{"id":258,"date":"2022-02-18T17:29:17","date_gmt":"2022-02-18T08:29:17","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/_manage\/?page_id=258"},"modified":"2025-07-07T09:07:01","modified_gmt":"2025-07-07T00:07:01","slug":"fcm","status":"publish","type":"page","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/fcm\/","title":{"rendered":"\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u90e8\u9580"},"content":{"rendered":"<section class=\"BlkAnchorArea\"><div class=\"BlkAnchorArea__inner\"><ul class=\"anchorMenu\"><li><a class=\"p-anchor\" href=\"#teacher\"><span>\u6559\u54e1<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#summary\"><span>\u6982\u8981<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#study\"><span>\u7814\u7a76<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#achieve\"><span>\u696d\u7e3e<\/span><\/a><\/li><\/ul><\/div><\/section>\r\n<section class=\"BlkArticle__Contents--notLead\">\r\n  <div class=\"BlkArticle__btnlink--multi\">\r\n    <div class=\"BlkArticle__btnlink\">\r\n      <p><a class=\"u-icon_jump\" href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/graduate\/medicine\/education\/facilities\/flow-cytom\/\"><span>\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u7d39\u4ecb<\/span><\/a><\/p>\r\n    <\/div>\r\n    <div class=\"BlkArticle__btnlink\">\r\n      <p><a class=\"u-icon_blank\" href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/\" target=\"_blank\" rel=\"noopener\"><span>\u90e8\u9580\u30db\u30fc\u30e0\u30da\u30fc\u30b8<\/span><\/a><\/p>\r\n    <\/div>\r\n  <\/div>\r\n<\/section>\r\n<a id=\"teacher\" name=\"teacher\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u90e8\u9580\u5c02\u4efb\u6559\u54e1<\/h2>\r\n  <table class=\"BlkArticle__tableNormal BlkArticle__tableNormal--topLeft\" width=\"100%\">\r\n    <tbody>\r\n      <tr>\r\n        <th>\u90e8\u9580\u9577<\/th>\r\n        <td><ul>\r\n            <li><a href=\"\/univ\/faculty\/medicine\/education\/staff\/detail\/?id=med29019\" class=\"arrow\">\u5927\u5c71\u3000\u5b66<\/a>\uff08\u76ae\u819a\u79d1\u5b66\u6559\u5ba4\u6559\u6388\uff09<\/li>\r\n          <\/ul><\/td>\r\n      <\/tr>\r\n    <\/tbody>\r\n  <\/table>\r\n  \n<!-- staffdb 2023.08.15 -->\n<div><table class=\"BlkArticle__tableNormal BlkArticle__tableNormal--topLeft\" width=\"100%\" data-update=\"2023.08.15\"><tbody><tr><th>\u51c6\u6559\u6388<\/th><td><ul class=\"list-on-td\"><li data-sort=\"90\uff0f62001\"><a href=\"\/univ\/faculty\/medicine\/education\/staffnew\/detail\/?id=med62001\" class=\"arrow\">\u9ad8\u6a4b\u3000\u826f<\/a><\/li><\/ul><\/td><\/tr><\/tbody><\/table><\/div> <\/section>\r\n<a id=\"summary\" name=\"summary\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u90e8\u9580\u6982\u8981<\/h2>\r\n  <p>\u672c\u90e8\u9580\u306f\u3001\u30ec\u30fc\u30b6\u30fc\u5149\u3092\u4f7f\u3063\u3066\u86cd\u5149\u6a19\u8b58\u3057\u305f\u7d30\u80de\u3092\u975e\u5e38\u306b\u9ad8\u901f\u3067\u5206\u6790\u30fb\u5206\u53d6\u3059\u308b\u300c\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\uff08Flow Cytometry, FCM\uff09\u300d\u3092\u5c02\u9580\u3068\u3059\u308b\u5171\u540c\u5229\u7528\u65bd\u8a2d\u3068\u3057\u3066\u30011990\u5e74\u306b\u8a2d\u7acb\u3055\u308c\u307e\u3057\u305f\u3002\u73fe\u5728\u306f\u4ee5\u4e0b\u306e4\u53f0\u306e\u88c5\u7f6e\u3092\u904b\u7528\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <ul class=\"BlkArticle__listLink\">\r\n    <li>\r\n    <\/li>\r\n    <li><a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/facsaria\" target=\"_blank\" class=\"u-icon_blank\" rel=\"noopener\">BD FACSAria\u2122 IIu\u30bb\u30eb\u30bd\u30fc\u30bf\u30fc<\/a><\/li>\r\n    <li><a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/bd-facsmelody\" target=\"_blank\" class=\"u-icon_blank\" rel=\"noopener\">BD FACSMelody\u2122 \u30bb\u30eb\u30bd\u30fc\u30bf\u30fc<\/a><\/li>\r\n    <li><a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/facscantoii\" target=\"_blank\" class=\"u-icon_blank\" rel=\"noopener\">BD FACSCanto\u2122 II \u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30fc\u30bf\u30fc<\/a><\/li>\r\n    <li><a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/facslyric\" target=\"_blank\" class=\"u-icon_blank\" rel=\"noopener\">BD FACSLyric\u2122 \u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30fc\u30bf\u30fc<\/a><\/li>\r\n      <p>\u3055\u3089\u306b\u3001\u78c1\u6c17\u306b\u3088\u3063\u3066\u7d30\u80de\u3092\u5206\u96e2\u3059\u308b QuadroMACS Separator \u3082\u904b\u7528\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u3002FACSMelody\u2122 \u30bb\u30eb\u30bd\u30fc\u30bf\u30fc<\/p>\r\n    <li><a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/quadromacs\" target=\"_blank\" class=\"u-icon_blank\" rel=\"noopener\">QuadroMacs Separator<\/a><\/li>\r\n  <\/ul>\r\n  <h3>\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc(Flow cytometry: FCM)\u3068\u306f<\/h3>\r\n  <p>\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\uff08Flow Cytometry: FCM\uff09\u306f\u3001\u7d30\u80de\u3092\u6db2\u4f53\u4e2d\u306b\u5206\u6563\u3055\u305b\u305f\u72b6\u614b\u3067\u7d30\u3044\u6d41\u308c\u3092\u4f5c\u308a\u3001\u305d\u3053\u306b\u30ec\u30fc\u30b6\u30fc\u5149\u3092\u5f53\u3066\u3066\u30011\u30641\u3064\u306e\u7d30\u80de\u306e\u7279\u5fb4\u3092\u5149\u5b66\u7684\u306b\u89e3\u6790\u3059\u308b\u6280\u8853\u3067\u3059\u3002\u5206\u6790\u3060\u3051\u3067\u306a\u304f\u3001\u7279\u5b9a\u306e\u7d30\u80de\u30921\u500b\u5358\u4f4d\u3067\u5206\u53d6\u3067\u304d\u308b\u88c5\u7f6e\u306f\u300c\u30bb\u30eb\u30bd\u30fc\u30bf\u30fc\u300d\u3068\u547c\u3070\u308c\u3001\u6700\u5927\u30671\u79d2\u9593\u306b3\u4e07\u500b\uff0830,000 cells\/sec\uff09\u3001\u6700\u59274\u7a2e\u985e\u306b\u5206\u3051\u3066\u5206\u53d6\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u5f53\u90e8\u9580\u3067\u306f4\u53f0\u306eFCM\u88c5\u7f6e\u304c\u7a3c\u50cd\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u3046\u3061 FACSMelody\u2122 \u3068 FACSAria\u2122 IIu \u306e2\u53f0\u304c\u30bb\u30eb\u30bd\u30fc\u30bf\u30fc\u6a5f\u80fd\u3092\u5099\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <h3>\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u306e\u5f79\u5272<\/h3>\r\n  <p>\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u306f\u3001\u5206\u5b50\u751f\u7269\u5b66\u3092\u306f\u3058\u3081\u3001\u75c5\u7406\u5b66\u3001\u514d\u75ab\u5b66\u3001\u6d77\u6d0b\u751f\u7269\u5b66\u306a\u3069\u5e45\u5e83\u3044\u5206\u91ce\u3067\u6d3b\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u86cd\u5149\u3067\u6a19\u8b58\u3057\u305f\u6297\u4f53\u3092\u4f7f\u3063\u3066\u76ee\u7684\u306e\u7d30\u80de\u3092\u8b58\u5225\u3059\u308b\u624b\u6cd5\u306f\u3001\u7d30\u80de\u306e\u5206\u5316\u7814\u7a76\u3060\u3051\u3067\u306a\u304f\u3001\u79fb\u690d\u533b\u7642\u3001\u816b\u760d\u514d\u75ab\u3001\u5316\u5b66\u7642\u6cd5\u3001\u907a\u4f1d\u5b66\u3001\u518d\u751f\u533b\u7642\u3068\u3044\u3063\u305f\u533b\u5b66\u9818\u57df\u3067\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u672c\u90e8\u9580\u304c\u904b\u55b6\u3059\u308b<u><a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/\" target=\"_blank\" rel=\"noopener\">FCM WEB Site<\/a><\/u> \u3067\u306f\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u306b\u95a2\u3059\u308b\u6700\u65b0\u60c5\u5831\u3001\u5229\u7528\u65b9\u6cd5\u3001\u86cd\u5149\u67d3\u8272\u306e\u30d2\u30f3\u30c8\u3084\u6280\u8853\u3001\u6e2c\u5b9a\u6642\u306e\u6ce8\u610f\u70b9\u3001\u5b66\u5916\u3078\u306e\u60c5\u5831\u63d0\u4f9b\u306a\u3069\u3092\u5e45\u5e83\u304f\u63b2\u8f09\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n\r\n<\/section>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u793e\u4f1a\u7684\u6d3b\u52d5<\/h2>\r\n  <p>\u672c\u90e8\u9580\u3067\u306f\u3001\u65e5\u672c\u7814\u7a76\u76ae\u819a\u79d1\u5b66\u4f1a\u306a\u3069\u3067\u306e\u7814\u7a76\u767a\u8868\u3092\u7a4d\u6975\u7684\u306b\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u5c02\u4efb\u8b1b\u5e2b\u306e\u9ad8\u6a4b\u306f\u3001\u65e5\u672c\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u5b66\u4f1a\u306e\u7406\u4e8b\u3068\u3057\u3066\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u306e\u666e\u53ca\u3084\u5553\u767a\u6d3b\u52d5\u306b\u643a\u308f\u3063\u3066\u3044\u307e\u3059\u30022023\u5e74\u5ea6\u306b\u306f\u300c\u7b2c33\u56de\u65e5\u672c\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u5b66\u4f1a\u5b66\u8853\u96c6\u4f1a\u300d\u306e\u5927\u4f1a\u9577\uff08www.33jcs.com\uff09\u30012024\u5e74\u5ea6\u306f\u526f\u4f1a\u9577\uff0834th-jcs.com\uff09\u3092\u52d9\u3081\u307e\u3057\u305f\u3002<u><a href=\"https:\/\/www.cytometry.jp\/\" target=\"_blank\" rel=\"noopener\">\u65e5\u672c\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u5b66\u4f1a<\/a><\/u><\/p>\r\n\r\n  <p class=\"u-mgt_50\">\u5f53\u90e8\u9580\u306e\u8a73\u7d30\u306f\u3001\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u90e8\u9580\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u3001X\uff08\u65e7Twitter\uff09\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\r\n  <ul class=\"BlkArticle__listLink\">\r\n    <li><a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/\" target=\"_blank\" class=\"u-icon_blank\" rel=\"noopener\">\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u90e8\u9580\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8<\/a><\/li>\r\n    <li><a href=\"https:\/\/twitter.com\/fcmserver\" target=\"_blank\" class=\"u-icon_blank\" rel=\"noopener\">X<\/a><\/li>\r\n  <\/ul>\r\n<\/section>\r\n<a id=\"study\" name=\"study\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u7814\u7a76\u30c6\u30fc\u30de<\/h2>\r\n  <p>\u672c\u90e8\u9580\u3067\u306f\u3001\u533b\u5b66\u90e8\u76ae\u819a\u79d1\u5b66\u6559\u5ba4\u3068\u5171\u540c\u3067\u3001\u5186\u5f62\u8131\u6bdb\u75c7\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3001\u91cd\u75c7\u85ac\u75b9\u306a\u3069\u306e\u75c5\u614b\u89e3\u660e\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u6210\u679c\u306f\u3001\u4e0b\u8a18\u306e\u3088\u3046\u306a\u56fd\u5185\u5916\u306e\u8457\u540d\u306a\u5b66\u4f1a\u3084\u79d1\u5b66\u96d1\u8a8c\u3067\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <ul class=\"BlkArticle__listLink\">\r\n    <li><a href=\"http:\/\/www.jsid.org\" target=\"_blank\" class=\"u-icon_blank\" rel=\"noopener\">\u65e5\u672c\u7814\u7a76\u76ae\u819a\u79d1\u5b66\u4f1a\uff08JSID\uff09<\/a><\/li>\r\n    <li><a href=\"https:\/\/esdr.org\" target=\"_blank\" class=\"u-icon_blank\" rel=\"noopener\">\u6b27\u5dde\u7814\u7a76\u76ae\u819a\u79d1\u5b66\u4f1a\uff08ESDR\uff09<\/a><\/li>\r\n    <li><a href=\"https:\/\/www.sidnet.org\" target=\"_blank\" class=\"u-icon_blank\" rel=\"noopener\">\u7c73\u56fd\u7814\u7a76\u76ae\u819a\u79d1\u5b66\u4f1a\uff08SID\uff09<\/a><\/li>\r\n  <\/ul>\r\n<\/section>\r\n<a id=\"achieve\" name=\"achieve\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u8fd1\u5e74\u306e\u4e3b\u306a\u696d\u7e3e<\/h2>\r\n  <ol class=\"BlkArticle__listNumber\">\r\n<li>\u9ad8\u6a4b \u826f, \u5927\u5c71 \u5b66\uff1a\u6025\u901f\u9032\u884c\u6027\u5186\u5f62\u8131\u6bdb\u75c7\u306b\u304a\u3051\u308bCD45RA\u518d\u767a\u73feCD8<sup>\uff0b<\/sup>\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u30e1\u30e2\u30ea\u30fcT\u7d30\u80de\u306e\u5897\u52a0\u3068\u70b9\u6ef4\u9759\u6ce8\u30d1\u30eb\u30b9\u7642\u6cd5\u3078\u306e\u4e0d\u5fdc\u6027\u306e\u76f8\u95a2\uff1a\u81e8\u5e8a\u76ae\u819a\u79d179\u5dfb5\u53f7 \u5897\u520a\u53f7\u7279\u96c6 \u6700\u8fd1\u306e\u30c8\u30d4\u30c3\u30af\u30b92025\u3000Clinical Dermatology 2025.P. 197-200<\/li>\r\n<li>\u7acb\u677e \u5065\u4e00<sup>1)<\/sup>, \u9ad8\u6a4b \u826f\uff08<sup>1<\/sup>\u56fd\u7acb\u5929\u6587\u53f0\u3000\u91ce\u8fba\u5c71\u5b87\u5b99\u96fb\u6ce2\u89b3\u6e2c\u6240\uff09\uff1a\uff3b\u7279\u5225\u5bfe\u8ac7\uff3d\u7b2c33\u56de\u65e5\u672c\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u5b66\u4f1a\u5b66\u8853\u96c6\u4f1a\u7279\u5225\u8b1b\u6f14\uff1a\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u30ea\u30b5\u30fc\u30c12025 \u5e74 34 \u5dfb 2\u53f7 p. 15-45.<\/li>\r\n<li>\u9ad8\u6a4b \u826f\uff1a\u7b2c 33 \u56de\u65e5\u672c\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u5b66\u8853\u7dcf\u4f1a\u596e\u95d8\u8a18 \uff0d\u5f8c\u7de8\uff0d\uff1a\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u30ea\u30b5\u30fc\u30c12024 \u5e74 34 \u5dfb 1\u53f7 p. 35-51.<\/li>\r\n<li>\u9ad8\u6a4b \u826f\uff1a\u7b2c 33 \u56de\u65e5\u672c\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u5b66\u8853\u7dcf\u4f1a\u596e\u95d8\u8a18 \uff0d\u524d\u7de8\uff0d\uff1a\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u30ea\u30b5\u30fc\u30c12024 \u5e74 33 \u5dfb 2 \u53f7 17-28.<\/li>\r\n    <li><b>Takahashi R<\/b>, Kinoshita-Ise M, Yamazaki Y, Fukuyama M, and Ohyama M: Increase in CD8+ Effector Memory T Cells Re-Expressing CD45RA Correlates with Intractability of Severe Alopecia Areata: Journal of Investigative Dermatology. <a href=\"https:\/\/doi.org\/10.1016\/j.jid.2024.01.006\" target=\"_blank\" class=\"u-icon_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.jid.2024.01.006<\/a>.<\/li>\r\n    <li><b>Takahashi R<\/b>, Shiohara T<sup>1<\/sup>, and Mizukawa Y<sup>1<\/sup> (<sup>1<\/sup>Department of Dermatology): Monocyte-Independent and -Dependent Regulation of Regulatory T-Cell Development in Mycoplasma Infection: The Journal of Infectious Diseases 223:1724-1732, 2021.<\/li>\r\n    <li><b>Takahashi R<\/b>, Sato Y, Kimishima M, Shiohara T and Ohyama M: Intracellular accumulation of PD-1 molecules in circulating T lymphocytes in advanced malignant melanoma: an implication for immune evasion mechanism. Int J Clin Oncol 12: doi: 10.1007\/s10147-020-01732-8, 2020.<\/li>\r\n    <li>Moro Y<sup>1<\/sup>, Kogashiwa Y<sup>2<\/sup>, Sakurai H<sup>3<\/sup>, <b>Takahashi R<\/b>, Kimura T<sup>3<\/sup>, Hirasaki M<sup>4<\/sup>, Matsumoto Y<sup>1<\/sup>, Sugasawa M<sup>2<\/sup>, Kohno N<sup>1,5<\/sup> (<sup>1<\/sup>Department of Otolaryngology, <sup>2<\/sup>Department of Head and Neck Surgery, Otolaryngology, Saitama Medical University International Medical Center, <sup>3<\/sup>Department of Pharmacology and Toxicology, <sup>4<\/sup>Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, <sup>5<\/sup>Department of Otolaryngology, Kosei Hospital) : In Vitro Study of the Anti-cancer Effect of Alternate-day 5-Fluorouracil in Head and Neck Cancer Cells. Anticancer Res 39:6041-6047, 2019. <\/li>\r\n    <li>Ushigome Y, Mizukawa Y, Kimishima M, Yamazaki Y, <b>Takahashi R<\/b>, Kano Y, Shiohara T: Monocytes are involved in the balance between regulatory T cells and Th17 cells in severe drug eruptions. Clin Exp Allergy 48:1453-1463, 2018.<\/li>\r\n    <li>Shimoda-Komatsu Y, Sato Y, Yamazaki Y, <b>Takahashi R<\/b>, Shiohara: A novel method to assess the potential role of sweating abnormalities in the pathogenesis of atopic dermatitis. Exp Dermatol 27:386-392, 2018.<\/li>\r\n    <li>Shiohara T, Ushigome Y, Kano Y, <b>Takahashi R<\/b>: Crucial role of viral reactivation in the development of severe drug eruptions: a comprehensive review. Clin Rev Allergy Immunol 49:192-202, 2015.<\/li>\r\n    <li>Shiohara T, Ushigome Y, Kano Y, and <b>Takahashi R<\/b>: Crucial Role of Viral Reactivation in the Development of Severe Drug Eruptions: a Comprehensive Review. Clinical Reviews in Allergy &amp; Immunology (Published online: 16 Apr 2014).<\/li>\r\n    <li><b>Takahashi R<\/b> Sato Y, Kurata M, Yamazaki Y, Kimishima M, and Shiohara T: Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions.\u3000 The Journal of Immunology 192: 969-978. 2014.<\/li>\r\n    <li>Hirahara , Kano Y,Mitsuyama Y, <b>Takahashi R<\/b>, Kimishima M, Shiohara T: Differences in immunological alterations and underlying viral infections in two well-defined severe drug eruptions. Clin Exp Dermatol 35: 863-868, 2010.<\/li>\r\n    <li><b>Takahashi R<\/b>., Kano Y ,Yamazaki Y, Kimishima M, Mizukawa Y, and Shiohara T: Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome. The Journal of Immunology 182:8071-79, 2009.<\/li>\r\n    <li>Shiohara T, Kano Y, and <b>Takahashi R<\/b> : Current concepts on the diagnosis and pathogenesis of drug-induced hypersensitivity syndrome. JMAJ 52:347-352, 2009.<\/li>\r\n    <li>Mizukawa Y, <b>Takahashi R<\/b>, Yamazaki Y, Kimishima M and Shiohara T: Fucosyltransferase VII positive, skin-homing T cells in the blood and skin lesions of atopic dermatitis patients. Exp Dermatol. 17: 170-6, 2008.<\/li>\r\n    <li>Kano Y, Hirahara K, Mitsuyama Y, <b>Takahashi R<\/b>, Shiohara T: Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption. Allergy 62: 1439-1444, 2007.<\/li>\r\n    <li>Hasannejad H, <b>Takahashi R (Corresponding author)<\/b>, Kimishima M, Hayakawa K, Shiohara T: Selective impairment of Toll-like receptor 2-mediated proinflammatory cytokine production by monocytes from patients with atopic dermatitis. J Allergy Clin Immunol,120, 69-75\uff0c2007.<\/li>\r\n    <li>Inaoka , Kimishima M, <b>Takahashi R<\/b>, Shiohara T: Non-steroidal anti-inflammatory drugs selectively inhibit cytokine production by NK cells and gamma delta T cells. Exp Dermatol, 15: 981-990, 2006.<\/li>\r\n    <li>Katsuta , Takigawa Y, Kimishima M, Inaoka M, <b>Takahashi R<\/b>, Shiohara T: NK cells and gamma delta+ T cells are phenotypically and functionally defective due to preferential apoptosis in patients with atopic dermatitis. The Journal of Immunology, 176: 7736-7744, 2006.<\/li>\r\n    <li>Shiohara T, Mizukawa Y, <b>Takahashi R<\/b>, Hayakawa J &amp; Hayakawa K: T-cell dynamics of inflammatory skin diseases. Expert Review of Clinical Immunology 1: 357-368\uff0c2005.<\/li>\r\n    <li><b>Takahashi R<\/b>, Mizukawa Y, Yamazaki Y, Hayakawa K, Hayakawa J, Kudo A and Shiohara T: In Vitro Differentiation from Naive to Mature E-Selectin Binding CD4 T Cells: Acquisition of Skin-Homing Properties Occurs Independently of Cutaneous Lymphocyte Antigen Expression. The Journal of Immunology, 171: 5769-5777, 2003.<\/li>\r\n    <li>Mizukawa Y, Shitara K, Yamazaki Y, Teraki Y, <b>Takahashi R<\/b>, Narimatsu H &amp; Shiohra T: Development and characterization of a monoclonal antibody specific for fucosyltransferase VII (Fuc-T VII): Discordant expression of CLA and Fuc-T VII in peripheral CD4+ and CD8+ T cells. J Invest Dermatol 117: 743-747, 2001.<\/li>\r\n    <li>Kawano TA, Aoki N, Homori M, Kawano K, Maki A, Kimura M, Yanagisawa A, Ohsaki T, <b>Takahashi R<\/b>, Shiohara T, Ishikawa K, Yoshino H: Mental stress and physical exercise increase platelet-dependent thrombin generation. Heart Vessels. 2000;15(6): 280-8.<\/li>\r\n    <li><b>Takahashi R<\/b>, Sekine N, and Nakatake T, Influence of monoclonal antiplatelet glyco-protein antibodies on in vitro human megakaryocyte colony formation and proplatelet formation: Blood, 93 (6): 1951-1958, 1999 \u7279\u8a18\u4e8b\u98051: \u672c\u8ad6\u6587\u306e\u56f3\u304cBlood 93 (6), 1999\u306e\u8868\u7d19\u306b\u63a1\u7528\u3055\u308c\u305f. \u7279\u8a18\u4e8b\u98052: \u672c\u8ad6\u6587\u8981\u65e8\u306e\u5b66\u4f1a\u767a\u8868\u300cInternational Association of Medical Laboratory Technologists (IAMLT), 23rd World Congress of Medical Technology, Singapore, June 28 &#8211; July 3, 19\u300d\u306f\uff0c\u300cGOOD POSTER DESIGN AWARD 1998 IAMLT\u300d\u3092\u53d7\u8cde. <\/li>\r\n  <\/ol>\r\n  <h3>\u65e5\u672c\u8a9e\u306e\u89e3\u8aac\u30fb\u66f8\u7c4d\u306a\u3069<\/h3>\r\n  <style>\r\n.icon_newwindow:after {\r\n  font-family: 'icomoon';\r\n  content: \"\\e913\";\r\n  color: #919191;\r\n  padding-left:.5em;\r\n  padding-right:.5em;\r\n}\r\n<\/style>\r\n  <ol class=\"BlkArticle__listNumber js-accordion\">\r\n    <li>YouTube\u30c1\u30e3\u30cd\u30eb\u300e\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fcde Night\u300f\u3067\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u306e\u89e3\u8aac\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u305c\u3072\u30c1\u30e3\u30cd\u30eb\u767b\u9332\u3092\u304a\u9858\u3044\u3057\u307e\u3059\u3002 <a href=\"https:\/\/www.youtube.com\/@kyorinfcm\/\" target=\"_blank\" class=\"icon_newwindow\" rel=\"noopener\">https:\/\/www.youtube.com\/@kyorinfcm\/<\/a> <\/li>\r\n  <\/ol>\r\n<\/section>\r\n","protected":false},"excerpt":{"rendered":"<p>\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u7d39\u4ecb \u90e8\u9580\u30db\u30fc\u30e0\u30da\u30fc\u30b8 \u90e8\u9580\u5c02\u4efb\u6559\u54e1 \u90e8\u9580\u9577 \u5927\u5c71\u3000\u5b66\uff08\u76ae\u819a\u79d1\u5b66\u6559\u5ba4\u6559\u6388\uff09 \u90e8\u9580\u6982\u8981 \u672c\u90e8\u9580\u306f\u3001\u30ec\u30fc\u30b6\u30fc\u5149\u3092\u4f7f\u3063\u3066\u86cd\u5149\u6a19\u8b58\u3057\u305f\u7d30\u80de\u3092\u975e\u5e38\u306b\u9ad8\u901f\u3067\u5206\u6790\u30fb\u5206\u53d6\u3059\u308b\u300c\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\uff08Flow Cytometr [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":24,"menu_order":2030,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"section":[6],"class_list":["post-258","page","type-page","status-publish","hentry","section-joint-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/258","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/comments?post=258"}],"version-history":[{"count":14,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/258\/revisions"}],"predecessor-version":[{"id":7238,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/258\/revisions\/7238"}],"up":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/24"}],"wp:attachment":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media?parent=258"}],"wp:term":[{"taxonomy":"section","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/section?post=258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}