{"id":1876,"date":"2018-09-22T09:24:13","date_gmt":"2018-09-22T00:24:13","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/_manage\/news\/1876\/"},"modified":"2025-07-11T09:51:19","modified_gmt":"2025-07-11T00:51:19","slug":"%e3%82%a4%e3%83%b3%e3%82%b9%e3%83%aa%e3%83%b3%e5%88%86%e6%b3%8c%e7%b4%b0%e8%83%9e%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%9f%e3%83%88%e3%82%b3%e3%83%b3%e3%83%89%e3%83%aa%e3%82%a2%e3%81%ae%e5%93%81-2","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/archive\/1876\/","title":{"rendered":"\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u7d30\u80de\u306b\u304a\u3051\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb\u304c\u660e\u3089\u304b\u306b"},"content":{"rendered":"<p align=\"right\"><b>\u9752\u67f3\u5171\u592a\u3000\uff08\u751f\u5316\u5b66\u6559\u5ba4\u3000\u8b1b\u5e2b\uff09<\/b><\/p>\r\n<p align=\"right\"><b>\u4eca\u6cc9\u7f8e\u4f73\u3000\uff08\u751f\u5316\u5b66\u6559\u5ba4\u3000\u6559\u6388\uff09<\/b><\/p>\r\n\r\n<h5>\u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8<\/h5>\r\n<ul style=\"list-style-position: outside; margin-left: 10px; padding-left: 10px; line-height: 1.5\">\r\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u7d30\u80de\u306b\u304a\u3051\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u54c1\u8cea\u7ba1\u7406\u306b\u91cd\u8981\u306aVAMP7\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8ceaAtg9a\u3068\u5171\u306b\u306f\u305f\u3089\u3044\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f<\/li>\r\n<li>VAMP7\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308bHrb\u3001SNAP-47\u3001Syntaxin16\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u7d30\u80de\u306b\u304a\u3051\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u54c1\u8cea\u7ba1\u7406\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/li>\r\n<\/ul>\r\n<br \/>\r\n\r\n<h5>\u6982\u8981<\/h5>\r\n<p>\u3000\u98df\u4e8b\u3092\u3057\u3066\u8840\u4e2d\u306e\u7cd6\uff08\u8840\u7cd6\uff09\u304c\u5897\u3048\u308b\u3068\u3001\u81b5\u81d3\u306b\u3042\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u7d30\u80de\u304b\u3089\u8840\u7cd6\u964d\u4e0b\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u5206\u6ccc\u3055\u308c\u3001\u8840\u7cd6\u5024\u304c\u4e0b\u304c\u308a\u307e\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u7d30\u80de\u306f\u8840\u7cd6\u4e0a\u6607\u306b\u4f34\u3063\u3066\u7d30\u80de\u5185\u3078\u53d6\u308a\u8fbc\u3093\u3060\u7cd6\u3092\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\uff08\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u5de5\u5834\uff09\u3067\u4ee3\u8b1d\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066ATP\uff08\u30a8\u30cd\u30eb\u30ae\u30fc\u901a\u8ca8\uff09\u3092\u7523\u751f\u3057\u3001\u3053\u308c\u306b\u3088\u308a\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u5206\u6ccc\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306b\u304a\u3044\u3066\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u975e\u5e38\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u3068\u3053\u308d\u304c\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u306f\u305f\u3089\u304d\u7d9a\u3051\u308b\u3068\u5f90\u3005\u306b\u50b7\u3064\u3044\u3066\u306f\u305f\u3089\u304d\u304c\u60aa\u304f\u306a\u3063\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u50b7\u3064\u3044\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u7d30\u80de\u5185\u306b\u6e9c\u307e\u308b\u3068ATP\u3092\u52b9\u7387\u3088\u304f\u7523\u751f\u3067\u304d\u306a\u304f\u306a\u3063\u3066\u3057\u307e\u3046\u305f\u3081\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u5206\u6ccc\u3057\u7d9a\u3051\u308b\u305f\u3081\u306b\u306f\u3001\u7d30\u80de\u306f\u50b7\u3064\u3044\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5206\u89e3\u3057\u3066\u7d30\u80de\u5185\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5e38\u306b\u30d5\u30ec\u30c3\u30b7\u30e5\u306a\u72b6\u614b\u306b\u4fdd\u3064\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\r\n\u3000\u7d30\u80de\u3092\u69cb\u6210\u3059\u308b\u90e8\u54c1\u306e\u3046\u3061\u3001\u4e0d\u8981\u306b\u306a\u3063\u305f\u90e8\u54c1\u3084\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u305f\u90e8\u54c1\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3068\u547c\u3070\u308c\u308b\u6a5f\u69cb\uff08\u7d30\u80de\u306e\u81ea\u98df\u4f5c\u7528\uff09\u306b\u3088\u3063\u3066\u5206\u89e3\u3055\u308c\u307e\u3059\u304c\u3001\u50b7\u3064\u3044\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3082\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u3088\u3063\u3066\u5206\u89e3\u3055\u308c\u307e\u3059\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u305f\uff12\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u7d30\u80de\u3067\u306f\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u3088\u308b\u5206\u89e3\u306e\u52b9\u7387\u304c\u4f4e\u4e0b\u3057\u3066\u3001\u50b7\u3064\u3044\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u901a\u5e38\u3088\u308a\u3082\u591a\u304f\u89b3\u5bdf\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u3088\u308b\u50b7\u3064\u3044\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5206\u89e3\u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\r\n\u3000\u3053\u308c\u307e\u3067\u306b\u79c1\u305f\u3061\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u7d30\u80de\u306b\u304a\u3051\u308b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u4ecb\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5206\u89e3\u306b\u306fVAMP7\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u3001VAMP7\u907a\u4f1d\u5b50\u6b20\u5931\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u5b9f\u9a13\u306b\u3088\u308a\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3001VAMP7\u304c\u3069\u306e\u3088\u3046\u306a\u6a5f\u69cb\u3067\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u5236\u5fa1\u3057\u3001\u50b7\u3064\u3044\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5206\u89e3\u3059\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u8abf\u3079\u307e\u3057\u305f\u3002VAMP7\u3068\u5c40\u5728\u3084\u6319\u52d5\u304c\u5171\u901a\u3059\u308b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u5236\u5fa1\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u63a2\u7d22\u3057\u3001\u307e\u305fVAMP7\u3068\u5171\u306b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u5236\u5fa1\u306b\u95a2\u4e0e\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u63a2\u7d22\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001VAMP7\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u5236\u5fa1\u306b\u5fc5\u9808\u306aAtg9a\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u5354\u540c\u3057\u3066\u306f\u305f\u3089\u304f\u3053\u3068\u306b\u3088\u308a\u3001\u50b7\u3064\u3044\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5206\u89e3\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001VAMP7\u3068\u7d50\u5408\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u3046\u3061\u3001Hrb\u3001SNAP-47\u3001Syntaxin16\u304cVAMP7\u3068\u540c\u69d8\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u4ecb\u3057\u3066\u50b7\u3064\u3044\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5206\u89e3\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4e0d\u5168\u306b\u3088\u308b\uff12\u578b\u7cd6\u5c3f\u75c5\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u3082\u306e\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br \/>\r\n\u3000\u3053\u306e\u7814\u7a76\u306f\u5927\u962a\u5927\u5b66\u3001\u5317\u91cc\u5927\u5b66\u3001\u7fa4\u99ac\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\u306e\u6210\u679c\u3067\u3042\u308a\u3001\u6587\u90e8\u79d1\u5b66\u7701\u79d1\u7814\u8cbb\uff08\u57fa\u76e4\u7814\u7a76C\uff09\u3001\u7fa4\u99ac\u5927\u5b66\u751f\u4f53\u8abf\u7bc0\u7814\u7a76\u6240\u5185\u5206\u6ccc\u30fb\u4ee3\u8b1d\u5b66\u5171\u540c\u7814\u7a76\u62e0\u70b9\u3001\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u82e5\u624b\u7814\u7a76\u52a9\u6210\u91d1\u3001\u6b66\u7530\u79d1\u5b66\u632f\u8208\u8ca1\u56e3\u3001\u65e5\u672c\u7cd6\u5c3f\u75c5\u8ca1\u56e3\u306e\u52a9\u6210\u3092\u53d7\u3051\u3066\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\r\n<br \/>\r\n\r\n\r\n<h5>\u63b2\u8f09\u8ad6\u6587<\/h5>\r\n\r\n<table class=\"citation\">\r\n <tr>\r\n  <td>\u767a\u8868\u96d1\u8a8c\uff1a<\/td><td>Endocrinology<\/td>\r\n <\/tr>\r\n<tr>\r\n  <td>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1a<\/td><td><a href=\"http:\/\/doi.org\/10.1210\/en.2018-00447\" target=\"_blank\" rel=\"noopener\">VAMP7 regulates autophagosome formation by supporting Atg9a functions in pancreatic &beta;-cells from male mice.<\/a><\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>\u7b46\u3000\u8005\uff1a<\/td><td>Kyota Aoyagi, Makoto Itakura, Toshiyuki Fukutomi, Chiyono Nishiwaki, Yoko Nakamichi, Seiji Trii, Tomohiko Makiyama, Akihiro Harada, Mica Ohara-Imaizumi<br \/>\uff08\u9752\u67f3\u5171\u592a\u3001\u677f\u5009\u8aa0\u3001\u798f\u51a8\u4fca\u4e4b\u3001\u897f\u8107\u77e5\u4e16\u4e43\u3001\u4e2d\u9053\u6d0b\u5b50\u3001\u9ce5\u5c45\u5f81\u53f8\u3001\u7267\u5c71\u667a\u5f66\u3001\u539f\u7530\u5f70\u5b8f\u3001\u4eca\u6cc9\u7f8e\u4f73\uff09<\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>DOI:<\/td>  <td>10.1210\/en.2018-00447<\/td>\r\n <\/tr>\r\n<\/table>\r\n<br \/>\r\n\r\n<div>\r\n<p>\u751f\u5316\u5b66\u6559\u5ba4\u306e\u8a73\u7d30\u306f<a href=\"http:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/biochemistry\/#met-1\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002\r\n<p>\u751f\u5316\u5b66\u6559\u5ba4 \u7d30\u80de\u751f\u7269\u5b66\u30b0\u30eb\u30fc\u30d7\u306e\u8a73\u7d30\u306f<a href=\"http:\/\/www.kyorin-u.ac.jp\/univ\/graduate\/medicine\/education\/departments\/biochemistry\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002\r\n<\/div>\r\n<br \/>\r\n<h5>\u554f\u3044\u5408\u308f\u305b\u5148<\/h5>\r\n<p class=\"noIndmt10\">\u674f\u6797\u5b66\u5712\u5e83\u5831\u5ba4<br \/>\r\n\u3000\u3000\u5e83\u5831\u5ba4\u3078\u306e\u304a\u554f\u3044\u5408\u308f\u305b\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/contact\/\">\u3053\u3061\u3089<\/a>\u307e\u3067<br \/>\r\n<\/p>","protected":false},"excerpt":{"rendered":"<p>\u9752\u67f3\u5171\u592a\u3000\uff08\u751f\u5316\u5b66\u6559\u5ba4\u3000\u8b1b\u5e2b\uff09 \u4eca\u6cc9\u7f8e\u4f73\u3000\uff08\u751f\u5316\u5b66\u6559\u5ba4\u3000\u6559\u6388\uff09 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