8c\uff0e53\u5dfbNo1\uff0e\uff531-4\uff0e2022.<\/li>\r\n  <\/ol>\r\n  <h3>\u65e5\u672c\u8a9e\u306e\u89e3\u8aac\u30fb\u66f8\u7c4d\u306a\u3069<\/h3>\r\n  <ol class=\"BlkArticle__listNumber\">\r\n    <li>\u5927\ufa11\u656c\u5b50\uff08\u5206\u62c5\u57f7\u7b46\uff09\uff1aH. pylori\u611f\u67d3\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32024\u6539\u8a02\u7248\uff0e\u65e5\u672c\u30d8\u30ea\u30b3\u30d0\u30af\u30bf\u30fc\u5b66\u4f1a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u4f5c\u6210\u59d4\u54e1\u4f1a\uff0e\u5148\u7aef\u533b\u5b66\u793e\uff0e2024.<\/li>\r\n    <li>\u4e2d\u5b66\u6821\u4fdd\u5065\u30cb\u30e5\u30fc\u30b9\uff0eNo.1820\uff0e\u52a0\u71b1\u4e0d\u5341\u5206\u306e\u8089\u306b\u6ce8\u610f\uff0e\u8178\u7ba1\u51fa\u8840\u6027\u5927\u8178\u83ccO-157\uff0e\u83cc\u3092\u3064\u3051\u306a\u3044\u3001\u5897\u3084\u3055\u306a\u3044\u3001\u3084\u3063\u3064\u3051\u308b\u306e\uff13\u70b9\u3067\u98df\u4e2d\u6bd2\u3092\u9632\u304e\u307e\u3057\u3087\u3046\uff0e2021\u5e746\u670828\u65e5\u53f7.<\/li>\r\n  <\/ol>\r\n<\/section>\r\n","protected":false},"excerpt":{"rendered":"<p>\u6559\u5ba4\u5c02\u4efb\u6559\u54e1 \u6559\u5ba4\u6982\u8981 \u5fae\u751f\u7269\u5b66\u5206\u91ce\u3067\u306f\u4e3b\u306b\u6d88\u5316\u5668\u306e\u7d30\u83cc\u611f\u67d3\u75c7\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u5ba4\u306e\u65b9\u91dd\u3068\u3057\u3066\u57fa\u790e\u7814\u7a76\u3092\u901a\u3057\u3066\u611f\u67d3\u75c7\u306e\u8a3a\u65ad\u3001\u75c5\u614b\u89e3\u660e\u3001\u6cbb\u7642\u306a\u3069\u81e8\u5e8a\u533b\u5b66\u3068\u306e\u9023\u643a\u3092\u5fd7\u5411\u3057\u305f\u611f\u67d3\u75c7\u5b66\u306e\u63a2\u6c42\u3092\u884c\u3046\u3053\u3068\u3092\u76ee\u6a19\u306b\u3057\u3066\u3044 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":24,"menu_order":90,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"section":[4],"class_list":["post-107","page","type-page","status-publish","hentry","section-basics"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/107","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/comments?post=107"}],"version-history":[{"count":19,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/107\/revisions"}],"predecessor-version":[{"id":7160,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/107\/revisions\/7160"}],"up":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/24"}],"wp:attachment":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media?parent=107"}],"wp:term":[{"taxonomy":"section","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/section?post=107"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}