{"id":1820,"date":"2017-06-09T09:25:21","date_gmt":"2017-06-09T00:25:21","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/_manage\/news\/1820\/"},"modified":"2025-07-11T09:52:54","modified_gmt":"2025-07-11T00:52:54","slug":"stx1a%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%ae%e9%9a%9c%e5%ae%b3%e3%81%a8%e8%87%aa%e9%96%89%e7%97%87%e3%82%b9%e3%83%9a%e3%82%af%e3%83%88%e3%83%a9%e3%83%a0%e3%81%ae%e9%96%a2%e9%80%a3%e3%82%92%e8%a7%a3","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/archive\/1820\/","title":{"rendered":"STX1A\u907a\u4f1d\u5b50\u306e\u969c\u5bb3\u3068\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u306e\u95a2\u9023\u3092\u89e3\u660e"},"content":{"rendered":"<p align=\"right\"><b>\u5c0f\u85e4 \u525b\u53f2 (\u5171\u540c\u7814\u7a76\u65bd\u8a2dRI\u90e8\u9580 \u52a9\u6559)<\/b><\/p>\r\n<p align=\"right\"><b>\u85e4\u539f \u667a\u5fb3 (\u7d30\u80de\u751f\u7406\u5b66\u6559\u5ba4 \u51c6\u6559\u6388)<\/b><\/p>\r\n<p align=\"right\"><b>\u8d64\u5ddd \u516c\u6717 (\u540d\u8a89\u6559\u6388)<\/b><\/p>\r\n\r\n\r\n<h5>\u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8<\/h5>\r\n<ul style=\"list-style-type: circle;\">\r\n<li>\u795e\u7d4c\u7d30\u80de\u3067\u306e\u30b7\u30ca\u30d7\u30b9\u4f1d\u9054\u3092\u5236\u5fa1\u3059\u308bSTX1A\u306e\u907a\u4f1d\u5b50\u304c\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\uff08ASD\uff09\u60a3\u8005\u306e\u4e00\u90e8\u3067\u6b20\u640d\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\u3002<\/li>\r\n<li>STX1A\u3092\u6b20\u640d\u3055\u305b\u305f\u30de\u30a6\u30b9\u306e\u8868\u73fe\u578b\u304cASD\u60a3\u8005\u3067\u307f\u3089\u308c\u308b\u75c7\u72b6\u3068\u985e\u4f3c\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/li>\r\n<li>STX1A\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u91cf\u306e\u5909\u52d5\u304cASD\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/li>\r\n<\/ul>\r\n<br \/>\r\n<h5>\u6982\u8981<\/h5>\r\n<p>\u30b7\u30ca\u30d7\u30b9\u524d\u7d42\u672b\u3067\u306e\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u653e\u51fa\u306a\u3069\u3001\u795e\u7d4c\u7d30\u80de\u3067\u306e\u958b\u53e3\u653e\u51fa\u3092\u5236\u5fa1\u3059\u308b\u86cb\u767d\u8cea\u306e1\u3064\u3068\u3057\u3066\u3001HPC-1\/Syntaxin1A(STX1A)\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002STX1A\u306f\u795e\u7d4c\u7d30\u80de\u306e\u5f62\u8cea\u819c\u306b\u591a\u304f\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u5185\u5206\u6ccc\u7d30\u80de\u306b\u3082\u305d\u306e\u767a\u73fe\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u6211\u3005\u306f\u3001STX1A\u907a\u4f1d\u5b50\u3092\u6b20\u640d\u3055\u305b\u305f\u30de\u30a6\u30b9\u3092\u4f5c\u6210\u3057\u3001\u305d\u306e\u8868\u73fe\u578b\u89e3\u6790\u3092\u884c\u3063\u3066\u304d\u307e\u3057\u305f\u3002STX1A\u907a\u4f1d\u5b50\u6b20\u640d\u30de\u30a6\u30b9\u306f\u3001\u307b\u3068\u3093\u3069\u6b63\u5e38\u306b\u767a\u80b2\u3059\u308b\u3082\u306e\u306e\u3001\u69d8\u3005\u306a\u7cbe\u795e\u795e\u7d4c\u75be\u60a3\u306b\u95a2\u308f\u308b\u30e2\u30ce\u30a2\u30df\u30f3\u304a\u3088\u3073\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\u7b49\u306e\u795e\u7d4c\u30da\u30d7\u30c1\u30c9\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u5b66\u7fd2\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3001\u793e\u4f1a\u884c\u52d5\u306e\u969c\u5bb3\u306a\u3069\u3001\u6b63\u5e38\u30de\u30a6\u30b9\u3068\u306f\u7570\u306a\u308b\u884c\u52d5\u69d8\u5f0f\u3092\u793a\u3059\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\uff08Fujiwara et al J Neurosci 2006\u3001E J Neurosci 2010\uff09\u3002\u3053\u308c\u3089\u306f\u30d2\u30c8\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\uff08ASD\uff09\u60a3\u8005\u3067\u307f\u3089\u308c\u308b\u75c7\u72b6\u3068\u985e\u4f3c\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u307e\u305f\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001STX1A\u907a\u4f1d\u5b50\u6b20\u640d\u30de\u30a6\u30b9\u306e\u793e\u4f1a\u884c\u52d5\u306e\u969c\u5bb3\u306f\u3001\u81ea\u9589\u6027\u969c\u5bb3\u3092\u8efd\u6e1b\u3055\u305b\u308b\u52b9\u679c\u304c\u3042\u308b\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u6539\u5584\u3055\u308c\u307e\u3057\u305f\uff08Fujiwara et al J Neurochem 2016\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u30d2\u30c8ASD\u3068STX1A\u907a\u4f1d\u5b50\u304c\u95a2\u9023\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3001\u4eca\u56de\u6211\u3005\u306f\u3001ASD\u60a3\u8005\u306eSTX1A\u907a\u4f1d\u5b50\u306b\u3064\u3044\u3066\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u5b9a\u91cf\u7684PCR\u306b\u3088\u308a\u8840\u7403\u7d30\u80de\u306b\u304a\u3051\u308bSTX1A\u306emRNA\u306e\u767a\u73fe\u91cf\u3092\u6e2c\u5b9a\u3057\u305f\u7d50\u679c\u3001\u591a\u304f\u306eASD\u60a3\u8005\u306b\u304a\u3044\u3066\u3001STX1A\u306e\u767a\u73fe\u91cf\u304c\u5065\u5e38\u8005\u3068\u6bd4\u3079\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u305d\u308c\u3089\u306e\u60a3\u8005\u306eSTX1A\u907a\u4f1d\u5b50\u306b\u3064\u3044\u3066\u30b3\u30d4\u30fc\u6570\u591a\u578b\uff08CNV\uff09\u89e3\u6790\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u305d\u306e\u4e00\u90e8\u306b\u304a\u3044\u3066STX1A\u907a\u4f1d\u5b50\u304c\u30cf\u30d7\u30ed\u30a4\u30c9(\u907a\u4f1d\u5b50\u6570\u304c\u534a\u6e1b)\u3068\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001STX1A\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u304c\u4e00\u90e8\u306eASD\u306e\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u4e00\u822c\u306b\u3001ASD\u306b\u306f\u30b7\u30ca\u30d7\u30b9\u6a5f\u80fd\u306e\u969c\u5bb3\u304c\u95a2\u308f\u308b\u3068\u63a8\u6e2c\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u3053\u306b\u306f\u8907\u6570\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306bASD\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u304c\u3044\u304f\u3064\u304b\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u30b7\u30ca\u30d7\u30b9\u4f1d\u9054\u3092\u76f4\u63a5\u5236\u5fa1\u3059\u308bSTX1A\u306f\u305d\u306e\u91cd\u8981\u306a\u539f\u56e0\u907a\u4f1d\u5b50\u306e1\u3064\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u307e\u305f\u3001STX1A\u907a\u4f1d\u5b50\u304c\u30cf\u30d7\u30ed\u30a4\u30c9\u306e\u60a3\u8005\u4ee5\u5916\u3067\u3082\u3001STX1A\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u5909\u52d5\u3057\u3066\u3044\u308b\u60a3\u8005\u4f8b\u304c\u4eca\u56de\u306e\u89e3\u6790\u3067\u591a\u6570\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u795e\u7d4c\u7d30\u80de\u306b\u304a\u3051\u308bSTX1A\u306e\u767a\u73fe\u91cf\u306e\u5909\u52d5\u304cASD\u306b\u95a2\u308f\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u4eca\u5f8c\u305d\u306e\u6a5f\u5e8f\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u306b\u3088\u308aASD\u306e\u75c5\u614b\u89e3\u660e\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\r\n<p>\u672c\u7814\u7a76\u306f\u3001\u770c\u7acb\u5e83\u5cf6\u5927\u5b66\u306e\u6797\u6559\u6388\u3089\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u79d1\u7814\u8cbb\u57fa\u76e4\u7814\u7a76(C)\u3001\u79d1\u7814\u8cbb\u57fa\u76e4\u7814\u7a76(B)\u3001\u79c1\u5b66\u4e8b\u696d\u56e3\u88dc\u52a9\u91d1\u306e\u52a9\u6210\u3092\u53d7\u3051\u3066\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\r\n<br \/>\r\n\r\n<br \/ class=\"fig0\">\r\n\r\n<h5>\u63b2\u8f09\u8ad6\u6587<\/h5>\r\n\r\n<table class=\"citation\">\r\n <tr>\r\n  <td>\u767a\u8868\u96d1\u8a8c\uff1a<\/td><td>Neuroscience Letters [ Vol.644 pp.5 &#8211; 9 (2017) ]<\/td>\r\n <\/tr>\r\n<tr>\r\n  <td>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1a<\/td><td><a href=\"http:\/\/doi.org\/10.1016\/j.neulet.2017.02.052\" target=\"_blank\" rel=\"noopener\">\r\nA part of patients with autism spectrum disorder has haploidy of HPC-1\/syntaxin1A gene that possibly causes behavioral disturbance as in experimentally gene ablated mice.<\/a><\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>\u7b46\u3000\u8005\uff1a<\/td><td>Takefumi Kofuji, Yuko Hayashi, Tomonori Fujiwara, Masumi Sanada, Masao Tamaru, Kimio Akagawa<br \/>(\u5c0f\u85e4\u525b\u53f2\u3001\u6797\u512a\u5b50\u3001\u85e4\u539f\u667a\u5fb3\u3001\u771f\u7530\u307e\u3059\u307f\u3001\u7530\u4e38\u653f\u7537\u3001\u8d64\u5ddd\u516c\u6717)<\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>DOI:<\/td>  <td>10.1016\/j.neulet.2017.02.052<\/td>\r\n <\/tr>\r\n<\/table>\r\n<br \/>\r\n\r\n<div>\r\n<p>\u7d30\u80de\u751f\u7269\u5b66\u6559\u5ba4\u306e\u8a73\u7d30\u306f<a href=\"http:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/cell-physiology\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u304b\u3089\u3054\u89a7\u4e0b\u3055\u3044\u3002\r\n<p>\u7d30\u80de\u751f\u7406\u5b66\u6559\u5ba4\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u8a73\u7d30\u306f<a href=\"http:\/\/www.kyorin-u.ac.jp\/univ\/graduate\/medicine\/education\/departments\/cell-physiol\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u304b\u3089\u3054\u89a7\u4e0b\u3055\u3044\u3002\r\n<\/div>\r\n<br \/>\r\n<h5>\u554f\u3044\u5408\u308f\u305b\u5148<\/h5>\r\n<p class=\"noIndmt10\">\u674f\u6797\u5b66\u5712\u5e83\u5831\u5ba4<br \/>\r\n\u3000\u3000\u5e83\u5831\u5ba4\u3078\u306e\u304a\u554f\u3044\u5408\u308f\u305b\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/contact\/\">\u3053\u3061\u3089<\/a>\u307e\u3067<br \/>\r\n<\/p>\r\n\r\n","protected":false},"excerpt":{"rendered":"<p>\u5c0f\u85e4 \u525b\u53f2 (\u5171\u540c\u7814\u7a76\u65bd\u8a2dRI\u90e8\u9580 \u52a9\u6559) \u85e4\u539f \u667a\u5fb3 (\u7d30\u80de\u751f\u7406\u5b66\u6559\u5ba4 \u51c6\u6559\u6388) \u8d64\u5ddd \u516c\u6717 (\u540d\u8a89\u6559\u6388) \u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8 \u795e\u7d4c\u7d30\u80de\u3067\u306e\u30b7\u30ca\u30d7\u30b9\u4f1d\u9054\u3092\u5236\u5fa1\u3059\u308bSTX1A\u306e\u907a\u4f1d\u5b50\u304c\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\uff08ASD\uff09\u60a3\u8005\u306e\u4e00\u90e8 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-1820","post","type-post","status-publish","format-standard","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/1820","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/comments?post=1820"}],"version-history":[{"count":1,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/1820\/revisions"}],"predecessor-version":[{"id":7315,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/1820\/revisions\/7315"}],"wp:attachment":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media?parent=1820"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/categories?post=1820"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/tags?post=1820"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}