{"id":87,"date":"2022-02-15T14:26:42","date_gmt":"2022-02-15T05:26:42","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/_manage\/?page_id=87"},"modified":"2025-06-23T13:38:04","modified_gmt":"2025-06-23T04:38:04","slug":"micro-anat","status":"publish","type":"page","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/micro-anat\/","title":{"rendered":"\u9855\u5fae\u89e3\u5256\u5b66\u6559\u5ba4"},"content":{"rendered":"<section class=\"BlkAnchorArea\"><div class=\"BlkAnchorArea__inner\"><ul class=\"anchorMenu\"><li><a class=\"p-anchor\" href=\"#teacher\"><span>\u6559\u54e1<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#summary\"><span>\u6982\u8981<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#study\"><span>\u7814\u7a76<\/span><\/a><\/li><li><a class=\"p-anchor\" href=\"#achieve\"><span>\u696d\u7e3e<\/span><\/a><\/li><\/ul><\/div><\/section> \r\n<!--section class=\"BlkArticle__Contents--notLead\">\r\n  <div class=\"BlkArticle__btnlink--multi\">\r\n    <div class=\"BlkArticle__btnlink\">\r\n      <p><a class=\"u-icon_blank\" href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/anat2\/\" target=\"_blank\" rel=\"noopener\"><span>\u6559\u5ba4\u30db\u30fc\u30e0\u30da\u30fc\u30b8<\/span><\/a><\/p>\r\n    <\/div>\r\n  <\/div>\r\n<\/section--> \r\n<a id=\"teacher\" name=\"teacher\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u6559\u5ba4\u5c02\u4efb\u6559\u54e1<\/h2>\r\n  \n<!-- staffdb 2023.08.15 -->\n<div><table class=\"BlkArticle__tableNormal BlkArticle__tableNormal--topLeft\" width=\"100%\" data-update=\"2023.08.15\"><tbody><tr><th>\u6559\u6388<\/th><td><ul class=\"list-on-td\"><li data-sort=\"900\uff0f46003\"><a href=\"\/univ\/faculty\/medicine\/education\/staffnew\/detail\/?id=med46003\" class=\"arrow\">\u5bae\u6771\u3000\u662d\u5f66<\/a><\/li><\/ul><\/td><\/tr><tr><th>\u6559\u6388\uff08\u7279\u4efb\uff09<\/th><td><ul class=\"list-on-td\"><li data-sort=\"9000\uff0f46002\"><a href=\"\/univ\/faculty\/medicine\/education\/staffnew\/detail\/?id=med46002\" class=\"arrow\">\u79cb\u5143\u3000\u7fa9\u5f18<\/a><\/li><\/ul><\/td><\/tr><tr><th>\u8b1b\u5e2b<\/th><td><ul class=\"list-on-td\"><li data-sort=\"80\uff0f46005\"><a href=\"\/univ\/faculty\/medicine\/education\/staffnew\/detail\/?id=med46005\" class=\"arrow\">\u83c5\u539f\u3000\u5927\u4ecb<\/a><\/li><\/ul><\/td><\/tr><\/tbody><\/table><\/div> <\/section>\r\n<a id=\"summary\" name=\"summary\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u6559\u5ba4\u6982\u8981<\/h2>\r\n  <p>\u9855\u5fae\u89e3\u5256\u5b66\u6559\u5ba4\u3067\u306f\u3001\u4e3b\u3068\u3057\u3066\u9855\u5fae\u93e1\u30ec\u30d9\u30eb\u3067\u306e\u89e3\u5256\u5b66\u3092\u6271\u3063\u3066\u3044\u307e\u3059\u3002\u9855\u5fae\u89e3\u5256\u5b66\u6559\u5ba4\u306e\u524d\u8eab\u306f\u89e3\u5256\u5b66\u7b2c2\u8b1b\u5ea7\u3067\u3001\u5e73\u91ce\u3000\u5bdb\u304c\u521d\u4ee3\u6559\u6388\u3068\u3057\u3066\u958b\u8a2d\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u30012000\u5e74\u3088\u308a\u5ddd\u4e0a\u901f\u4eba\u30012019\u5e74\u3088\u308a\u79cb\u5143\u7fa9\u5f18\u30012024\u5e74\u3088\u308a\u5bae\u6771\u662d\u5f66\u306b\u5f15\u7d99\u304c\u308c\u73fe\u5728\u306e\u5f62\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\r\n  <p>\u5bae\u6771\u306f\u5927\u5b66\u9662\u5171\u540c\u7814\u7a76\u65bd\u8a2d \u96fb\u5b50\u9855\u5fae\u93e1\u90e8\u9580\u306e\u90e8\u9580\u9577\u3092\u517c\u52d9\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u6559\u80b2\u306e\u7279\u8272<\/h2>\r\n  <p>\u5b66\u90e8\u6559\u80b2\u3067\u306f\u3001\u533b\u5b66\u90e8\uff12\u5e74\u751f\u306e\u7d44\u7e54\u89e3\u5256\u5b66\u304a\u3088\u3073\u7d44\u7e54\u89e3\u5256\u5b66\u5b9f\u7fd2\u3092\u62c5\u5f53\u3057\u3066\u3044\u307e\u3059\u3002\u7d44\u7e54\u89e3\u5256\u5b66\u5b9f\u7fd2\u306f\u3001\u7d04\uff12\u30f6\u6708\u9593\u306b100\u679a\u4ee5\u4e0a\u306e\u7d44\u7e54\u6a19\u672c\u3092\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3057\u3066\u3044\u304f\u30cf\u30fc\u30c9\u306a\u5b9f\u7fd2\u3067\u3059\u3002\u5b66\u751f\u306f\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3055\u308c\u308b\u69cb\u9020\u3092\u3072\u3068\u3064\u3072\u3068\u3064\u78ba\u8a8d\u3057\u3001\u6559\u54e1\u3068\u8cea\u7591\u5fdc\u7b54\u3092\u7e70\u308a\u8fd4\u3057\u306a\u304c\u3089\u3001\u4eba\u4f53\u306e\u69cb\u9020\u3068\u6a5f\u80fd\u3068\u3092\u95a2\u9023\u3065\u3051\u3066\u6574\u7406\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\r\n  <p>\u5927\u5b66\u9662\u6559\u80b2\u3067\u306f\u3001\u9855\u5fae\u89e3\u5256\u5b66\u3068\u7d44\u7e54\u7d30\u80de\u5316\u5b66\u3092\u62c5\u5f53\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u793e\u4f1a\u7684\u6d3b\u52d5<\/h2>\r\n  <p>\u8fd1\u5e74\u306e\u793e\u4f1a\u7684\u6d3b\u52d5\u306b\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\r\n  <ul class=\"BlkArticle__listCircle\">\r\n    <li>2019\u5e7411\u670829\uff5e30\u65e5\u3000\u65e5\u672c\u9855\u5fae\u93e1\u5b66\u4f1a \u7b2c62\u56de\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\uff08\u6d66\u548c\u3001\u5408\u540c\u958b\u50ac\u3000\u7b2c44\u56de\u95a2\u6771\u652f\u90e8\u8b1b\u6f14\u4f1a\uff09\u3092\u958b\u50ac\uff08\u5b9f\u884c\u59d4\u54e1\u9577\u3000\u79cb\u5143\uff09<\/li>\r\n    <li>2017\u5e7411\u670825\u65e5\u3000\u674f\u6797\u5927\u5b66 \u9ad8\u5927\u63a5\u7d9a\u4f01\u753b\u300c\u96fb\u5b50\u9855\u5fae\u93e1\u4f53\u9a13\u5b9f\u7fd2\u300d\u3092\u958b\u50ac\uff08\u96fb\u5b50\u9855\u5fae\u93e1\u90e8\u9580\u3068\u5171\u540c\uff09<\/li>\r\n    <li>2016\u5e749\u67083\uff5e4\u65e5\u3000\u7b2c57\u56de\u65e5\u672c\u7d44\u7e54\u7d30\u80de\u5316\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u96c6\u4f1a\u3092\u958b\u50ac\uff08\u5b9f\u884c\u59d4\u54e1\u9577\u3000\u5ddd\u4e0a\uff09<\/li>\r\n  <\/ul>\r\n  <p>\u3053\u306e\u4ed6\u306b\u3082\u3001\u6559\u5ba4\u54e1\u306f\u3001\u6240\u5c5e\u3059\u308b\u5b66\u4f1a\u306a\u3069\u306e\u6d3b\u52d5\u3092\u901a\u3057\u3066\u793e\u4f1a\u8ca2\u732e\u6d3b\u52d5\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<a id=\"study\" name=\"study\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u7814\u7a76\u306e\u6982\u8981\u3068\u5927\u5b66\u9662\u6307\u5c0e<\/h2>\r\n  <p>\u9855\u5fae\u89e3\u5256\u5b66\u6559\u5ba4\u306f\u3001\u5927\u5b66\u9662\u6559\u80b2\u306b\u304a\u3044\u3066\u9855\u5fae\u89e3\u5256\u5b66\u3068\u7d44\u7e54\u7d30\u80de\u5316\u5b66\u3092\u62c5\u5f53\u3057\u3066\u3044\u307e\u3059\u3002\u4e3b\u305f\u308b\u7814\u7a76\u30c6\u30fc\u30de\u306f\u3001\u7d44\u7e54\u7d30\u80de\u5316\u5b66\u7684\u624b\u6cd5\u3092\u7528\u3044\u305f\u7d44\u7e54\u00b7\u7d30\u80de\u306e\u6a5f\u80fd\u7684\u69cb\u9020\u306e\u89e3\u6790\u3067\u3059\u3002\u5149\u5b66\u9855\u5fae\u93e1\uff08\u5171\u7126\u70b9\u30ec\u30fc\u30b6\u30fc\u9855\u5fae\u93e1\u7b49\uff09\u3084\u96fb\u5b50\u9855\u5fae\u93e1\u30ec\u30d9\u30eb\u3067\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u4e2d\u5fc3\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u751f\u5316\u5b66\u7684\u3001\u5206\u5b50\u751f\u7269\u5b66\u7684\u624b\u6cd5\u3082\u7528\u3044\u307e\u3059\u3002\u5b9f\u9a13\u6750\u6599\u3068\u3057\u3066\u306f\u5168\u8eab\u306e\u307b\u3068\u3093\u3069\u306e\u5668\u5b98\u3092\u5bfe\u8c61\u3068\u3057\u3001\u6b63\u5e38\u7d44\u7e54\u3060\u3051\u3067\u306a\u304f\u5404\u7a2e\u75be\u60a3\uff08\u764c\u3001\u7cd6\u5c3f\u75c5\u306a\u3069\uff09\u306e\u7d44\u7e54\u3084\u75be\u60a3\u30e2\u30c7\u30eb\u52d5\u7269\u3001\u767a\u751f\u7570\u5e38\u306a\u3069\u3082\u6271\u3044\u307e\u3059\u3002\u514d\u75ab\u7d44\u7e54\u7d30\u80de\u5316\u5b66\u3001in situ hybridization\u3001\u907a\u4f1d\u5b50\u5c0e\u5165\u306a\u3069\u306e\u624b\u6cd5\u3092\u7528\u3044\u3066\u3001\u5404\u7a2e\u751f\u4f53\u6210\u5206\u306e\u5c40\u5728\u3068\u6a5f\u80fd\u3092\u89e3\u6790\u3057\u307e\u3059\u3002\u5927\u5b66\u9662\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u96fb\u5b50\u9855\u5fae\u93e1\u90e8\u9580\u3068\u3082\u7dca\u5bc6\u306b\u9023\u643a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <p>\u6559\u80b2\u30b9\u30bf\u30c3\u30d5\u306f3\u540d\u3067\u3001\u6b21\u9805\u306b\u8ff0\u3079\u308b\u3088\u3046\u306a\u69d8\u3005\u306a\u7814\u7a76\u30c6\u30fc\u30de\u306b\u6cbf\u3063\u3066\u7814\u7a76\u4e26\u3073\u306b\u5927\u5b66\u9662\u6559\u80b2\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u4ee5\u5916\u306b\u3082\u3001\u4ed6\u306e\u5c02\u9580\u5206\u91ce\u306e\u5927\u5b66\u9662\u306b\u7c4d\u3092\u7f6e\u3044\u305f\u9662\u751f\u3084\u4ed6\u6559\u5ba4\u306e\u7814\u7a76\u8005\u304c\u72ec\u81ea\u306e\u7814\u7a76\u30c6\u30fc\u30de\u306e\u3082\u3068\u3067\u7d44\u7e54\u7d30\u80de\u5316\u5b66\u7684\u7814\u7a76\u306e\u305f\u3081\u306b\u6765\u8a2a\u3059\u308b\u4f8b\u3082\u591a\u304f\u3001\u305d\u306e\u305f\u3081\u306e\u69d8\u3005\u306a\u30b5\u30dd\u30fc\u30c8\u4f53\u5236\u3082\u3068\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u4ed6\u5927\u5b66\u3001\u4ed6\u7814\u7a76\u6a5f\u95a2\u3068\u306e\u5171\u540c\u7814\u7a76\u3082\u6d3b\u767a\u306b\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <p>\u5275\u8a2d\u4ee5\u6765\u3001\u5f53\u6559\u5ba4\u3067\u306e\u7814\u7a76\u6210\u679c\u3092\u57fa\u306b\u3057\u3066\u5b66\u4f4d\u3092\u53d6\u5f97\u3057\u305f\u7814\u7a76\u8005\u306f\u5b66\u5185\u5916\u542b\u3081\u3066100\u540d\u4ee5\u4e0a\u306b\u53ca\u3073\u307e\u3059\u3002<\/p>\r\n<\/section>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u7814\u7a76\u30c6\u30fc\u30de<\/h2>\r\n  <p>\u7814\u7a76\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306f\u3001\u5404\u6559\u54e1\u304c\u4e2d\u5fc3\u3068\u306a\u308a\u3001\u7cd6\u30bf\u30f3\u30d1\u30af\u3084\u7cd6\u8102\u8cea\u306a\u3069\u3092\u69cb\u6210\u3059\u308b\u7cd6\u9396\u3084\u7cd6\u8ee2\u79fb\u9175\u7d20\u3001\u30db\u30eb\u30e2\u30f3\u3084\u305d\u306e\u53d7\u5bb9\u4f53\u306a\u3069\u306e\u60c5\u5831\u3092\u62c5\u3046\u5206\u5b50\u3001\u767a\u751f\u904e\u7a0b\u3067\u306e\u5236\u5fa1\u306b\u95a2\u308f\u308b\u56e0\u5b50\u306a\u3069\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5177\u4f53\u7684\u306a\u7814\u7a76\u8ab2\u984c\u3092\u8a2d\u5b9a\u3057\u3066\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <!--div class=\"BlkColumn\">\r\n    <div class=\"BlkColumn__left\">\r\n      <div class=\"BlkArticle__figureList\">\r\n        <figure><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/2024\/07\/aorta.jpg\" width=\"465\" alt=\"\">\r\n          <figcaption><b>\u30e9\u30c3\u30c8\u5927\u52d5\u8108\u306b\u304a\u3051\u308b O-GlcNAc \u8ee2\u79fb\u9175\u7d20\u306e\u5c40\u5728\uff0e<\/b><br>\r\n            O-GlcNAc \u8ee2\u79fb\u9175\u7d20\uff08\u8d64\uff09\u3001\u30a2\u30af\u30c1\u30f3\uff08\u7dd1\uff09\u3001\u6838\uff08\u9752\uff09\uff0e<\/figcaption>\r\n        <\/figure>\r\n      <\/div>\r\n    <\/div>\r\n    <div class=\"BlkColumn__right\">\r\n      <div class=\"BlkArticle__figureList\">\r\n        <figure><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/2024\/07\/mtop3.jpg\" width=\"465\" alt=\"\">\r\n          <figcaption><b>\u30de\u30a6\u30b9\u7cbe\u5de3\u306e\u7cbe\u7d30\u7ba1\uff08\u90e8\u5206\uff09\uff0e<\/b><br>\r\n            DNA \u3092\u7dd1\u306b\u3001RNA\u3092\u8d64\u306b\u6a19\u8b58\uff0eS: \u30bb\u30eb\u30c8\u30ea\u7d30\u80de\u3001G: \u7cbe\u7956\u7d30\u80de\u3001P: \u30d1\u30ad\u30c6\u30f3\u671f\u4e00\u6b21\u7cbe\u6bcd\u7d30\u80de\u3001T: \u7cbe\u5b50\u7d30\u80de\uff0e<\/figcaption>\r\n        <\/figure>\r\n      <\/div>\r\n    <\/div>\r\n  <\/div-->\r\n  <h3>\u5927\u8178\u306e\u5065\u5eb7\u3092\u652f\u3048\u308b\u3008\u676f\u7d30\u80de\u3009\u306e\u591a\u69d8\u6027\uff1a\u30e0\u30c1\u30f3\u5c64\u5f62\u6210\u306e\u7d30\u80de\u57fa\u76e4\u306e\u518d\u5b9a\u7fa9<\/h3>\r\n  <p>\u7d44\u7e54\u5b66\u306e\u6559\u79d1\u66f8\u306b\u6319\u3052\u3089\u308c\u3066\u3044\u308b\u7d30\u80de\u7a2e\u306e\u591a\u304f\u306f\u3001\u305d\u306e\u5f62\u614b\u7684\u7279\u5fb4\u306b\u3082\u3068\u3065\u3044\u3066\u5206\u985e\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u7d30\u80de\u7a2e\u306f\u6027\u8cea\u3084\u6a5f\u80fd\u306e\u7570\u306a\u308b\u30b5\u30d6\u30bf\u30a4\u30d7\u306b\u3055\u3089\u306b\u5206\u985e\u3067\u304d\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u3001\u3053\u3046\u3057\u305f\u7d30\u80de\u306e\u591a\u69d8\u6027\u304c\u5065\u5eb7\u3068\u75be\u60a3\u306b\u3069\u3046\u95a2\u4e0e\u3059\u308b\u304b\u3001\u3068\u304f\u306b\u30b5\u30d6\u30bf\u30a4\u30d7\u306e\u300c\u5206\u5e03\u300d\u3068\u300c\u6a5f\u80fd\u300d\u306e\u95a2\u4fc2\u306b\u6ce8\u76ee\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n  <p>\u305d\u306e\u4e00\u3064\u3068\u3057\u3066\u3001\u5927\u8178\u306e\u5185\u8154\u3092\u8986\u3046\u30e0\u30c1\u30f3\u5c64\u306e\u5f62\u6210\u3092\u62c5\u3046\u3008\u676f\u7d30\u80de\u3009\u306b\u7740\u76ee\u3057\u3066\u3044\u307e\u3059\u3002\u30e0\u30c1\u30f3\u5c64\u306f\u7d44\u7e54\u306e\u4fdd\u8b77\u3084\u8178\u5185\u7d30\u83cc\u53e2\u306e\u5f62\u6210\u306b\u91cd\u8981\u3067\u3059\u3002\u305d\u306e\u4e3b\u8981\u6210\u5206\u3067\u3042\u308b\u7cd6\u9396\u306e\u7a2e\u985e\u306f\u5927\u8178\u306b\u6cbf\u3063\u3066\u9023\u7d9a\u7684\u306b\u5909\u5316\u3057\u3001\u3053\u306e\u7a7a\u9593\u7684\u30d1\u30bf\u30fc\u30f3\u304c\u30e0\u30c1\u30f3\u5c64\u306e\u306f\u305f\u3089\u304d\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u5f62\u6210\u6a5f\u69cb\u306f\u4e0d\u660e\u3067\u3057\u305f\u3002<\/p>\r\n  <p>\u79c1\u305f\u3061\u306f\u3001\u676f\u7d30\u80de\u306e\u30b5\u30d6\u30bf\u30a4\u30d7\u3067\u3042\u308bdeep crypt secretory\uff08DCS\uff09\u7d30\u80de\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u676f\u7d30\u80de\u3068\u306e\u9055\u3044\u306f\u6ce8\u76ee\u3055\u308c\u3066\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u79c1\u305f\u3061\u304c\u660e\u3089\u304b\u306b\u3057\u305fDCS\u306e\u5206\u5e03\u3068\u7523\u751f\u3059\u308b\u7cd6\u9396\u306e\u7279\u5fb4\u306f\u3001DCS\u304c\u72ec\u81ea\u306e\u5f79\u5272\u3092\u6301\u3064\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3068\u304f\u306bDCS\u304c\u5927\u8178\u306b\u6cbf\u3063\u3066\u52fe\u914d\u72b6\u306b\u5206\u5e03\u3059\u308b\u3053\u3068\u306f\u3001\u7cd6\u9396\u30d1\u30bf\u30fc\u30f3\u306e\u5f62\u6210\u3092\u901a\u3058\u3001\u30e0\u30c1\u30f3\u5c64\u306e\u306f\u305f\u3089\u304d\u3068\u5bc6\u63a5\u306b\u95a2\u4fc2\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u77e5\u898b\u306f\u3001\u30e0\u30c1\u30f3\u5c64\u304c\u95a2\u308f\u308b\u5fae\u751f\u7269\u5b66\u30fb\u514d\u75ab\u5b66\u30fb\u6804\u990a\u5b66\u306a\u3069\u306e\u5e83\u7bc4\u306a\u5206\u91ce\u306b\u304a\u3044\u3066\u3082\u3001\u65b0\u305f\u306a\u7406\u89e3\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\r\n  <p>\u3055\u3089\u306b\u3001DCS\u306e\u5206\u5e03\u3084\u6a5f\u80fd\u306e\u7570\u5e38\u304c\u7d44\u7e54\u306e\u4fdd\u8b77\u3084\u8178\u5185\u7d30\u83cc\u53e2\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u3082\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u30e0\u30c1\u30f3\u5c64\u306e\u7570\u5e38\u3068\u75be\u60a3\u306e\u95a2\u4fc2\u306e\u7406\u89e3\u306b\u65b0\u305f\u306a\u8996\u70b9\u3092\u63d0\u4f9b\u3067\u304d\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\uff08\u83c5\u539f\uff09<\/p>\r\n  <h3>O-GlcNAc \u53ca\u3073 O-GlcNAc \u8ee2\u79fb\u9175\u7d20\u306e\u6a5f\u80fd\u89e3\u6790<\/h3>\r\n  <p>O\u7d50\u5408\u578b\u03b2-N-\u30a2\u30bb\u30c1\u30eb\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\uff08O-GlcNAc\uff09 \u304c\u6838\u3084\u7d30\u80de\u8cea\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u4ed8\u52a0\u3055\u308c\u308b\u7ffb\u8a33\u5f8c\u4fee\u98fe\u3067\u3042\u308b\u3053\u3068\u306b\u7740\u76ee\u3057\u3001\u81b5\u5cf6\u3001\u814e\u7cf8\u7403\u4f53\u3001\u8133\u306a\u3069\u306b\u304a\u3051\u308b\u5c40\u5728\u3092\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u7684\u306b\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u7cd6\u4fee\u98fe\u306f\u8840\u7cd6\u8abf\u7bc0\u3078\u306e\u95a2\u4e0e\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u7cd6\u5c3f\u75c5\u3068\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u30d8\u30ad\u30bd\u30b5\u30df\u30f3\u4ee3\u8b1d\u7cfb\u3092\u901a\u3058\u3066\u89e3\u6790\u4e2d\u3067\u3059\u3002\uff08\u79cb\u5143\uff09<\/p>\r\n  <h3>\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306e\u7814\u7a76<\/h3>\r\n  <p>\u7279\u306b\u57fa\u5e95\u819c\u306b\u7126\u70b9\u3092\u5f53\u3066\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u5b50\u3084\u30ac\u30ec\u30af\u30c1\u30f3\u306a\u3069\u306e\u69cb\u6210\u6210\u5206\u304c\u7d30\u80de\u6a5f\u80fd\u3084\u75c5\u614b\u5f62\u6210\u306b\u679c\u305f\u3059\u5f79\u5272\u3092\u3001\u5206\u5b50\u751f\u7269\u5b66\u7684\u304a\u3088\u3073\u7d44\u7e54\u7d30\u80de\u5316\u5b66\u7684\u624b\u6cd5\u3067\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002\uff08\u79cb\u5143\uff09<\/p>\r\n  <h3>\u76ae\u819a\u306e\u767a\u751f\u7814\u7a76<\/h3>\r\n  <p>\u30cb\u30ef\u30c8\u30ea\u304a\u3088\u3073\u30de\u30a6\u30b9\u80da\u3092\u30d3\u30bf\u30df\u30f3A\u5b58\u5728\u4e0b\u3067\u57f9\u990a\u3057\u3001\u8868\u76ae\u306e\u7c98\u6db2\u5316\u751f\u3084\u89d2\u8cea\u5668\u5b98\uff08\u7fbd\u6bdb\u3001\u9c57\u3001\u6bdb\uff09\u306e\u5f62\u6210\u306b\u304a\u3051\u308bHomeobox\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3068\u6a5f\u80fd\u3092\u691c\u8a0e\u3057\u3066\u3044\u307e\u3059\u3002\uff08\u79cb\u5143\uff09<\/p>\r\n  <h3>\u30d7\u30e9\u30ba\u30de\u7167\u5c04\u306b\u3088\u308b\u7d44\u7e54\u3001\u7d30\u80de\u3078\u306e\u5f71\u97ff<\/h3>\r\n  <p>\u30d7\u30e9\u30ba\u30de\u7167\u5c04\u306e\u4f4e\u4fb5\u8972\u306a\u6b62\u8840\u52b9\u679c\u3068\u5275\u50b7\u6cbb\u7652\u4fc3\u9032\u6a5f\u69cb\u3092\u96fb\u5b50\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3057\u3001\u30ac\u30ec\u30af\u30c1\u30f3\u3092\u6307\u6a19\u3068\u3057\u3066\u7cd6\u9396\u4fee\u98fe\u306e\u5909\u5316\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u30d7\u30e9\u30ba\u30de\u533b\u7642\u306e\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u3092\u5f62\u614b\u5b66\u7684\u306b\u691c\u8a3c\u3057\u3066\u3044\u307e\u3059\u3002\uff08\u79cb\u5143\uff09<\/p>\r\n  <h3>\u7cbe\u7d30\u7ba1\u4e0a\u76ae\u5468\u671f\u3001\u7cbe\u4e0a\u76ae\u306e\u6ce2\u306e\u5f62\u6210\u6a5f\u69cb<\/h3>\r\n  <p>\u7cbe\u5de3\u306e\u7cbe\u7d30\u7ba1\u3067\u306f\u3001\u7cbe\u5b50\u767a\u751f\u306e\u9032\u884c\u3092\u793a\u3059\u300c\u7cbe\u4e0a\u76ae\u5468\u671f\u300d\u304c\u7cbe\u7d30\u7ba1\u306b\u6cbf\u3063\u3066\u914d\u5217\u3057\u3001\u6ce2\u72b6\u306b\u7e70\u308a\u8fd4\u3055\u308c\u308b\u300c\u7cbe\u4e0a\u76ae\u306e\u6ce2\u300d\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002\u79c1\u9054\u306f\u3001\u7cbe\u4e0a\u76ae\u306e\u6ce2\u304c\u7537\u6027\u30db\u30eb\u30e2\u30f3\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u7cbe\u5de3\u5185\u306e\u6db2\u6027\u56e0\u5b50\u306b\u3088\u3063\u3066\u8abf\u7bc0\u3055\u308c\u3001\u305d\u306e\u8abf\u7bc0\u304c\u52a0\u9f62\u3068\u3068\u3082\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u3092\u3001\u30de\u30a6\u30b9\u3092\u4f7f\u3063\u3066\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u8abf\u7bc0\u304c\u6b63\u5e38\u306b\u884c\u308f\u308c\u308b\u306e\u306b\u5fc5\u8981\u306a\u8981\u7d20\u306f\u4f55\u304b\u306b\u3064\u3044\u3066\u3001\u8ffd\u6c42\u3057\u3066\u3044\u307e\u3059\u3002\uff08\u5bae\u6771\uff09<\/p>\r\n<\/section>\r\n<a id=\"achieve\" name=\"achieve\"><\/a>\r\n<section class=\"BlkArticle__Contents BlkArticle__Contents--notLead\">\r\n  <h2>\u8fd1\u5e74\u306e\u4e3b\u306a\u696d\u7e3e<\/h2>\r\n  <ol class=\"BlkArticle__listNumber\">\r\n    <li>Ogawa Y, Miura Y, Ikemoto M, Ohnishi A, Goto Y, Aoki K, Motokurumada Y, Akimoto Y, Endo T, Tsujimoto M, Yanoshita R: Distinguishing two distinct types of salivary extracellular vesicles: a potential tool for understanding their pathophysiological roles.  Front Mol Biosci Sec Cellular Biochemistry 11: 2024. DOI: 10.3389\/fmolb.2024.1278955<\/li>\r\n    <li>Cacheux J, Bancaud A, Alcaide D, Suehiro J, Akimoto Y, Sakurai H, Matsunaga Y: Deformation, but not convection, induced by intraluminal pressure enhances transport through microvessels.  iScience 26(7): 107141, 2023.<\/li>\r\n    <li>Wada H, Miyoshi J, Kuronuma S, Nishinarita Y, Oguri N, Hibi N, Takeuchi O, Akimoto Y, Lee STM, Matsuura M, Kobayashi T, Hibi T, Hisamatsu T: Alterations of intestinal microbiota by 5-aminosalicylic acid exert a protective effect on colitis in a murine inflammatory bowel disease model.  Sci Rep 13(1): 12241, 2023.<\/li>\r\n    <li>Takada M, Fukuhara D, Takiura T, Nishibori Y, Kotani M, Kiuchi Z, Kudo A, Beltcheva O, Ito-Nitta N, Nitta KR, Kimura T, Suehiro J, Katada T, Takematsu H, Yan K: Involvement of GLCCI1 in mouse spermatogenesis.  FASEB J. 37(1). e22680. 2023.<\/li>\r\n    <li>Uchida A, Imaimatsu K, Suzuki H, Han X, Ushioda H, Uemura M, Imura-Kishi K, Hiramatsu R, Takase HM, Hirate Y, Ogura A, Kanai-Azuma M, Kudo A, Kanai Y: SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse.  Nat Commun. 13(1). 7860. 2022.<\/li>\r\n    <li>Zachara NE, Akimoto Y, Boyce M, Hart GW: Chapter 19. The O-GlcNAc Modification.  In: Essentials of Glycobiology. 4th edition. Varki A et al. editors. Cold Spring Harbor (NY). Cold Spring Harbor Laboratory Press. 2022.<\/li>\r\n    <li>Ogawa Y, Akimoto Y, Ikemoto M, Goto Y, Ishikawa A, Ohta S, Takase Y, Kawakami H, Tsujimoto M, Yanoshita R: Stability of human salivary extracellular vesicles containing dipeptidyl peptidase IV under simulated gastrointestinal tract conditions.  Biochem Biophys Rep. 27: 101034. 2021.<\/li>\r\n    <li>Akimoto Y, Miura Y, Endo T, Hart GW: 5.08: <i>O<\/i>-GlcNAcylation and diabetes.  In: Comprehensive Glycoscience. 2nd ed. Barchi J editor. Volume 5: Glycans in Development, Health and Disease. Elsevier. 2021. 133-148.<\/li>\r\n    <li>Pecori F, Akimoto Y, Hanamatsu H, Furukawa J, Shinohara Y, Ikehara Y, Nishihara S: Mucin-type <i>O<\/i>-glycosylation controls pluripotency in mouse embryonic stem cells via Wnt receptor endocytosis.  J Cell Sci. 133(20): jcs245845. 2020.<\/li>\r\n    <li>Akimoto Y, Yan K, Miura Y, Tsumoto H, Toda T, Fukutomi T, Sugahara D, Kudo A, Arai T, Chiba Y, Kaname S, Hart GW, Endo T, Kawakami H: <i>O<\/i>-GlcNAcylation and phosphorylation of \u03b2-actin Ser<sup>199<\/sup> in diabetic nephropathy.  Am J Physiol Renal Physiol 317(5): F1359-F1374. 2019.<\/li>\r\n    <li>Itoh K, Akimoto Y, Kondo S, Ichimiya T, Aoki K, Tiemeyer M, Nishihara S: Glucuronylated core 1 glycans are required for precise localization of neuromuscular junctions and normal formation of basement membranes on <i>Drosophila<\/i> muscles.  Dev Biol 436(2): 108-124. 2018.<\/li>\r\n    <li>Akimoto Y, Ikehara S, Yamaguchi T, Kim J, Kawakami H, Shimizu N, Hori M, Sakakita H, Ikehara Y: Chapter 6.4. Molecular morphological analysis of the effect of plasma irradiation on cells, tissue.  In: Plasma Medical Science. 1st ed. Toyokuni S, et al., editors. Tokyo, Academic Press. 336-345. 2018.<\/li>\r\n    <li>Yoshimura T, Watanabe T, Kuramochi-Miyagawa S, Takemoto N, Shiromoto Y, Kudo A, Kanai-Azuma M, Tashiro F, Miyazaki S, Katanaya A, Chuma S, Miyazaki JI: Mouse GTSF1 is an essential factor for secondary piRNA biogenesis. EMBO Rep 19(4): e42054. 2018.<\/li>\r\n    <li>Sugahara D, Kobayashi Y, Akimoto Y, Kawakami H: Mouse intestinal niche cells express a distinct \u03b11,2-fucosylated glycan recognized by a lectin from <i>Burkholderia cenocepacia<\/i>. Glycobiology 27(3): 246-253. 2017.<\/li>\r\n  <\/ol>\r\n  <h3>\u65e5\u672c\u8a9e\u306e\u89e3\u8aac\u30fb\u66f8\u7c4d\u306a\u3069<\/h3>\r\n  <ol class=\"BlkArticle__listNumber\">\r\n    <li>\u5ddd\u4e0a\u901f\u4eba\uff0c\u677e\u6751\u8b93\u5152\uff08\u76e3\u8a33\uff09\u5ddd\u4e0a\u901f\u4eba\uff0c\u79cb\u5143\u7fa9\u5f18\uff0c\u5bae\u6771\u662d\u5f66\uff0c\u83c5\u539f\u5927\u4ecb \u4ed6\uff08\u5206\u62c5\u7ffb\u8a33\uff09\uff1a\u30ac\u30fc\u30c8\u30ca\u30fc\uff0f\u30cf\u30a4\u30a2\u30c3\u30c8\u7d44\u7e54\u5b66 \u7b2c4\u7248\uff0e\u6771\u4eac\uff0c\u30e1\u30c7\u30a3\u30ab\u30eb\u30fb\u30b5\u30a4\u30a8\u30f3\u30b9\u30fb\u30a4\u30f3\u30bf\u30fc\u30ca\u30b7\u30e7\u30ca\u30eb\uff0c2024.<\/li>\r\n    <li>\u5742\u4e95\u5efa\u96c4\uff0c\u5ddd\u4e0a\u901f\u4eba\uff0c\u7af9\u7530\u6247\uff08\u76e3\u8a33\uff09\u5ddd\u4e0a\u901f\u4eba\uff0c\u79cb\u5143\u7fa9\u5f18\uff0c\u5bae\u6771\u662d\u5f66 \u4ed6\uff08\u5206\u62c5\u7ffb\u8a33\uff09\uff1a\u30b8\u30e5\u30f3\u30b1\u30a4\u30e9\u7d44\u7e54\u5b66 \u7b2c6\u7248\uff08\u539f\u845716\u7248\uff09\uff0e\u6771\u4eac\uff0c\u4e38\u5584\u51fa\u7248\uff0c2024.<\/li>\r\n    <li>\u5bae\u6771\u662d\u5f66\uff0c\u79cb\u5143\u7fa9\u5f18\uff1a \u5b66\u8853\u753b\u50cf\u306e\u53d6\u308a\u6271\u3044\u3068\u753b\u50cf\u89e3\u6790\u306b\u3088\u308b\u6570\u5024\u5316\u306e\u57fa\u790e\uff0e\u7d44\u7e54\u7d30\u80de\u5316\u5b662024\uff0e\u65e5\u672c\u7d44\u7e54\u7d30\u80de\u5316\u5b66\u4f1a \u7de8\u96c6\uff0e\u5b66\u969b\u4f01\u753b\uff0e2024\uff0e123-130.<\/li>\r\n    <li>\u79cb\u5143\u7fa9\u5f18\uff08\u5171\u7de8\uff09\uff0c\u79cb\u5143\u7fa9\u5f18\uff0c\u5bae\u6771\u662d\u5f66 \u4ed6\uff08\u5206\u62c5\u57f7\u7b46\uff09\uff1a\u65b0 \u96fb\u9855\u5165\u9580\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\uff08\u96fb\u9855\u5165\u9580\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u6539\u8a02\u7b2c3\u7248\uff09\uff0e\u65e5\u672c\u9855\u5fae\u93e1\u5b66\u4f1a \u96fb\u5b50\u9855\u5fae\u93e1\u6280\u8853\u8a8d\u5b9a\u59d4\u54e1\u4f1a \u7de8\u96c6\uff0e\u56fd\u969b\u6587\u732e\u793e\uff0e2022.<\/li>\r\n    <li>\u79cb\u5143\u7fa9\u5f18\uff0c\u6c60\u539f\u8b72\uff1a\u900f\u904e\u578b\u96fb\u5b50\u9855\u5fae\u93e1\uff0e\u8ad6\u6587\u56f3\u8868\u3092\u8aad\u3080\u4f5c\u6cd5 \u5b9f\u9a13\u533b\u5b66\u5225\u518a\uff0e\u725b\u5cf6\u4fca\u548c\uff0c\u4e2d\u5c71\u656c\u4e00 \u7de8\u96c6\uff0e\u7f8a\u571f\u793e\uff0e2022. 61-63.<\/li>\r\n    <li>\u79cb\u5143\u7fa9\u5f18\uff0c\u5bae\u6771\u662d\u5f66\uff1a\u96fb\u5b50\u9855\u5fae\u93e1\u306e\u57fa\u790e\u3068\u5fdc\u7528\uff0e\u7d44\u7e54\u7d30\u80de\u5316\u5b662022\uff0e\u65e5\u672c\u7d44\u7e54\u7d30\u80de\u5316\u5b66\u4f1a \u7de8\u96c6\uff0e\u6771\u4eac\uff0c\u5b66\u969b\u4f01\u753b\uff0c2022\uff0e133-148.<\/li>\r\n  <\/ol>\r\n<\/section>\r\n","protected":false},"excerpt":{"rendered":"<p>\u6559\u5ba4\u5c02\u4efb\u6559\u54e1 \u6559\u5ba4\u6982\u8981 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