{"id":1849,"date":"2018-03-08T15:32:58","date_gmt":"2018-03-08T06:32:58","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/_manage\/news\/1849\/"},"modified":"2025-07-11T09:52:02","modified_gmt":"2025-07-11T00:52:02","slug":"%e3%82%a2%e3%83%95%e3%83%aa%e3%82%ab%e3%83%84%e3%83%a1%e3%82%ac%e3%82%a8%e3%83%ab%e5%89%8d%e8%85%8e%e3%82%92%e3%83%a2%e3%83%87%e3%83%ab%e3%81%a8%e3%81%97%e3%81%9fnotch%e3%82%b7%e3%82%b0%e3%83%8a","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/archive\/1849\/","title":{"rendered":"\u30a2\u30d5\u30ea\u30ab\u30c4\u30e1\u30ac\u30a8\u30eb\u524d\u814e\u3092\u30e2\u30c7\u30eb\u3068\u3057\u305fNotch\u30b7\u30b0\u30ca\u30eb\u306b\u3088\u308b\u814e\u5c3f\u7d30\u7ba1\u306e\u5206\u5316\u5236\u5fa1\u306e\u89e3\u660e"},"content":{"rendered":"<p align=\"right\"><b>\u5805\u7530\u667a\u4e45\uff08\u85ac\u7406\u5b66\u6559\u5ba4\u3001\u52a9\u6559\uff09<\/b><br \/>\r\n<b>\u6afb\u4e95\u88d5\u4e4b\uff08\u85ac\u7406\u5b66\u6559\u5ba4\u3001\u6559\u6388\uff09<\/b><\/p>\r\n\r\n<h5>\u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8<\/h5>\r\n<ul>\r\n<li>\u814e\u81d3\u306e\u524d\u99c6\u7d30\u80de\u304b\u3089\u5c3f\u7d30\u7ba1\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u304c\u78ba\u7acb\u3055\u308c\u308b\u969b\u306b\u3001Notch\u30b7\u30b0\u30ca\u30eb\u306e\u9069\u5207\u306a\u6d3b\u6027\u5316\u3068\u6291\u5236\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f<\/li>\r\n<li>\u30cd\u30d5\u30ed\u30f3\u3092\u69cb\u6210\u3059\u308b\u7cf8\u7403\u4f53\u3068\u8fd1\u4f4d\u5c3f\u7d30\u7ba1\u306e\u5206\u5316\u306b\u306fNotch\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f<\/li>\r\n<li>\u9060\u4f4d\u5c3f\u7d30\u7ba1\u306e\u5206\u5316\u3068\u7ba1\u8154\u69cb\u9020\u306e\u5f62\u6210\u306b\u306fNotch\u30b7\u30b0\u30ca\u30eb\u306e\u6291\u5236\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f<\/li>\r\n<\/ul>\r\n<br \/>\r\n\r\n<h5>\u6982\u3000\u8981<\/h5>\r\n<p>\u3000\u814e\u81d3\u306f\u3001\u8840\u6db2\u4e2d\u306e\u6c34\u5206\u3084\u7121\u6a5f\u7269\u3001\u6709\u6a5f\u7269\u3092\u308d\u904e\u3059\u308b\u3053\u3068\u3067\u5c3f\u3092\u751f\u6210\u3057\u3001\u4f53\u6db2\u306e\u7d44\u6210\u3092\u7dad\u6301\u3059\u308b\u5f79\u5272\u3092\u62c5\u3046\u81d3\u5668\u3067\u3059\u3002\u3053\u308c\u306f\u30cd\u30d5\u30ed\u30f3\u3068\u547c\u3070\u308c\u308b\u57fa\u672c\u5358\u4f4d\u304c\u96c6\u5408\u3057\u3066\u3067\u304d\u3066\u304a\u308a\u3001\u89e3\u5256\u5b66\u7684\u306b\u7cf8\u7403\u4f53\u3001\u8fd1\u4f4d\u5c3f\u7d30\u7ba1\u3001\u30d8\u30f3\u30ec\u306e\u30eb\u30fc\u30d7\u3001\u9060\u4f4d\u5c3f\u7d30\u7ba1\u3001\u96c6\u5408\u7ba1\u3068\u547c\u3070\u308c\u308b\u9818\u57df\u306b\u7d30\u304b\u304f\u5206\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u30d2\u30c8\u306e\u5834\u5408\u306f\u4e00\u3064\u306e\u814e\u81d3\u306b\u3064\u304d\u3001\u304a\u3088\u305d100\u4e07\u306e\u30cd\u30d5\u30ed\u30f3\u304c\u5b58\u5728\u3059\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<p>\u3000\u814e\u81d3\u306e\u767a\u751f\u306b\u304a\u3044\u3066\u3001\u30cd\u30d5\u30ed\u30f3\u306e\u5404\u9818\u57df\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u306f\u3001\u4e2d\u80da\u8449\u3092\u8d77\u6e90\u3068\u3059\u308b\u814e\u81d3\u306e\u524d\u99c6\u7d30\u80de\u304c\u5206\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5f62\u6210\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u904e\u7a0b\u306b\u306f\u591a\u304f\u306e\u907a\u4f1d\u5b50\u304c\u8907\u96d1\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u4ed5\u7d44\u307f\u306f\u3044\u307e\u3060\u4e0d\u660e\u306a\u70b9\u304c\u6b8b\u3063\u3066\u3044\u307e\u3059\u3002\u52a0\u3048\u3066\u3001\u30d2\u30c8\u3084\u30de\u30a6\u30b9\u3067\u306f\u591a\u6570\u306e\u30cd\u30d5\u30ed\u30f3\u304c\u5f62\u6210\u3055\u308c\u308b\u904e\u7a0b\u3067\u3042\u308b\u304c\u3086\u3048\u306b\u8a73\u7d30\u306a\u89e3\u6790\u304c\u56f0\u96e3\u3067\u3042\u308a\u3001\u3088\u308a\u30b7\u30f3\u30d7\u30eb\u306a\u5b9f\u9a13\u7cfb\u3092\u7528\u3044\u308b\u3053\u3068\u304c\u671b\u307e\u308c\u307e\u3059\u3002<\/p>\r\n<p>\u3000\u305d\u3053\u3067\u6211\u3005\u306f\u3001\u30cd\u30d5\u30ed\u30f3\u3092\u4e00\u3064\u3057\u304b\u6301\u305f\u306a\u3044\u30a2\u30d5\u30ea\u30ab\u30c4\u30e1\u30ac\u30a8\u30eb\u80da\u3092\u89e3\u6790\u30e2\u30c7\u30eb\u3068\u3057\u3066\u7528\u3044\u308b\u3053\u3068\u306b\u3057\u307e\u3057\u305f\u3002\u767a\u751f\u5b66\u7814\u7a76\u3067\u591a\u7528\u3055\u308c\u308b\u30a2\u30d5\u30ea\u30ab\u30c4\u30e1\u30ac\u30a8\u30eb\u306f\u5375\u751f\u3067\u3042\u308b\u305f\u3081\u3001\u767a\u751f\u904e\u7a0b\u3092\u4f53\u5916\u3067\u8ffd\u8de1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3046\u3048\u3001\u907a\u4f1d\u5b50\u306e\u904e\u5270\u767a\u73fe\u3084\u6a5f\u80fd\u963b\u5bb3\u3092\u300c\u9855\u5fae\u6ce8\u5165\u6cd5\u300d\u3068\u547c\u3070\u308c\u308b\u65b9\u6cd5\u3067\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u814e\u81d3\u306e\u524d\u99c6\u7d30\u80de\u304b\u3089\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u7570\u306a\u308b\u7a2e\u985e\u306e\u7d30\u80de\u304c\u751f\u307f\u51fa\u3055\u308c\u308b\u306e\u304b\u3092\u3001\u7d30\u80de\u306e\u5206\u5316\u5236\u5fa1\u306b\u91cd\u8981\u3068\u3055\u308c\u308bNotch\u30b7\u30b0\u30ca\u30eb\u306b\u7740\u76ee\u3057\u3066\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u8a66\u307f\u307e\u3057\u305f\u3002<\/p>\r\n<p>\u3000\u306f\u3058\u3081\u306b\u3001\u814e\u81d3\u304c\u5f62\u6210\u3055\u308c\u308b\u9818\u57df\u3067Notch\u30b7\u30b0\u30ca\u30eb\u3092\u6d3b\u6027\u5316\u3055\u305b\u305f\u3068\u3053\u308d\u3001\u7cf8\u7403\u4f53\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u6570\u304c\u5897\u52a0\u3057\u3001\u9060\u4f4d\u5c3f\u7d30\u7ba1\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u306f\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u52a0\u3048\u3066\u3001\u9060\u4f4d\u5c3f\u7d30\u7ba1\u306f\u672c\u6765\u3067\u3042\u308c\u3070\u3001\u4f38\u9577\u3057\u3066\u7dcf\u6392\u51fa\u8154\u3092\u5f62\u6210\u3057\u307e\u3059\u304c\u3001\u5c3f\u7d30\u7ba1\u306e\u4f38\u9577\u306f\u963b\u5bb3\u3055\u308c\u3001\u7dcf\u6392\u51fa\u8154\u3082\u5f62\u6210\u3055\u308c\u306a\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\r\n<p>\u3000\u6b21\u306b\u3001\u814e\u81d3\u306e\u4e88\u5b9a\u5f62\u6210\u9818\u57df\u3067\u3001Notch\u30b7\u30b0\u30ca\u30eb\u3092\u6291\u5236\u3057\u305f\u3068\u3053\u308d\u3001\u7cf8\u7403\u4f53\u304a\u3088\u3073\u8fd1\u4f4d\u5c3f\u7d30\u7ba1\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u6570\u306f\u6e1b\u5c11\u3057\u3001\u9060\u4f4d\u5c3f\u7d30\u7ba1\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u306f\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u3001\u7cf8\u7403\u4f53\u304a\u3088\u3073\u8fd1\u4f4d\u5c3f\u7d30\u7ba1\u306e\u5206\u5316\u306b\u306f\u3001Notch\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u304c\u5fc5\u8981\u3067\u3001\u9060\u4f4d\u5c3f\u7d30\u7ba1\u306e\u5206\u5316\u306b\u306f\u3001Notch\u30b7\u30b0\u30ca\u30eb\u304c\u6291\u5236\u3055\u308c\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u7d44\u7e54\u5b66\u7684\u306a\u89e3\u6790\u304b\u3089\u3001\u5c3f\u7d30\u7ba1\u306e\u7ba1\u8154\u306e\u5f62\u6210\u306b\u3082\u3001Notch\u30b7\u30b0\u30ca\u30eb\u306e\u6291\u5236\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\r\n<p>\u3000\u30a2\u30d5\u30ea\u30ab\u30c4\u30e1\u30ac\u30a8\u30eb\u80da\u306e\u814e\u81d3\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u540c\u3058\u810a\u690e\u52d5\u7269\u3067\u3042\u308b\u30d2\u30c8\u306b\u3082\u7a2e\u3092\u8d85\u3048\u3066\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3001\u814e\u81d3\u306e\u767a\u751f\u6a5f\u5e8f\u3092\u89e3\u660e\u3059\u308b\u306e\u306b\u5f79\u7acb\u3064\u3070\u304b\u308a\u3067\u306a\u304f\u3001\u518d\u751f\u533b\u7642\u306e\u9032\u6b69\u306b\u3082\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\r\n<br \/>\r\n<p>\u3000\u672c\u7814\u7a76\u306f\u3001\u79d1\u7814\u8cbb\u82e5\u624b\u7814\u7a76(B)\u306e\u52a9\u6210\u3092\u53d7\u3051\u3066\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\r\n\r\n\r\n<figure id=\"Fig.1\" class=\"fig1\">\r\n<a href=\"\/univ\/faculty\/medicine\/uploads\/assets\/2018\/03\/08\/Fig1.jpg\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/assets\/2018\/03\/08\/Fig1.jpg\" width=\"550\" alt=\"Notch\u30b7\u30b0\u30ca\u30eb\u306b\u3088\u308b\u30cd\u30d5\u30ed\u30f3\u5f62\u6210\u306e\u5236\u5fa1\u6a5f\u69cb\" border=\"0\"><\/a>\r\n<figcaption><\/figcaption>\r\n<\/figure>\r\n\r\n\r\n<br \/ class=\"fig0\">\r\n\r\n<h5>\u63b2\u8f09\u8ad6\u6587<\/h5>\r\n\r\n<table class=\"citation\">\r\n <tr>\r\n  <td width=93>\u767a\u8868\u96d1\u8a8c\uff1a<\/td><td width=560>Developmental Dynamics [ Vol.245, pp.472 &#8211; 482 (2016) ]<\/td>\r\n <\/tr>\r\n<tr>\r\n  <td>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1a<\/td><td><a href=\"http:\/\/doi.org\/10.1002\/dvdy.24386\" target=\"_blank\" rel=\"noopener\">Proper Notch activity is necessary for the establishment of proximal cells and differentiation of intermediate, distal, and connecting tubule in Xenopus pronephros development.<\/a><\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>\u7b46\u3000\u8005\uff1a<\/td><td>Tomohisa Katada, Hiroyuki Sakurai <br \/> \uff08\u5805\u7530\u667a\u4e45\u3001\u6afb\u4e95\u88d5\u4e4b\uff09<\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>DOI:<\/td>  <td>10.1002\/dvdy.24386<\/td>\r\n <\/tr>\r\n<\/table>\r\n<br \/>\r\n<div>\r\n<p>\u85ac\u7406\u5b66\u6559\u5ba4\u306e\u8a73\u7d30\u306f<a href=\"http:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/pharmacology\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002\r\n<p>\u85ac\u7406\u5b66\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u8a73\u7d30\u306f<a href=\"http:\/\/www.kyorin-u.ac.jp\/univ\/graduate\/medicine\/education\/departments\/pharmacol-toxicol\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002\r\n<\/div>\r\n<br \/>\r\n<h5>\u554f\u3044\u5408\u308f\u305b\u5148<\/h5>\r\n<p class=\"noIndmt10\">\u674f\u6797\u5b66\u5712\u5e83\u5831\u5ba4<br \/>\r\n\u3000\u3000\u5e83\u5831\u5ba4\u3078\u306e\u304a\u554f\u3044\u5408\u308f\u305b\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/contact\/\">\u3053\u3061\u3089<\/a>\u307e\u3067<br \/>\r\n<\/p>","protected":false},"excerpt":{"rendered":"<p>\u5805\u7530\u667a\u4e45\uff08\u85ac\u7406\u5b66\u6559\u5ba4\u3001\u52a9\u6559\uff09 \u6afb\u4e95\u88d5\u4e4b\uff08\u85ac\u7406\u5b66\u6559\u5ba4\u3001\u6559\u6388\uff09 \u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8 \u814e\u81d3\u306e\u524d\u99c6\u7d30\u80de\u304b\u3089\u5c3f\u7d30\u7ba1\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u304c\u78ba\u7acb\u3055\u308c\u308b\u969b\u306b\u3001Notch\u30b7\u30b0\u30ca\u30eb\u306e\u9069\u5207\u306a\u6d3b\u6027\u5316\u3068\u6291\u5236\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f \u30cd\u30d5\u30ed\u30f3\u3092\u69cb\u6210\u3059\u308b\u7cf8\u7403 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