{"id":119,"date":"2022-02-15T15:36:09","date_gmt":"2022-02-15T06:36:09","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/_manage\/?page_id=119"},"modified":"2024-08-02T09:43:51","modified_gmt":"2024-08-02T00:43:51","slug":"chemistry","status":"publish","type":"page","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/chemistry\/","title":{"rendered":"\u5316\u5b66\u6559\u5ba4"},"content":{"rendered":"<section class=\"BlkAnchorArea\"><div class=\"BlkAnchorArea__inner\"><ul class=\"anchorMenu\"><li><a class=\"p-anchor\" href=\"#teacher\"><span>\u6559\u54e1<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#summary\"><span>\u6982\u8981<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#study\"><span>\u7814\u7a76<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#achieve\"><span>\u696d\u7e3e<\/span><\/a><\/li><\/ul><\/div><\/section> <a id=\"teacher\" name=\"teacher\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u6559\u5ba4\u5c02\u4efb\u6559\u54e1<\/h2>\r\n  \n<!-- staffdb 2023.08.15 -->\n<div><table class=\"BlkArticle__tableNormal BlkArticle__tableNormal--topLeft\" width=\"100%\" data-update=\"2023.08.15\"><tbody><tr><th>\u6559\u6388<\/th><td><ul class=\"list-on-td\"><li data-sort=\"9000\uff0f58002\"><a href=\"\/univ\/faculty\/medicine\/education\/staffnew\/detail\/?id=med58002\" class=\"arrow\">\u4e11\u4e38\u3000\u771f<\/a><\/li><\/ul><\/td><\/tr><tr><th>\u51c6\u6559\u6388<\/th><td><ul class=\"list-on-td\"><li data-sort=\"800\uff0f48003\"><a href=\"\/univ\/faculty\/medicine\/education\/staffnew\/detail\/?id=med48003\" class=\"arrow\">\u9808\u8cc0\u3000\u572d<\/a><\/li><\/ul><\/td><\/tr><tr><th>\u8b1b\u5e2b<\/th><td><ul class=\"list-on-td\"><li data-sort=\"900\uff0f58003\"><a href=\"\/univ\/faculty\/medicine\/education\/staffnew\/detail\/?id=med58003\" class=\"arrow\">\u5c71\u672c\u3000\u5e78\u5b50<\/a><\/li><\/ul><\/td><\/tr><\/tbody><\/table><\/div> <\/section>\r\n<a id=\"summary\" name=\"summary\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u6559\u5ba4\u6982\u8981<\/h2>\r\n  <p>\u5316\u5b66\u6559\u5ba4\u306f\u3001\u674f\u6797\u5927\u5b66\u533b\u5b66\u90e8\u533b\u5b66\u9032\u5b66\u904e\u7a0b\u306e\u5b66\u751f\u306e\u6559\u80b2\u3092\u76ee\u7684\u3068\u3057\u3066\u3001\u77f3\u5ddd\u52c9\u6c0f\u3092\u521d\u4ee3\u6559\u6388\u3068\u3057\u3066\u3001\u662d\u548c45\u5e74\u306b\u958b\u8a2d\u3055\u308c\u307e\u3057\u305f\u3002\u5e73\u62105\u5e74\u3001\u798f\u5d8b\u7fa9\u535a\u524d\u6559\u6388\u306e\u7740\u4efb\u3068\u3068\u3082\u306b\u3001\u533b\u5b66\u90e8\u521d\u5e74\u5ea6\u306e\u5b66\u751f\u306b\u5bfe\u3059\u308b\u751f\u5316\u5b66\u306e\u57fa\u790e\u6559\u80b2\u3068\u3001\u300c\u30a4\u30aa\u30f3\u8f38\u9001ATPase\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u5909\u63db\u6a5f\u69cb\u300d\u3092\u30c6\u30fc\u30de\u306b\u7814\u7a76\u3092\u884c\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u73fe\u5728\u306f\u3001\u5b66\u751f\u306e\u57fa\u790e\u6559\u80b2\u3092\u62c5\u5f53\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u7814\u7a76\u9762\u3067\u306f\u3001\u30a4\u30aa\u30f3\u8f38\u9001ATPase\u306e\u53cd\u5fdc\u901f\u5ea6\u8ad6\u7684\u7814\u7a76\u3092\u3055\u3089\u306b\u9032\u3081\u3001\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u305f\u86cb\u767d\u8cea\u767a\u73fe\u7cfb\u3092\u7528\u3044\u305f\u30b4\u30eb\u30b8\u4f53\u306b\u5b58\u5728\u3059\u308b\u30a4\u30aa\u30f3\u8f38\u9001ATPase\u306e\u6a5f\u80fd\u8abf\u7bc0\u3084\u7d30\u80de\u5185\u8f38\u9001\u6a5f\u69cb\u306e\u89e3\u660e\u3001\u3055\u3089\u306b\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306b\u304a\u3051\u308b\u30b4\u30eb\u30b8\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u306a\u3069\u306e\u7814\u7a76\u306b\u5bfe\u8c61\u3092\u5e83\u3052\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u6559\u80b2\u306e\u7279\u8272<\/h2>\r\n  <p>\u5b66\u751f\u6559\u80b2\u306b\u304a\u3044\u3066\u306f\u3001\u751f\u4f53\u7269\u8cea\u306e\u5316\u5b66\u7684\u57fa\u76e4\u3092\u8b1b\u7fa9\u3059\u308b\u300c\u751f\u4f53\u5316\u5b66\u300d\u3068\u3001\u73fe\u4ee3\u533b\u5b66\u7814\u7a76\u304c\u57fa\u76e4\u3068\u3059\u308b\u751f\u5316\u5b66\u5b9f\u9a13\u6cd5\u306e\u521d\u6b69\u6bb5\u968e\u3092\u5b66\u3076\u300c\u751f\u4f53\u5316\u5b66\u5b9f\u7fd2\u300d\u3092\u3001\u533b\u5b66\u90e8\u521d\u5e74\u5ea6\u306e\u5b66\u751f\u306b\u5bfe\u3057\u3066\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3044\u305a\u308c\u3082\u3001\u533b\u5b66\u90e8\u3067\u5b66\u3076\u3001\u4ee3\u8b1d\u751f\u5316\u5b66\u3084\u85ac\u7406\u5b66\u3067\u5b66\u7fd2\u3059\u308b\u5185\u5bb9\u306e\u57fa\u790e\u3068\u306a\u308b\u3082\u306e\u3067\u3059\u3002\u307e\u305f\u3001\u9ad8\u6821\u3067\u5316\u5b66\u3092\u9078\u629e\u305b\u305a\u306b\u9032\u5b66\u3057\u305f\u5b66\u751f\u3092\u5bfe\u8c61\u3068\u3057\u305f\u300c\u5165\u9580\u5316\u5b66\u300d\u3082\u62c5\u5f53\u3057\u3066\u3044\u307e\u3059\u3002\u9ad8\u6821\u7406\u79d1\u3068\u5927\u5b66\u306b\u304a\u3051\u308b\u79d1\u5b66\u306e\u77e5\u8b58\u306e\u9694\u305f\u308a\u3092\u57cb\u3081\u3001\u73fe\u4ee3\u751f\u5316\u5b66\u3092\u4fee\u3081\u3055\u305b\u308b\u305f\u3081\u3001\u30b9\u30bf\u30c3\u30d5\u4e00\u540c\u5354\u529b\u3057\u3066\u3001\u533b\u5b66\u90e8\u306e\u521d\u5e74\u5ea6\u6559\u80b2\u306b\u9081\u9032\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u793e\u4f1a\u7684\u6d3b\u52d5<\/h2>\r\n  <p>\u6559\u5ba4\u54e1\u306e\u4e3b\u306a\u6240\u5c5e\u5b66\u4f1a\u306f\u3001\u65e5\u672c\u751f\u5316\u5b66\u4f1a\u3001\u65e5\u672c\u751f\u7269\u7269\u7406\u5b66\u4f1a\u3001\u65e5\u672c\u8fb2\u82b8\u5316\u5b66\u4f1a\u3001\u65e5\u672c\u795e\u7d4c\u5316\u5b66\u4f1a\u7b49\u3067\u3059\u3002\u305d\u308c\u305e\u308c\u306e\u5b66\u4f1a\u767a\u8868\u306e\u6a5f\u4f1a\u306b\u304a\u3044\u3066\u3001\u5e38\u306b\u65b0\u3057\u3044\u60c5\u5831\u3092\u767a\u4fe1\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<a id=\"study\" name=\"study\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u5927\u5b66\u9662\u306e\u7279\u8272<\/h2>\r\n  <p>\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30b9\u30bf\u30c3\u30d5\u306e\u4eba\u6570\u306f\u5c11\u306a\u3044\u3067\u3059\u304c\u3001\u751f\u5316\u5b66\u306e\u57fa\u672c\u7684\u306a\u5b9f\u9a13\u6280\u6cd5\u3092\u5b66\u3076\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u5c06\u6765\u306e\u7814\u7a76\u6d3b\u52d5\u306b\u5fc5\u9808\u306e\u3001\u72ec\u5275\u7684\u3001\u5275\u9020\u7684\u767a\u60f3\u306e\u5143\u3068\u306a\u308b\u3088\u3046\u306a\u3001\u79d1\u5b66\u7684\u306a\u601d\u8003\u65b9\u6cd5\u3092\u5b66\u3076\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\r\n  <p>\u5f53\u7814\u7a76\u5ba4\u306e\u73fe\u5728\u306e\u7814\u7a76\u30c6\u30fc\u30de\u306f\u3001\u4ee5\u4e0b\u306b\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u5927\u5b66\u9662\u30fb\u533b\u5b66\u7814\u7a76\u8b1b\u7fa9II\u3084\u7814\u7a76\u4ea4\u6d41\u4f1a\u306a\u3069\u3067\u3082\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u7814\u7a76\u30c6\u30fc\u30de<\/h2>\r\n  <p>\u7d30\u80de\u5185\u3067\u306f\u69d8\u3005\u306a\u30a4\u30aa\u30f3\u304c\u751f\u4f53\u53cd\u5fdc\u306e\u5236\u5fa1\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u7d30\u80de\u5185\u30a4\u30aa\u30f3\u74b0\u5883\u306e\u5909\u5316\u306b\u3088\u3063\u3066\u3001\u7d30\u80de\u5206\u88c2\u3084\u7d30\u80de\u904b\u52d5\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306a\u3069\u69d8\u3005\u306a\u7d30\u80de\u5fdc\u7b54\u304c\u8d77\u3053\u308a\u307e\u3059\u3002\u7d30\u80de\u5185\u306e\u30a4\u30aa\u30f3\u74b0\u5883\u3092\u7dad\u6301\u3057\u3066\u3044\u308b\u50cd\u304d\u3092\u3057\u3066\u3044\u308b\u3082\u306e\u304c\u3001\u3055\u307e\u3056\u307e\u306a\u30a4\u30aa\u30f3\u8f38\u9001 ATPase \u3067\u3059\u3002\u3053\u306e ATPase \u306e\u4e2d\u306b\u306f\u3001\u30a4\u30aa\u30f3\u8f38\u9001\u6a5f\u69cb\u3084\u6a5f\u80fd\u8abf\u7bc0\u6a5f\u69cb\u304c\u5341\u5206\u306b\u306f\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u306a\u3044\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u7d30\u80de\u5185\u3084\u30aa\u30eb\u30ac\u30cd\u30e9\u5185\u8154\u306e\u30a4\u30aa\u30f3\u74b0\u5883\u306e\u4e71\u308c\u306f\u3001\u7d30\u80de\u3092\u7570\u5e38\u306a\u72b6\u614b\u306b\u9665\u3089\u305b\u3001\u7d30\u80de\u6b7b\u3092\u5f15\u304d\u8d77\u3053\u3059\u7d50\u679c\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306a\u3069\u306e\u75be\u75c5\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\r\n  <p>\u6211\u3005\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30b4\u30eb\u30b8\u4f53\u306b\u5b58\u5728\u3059\u308b Ca<sup>2+<\/sup>\/Mn<sup>2+<\/sup>\u8f38\u9001ATPase \u306e\u6a5f\u80fd\u89e3\u6790\u3084\u30b4\u30eb\u30b8\u4f53\u5185\u8154\u3078\u306e\u30a4\u30aa\u30f3\u8f38\u9001\u3092\u8abf\u7bc0\u3059\u308b\u4ed5\u7d44\u307f\u306e\u89e3\u660e\u306a\u3069\u3092\u76ee\u6307\u3057\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8fd1\u5e74\u306f\u3001\u30b4\u30eb\u30b8\u4f53\u306a\u3069\u306e\u30aa\u30eb\u30ac\u30cd\u30e9\u306e\u30a4\u30aa\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u4e71\u308c\u306a\u3069\u306b\u3088\u308b\u30aa\u30eb\u30ac\u30cd\u30e9\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308a\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u767a\u75c7\u6a5f\u69cb\u306e\u89e3\u660e\u3078\u3068\u3001\u7814\u7a76\u304c\u767a\u5c55\u3057\u3066\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <h3>Ca<sup>2+<\/sup>\/Mn<sup>2+<\/sup> \u8f38\u9001 ATPase SPCA \u306e\u6a5f\u80fd\u89e3\u6790<\/h3>\r\n  <p>\u7d30\u80de\u5185\u3067\u69d8\u3005\u306a\u7d30\u80de\u5fdc\u7b54\u3092\u5236\u5fa1\u3059\u308b Ca<sup>2+<\/sup> \u306f\u3001Ca<sup>2+<\/sup>\u30c1\u30e3\u30cd\u30eb\u3084 Ca<sup>2+<\/sup>\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u3001\u305d\u3057\u3066 Ca<sup>2+<\/sup>\u8f38\u9001ATPase \u306e\u50cd\u304d\u3067\u3001\u305d\u306e\u7d30\u80de\u5185\u52d5\u614b\u304c\u53b3\u5bc6\u306b\u8abf\u7bc0\u3055\u308c\u3066\u3044\u307e\u3059\u3002Ca<sup>2+<\/sup>\/Mn<sup>2+<\/sup>\u8f38\u9001ATPase \u3067\u3042\u308b SPCA \u3082\u305d\u306e\u8abf\u7bc0\u3092\u62c5\u3046\u5206\u5b50\u3067\u3059\u3002\u6bd4\u8f03\u7684\u6700\u8fd1\u306b\u306a\u3063\u3066\u898b\u51fa\u3055\u308c\u305f SPCA \u306e\u751f\u7406\u6a5f\u80fd\u306b\u306f\u3001\u307e\u3060\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001SPCA \u304c\u7d30\u80de\u5185\u3067\u3069\u306e\u3088\u3046\u306a\u5206\u5b50\u3068\u95a2\u308f\u308a\u3092\u6301\u3064\u306e\u304b\u3001\u3069\u306e\u3088\u3046\u306a\u7d30\u80de\u74b0\u5883\u3067\u6d3b\u767a\u306b\u6a5f\u80fd\u3059\u308b\u306e\u304b\u3001\u307e\u305f\u305d\u308c\u3089\u304c\u7d30\u80de\u5185\u306e Ca<sup>2+<\/sup>\u52d5\u614b\u306e\u7dad\u6301\u306b\u3069\u306e\u3088\u3046\u306b\u5bc4\u4e0e\u3059\u308b\u306e\u304b\u306a\u3069\u3001\u307e\u3063\u305f\u304f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u6211\u3005\u306f\u3001SPCA \u306e\u76f8\u4e92\u4f5c\u7528\u5206\u5b50\u306e\u63a2\u7d22\u3068\u89e3\u6790\u3001\u7279\u7570\u7684\u963b\u5bb3\u5264\u306e\u63a2\u7d22\u306a\u3069\u3092\u901a\u3057\u3066\u3001\u3053\u306e\u5206\u5b50\u306e\u751f\u7406\u6a5f\u80fd\u306e\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <h3>\u7d30\u80de\u5185\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3068\u795e\u7d4c\u5909\u6027\u75be\u60a3<\/h3>\r\n  <p>\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u898b\u3089\u308c\u308b\u7d30\u80de\u6b7b\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306b\u7279\u6709\u306a\u4e0d\u826f\u86cb\u767d\u8cea\u306e\u84c4\u7a4d\u3084\u30aa\u30eb\u30ac\u30cd\u30e9\u306e\u6a5f\u80fd\u969c\u5bb3\u304c\u5f15\u304d\u91d1\u3068\u306a\u308a\u3001\u30aa\u30eb\u30ac\u30cd\u30e9\u9593\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u7834\u7dbb\u304c\u539f\u56e0\u3067\u8d77\u3053\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4eee\u8aac\u306e\u3082\u3068\u3001\u672a\u3060\u6a5f\u5e8f\u306e\u4e0d\u660e\u306a\u5b64\u767a\u6027\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u6a5f\u5e8f\u306e\u7406\u89e3\u3068\u6839\u672c\u7684\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u5411\u3051\u305f\u57fa\u76e4\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u5bfe\u8c61\u3068\u3057\u3066\u306f\u3001\u30d2\u30c8\u3092\u542b\u3081\u305f\u970a\u9577\u985e\u304b\u3089\u3052\u3063\u6b6f\u985e\u306b\u81f3\u308b\u307e\u3067\u3001\u69d8\u3005\u306a\u54fa\u4e73\u985e\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u30fb\u30b0\u30ea\u30a2\u306a\u3069\u306e\u795e\u7d4c\u7d30\u80de\u304c\u4e3b\u306a\u7814\u7a76\u6750\u6599\u3067\u3059\u3002\u7126\u70b9\u3092\u5f53\u3066\u3066\u3044\u308b\u5177\u4f53\u7684\u306a\u5206\u5b50\u3068\u3057\u3066\u306f\u3001\u7d30\u80de\u5185\u306e\u5c0f\u80de\u4f53\u304b\u3089\u30b4\u30eb\u30b8\u4f53\u306b\u304b\u3051\u3066\u5c40\u5728\u3059\u308b SNARE \u30bf\u30f3\u30d1\u30af\u8cea Syx5 \u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u30dd\u30f3\u30d7\u3067\u3042\u308b SPCA \u3067\u3059\u3002\u69d8\u3005\u306a\u30b9\u30c8\u30ec\u30b9\u523a\u6fc0\u306b\u5fdc\u7b54\u3057\u3066\u7d30\u80de\u5185\u3067\u8d77\u3053\u308b\u4e00\u9023\u306e\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u6a5f\u69cb\u3078\u306e\u305d\u308c\u3089\u5206\u5b50\u306e\u95a2\u4e0e\u3092\u660e\u3089\u304b\u306b\u3059\u3079\u304f\u3001\u5206\u5b50\u751f\u7269\u5b66\u30fb\u751f\u5316\u5b66\u30fb\u751f\u7406\u5b66\u30fb\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u7684\u624b\u6cd5\u3092\u306f\u3058\u3081\u3001\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3001\u767a\u5149\u691c\u51fa\u306e\u624b\u6cd5\u3082\u99c6\u4f7f\u3057\u3066\u7814\u7a76\u3092\u3057\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u306e\u8a73\u7d30\u306b\u3064\u3044\u3066\u306f\u3001\u9808\u8cc0\u306e\u6559\u54e1\u7d39\u4ecb\u306e\u30da\u30fc\u30b8\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002\u307e\u305f\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u30fb\u533b\u5b66\u7814\u7a76\u8b1b\u7fa9II\u3067\u7c21\u5358\u306a\u7814\u7a76\u7d39\u4ecb\u3092\u884c\u3046\u4e88\u5b9a\u3067\u3059\u306e\u3067\u3001\u305d\u3061\u3089\u306e\u8b1b\u7fa9\u3092\u53c2\u8003\u306b\u3057\u3066\u3044\u305f\u3060\u304f\u3053\u3068\u3082\u53ef\u80fd\u3067\u3059\u3002\u7814\u7a76\u306b\u53c2\u52a0\u5e0c\u671b\u306e\u65b9\u306f\u533b\u5b66\u90e8\u4e8b\u52d9\u8ab2\u30fb\u5927\u5b66\u9662\u4fc2\u3082\u3057\u304f\u306f\u9808\u8cc0\u3042\u3066\u306b\u3054\u9023\u7d61\u304f\u3060\u3055\u3044\u3002<\/p>\r\n<\/section>\r\n<a id=\"achieve\" name=\"achieve\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u8fd1\u5e74\u306e\u4e3b\u306a\u696d\u7e3e<\/h2>\r\n  <ol class=\"BlkArticle__listNumber\">\r\n    <li>Suga K, Yamamoto-Hijikata S, Terao Y, Akagawa K, Ushimaru M: Golgi stress induces upregulation of the ER-Golgi SNARE Syntaxin-5, altered \u03b2APP processing, and Caspase-3-dependent apoptosis in NG108-15 cells. Mol Cell Neurosci., 121:103754 (2022)<\/li>\r\n    <li>Yamamoto-Hijikata S, Suga K, Homareda H, Ushimaru M: Inhibition of the human secretory pathway Ca<sup>2+<\/sup>, Mn<sup>2+<\/sup>-ATPase1a by 1,3-thiazole derivatives. Biochem Biophys Res Commun., 614:56-62 (2022)<\/li>\r\n    <li>Sakurai T, Fukutomi T, Yamamoto S, Nozaki N, Kizaki T: Physical Activity Attenuates the Obesity-Induced Dysregulated Expression of Brown Adipokines in Murine Interscapular Brown Adipose Tissue. Int. J. Mol. Sci., 22(19):10391 (2021)<\/li>\r\n    <li>Takahashi T, Minami S, Tsuchiya Y, Tajima K, Sakai N, Suga K, Hisanaga S, Ohbayashi N, Fukuda M, Kawahara H: Cytoplasmic control of Rab family small GTPases through BAG6. EMBO Rep., e46794. (2019)<\/li>\r\n    <li>Homareda H, Otsu M, Yamamoto S, Ushimaru M, Ito S1, Fukutomi T, Jo T, Eishi Y, Hara Y: A possible mechanism for low affinity of silkworm Na<sup>+<\/sup>\/K<sup>+<\/sup>-ATPase for K. J Bioenerg Biomembr., 49(6): 463-472, (2017)<\/li>\r\n    <li>Yamamoto S, Takehara M, Ushimaru M.: Inhibitory action of linoleamide and oleamide toward sarco\/endoplasmic reticulum Ca<sup>2+<\/sup>-ATPase. Biochim Biophys Acta., 1861(1 Pt A):3399-3405 (2017)<\/li>\r\n    <li>Yamamoto S, Takehara M, Kabashima Y, Fukutomi T, Ushimaru M: Identification of novel inhibitors of human SPCA2. Biochem Biophys Res Commun., 477(2):266-70 (2016)<\/li>\r\n    <li>Yamamoto S, Kimura T, Tachiki T, Anzai N, Sakurai T, Ushimaru M.: The involvement of L-type amino acid transporters in theanine transport. Biosci Biotechnol Biochem., 76(12):2230-5 (2012)<\/li>\r\n    <li>Yamamoto, S., Morihara, Y., Wakayama, M., and Tachiki, T.: Theanine production by coupled fermentation with energy transfer using \u03b3-glutamylmethylamide synthetase of Methylovorus mays No. 9. Biosci Biotechnol Biochem., 72(5):1206-11 (2008)<\/li>\r\n    <li>Yamamoto, S., Wakayama, M., and Tachiki, T.: Cloning and expression of Methylovorus mays No. 9 gene encoding \u03b3-glutamylmethylamide synthetase: an enzyme usable for theanine formation by coupling with alcoholic fermentation system of baker\u2019s yeast. Biosci. Biotechnol. Biochem., 72(1):101-109 (2008)<\/li>\r\n  <\/ol>\r\n<\/section>\r\n","protected":false},"excerpt":{"rendered":"<p>\u6559\u5ba4\u5c02\u4efb\u6559\u54e1 \u6559\u5ba4\u6982\u8981 \u5316\u5b66\u6559\u5ba4\u306f\u3001\u674f\u6797\u5927\u5b66\u533b\u5b66\u90e8\u533b\u5b66\u9032\u5b66\u904e\u7a0b\u306e\u5b66\u751f\u306e\u6559\u80b2\u3092\u76ee\u7684\u3068\u3057\u3066\u3001\u77f3\u5ddd\u52c9\u6c0f\u3092\u521d\u4ee3\u6559\u6388\u3068\u3057\u3066\u3001\u662d\u548c45\u5e74\u306b\u958b\u8a2d\u3055\u308c\u307e\u3057\u305f\u3002\u5e73\u62105\u5e74\u3001\u798f\u5d8b\u7fa9\u535a\u524d\u6559\u6388\u306e\u7740\u4efb\u3068\u3068\u3082\u306b\u3001\u533b\u5b66\u90e8\u521d\u5e74\u5ea6\u306e\u5b66\u751f\u306b\u5bfe\u3059\u308b\u751f\u5316\u5b66\u306e\u57fa\u790e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":24,"menu_order":140,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"section":[4],"class_list":["post-119","page","type-page","status-publish","hentry","section-basics"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/119","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/comments?post=119"}],"version-history":[{"count":9,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/119\/revisions"}],"predecessor-version":[{"id":5599,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/119\/revisions\/5599"}],"up":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/24"}],"wp:attachment":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media?parent=119"}],"wp:term":[{"taxonomy":"section","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/section?post=119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}