{"id":4394,"date":"2023-06-12T10:46:10","date_gmt":"2023-06-12T01:46:10","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/?page_id=4394"},"modified":"2025-06-24T12:03:08","modified_gmt":"2025-06-24T03:03:08","slug":"cystitis","status":"publish","type":"page","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/cystitis\/","title":{"rendered":"\u9593\u8cea\u6027\u8180\u80f1\u708e\u533b\u5b66\u8b1b\u5ea7"},"content":{"rendered":"<section class=\"BlkAnchorArea\"><div class=\"BlkAnchorArea__inner\"><ul class=\"anchorMenu\"><li><a class=\"p-anchor\" href=\"#teacher\"><span>\u6559\u54e1<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#summary\"><span>\u6982\u8981<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#study\"><span>\u7814\u7a76<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#achieve\"><span>\u696d\u7e3e<\/span><\/a><\/li><\/ul><\/div><\/section>\r\n      <!--div class=\"BlkArticle__Lead\">\r\n        <p 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Tomonori Y, Furuta A, Matsuo T, Tomoe H, Kakizaki H, Matsukawa Y, Ogawa T, Mitsui T, Masumori N, Inamura S, Enomoto Y, Nomiya A, Maeda D, Igawa Y, Kume H, Homma Y: Clinical manifestations of interstitial cystitis and bladder pain syndrome: Analysis of a patient registry in Japan. Int J Urol. 32 (1): 103-109, 2025.<\/li>\r\n<li>Horie M, Akiyama Y, Katoh H, Taguchi S, Nakamura M, Mizuguchi K, Ito Y, Matsushita T, Ushiku T, Ishikawa S, Goto A, Kume H, Homma Y, Maeda D: APRIL\/BAFF upregulation is associated with clonal B-cell expansion in Hunner-type interstitial cystitis. J Pathol 264 (10): 383\u2013395, 2024.<\/li>\r\n<li>Homma Y, Akiyama Y, Kim JH, Chuang YC, Jeong SJ, Meng E, Kitta T, Jhang JF, Furuta A, Lee KS, Maeda D: Definition change and update of clinical guidelines for interstitial cystitis and bladder pain syndrome. LUTS 16 (9): e12532, 2024.<\/li>\r\n<li>Akiyama Y, Sonehara K, Maeda D, Katoh H, Naito T, Yamamoto K, Project Biobank Japan, Morisaki T, Ishikawa S, Ushiku T, Kume H, Homma Y, Okada Y: Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis. Cell Rep Med 4:101114. 2023.<\/li>\r\n<li>Akiyama Y, Niimi A, Nomiya A, Taguchi S, Yamada Y, Sato Y, Yamada D, Maeda D, Ushiku U, Kume H, Homma Y: Efficacy and safety of low-dose oral prednisolone for patients with refractory Hunner-type interstitial cystitis. Eur Urol Open Sci 56: 1-8, 2023.<\/li>\r\n<li>Akiyama Y, Niimi A, Nomiya A, Taguchi S, Yamada Y, Sato Y, Kawai T, Yamada D, Kume H, Homma Y: Efficacy and safety of intravesical dimethyl sulfoxide treatment for patients with refractory Hunner-type interstitial cystitis: Real-world data postofficial approval in Japan. Int J Urol 31: 111-8, 2024.<\/li>\r\n<li>Akiyama Y, Harada K, Miyakawa J, Kreder KJ, O&#8217;Donnell MA, Daichi M, Katoh H, Hori M, Owari K, Futami K, Ishikawa S, Ushiku T, Kume H, Homma Y, Luo Y: Th1\/17 polarization and potential treatment by an anti-interferon-gamma DNA aptamer in Hunner-type interstitial cystitis. iScience 26: 108262, 2023.<\/li>\r\n<li>Kamei J, Sugihara T, Yasunaga H, Matsui H, Sasabuchi Y, Fujimura T, Homma Y, Kume H: Impact of early ureteral drainage on mortality in obstructive pyelonephritis with urolithiasis: an analysis of the Japanese National Database. World U Urol 41: 1365-71, 2023.<\/li>\r\n<li>Iwaki T, Akiyama Y, Nosato H, Kinjo M, Niimi A, Taguchi S, Yamada Y, Sato Y, Kawai T, Yamada D, Sakanashi H, Kume H, Homma Y, Fukuhara H: Deep learning models for cystoscopic recognition of Hunner lesion in interstitial cystitis. Eur Urol Open Sci 49: 44-50, 2023.<\/li>\r\n<li>Akiyama Y, Niimi A, Igawa Y, Nomiya A, Yamada Y, Sato Y, Kawai T, Yamada D, Kume H, Homma Y: Cystectomy for patients with Hunner-type interstitial cystitis at a tertiary referral center in Japan. Low Urin Tract Symptoms 14: 102-8, 2022. <\/li>\r\n<li>Seito T, Ishikawa A, Tsuru I, Hikatsu M, Bae Y, Homma Y: A case of cystic mucinous adenocarcinoma of the prostate treated by robot-assisted radical prostatectomy. Urol Case Rep 41: 101982, 2022. <\/li>\r\n<li>Akiyama Y, Miyakawa J, Donnell MA, Kreder KJ, Luo Y, Maeda D, Ushiku T, Kume H, Homma Y: Overexpression of HIF1 alpha in Hunner lesions of interstitial cystitis: Pathophysiological implications. J Urol 207: 635-646, 2022.<\/li>\r\n<li>Akiyama Y, Yao JR, Kreder KJ, O&#8217;Donnell MA, Lutgendorf SK, Lyu D, Maeda D, Kume H, Homma Y, Luo Y: Autoimmunity to urothelial antigen causes bladder inflammation, pelvic pain, and voiding dysfunction: A novel animal model for Hunner-type interstitial cystitis. Am J Phy Ren Phy 320: F174-F182, 2021.<\/li>\r\n<li>Akiyama Y, Zaitsu M, Watanabe D, Yoshimura I, Niimi A, Nomiya A, Yamada Y, Sato Y, Nakamura M, Kawai T, Yamada D, Suzuki M, Kume H, Homma Y: Relationship between the frequency of electrocautery of Hunner lesions and changes in bladder capacity in patients with Hunner type interstitial cystitis. Sci Rep 11: 105, 2021.<\/li>\r\n<li>Yoshimura N, Homma Y, Tomoe H, Otsuka A, Kitta T, Masumori N, Akiyama Y, Niimi A, Mitsui T, Nanri M, Namima T, Takei M, Yamaguchi A, Sekiguchi Y, Kajiwara M, Kobayashi S, Ameda K, Ohashi Y, Sakamoto S, Muraki O, Shishido T, Kageyama S, Kokura K, Okazoe H, Yamanishi T, Watanabe T, Uno T, Ohinata A, Ueda T: Efficacy and safety of intravesical instillation of KRP-116d (50% dimethyl sulfoxide solution) for interstitial cystitis\/bladder pain syndrome in Japanese patients: A multicenter, randomized, double-blind, placebo-controlled, clinical study. Int J Urol 28: 545-553, 2021.<\/li>\r\n<li>Akiyama Y, Luo Y, Hanno PM, Maeda D, Homma Y: Interstitial cystitis\/bladder pain syndrome: The evolving landscape, animal models and future perspectives. Int J Urol 27: 491-503, 2020.<\/li>\r\n<li>Homma Y, Akiyama Y, Tomoe H, Furuta A, Ueda T, Maeda D, Lin AT, Kuo HC, Lee MH, Oh SJ, Kim JC, Lee KS: Clinical guidelines for interstitial cystitis\/bladder pain syndrome. Int J Urol 27: 578-589, 2020. <\/li>\r\n<li>Akiyama Y, Homma Y, Maeda D: Pathology and terminology of interstitial cystitis\/bladder pain syndrome: A review. Histol Histopathol 34:25-32, 2019.<\/li>\r\n<li>Akiyama Y, Maeda D, Katoh H, Morikawa T, Niimi A, Nomiya A, Sato Y, Kawai T, Goto A, Fujimura T, Fukuhara H, Nakagawa T, Igawa Y, Ishikawa S, Fukayama M, Kume H, Homma Y: Molecular taxonomy of interstitial cystitis\/bladder pain syndrome based on whole transcriptome profiling by next-generation RNA sequencing of bladder mucosal biopsies. J Urol 202: 290-300, 2019.<\/li>\r\n<li>Homma Y: Interstitial cystitis, bladder pain syndrome, hypersensitive bladder, and interstitial cystitis\/bladder pain syndrome &#8211; clarification of definitions and relationships. Int J Urol 26 Suppl 1: 20-24, 2019.<\/li>\r\n<li>Niimi A, Igawa Y, Aizawa N, Honma T, Nomiya A, Akiyama Y, Kamei J, Fujimura T, Fukuhara H, Homma Y: Diagnostic value of urinary CXCL10 as a biomarker for predicting Hunner type interstitial cystitis. Neurourol Urodyn 37: 1113-1119, 2018.<\/li>\r\n<li>Akiyama Y, Maeda D, Morikawa T, Niimi A, Nomiya A, Yamada Y, Igawa Y, Goto A, Fukayama M, Homma Y: Digital quantitative analysis of mast cell infiltration in interstitial cystitis. Neurourol Urodyn 37: 650-657, 2018.<\/li>\r\n<li>Ichihara K, Aizawa N, Akiyama Y, Kamei J, Masumori N, Andersson KE, Homma Y, Igawa Y: Toll-like receptor 7 is overexpressed in the bladder of Hunner-type interstitial cystitis, and its activation in the mouse bladder can induce cystitis and bladder pain. Pain 158: 1538-1545, 2017.<\/li>\r\n<li>Doggweiler R, Whitmore KE, Meijlink JM, Drake MJ, Frawley H, Nordling J, Hanno P, Fraser MO, Homma Y, Garrido G, Gomes MJ, Elneil S, van de Merwe JP, Lin ATL, Tomoe H: A standard for terminology in chronic pelvic pain syndromes: A report from the chronic pelvic pain working group of the international continence society. Neurourol Urodyn 36: 984-1008, 2017.<\/li>\r\n        <\/ol>\r\n<h3>\u65e5\u672c\u8a9e\u306e\u89e3\u8aac\u30fb\u66f8\u7c4d\u306a\u3069<\/h3>\r\n <ol class=\"BlkArticle__listNumber js-accordion\">\r\n<li>\u9593\u8cea\u6027\u8180\u80f1\u708e\u30fb\u8180\u80f1\u75db\u75c7\u5019\u7fa4\uff0d\u60a3\u8005\u3055\u3093\u306e\u7406\u89e3\u306e\u305f\u3081\u306b\uff0d<br>\r\n\u8457\u8005\uff1a\u79cb\u5c71\u4f73\u4e4b\u3001\u65b0\u7f8e\u6587\u5f69\u3001\u91ce\u5bae\u3000\u660e\u3001\u672c\u9593\u4e4b\u592b<br>\r\n\u533b\u5b66\u56f3\u66f8\u51fa\u7248\u682a\u5f0f\u4f1a\u793e\u30002022\u5e74\u767a\u884c<\/li>\r\n<li>\u9593\u8cea\u6027\u8180\u80f1\u708e\u30fb\u8180\u80f1\u75db\u75c7\u5019\u7fa4\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3<br>\r\n\u7de8\u8005\uff1a\u65e5\u672c\u9593\u8cea\u6027\u8180\u80f1\u708e\u7814\u7a76\u4f1a\u30fb\u65e5\u672c\u6ccc\u5c3f\u5668\u79d1\u5b66\u4f1a<br>\r\n\u30ea\u30c3\u30c1\u30d2\u30eb\u30e1\u30c7\u30a3\u30ab\u30eb\u30002019\u5e74\u767a\u884c\u3000<\/li>\r\n <\/ol>\r\n      <\/section>","protected":false},"excerpt":{"rendered":"<p>\u8b1b\u5ea7\u6559\u54e1 \u8b1b\u5ea7\u6982\u8981 \u9593\u8cea\u6027\u8180\u80f1\u708e\u3068\u306f\u3001\u539f\u56e0\u4e0d\u660e\u306e\u5f37\u3044\u8180\u80f1\u75db\u3092\u751f\u3058\u308b\u75be\u60a3\u3067\u3042\u308b\u3002\u6bd4\u8f03\u7684\u7a00\u3067\u306f\u3042\u308b\u304c\u60a3\u8005\u306eQOL\u306f\u8457\u3057\u304f\u640d\u306a\u308f\u308c\u3001\u6ccc\u5c3f\u5668\u79d1\u9818\u57df\u3067\u552f\u4e00\u306e\u6307\u5b9a\u96e3\u75c5\u3068\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u6ccc\u5c3f\u5668\u79d1\u5c02\u9580\u533b\u306e\u4e2d\u3067\u3082\u8a3a\u65ad\u30fb\u6cbb\u7642\u6cd5\u304c\u6a19\u6e96\u5316\u3055\u308c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":24,"menu_order":53,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"section":[],"class_list":["post-4394","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/4394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/comments?post=4394"}],"version-history":[{"count":9,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/4394\/revisions"}],"predecessor-version":[{"id":7138,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/4394\/revisions\/7138"}],"up":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/pages\/24"}],"wp:attachment":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media?parent=4394"}],"wp:term":[{"taxonomy":"section","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/section?post=4394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}