{"id":145,"date":"2022-02-16T17:27:18","date_gmt":"2022-02-16T08:27:18","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/_manage\/?page_id=145"},"modified":"2024-09-07T13:48:15","modified_gmt":"2024-09-07T04:48:15","slug":"diab-endocr-metab","status":"publish","type":"page","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/diab-endocr-metab\/","title":{"rendered":"\u7cd6\u5c3f\u75c5\u30fb\u5185\u5206\u6ccc\u30fb\u4ee3\u8b1d\u5185\u79d1\u5b66\u6559\u5ba4"},"content":{"rendered":"<section class=\"BlkAnchorArea\"><div class=\"BlkAnchorArea__inner\"><ul class=\"anchorMenu\"><li><a class=\"p-anchor\" href=\"#teacher\"><span>\u6559\u54e1<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#summary\"><span>\u6982\u8981<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#study\"><span>\u7814\u7a76<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#achieve\"><span>\u696d\u7e3e<\/span><\/a><\/li><\/ul><\/div><\/section>\r\n<section class=\"BlkArticle__Contents--notLead\">\r\n  <div class=\"BlkArticle__btnlink--multi\">\r\n    <div class=\"BlkArticle__btnlink\">\r\n      <p><a class=\"u-icon_blank\" href=\"https:\/\/www.kyorin-u.ac.jp\/hospital\/clinic\/inter07\/\" target=\"_blank\" rel=\"noopener\"><span>\u8a3a\u7642\u79d1\u7d39\u4ecb\uff08\u4ed8\u5c5e\u75c5\u9662\uff09<\/span><\/a><\/p>\r\n    <\/div>\r\n    <div class=\"BlkArticle__btnlink\">\r\n      <p><a class=\"u-icon_blank\" href=\"https:\/\/www.kyorin-u.ac.jp\/hospital\/suginami\/examination\/dm.html\" target=\"_blank\" rel=\"noopener\"><span>\u8a3a\u7642\u79d1\u7d39\u4ecb\uff08\u4ed8\u5c5e\u6749\u4e26\u75c5\u9662\uff09<\/span><\/a><\/p>\r\n    <\/div>\r\n    <div class=\"BlkArticle__btnlink\">\r\n      <p><a class=\"u-icon_blank\" href=\"http:\/\/kyorin-dem.com\/\" target=\"_blank\" rel=\"noopener\"><span>\u6559\u5ba4\u30db\u30fc\u30e0\u30da\u30fc\u30b8<\/span><\/a><\/p>\r\n    <\/div>\r\n    <div class=\"BlkArticle__btnlink\">\r\n      <p><a 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class=\"arrow\">\u9ad8\u6a4b\u3000\u548c\u4eba<\/a><\/li><\/ul><\/td><\/tr><\/tbody><\/table><\/div>\r\n  <h3>\u4ed8\u5c5e\u6749\u4e26\u75c5\u9662<\/h3>\r\n  \n<!-- staffdb 2023.08.15 -->\n<div><table class=\"BlkArticle__tableNormal BlkArticle__tableNormal--topLeft\" width=\"100%\" data-update=\"2023.08.15\"><tbody><tr><th>\u52a9\u6559<\/th><td><ul class=\"list-on-td\"><li data-sort=\"0\uff0f16023\"><a href=\"\/univ\/faculty\/medicine\/education\/staffnew\/detail\/?id=med16023\" class=\"arrow\">\u5cf6\u77e2\u3000\u6c99\u898f\u5b50<\/a><\/li><\/ul><\/td><\/tr><\/tbody><\/table><\/div> <\/section>\r\n<a id=\"summary\" name=\"summary\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u6559\u5ba4\u6982\u8981<\/h2>\r\n  <p>\u7cd6\u5c3f\u75c5\u30fb\u5185\u5206\u6ccc\u30fb\u4ee3\u8b1d\u5185\u79d1\u5b66\u6559\u5ba4\u3067\u306f\u3001\u7cd6\u5c3f\u75c5\u5b66\u3068\u5185\u5206\u6ccc\u30fb\u4ee3\u8b1d\u5b66\u306e\u7814\u7a76\u3068\u6559\u80b2\u3092\u7cbe\u529b\u7684\u306b\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u65e5\u5e38\u81e8\u5e8a\u306e\u4e2d\u304b\u3089\u75be\u60a3\u306e\u75c5\u614b\u89e3\u660e\u3078\u3068\u3064\u306a\u304c\u308b\u7591\u554f\u70b9\u3092\u898b\u3044\u3060\u3057\u3001\u8a3a\u7642\u306e\u4e2d\u3067\u306e\u81e8\u5e8a\u533b\u5b66\u7814\u7a76\u306f\u3082\u3068\u3088\u308a\u3001\u57fa\u790e\u533b\u5b66\u7814\u7a76\u3078\u3068\u53cd\u6620\u3055\u305b\u3066\u3044\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u81ea\u3089\u306e\u8003\u3048\u3067\u5f97\u3089\u308c\u305f\u6210\u679c\u304c\u3001\u6b21\u4e16\u4ee3\u306e\u8a3a\u7642\u6280\u8853\u306e\u5411\u4e0a\u3078\u3068\u3064\u306a\u304c\u308b\u7814\u7a76\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u6559\u80b2\u9762\u3067\u306f\u7d04400\u4e07\u4eba\u304c\u5c45\u4f4f\u3059\u308b\u897f\u6771\u4eac\u552f\u4e00\u306e\u5927\u5b66\u533b\u5b66\u90e8\u306e\u5229\u70b9\u3092\u751f\u304b\u3057\u3001\u306a\u304b\u306a\u304b\u666e\u6bb5\u3067\u306f\u7d4c\u9a13\u3067\u304d\u306a\u3044\u5e0c\u306a\u75c7\u4f8b\u3082\u591a\u304f\u96c6\u307e\u3063\u3066\u304f\u308b\u305f\u3081\u3001\u5145\u5b9f\u3057\u305f\u81e8\u5e8a\u6559\u80b2\u304c\u884c\u308f\u308c\u3066\u304a\u308a\u3001\u6559\u5ba4\u4e3b\u4efb\u30fb\u8a3a\u7642\u79d1\u9577\u306e\u5b89\u7530 \u548c\u57fa\u6559\u6388\u306f\u3058\u3081\u6559\u5ba4\u54e1\u5168\u54e1\u304c\u5207\u78cb\u7422\u78e8\u3057\u306a\u304c\u3089\u3001\u3088\u308a\u8cea\u306e\u9ad8\u3044\u8a3a\u7642\u6280\u8853\u306e\u5411\u4e0a\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <h3>\u8a3a\u7642<\/h3>\r\n  <p>\u7cd6\u5c3f\u75c5\u8a3a\u7642\u306b\u304a\u3044\u3066\u304d\u3081\u7d30\u3084\u304b\u306a\u60a3\u8005\u6559\u80b2\u3084\u751f\u6d3b\u6307\u5c0e\u3092\u884c\u3046\u305f\u3081\u306b\u3001\u773c\u79d1\u533b\u5e2b\u3001\u3055\u3089\u306b\u306f\u7cd6\u5c3f\u75c5\u7642\u990a\u6307\u5c0e\u58eb\u306e\u8cc7\u683c\u3092\u6709\u3059\u308b\u7ba1\u7406\u6804\u990a\u58eb\u30fb\u770b\u8b77\u5e2b\u30fb\u85ac\u5264\u5e2b\u3084\u81e8\u5e8a\u691c\u67fb\u6280\u5e2b\u306e\u4eba\u3005\u3068\u3068\u3082\u306b\u7cd6\u5c3f\u75c5\u6559\u5ba4\u3092\u6bce\u65e5\u958b\u50ac\u3059\u308b\u306a\u3069\u3001\u7dbf\u5bc6\u306a\u30c1\u30fc\u30e0\u533b\u7642\u3092\u5b9f\u8df5\u3057\u3066\u3044\u307e\u3059\u3002\u98df\u4e8b\u30fb\u904b\u52d5\u7642\u6cd5\u306b\u52a0\u3048\u3066\u75c5\u614b\u306b\u57fa\u3065\u304f\u5185\u670d\u85ac\u306e\u9078\u629e\u306a\u3089\u3073\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u7642\u6cd5\uff08\u5f37\u5316\u7642\u6cd5\u3092\u542b\u3080\uff09\u3092\u5b9f\u65bd\u3057\u3066\u304a\u308a\u3001\u8840\u7cd6\u5909\u52d5\u304c\u8457\u3057\u3044\u75c7\u4f8b\u306b\u306f\uff23\uff33\uff29\uff29\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u30dd\u30f3\u30d7\uff09\u306e\u5c0e\u5165\u3082\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3088\u308a\u53b3\u683c\u306a\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3092\u3081\u3056\u3057\u3066\u3001CGMS\uff08\u6301\u7d9a\u8840\u7cd6\u30e2\u30cb\u30bf\u30fc\u30b7\u30b9\u30c6\u30e0\uff09\u3092\u7528\u3044\u305f\u6cbb\u7642\u3082\u5b9f\u65bd\u3057\u3066\u3044\u307e\u3059\u3002\u773c\u79d1\u30fb\u814e\u81d3\u5185\u79d1\u3068\u3082\u9023\u643a\u3092\u5bc6\u63a5\u306b\u3057\u3001\u5408\u4f75\u75c7\u306e\u65e9\u671f\u8a3a\u65ad\u3068\u305d\u306e\u75c5\u671f\u306b\u5fdc\u3058\u305f\u7684\u78ba\u306a\u6cbb\u7642\u3092\u5b9f\u8df5\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u7cd6\u5c3f\u75c5\u7db2\u819c\u75c7\u3084\u767d\u5185\u969c\u306a\u3069\u306e\u7cd6\u5c3f\u75c5\u773c\u5408\u4f75\u75c7\u306b\u5bfe\u3057\u3066\u306f\u3001\u773c\u79d1\u3068\u306e\u5171\u540c\u3067\u7279\u6b8a\u5916\u6765\u3092\u5b9a\u671f\u7684\u306b\u958b\u8a2d\u3057\u3001\u65e9\u671f\u8a3a\u65ad\u304b\u3089\u6cbb\u7642\u3001\u305d\u3057\u3066\u7cd6\u5c3f\u75c5\u306e\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u7dad\u6301\u306b\u3064\u3044\u3066\u7dcf\u5408\u7684\u306a\u7ba1\u7406\u3092\u3059\u3059\u3081\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u598a\u5a20\u7cd6\u5c3f\u75c5\u3084\u7cd6\u5c3f\u75c5\u5408\u4f75\u598a\u5a20\u306e\u75c7\u4f8b\u306b\u3064\u3044\u3066\u3001\u7523\u5a66\u4eba\u79d1\u3068\u306e\u5354\u529b\u95a2\u4fc2\u306e\u4e0b\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u304b\u3089\u6cbb\u7642\u3068\u7ba1\u7406\u306b\u81f3\u308b\u307e\u3067\u4e00\u5143\u5316\u306e\u3046\u3048\u7dcf\u5408\u7684\u306a\u6cbb\u7642\u3092\u3059\u3059\u3081\u3066\u3044\u307e\u3059\u3002\u5185\u5206\u6ccc\u30fb\u4ee3\u8b1d\u75be\u60a3\u306b\u3064\u3044\u3066\u306f\u3001\u69d8\u3005\u306a\u8ca0\u8377\u8a66\u9a13\u306b\u3088\u308b\u6a5f\u80fd\u691c\u67fb\u3068\u753b\u50cf\u8a3a\u65ad\u304b\u3089\u5f97\u3089\u308c\u308b\u60c5\u5831\u3092\u99c6\u4f7f\u3057\u3066\u3001\u7684\u78ba\u306a\u8a3a\u65ad\u3092\u8fc5\u901f\u306b\u884c\u3044\u3001\u500b\u3005\u306e\u75c5\u614b\u306b\u5373\u3057\u305f\u6cbb\u7642\u3092\u9032\u3081\u308b\u3068\u3068\u3082\u306b\u3001\u5916\u79d1\u7684\u6cbb\u7642\u304c\u5fc5\u8981\u306a\u969b\u306f\u75c7\u4f8b\u306b\u5fdc\u3058\u3066\u7532\u72b6\u817a\u5916\u79d1\u3001\u8133\u795e\u7d4c\u5916\u79d1\u3001\u6ccc\u5c3f\u5668\u79d1\u3068\u5bc6\u63a5\u306a\u9023\u643a\u3092\u56f3\u308a\u5b9f\u7e3e\u3092\u3042\u3052\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u5730\u57df\u793e\u4f1a\u306b\u304a\u3051\u308b\u6d3b\u52d5\u306e\u4e00\u74b0\u3068\u3057\u3066\u3001\u5730\u57df\u9023\u643a\u30d1\u30b9\u3092\u5c0e\u5165\u3057\u3001\u5730\u57df\u8a3a\u7642\u306b\u3082\u7a4d\u6975\u7684\u306b\u53c2\u52a0\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <h3>\u6559\u80b2\u30fb\u7814\u7a76<\/h3>\r\n  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id=\"study\" name=\"study\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u53ca\u3073\u7814\u7a76\u8ab2\u984c<\/h2>\r\n  <p>\u7cd6\u5c3f\u75c5\u30fb\u5185\u5206\u6ccc\u30fb\u4ee3\u8b1d\u5185\u79d1\u5b66\u306f\u5b89\u7530 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 <h3>\u7cd6\u5c3f\u75c5\u30fb\u5185\u5206\u6ccc\u30fb\u4ee3\u8b1d\u5185\u79d1\u5b66\u306e6\u3064\u306e\u7814\u7a76\u73ed\u306b\u3064\u3044\u3066<\/h3>\r\n  <p>\u7814\u7a76\u73ed\u306f\u3001(1) \u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u6a5f\u69cb\u7814\u7a76\u73ed\u3001(2) \u30a4\u30f3\u30b9\u30ea\u30f3\u4f5c\u7528\u6a5f\u69cb\u7814\u7a76\u73ed\u3001(3) \u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u7814\u7a76\u73ed\u3001(4) \u7cd6\u5c3f\u75c5\u767a\u75c7\u6a5f\u69cb\u7814\u7a76\u73ed\u3001(5) \u5185\u5206\u6ccc\u75be\u60a3\u75c5\u614b\u751f\u7406\u7814\u7a76\u73ed\u3001(6) \u81e8\u5e8a\u5185\u5206\u6ccc\u7814\u7a76\u73ed\u306e6\u3064\u306e\u73ed\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u304a\u308a\u3001\u5e83\u304f\u57fa\u790e\u7cfb\u6559\u5ba4(\u885b\u751f\u5b66\u30fb\u516c\u8846\u885b\u751f\u5b66\u6559\u5ba4\u3084\u751f\u5316\u5b66\u6559\u5ba4\u306a\u3069)\u3084\u81e8\u5e8a\u7cfb\u6559\u5ba4(\u773c\u79d1\u5b66\u6559\u5ba4\u3001\u8133\u795e\u7d4c\u5916\u79d1\u5b66\u6559\u5ba4\u3001\u81e8\u5e8a\u691c\u67fb\u533b\u5b66\u6559\u5ba4\u3084\u7523\u5a66\u4eba\u79d1\u5b66\u6559\u5ba4\u306a\u3069)\u3068\u3082\u5171\u540c\u3067\u4ed5\u4e8b\u3092\u9032\u3081\u3066\u304a\u308a\u307e\u3002\u3053\u306e\u7d50\u679c\u3001\u6570\u3005\u306e\u6700\u65b0\u77e5\u898b\u304c\u5f97\u3089\u308c\u3066\u304a\u308a\u3001\u591a\u304f\u306e\u696d\u7e3e\u304c\u82f1\u6587\u8a8c\u306b\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4ee5\u4e0b\u306b6\u3064\u306e\u7814\u7a76\u73ed\u306e\u7814\u7a76\u6982\u8981\u3092\u304a\u793a\u3057\u3057\u307e\u3059\u3002<\/p>\r\n<h4>(1) \u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u6a5f\u69cb\u7814\u7a76\u73ed<\/h4>\r\n  <p>\u7cd6\u5c3f\u75c5\u767a\u75c7\u306b\u304a\u3051\u308b\u91cd\u5927\u306a\u75c5\u56e0\u306e\u3072\u3068\u3064\u3068\u3055\u308c\u3066\u3044\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u969c\u5bb3\u306e\u89e3\u660e\u306b\u5c11\u3057\u3067\u3082\u8fd1\u3065\u304f\u3088\u3046\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u6a5f\u69cb\u306b\u95a2\u3057\u5206\u5b50\u751f\u7269\u7684\u624b\u6cd5\u3092\u7528\u3044\u3001\u57fa\u790e\u7684\u7814\u7a76\u3092\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002\u30e9\u30c3\u30c8\u3084\u30de\u30a6\u30b9\u306e\u81b5\u81d3\u304b\u3089\u53d6\u308a\u51fa\u3057\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u7d30\u80de\u3067\u3042\u308b &beta; \u7d30\u80de\u3092\u542b\u3080\u30e9\u30f3\u30b2\u30eb\u30cf\u30f3\u30b9\u6c0f\u5cf6\u3084\u30a4\u30f3\u30b9\u30ea\u30ce\u30fc\u30de\u7d30\u80de\u3067\u3042\u308b MIN6 \u7d30\u80de\u3092\u4f7f\u7528\u3057\u3001\u5404\u7a2e\u85ac\u5264\u306a\u3089\u3073\u306b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306a\u3069\u3092\u542b\u3080\u591a\u69d8\u306a\u751f\u7406\u6d3b\u6027\u3092\u6709\u3059\u308b\u7a2e\u3005\u306e\u56e0\u5b50\u3092\u7528\u3044\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5206\u6ccc\u306a\u3089\u3073\u306b\u5408\u6210\u306b\u304a\u3088\u307c\u3059\u5f71\u97ff\u3001\u7d30\u80de\u5185\u4ee3\u8b1d\u6a5f\u69cb\u306b\u3064\u3044\u3066\u691c\u8a0e\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u8fd1\u5e74\u306b\u306a\u308a\u3001&beta; \u7d30\u80de\u304b\u3089\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u4ee5\u5916\u306e\u5206\u6ccc\u7269\u8cea\uff08MCP-1\u3001VEGF \u306a\u3069\uff09\u306b\u3064\u3044\u3066\u3082\u305d\u306e\u5236\u5fa1\u6a5f\u69cb\u53ca\u3073\u75c5\u614b\u751f\u7406\u5b66\u7684\u4f5c\u7528\u306b\u3064\u3044\u3066\u691c\u8a0e\u3092\u9032\u3081\u3066\u304a\u308a\u3001\u4eca\u5f8c\u7cd6\u5c3f\u75c5\u72b6\u614b\u4e0b\u306e\u81b5\u30e9\u30f3\u30b2\u30eb\u30cf\u30f3\u30b9\u6c0f\u5cf6\u306b\u304a\u3051\u308b\u3053\u308c\u3089\u306e\u5206\u5b50\u306e\u65b0\u305f\u306a\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u8003\u3048\u3066\u304a\u308a\u307e\u3059\u3002\u307e\u305f\u3053\u308c\u3089\u57fa\u790e\u7814\u7a76\u3068\u306f\u5225\u306b\u81e8\u5e8a\u7684\u7814\u7a76\u3082\u884c\u306a\u308f\u308c\u3066\u304a\u308a\u3001\u81b5 &beta; \u7d30\u80de\u5185\u3067\u306e\u30d7\u30ed\u30a4\u30f3\u30b9\u30ea\u30f3\u304b\u3089\u30a4\u30f3\u30b9\u30ea\u30f3\u3078\u306e\u5909\u63db\u904e\u7a0b\u304c\u7cd6\u5c3f\u75c5\u72b6\u614b\u4e0b\u3067\u969c\u5bb3\u3055\u308c\u3066\u3044\u308b\u73fe\u8c61\u3092\u660e\u3089\u304b\u3059\u308b\u3053\u3068\u3001\u306a\u3089\u3073\u306b\u305d\u306e\u7570\u5e38\u306b\u95a2\u3059\u308b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u306b\u7740\u624b\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u3053\u308c\u3089\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u305f\u65b0\u77e5\u898b\u306f\u3001\u6d77\u5916\u306e\u82f1\u6587\u8a8c\u306b\u6295\u7a3f\u3059\u308b\u3053\u3068\u306f\u3082\u3061\u308d\u3093\u306e\u3053\u3068\u3001\u6bce\u5e74\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u3084\u95a2\u9023\u3059\u308b\u7814\u7a76\u4f1a\u3067\u968f\u6642\u5831\u544a\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\r\n\r\n<h4>(2) \u30a4\u30f3\u30b9\u30ea\u30f3\u4f5c\u7528\u6a5f\u69cb\u7814\u7a76\u73ed<\/h4>\r\n  <p>2\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u306b\u306f\u3001\u81b5\u81d3\u304b\u3089\u306e &ldquo;\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u4f4e\u4e0b&rdquo; \u3068\u3001\u7b4b\u8089\u3084\u8102\u80aa\u306a\u3069\u306b\u304a\u3051\u308b &ldquo;\u30a4\u30f3\u30b9\u30ea\u30f3\u4f5c\u7528\u306e\u4f4e\u4e0b&rdquo; \u306e\u4e21\u8005\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u91cd\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u3064\u3067\u3042\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u4f5c\u7528\u306e\u7814\u7a76\u306f\u3001\u7b4b\u8089\u3084\u8102\u80aa\u7d30\u80de\u3001\u9aa8\u82bd\u7d30\u80de\u3042\u308b\u3044\u306f\u809d\u7d30\u80de\u3092\u7528\u3044\u3066\u751f\u5316\u5b66\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u53ef\u80fd\u3067\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u4f5c\u7528\u6a5f\u69cb\u7814\u7a76\u6591\u3067\u306f\u3001\u4e3b\u306b\u8102\u80aa\u7d30\u80de\u306b\u304a\u3051\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u7d50\u5408\u4ee5\u964d\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3084\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u4f5c\u7528\u7269\u8cea\u306b\u3088\u308b\u7d30\u80de\u3078\u306e\u7cd6\u53d6\u308a\u8fbc\u307f\u3068\u7cd6\u8f38\u9001\u62c5\u4f53\u3078\u53ca\u307c\u3059\u5f71\u97ff\u3001\u3055\u3089\u306b\u306f\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u30a2\u30c7\u30a3\u30dd\u30ab\u30a4\u30f3\u306e\u5206\u6ccc\u5236\u5fa1\u6a5f\u69cb\u3084\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001ER \u30b9\u30c8\u30ec\u30b9\u3001mitochondrial uncoupling\u3001\u71b1\u523a\u6fc0\u306a\u3069\u306e\u75c5\u614b\u3078\u306e\u4f5c\u7528\u6a5f\u5e8f\u306a\u3069\u306b\u3064\u3044\u3066\u691c\u8a0e\u3092\u884c\u3044\u3001&ldquo;\u30a4\u30f3\u30b9\u30ea\u30f3\u4f5c\u7528\u306e\u4f4e\u4e0b&rdquo; \u3059\u306a\u308f\u3061\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u3082\u305f\u3089\u3055\u308c\u308b\u6a5f\u5e8f\u306e\u89e3\u660e\u3092\u9042\u884c\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u8a98\u5c0e\u306b\u304a\u3051\u308b key factor \u3068\u306a\u3063\u3066\u3044\u308b\u80a5\u5927\u5316\u8102\u80aa\u7d30\u80de\u304b\u3089\u306e\u4f4e\u9178\u7d20\u975e\u4f9d\u5b58\u7684\u306a\u8840\u7ba1\u65b0\u751f\u56e0\u5b50 VEGF120 \u306e\u5206\u6ccc\u5236\u5fa1\u6a5f\u69cb\u3092\u89e3\u660e\u3057\u305f\u7814\u7a76\u3001\u306a\u3089\u3073\u306b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068 mitochondrial uncoupling \u304c \u6210\u719f\u8102\u80aa\u7d30\u80de\u3088\u308a\u5206\u6ccc\u3055\u308c\u308b\u30a2\u30c7\u30a3\u30dd\u30ab\u30a4\u30f3\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3068\u305d\u306e\u5236\u5fa1\u6a5f\u69cb\u3092\u89e3\u660e\u3057\u305f\u7814\u7a76\u306f\u3001\u305d\u308c\u3089\u306e\u7d50\u679c\u304c\u305d\u308c\u305e\u308c2013\u5e74\u30682012\u5e74\u306b\u82f1\u6587\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u3053\u6570\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u8102\u80aa\u7d44\u7e54\u306e\u6162\u6027\u708e\u75c7\u3068\u7cd6\u5c3f\u75c5\u306e\u95a2\u9023\u6027\u306b\u3064\u3044\u3066\u3082\u7814\u7a76\u3092\u3059\u3059\u3081\u3066\u304a\u308a\u3001\u306a\u304b\u3067\u3082\u305d\u306e\u4e21\u8005\u3092\u7d50\u3073\u3064\u3051\u308b\u6700\u3082\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3042\u308b\u30b1\u30e2\u30ab\u30a4\u30f3\u306e MCP-1 \u306b\u95a2\u3057\u307e\u3057\u3066\u306f\u3001\u6700\u8fd1\u79c1\u9054\u304c\u80a5\u5927\u5316\u8102\u80aa\u7d30\u80de\u306b\u304a\u3051\u308b\u5206\u6ccc\u5236\u5fa1\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3057\u82f1\u6587\u8a8c\u306b\u767a\u8868\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u73fe\u5728\u57fa\u790e\u30fb\u81e8\u5e8a\u7814\u7a76\u306e\u4e21\u8005\u306b\u304a\u3044\u3066\u4e3b\u8981\u306a\u67f1\u306e\u3072\u3068\u3064\u3068\u306a\u3063\u3066\u3044\u308b\u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u306a\u3069\u6d88\u5316\u7ba1\u30db\u30eb\u30e2\u30f3\u306b\u95a2\u3059\u308b\u7814\u7a76\u3082\u884c\u306a\u3063\u3066\u304a\u308a\u3001\u4e2d\u3067\u3082\u30b0\u30ec\u30ea\u30f3\u306b\u95a2\u3057\u307e\u3057\u3066\u306f\u3001\u591a\u304f\u306e\u7814\u7a76\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u4e2d\u67a2\u4f5c\u7528\u306b\u6bd4\u8f03\u3057\u5168\u304f\u3068\u3044\u3063\u3066\u3044\u3044\u307b\u3069\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u672b\u68a2\u4f5c\u7528\u3001\u306a\u304b\u3067\u3082\u7a2e\u3005\u306e\u30a2\u30c7\u30a3\u30dd\u30ab\u30a4\u30f3\u5206\u6ccc\u5236\u5fa1\u6a5f\u69cb\u3092\u542b\u3080\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u95a2\u9023\u4f5c\u7528\u3092\u89e3\u660e\u3057\u30012015\u5e74\u6d77\u5916\u306e\u82f1\u6587\u96d1\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\r\n\r\n<h4>(3) \u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u7814\u7a76\u73ed<\/h4>\r\n  <p>\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u7814\u7a76\u73ed\u3068\u3057\u3066\u306f\u3001\u6570\u3042\u308b\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u306e\u306a\u304b\u3067\u3082\u7279\u306b\u9aa8\u4ee3\u8b1d\u306a\u3089\u3073\u306b\u5927\u8840\u7ba1\u969c\u5bb3\u306b\u95a2\u3057\u3066\u7cbe\u529b\u7684\u306b\u7814\u7a76\u6d3b\u52d5\u3092\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u9aa8\u4ee3\u8b1d\u7570\u5e38\u306b\u95a2\u3057\u307e\u3057\u3066\u306f\u3001\u6211\u3005\u306f\u305d\u306e\u767a\u75c7\u306b\u304a\u3051\u308b\u30a4\u30cb\u30b7\u30a8\u30fc\u30bf\u30fc\u306e\u3072\u3068\u3064\u304c\u3001\u7cd6\u5c3f\u75c5\u306b\u9ad8\u983b\u5ea6\u306b\u5408\u4f75\u3059\u308b\u8102\u8cea\u7570\u5e38\u75c7\uff08\u9ad8\u8102\u8840\u75c7\uff09\u72b6\u614b\u4e0b\u3067\u9aa8\u82bd\u7d30\u80de\u3088\u308a\u5206\u6ccc\u304c\u5897\u5927\u3059\u308b VEGF120 \u3067\u3042\u308b\u3053\u3068\u3092\u4e16\u754c\u306b\u5148\u99c6\u3051\u3066\u767a\u898b\u3057\uff08\u3053\u306e VEGF120 \u306b\u3088\u308a\u7b2c\u4e00\u7fa9\u7684\u306b\u7834\u9aa8\u7d30\u80de\u306e\u7570\u5e38\u6d3b\u6027\u5316\u304c\u751f\u3058\u3001\u305d\u306e\u5f8c\u9aa8\u4ee3\u8b1d\u306e\u30ab\u30c3\u30d7\u30ea\u30f3\u30b0\u304c\u7834\u7dbb\u3057\u3066\u9aa8\u5438\u53ce\u512a\u4f4d\u306b\u50be\u304f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\uff09\u3001\u3055\u3089\u306b\u305d\u306e\u5206\u6ccc\u5236\u5fa1\u6a5f\u69cb\u3082\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u3053\u308c\u3089\u7d50\u679c\u3092\u307e\u3068\u3081\u305f\u7814\u7a76\u8ad6\u6587\u3092\u82f1\u6587\u8a8c\u306b\u6295\u7a3f\u3057\u53d7\u7406\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u3002\u52a0\u3048\u3066\u3001\u81e8\u5e8a\u7684\u306a\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u9ad8\u8840\u7cd6\u72b6\u614b\u304c\u7d9a\u304f\u3053\u3068\u306b\u3088\u3063\u3066\u304a\u3053\u308b\u9aa8\u91cf\u6e1b\u5c11\u306e\u75c5\u614b\u304a\u3088\u3073\u305d\u306e\u539f\u56e0\u3092\u81e8\u5e8a\u7684\u7acb\u5834\u304b\u3089\u3082\u30a2\u30d7\u30ed\u30fc\u30c1\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u7279\u306b\u9aa8\u82bd\u7d30\u80de\u306b\u3088\u308a\u7523\u751f\u3055\u308c\u308b\u30aa\u30b9\u30c6\u30aa\u30ab\u30eb\u30b7\u30f3\u306b\u95a2\u3057\u3066\u306f\u3001\u57fa\u790e\u306a\u3089\u3073\u306b\u81e8\u5e8a\u306e\u4e21\u9762\u304b\u3089\u305d\u306e\u75c5\u56e0\u8ad6\u7684\u610f\u7fa9\u3092\u8ffd\u8de1\u4e2d\u3067\u3059\u3002\u3055\u3089\u306b\u6700\u8fd1\u6ce8\u76ee\u3092\u6d74\u3073\u3066\u3044\u308b\u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u95a2\u9023\u85ac\uff08DPP4 \u963b\u5bb3\u85ac\u3084 GLP-1 \u30a2\u30ca\u30ed\u30b0\u88fd\u5264\uff09\u306e\u9aa8\u4ee3\u8b1d\u7570\u5e38\u306b\u5bfe\u3059\u308b\u6539\u5584\u4f5c\u7528\u306e\u81e8\u5e8a\u7684\u691c\u8a0e\u306b\u7740\u624b\u3057\u3001\u305d\u306e\u52b9\u679c\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u6790\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u5927\u8840\u7ba1\u969c\u5bb3\u306b\u95a2\u3057\u307e\u3057\u3066\u306f\u3001\u57fa\u790e\u7684\u306a\u7814\u7a76\u3068\u3057\u3066\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u30e2\u30c7\u30eb\u3068\u3057\u3066 HUVEC \u3092\u4f7f\u7528\u3057\u3001\u305d\u306e\u767a\u75c7\u30fb\u9032\u5c55\u3092\u5236\u5fa1\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u52b1\u3093\u3067\u304a\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u81e8\u5e8a\u7684\u306a\u9762\u304b\u3089\u306f\u3001\u9838\u52d5\u8108\u8d85\u97f3\u6ce2\u691c\u67fb\u306b\u3088\u308b\u9838\u52d5\u8108\u306e\u89e3\u6790\u3092\u57fa\u76e4\u3068\u3057\u3066\u8133\u8840\u7ba1\u30fb\u51a0\u8840\u7ba1\u306f\u52ff\u8ad6\u3001\u5168\u8eab\u306e\u5927\u8840\u7ba1\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u56e0\u5b50\u3092\u53ef\u80fd\u306a\u9650\u308a\u53ce\u96c6\u3057\u305f\u3046\u3048\u3067\u306e\u89e3\u6790\u30fb\u691c\u8a0e\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u52d5\u8108\u786c\u5316\u306b\u5bfe\u3059\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3084 AGEs \uff08\u5f8c\u671f\u7cd6\u5316\u6700\u7d42\u7523\u7269\uff09\u306e\u95a2\u4e0e\u306a\u3069\u306b\u3064\u3044\u3066\u306f\u91cd\u70b9\u7684\u306b\u691c\u8a0e\u3092\u52a0\u3048\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u3053\u308c\u3089\u306e\u6210\u679c\u306f\u65e5\u672c\u9aa8\u4ee3\u8b1d\u5b66\u4f1a\u3084\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u3067\u767a\u8868\u3059\u308b\u3053\u3068\u306f\u3082\u3061\u308d\u3093\u3001\u6d77\u5916\u306e\u82f1\u6587\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3055\u3089\u306a\u308b\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u3092\u78ba\u7acb\u3057\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u751f\u6d3b\u306e\u8cea\u306e\u5411\u4e0a\u3092\u76ee\u6307\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\r\n\r\n<h4>(4) \u7cd6\u5c3f\u75c5\u767a\u75c7\u6a5f\u69cb\u7814\u7a76\u73ed<\/h4>\r\n  <p>\u7cd6\u5c3f\u75c5\u767a\u75c7\u306e\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4f4e\u4e0b\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u5897\u5927\u306e\u4e21\u8005\u3092\u7d71\u5408\u3057\u3001\u7cd6\u5c3f\u75c5\u767a\u75c7\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7dcf\u62ec\u7684\u306a\u7acb\u5834\u3088\u308a\u89e3\u660e\u3059\u308b\u305f\u3081\u3001\u81e8\u5e8a\u53ca\u3073\u57fa\u790e\u306e\u4e21\u9762\u3088\u308a\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u3001\u6700\u8fd1\u306b\u306a\u308a\u308f\u304c\u56fd\u306b\u304a\u3044\u3066\u3082\u7814\u7a76\u304c\u76db\u3093\u3068\u306a\u3063\u3066\u3044\u308b\u6442\u98df\u8abf\u7bc0\u56e0\u5b50\uff08\u4f8b\u3048\u3070\u30b0\u30ec\u30ea\u30f3\u3084\u30ec\u30d7\u30c1\u30f3\u306a\u3069\uff09\u306b\u3064\u3044\u3066\u3001\u7cd6\u5c3f\u75c5\u306b\u76f4\u63a5\u7684\u307e\u305f\u306f\u9593\u63a5\u7684\u306b\u95a2\u4e0e\u3059\u308b\u7a2e\u3005\u306e\u8981\u56e0\u3068\u306e\u95a2\u9023\u6027\u306e\u8a55\u4fa1\u3092\u5e83\u7bc4\u306b\u308f\u305f\u308a\u89e3\u6790\u3057\u3066\u3044\u308b\u81e8\u5e8a\u9762\u306b\u52a0\u3048\u3001 3T3-L1 \u8102\u80aa\u7d30\u80de\u306a\u3069\u3092\u4f7f\u7528\u3057\u57fa\u790e\u7684\u306b\u3082\u7814\u7a76\u3092\u7d9a\u3051\u3066\u304a\u308a\u307e\u3059\u3002\u7279\u306b\u30b0\u30ec\u30ea\u30f3\u306b\u95a2\u3057\u307e\u3057\u3066\u306f\u3001\u5148\u306e(2)\u30a4\u30f3\u30b9\u30ea\u30f3\u4f5c\u7528\u6a5f\u69cb\u7814\u7a76\u73ed\u306e\u9805\u3067\u8a18\u8f09\u3057\u305f\u3068\u304a\u308a\u3001\u57fa\u790e\u7684\u306a\u9762\u304b\u3089\u306f\u30a2\u30c7\u30a3\u30dd\u30ab\u30a4\u30f3\u5206\u6ccc\u5236\u5fa1\u6a5f\u69cb\u3092\u542b\u3081\u305f\u672b\u68a2\u306b\u304a\u3051\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u95a2\u9023\u4f5c\u7528\u306e\u89e3\u660e\u304c\u63a8\u9032\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u7814\u7a76\u306a\u3089\u3073\u306b\u73fe\u5728\u4e26\u884c\u3057\u3066\u884c\u306a\u308f\u308c\u3066\u3044\u308b\u30b0\u30ec\u30ea\u30f3\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u89e3\u6790\u3057\u3066\u3044\u308b\u7814\u7a76\u3092\u542b\u3081\u305f\u57fa\u790e\u7814\u7a76\u306e\u7d50\u679c\u306b\u3001\u3055\u3089\u306b\u81e8\u5e8a\u7814\u7a76\u304b\u3089\u968f\u6642\u5f97\u3089\u308c\u308b\u30c7\u30fc\u30bf\u3092\u878d\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u7cd6\u5c3f\u75c5\u767a\u75c7\u3068\u305d\u306e\u4e88\u9632\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u4eca\u307e\u3067\u3068\u306f\u7570\u306a\u3063\u305f\u65b0\u305f\u306a\u8996\u70b9\u3088\u308a\u89e3\u660e\u3067\u304d\u308b\u3068\u4fe1\u3058\u3066\u304a\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u8102\u80aa\u7d30\u80de\u306b\u304a\u3044\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u60f9\u8d77\u3059\u308b\u7a2e\u3005\u306e\u8102\u80aa\u9178\u306b\u52a0\u3048\u3066\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3084\u60aa\u7389\u30a2\u30c7\u30a3\u30dd\u30ab\u30a4\u30f3\uff08MCP-1 \u3084 TNF-&alpha; \u306a\u3069\uff09\u306e\u7cd6\u5c3f\u75c5\u767a\u75c7\u306b\u304a\u3051\u308b\u5f79\u5272\u3068\u305d\u306e\u5206\u5b50\u6a5f\u69cb\u3001\u306a\u3089\u3073\u306b GLP-1 \u306a\u3069\u306e\u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u95a2\u9023\u56e0\u5b50\u3068\u7cd6\u5c3f\u75c5\u767a\u75c7\u3068\u306e\u7d50\u3073\u3064\u304d\u306b\u3064\u304d\u307e\u3057\u3066\u3082\u3001\u57fa\u790e\u3068\u81e8\u5e8a\u3092\u878d\u5408\u3055\u305b\u305f\u72ec\u7279\u306e\u7814\u7a76\u65b9\u6cd5\u306b\u3088\u308a\u691c\u8a0e\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u81b5 &beta; \u7d30\u80de\u304b\u3089\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u969c\u5bb3\u306b\u95a2\u4e0e\u3059\u308b\u56e0\u5b50\u3082\u542b\u3081\u3066\u591a\u89d2\u7684\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u3001\u3053\u308c\u307e\u3067\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u306a\u3044\u3088\u3046\u306a\u89b3\u5bdf\u7d50\u679c\u304c\u5f97\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u6700\u8fd1\u8a71\u984c\u306b\u306a\u3063\u3066\u3044\u308b\u7cd6\u8cea\u5236\u9650\u98df\u306e\u7cd6\u5c3f\u75c5\u3001\u80a5\u6e80\u306e\u767a\u75c7\u30fb\u9032\u5c55\u306a\u3069\u306b\u5bfe\u3059\u308b\u5f71\u97ff\u306b\u95a2\u3057\u307e\u3057\u3066\u3082\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u3092\u4f7f\u7528\u3057\u305f\u8a73\u7d30\u306a\u691c\u8a0e\u306b\u52a0\u3048\u3001\u81e8\u5e8a\u9762\u304b\u3089\u5f97\u3089\u308c\u305f\u6570\u591a\u304f\u306e\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u4eca\u307e\u3067\u306b\u78ba\u8a8d\u3055\u308c\u305f\u7d50\u679c\u3068\u306f\u7570\u306a\u308b\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\u7d50\u679c\u304c\u5831\u544a\u3067\u304d\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u65b0\u77e5\u898b\u306f\u82f1\u6587\u8a8c\u3078\u306e\u6295\u7a3f\u306a\u3089\u3073\u306b\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u3084\u95a2\u9023\u3059\u308b\u7814\u7a76\u4f1a\u3067\u6bce\u5e74\u767a\u8868\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\r\n\r\n<h4>(5) \u5185\u5206\u6ccc\u75be\u60a3\u75c5\u614b\u751f\u7406\u7814\u7a76\u73ed<\/h4>\r\n  <p>\u751f\u4f53\u5185\u306b\u306f\u3001\u591a\u69d8\u306a\u5185\u5206\u6ccc\u7d44\u7e54\u304c\u5b58\u5728\u3057\u307e\u3059\u304c\u3001\u308f\u304c\u7814\u7a76\u73ed\u3067\u306f\u305d\u308c\u3089\u7d44\u7e54\u9593\u306e\u65b0\u305f\u306a\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u89e3\u660e\u3068\u81e8\u5e8a\u7684\u5fdc\u7528\u306b\u81e8\u5e8a\u3068\u57fa\u790e\u4e21\u9762\u3088\u308a\u30a2\u30d7\u30ed\u30fc\u30c1\u3057\u7d9a\u3051\u3066\u304a\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u305d\u306e\u7814\u7a76\u6210\u679c\u306e\u306a\u304b\u306e\u3072\u3068\u3064\u3067\u3042\u308b\u4e2d\u67a2\u6027\u5c3f\u5d29\u75c7\u60a3\u8005\u306b\u5bfe\u3057\u3066\u9ad8\u5f35\u98df\u5869\u6c34\u8ca0\u8377\u8a66\u9a13\u3092\u65bd\u884c\u3057\u3066\u5f97\u3089\u308c\u305f\u7d50\u679c\u306e\u89e3\u6790\u306b\u3088\u308a\u3001\u8840\u6f3f\u6d78\u900f\u5727\u306e\u4e0a\u6607\u304c AVP 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 <p>\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u5185\u79d1\u5b66\uff08\u7cd6\u5c3f\u75c5\u30fb\u5185\u5206\u6ccc\u30fb\u4ee3\u8b1d\u5185\u79d1\u5b66\uff09\u306f\u57fa\u790e\u53ca\u3073\u81e8\u5e8a\u7814\u7a76\u306e\u4e21\u9762\u306b\u304a\u3044\u3066\u6700\u5148\u7aef\u304b\u3064\u30e6\u30cb\u30fc\u30af\u306a\u7814\u7a76\u3092\u884c\u3046\u4e00\u65b9\u3001\u305d\u306e\u7814\u7a76\u6210\u679c\u3092\u75be\u60a3\u306e\u6cbb\u7642\u306b\u5f79\u7acb\u3066\u3066\u304a\u308a\u307e\u3059\u3002\u79c1\u9054\u4e00\u540c\u306f\u3001\u307f\u306a\u3055\u3093\u3068\u4e00\u7dd2\u306b\u8a3a\u7642\u306a\u3089\u3073\u306b\u7814\u7a76\u304c\u884c\u3048\u308b\u3053\u3068\u3092\u5fc3\u3088\u308a\u697d\u3057\u307f\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5206\u91ce\u306b\u8208\u5473\u306e\u3042\u308b\u65b9\u3001\u307e\u305f\u306f\u4f55\u304b\u5fa1\u8cea\u554f\u7b49\u3042\u308a\u307e\u3057\u305f\u3089\u3001\u7cd6\u5c3f\u75c5\u30fb\u5185\u5206\u6ccc\u30fb\u4ee3\u8b1d\u5185\u79d1\u5b66\u30b9\u30bf\u30c3\u30d5\u306b\u6c17\u8efd\u306b\u58f0\u3092\u304b\u3051\u3066\u4e0b\u3055\u3044\u3002<\/p>\r\n\r\n<\/section>\r\n<a id=\"achieve\" name=\"achieve\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u8fd1\u5e74\u306e\u4e3b\u306a\u696d\u7e3e<\/h2>\r\n  <ol class=\"BlkArticle__listNumber\">\r\n    <li>K.Hirota, H.Keino, M.Inoue, H.Ishida, and A.Hirakata. Comparisons of microRNA expression profiles in vitreous humor between eyes with macular hole and eyes with proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 253 : 335-342, 2015.<\/li>\r\n    <li>H.Katsuta, S.Ozawa, K.Suzuki, K.Takahashi, T.Tanaka, Y.Sumitani, S.Nishida, T.Kondo, T.Hosaka, and H.Ishida. The association between impaired proinsulin processing and type 2 diabetes mellitus in non-obese Japanese individuals. Endocr J 62(6) : 485-492, 2015.<\/li>\r\n    <li>J.Ogasawara, T.Izawa, T.Sakurai,  K.Shirota, Y.Ishibashi, Y.Ohira, H.Ishida, H.Ohno, and T.Kizaki. Habitual exercise training acts as a physiological stimulator for constant activation of lipolytic enzymes in primary white adipocytes. Biochem Biophys Res Commun 464 : 348-353, 2015.<\/li>\r\n    <li>T.Iuchi\u00b9, T.Hosaka, M.Shiroishi\u00b2, H.Ono\u00b9, K.Inukai, T.Sumita\u00b9, G.Sakai\u00b9, S.Katayama\u00b9, and T. Awata\u00b9 (\u00b9Saitama Medical University Hospital, \u00b2AgricalturalTechnology Institute of Nagano Farmers&#8217;Federeation). Influence of treatment with extracts of Hypsyzigus marmoreus mushroom on body composition during obesity development in KK-Ay mice. J Nutr Sci Vitaminol (Tokyo) 61(1):96-100, 2015.<\/li>\r\n    <li>Y.Sumitani, T.Hosaka, Y.Susaki\u00b9, Y.Fujisawa\u00b2, K.Kuriyama\u00b3, Y.Tsukada\u00b3, T.Yokoyama\u2074, J.Ogasawara\u2075, S.Nishida, K.Inukai, Y.Okajima\u2076, H.Ohno\u2077, and H.Ishida (\u00b9 Kyorin University Hospital, Department of Rehabilitation, \u00b2, Kyorin University, Department of Physical Therapy, \u00b3Kyorin University Hospital, Department of Clinical Nutrition, \u2074Seiko Epson, Planning &amp; Design Department, \u2075Kyorin University, Department of Molecular Predictive Medicine and Sport Science, \u2076Kyorin University, Department of Rehabilitation Medicine, \u2077Higashiyamato Hospital). Clinical effect of real time pulse rate monitoring with portable pulsimeter on physical exercise therapy for male patients with type 2 diabetes. Diabetology International accepted.<\/li>\r\n  <\/ol>\r\n<\/section>","protected":false},"excerpt":{"rendered":"<p>\u8a3a\u7642\u79d1\u7d39\u4ecb\uff08\u4ed8\u5c5e\u75c5\u9662\uff09 \u8a3a\u7642\u79d1\u7d39\u4ecb\uff08\u4ed8\u5c5e\u6749\u4e26\u75c5\u9662\uff09 \u6559\u5ba4\u30db\u30fc\u30e0\u30da\u30fc\u30b8 \u5c02\u9580\u7814\u4fee\u30d7\u30ed\u30b0\u30e9\u30e0 \u6559\u5ba4\u5c02\u4efb\u6559\u54e1 \u4ed8\u5c5e\u75c5\u9662\u30fb\u4e09\u9df9\u30ad\u30e3\u30f3\u30d1\u30b9 \u4ed8\u5c5e\u6749\u4e26\u75c5\u9662 \u6559\u5ba4\u6982\u8981 \u7cd6\u5c3f\u75c5\u30fb\u5185\u5206\u6ccc\u30fb\u4ee3\u8b1d\u5185\u79d1\u5b66\u6559\u5ba4\u3067\u306f\u3001\u7cd6\u5c3f\u75c5\u5b66\u3068\u5185\u5206\u6ccc\u30fb\u4ee3\u8b1d\u5b66\u306e\u7814\u7a76 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":24,"menu_order":1060,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"section":[5],"class_list":["post-145","page","type-page","status-publish","hentry","section-clinical"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/comments?post=145"}],"version-history":[{"count":8,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/145\/revisions"}],"predecessor-version":[{"id":5984,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/145\/revisions\/5984"}],"up":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/24"}],"wp:attachment":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media?parent=145"}],"wp:term":[{"taxonomy":"section","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/section?post=145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}