{"id":2329,"date":"2022-03-30T17:47:24","date_gmt":"2022-03-30T08:47:24","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/_manage\/archive\/2329\/"},"modified":"2025-07-11T09:46:12","modified_gmt":"2025-07-11T00:46:12","slug":"%e8%85%8e%e8%87%93%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%a1%e3%82%ab%e3%83%8e%e3%83%81%e3%83%a3%e3%83%8d%e3%83%abpiezo2%e3%81%ae%e7%99%ba%e7%8f%be%e3%81%a8%e3%81%9d%e3%81%ae%e5%bd%b9%e5%89%b2","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/archive\/2329\/","title":{"rendered":"\u814e\u81d3\u306b\u304a\u3051\u308b\u30e1\u30ab\u30ce\u30c1\u30e3\u30cd\u30ebPiezo2\u306e\u767a\u73fe\u3068\u305d\u306e\u5f79\u5272\u306e\u89e3\u660e"},"content":{"rendered":"<head>\r\n <style type=\"text\/css\">\r\n <!--\r\n        .fig1 {float:left;}\r\n        .fig2 {float:right;}\r\n        .fig0 {clear:both;}\r\n\r\n-->\r\n <\/style>\r\n <\/head>\r\n\r\n<div 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fide\uff08\u3053\u308c\u305e\u771f\u6253\uff01\u3068\u3044\u3046\u610f\u5473\u3067\u3059\uff09\u306a\u5206\u5b50\u3067\u3042\u308b\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30ebPiezo1, Piezo2\u304c2010\u5e74\u306b\u767a\u898b\u3055\u308c\u3001\u767a\u898b\u8005\u306eArdem Patapoutian\u535a\u58eb\u306b\u6628\u5e74\u30ce\u30fc\u30d9\u30eb\u8cde\u304c\u8d08\u3089\u308c\u305f\u3068\u3044\u3046\u308f\u3051\u3067\u3059\u3002\u3053\u306e\u5206\u5b50\u306f\u3001\u76ae\u819a\u306e\u304f\u3059\u3050\u3063\u305f\u3055\u3001\u8eab\u4f53\u306e\u4f4d\u7f6e\u611f\u899a\u3001\u606f\u306e\u5438\u3044\u8fbc\u307f\u3001\u8180\u80f1\u306e\u6392\u5c3f\u306a\u3069\u3001\u601d\u3044\u306e\u307b\u304b\u306b\u5e45\u5e83\u3044\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n\r\n<p><b>\u814e\u81d3\u306e\u30e1\u30ab\u30ce\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\uff1a\u7cf8\u7403\u4f53\u3067\u306ePiezo2\u306e\u767a\u73fe\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ab\u30eb\u306a\u8abf\u7bc0<\/b><br>\r\n\u814e\u81d3\u306f\u8840\u5727\u30fb\u4f53\u6db2\u91cf\u306a\u3069\u306e\u8840\u884c\u52d5\u614b\u3092\u611f\u77e5\u3057\u3001\u30ec\u30cb\u30f3\u30fb\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\u306a\u3069\u3092\u4ecb\u3057\u3066\u3053\u308c\u3089\u306e\u6052\u5e38\u6027\u3092\u62c5\u3046\u4e2d\u5fc3\u7684\u81d3\u5668\u3067\u3059\u3002\u307e\u305f\u9ad8\u8840\u5727\u304c\u7d9a\u304f\u3068\u3001\u9ad8\u8840\u5727\u6027\u814e\u969c\u5bb3\u3082\u8d77\u3053\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u814e\u81d3\u306e\u30e1\u30ab\u30ce\u30bb\u30f3\u30b7\u30f3\u30b0\u306e\u91cd\u8981\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u304c\u3001\u305d\u306e\u5b9f\u4f53\u306f\u8b0e\u306b\u5305\u307e\u308c\u3066\u304a\u308a\u3001\u7279\u306b\u814e\u81d3\u306b\u304a\u3051\u308bPiezo2\u30c1\u30e3\u30cd\u30eb\u306b\u3064\u3044\u3066\u306f\u4e16\u754c\u3067\u3082\u5148\u884c\u7814\u7a76\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u3053\u3067\u79c1\u305f\u3061\u306f\u3055\u3063\u305d\u304f\u305d\u306e\u7814\u7a76\u306b\u53d6\u308a\u7d44\u307f\u307e\u3057\u305f\u3002<br>\r\n\u307e\u305aRNAscope\u3068\u3044\u3046\u6700\u65b0\u92ed\u306ein situ\u30cf\u30a4\u30d6\u30ea\u30c0\u30a4\u30bc\u30fc\u30b7\u30e7\u30f3\u306e\u6280\u8853\u3092\u7528\u3044\u3001Piezo2\u304c\u30de\u30a6\u30b9\u814e\u81d3\u306e\u30e1\u30b5\u30f3\u30ae\u30a6\u30e0\u7d30\u80de\u3068\u3001\u508d\u7cf8\u7403\u4f53\u88c5\u7f6e\u306e\u30ec\u30cb\u30f3\u7523\u751f\u7d30\u80de\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002Patapoutian\u535a\u58eb\u304b\u3089\u3054\u63d0\u4f9b\u9802\u3044\u305fPiezo2GFP\u30ec\u30dd\u30fc\u30bf\u30fc\u30de\u30a6\u30b9\u3067\u3082\u540c\u69d8\u306e\u767a\u73fe\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002<br>\r\n\u30e1\u30b5\u30f3\u30ae\u30a6\u30e0\u7d30\u80de\u306f\u7cf8\u7403\u4f53\u5168\u4f53\u306e\u69cb\u9020\u3092\u30e1\u30ab\u30cb\u30ab\u30eb\u306b\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3059\u3057\u3001\u307e\u305f\u508d\u7cf8\u7403\u4f53\u88c5\u7f6e\u306f\u8840\u884c\u52d5\u614b\u3092\u611f\u77e5\u3057\u3066\u30ec\u30cb\u30f3\u7523\u751f\u3092\u8abf\u7bc0\u3059\u308b\u3001\u3068\u3082\u306b\u30e1\u30ab\u30ce\u30bb\u30f3\u30b7\u30f3\u30b0\u6a5f\u69cb\u306b\u91cd\u8981\u306a\u7d30\u80de\u3067\u3059\u3002\u5b9f\u969b\u3001\u8131\u6c34\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3067\u8840\u884c\u529b\u5b66\u7684\u8ca0\u8377\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3068\u3001\u30e1\u30b5\u30f3\u30ae\u30a6\u30e0\u7d30\u80de\u3067\u306ePiezo2\u767a\u73fe\u306f\u6e1b\u5c11\u3057\u3001\u9006\u306b\u30ec\u30cb\u30f3\u7523\u751f\u7d30\u80de\u3067\u306e\u30ec\u30cb\u30f3\u907a\u4f1d\u5b50\u767a\u73fe\u5897\u52a0\u3068\u30d1\u30e9\u30ec\u30eb\u306bPiezo2\u767a\u73fe\u306f\u8457\u660e\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u4f38\u5c55\u523a\u6fc0\u3092\u4e0e\u3048\u308b\u7279\u6b8a\u306a\u7d30\u80de\u57f9\u990a\u7cfb\u3067\u30ec\u30cb\u30f3\u7523\u751f\u7d30\u80de\u3092\u57f9\u990a\u3057\u3001Piezo2\u907a\u4f1d\u5b50\u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3059\u308b\u3068\u3001\u30ec\u30cb\u30f3\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306f\u6709\u610f\u306b\u6291\u5236\u3055\u308c\u307e\u3057\u305f\u3002<br>\r\n\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u4eca\u307e\u3067\u8b0e\u306b\u5305\u307e\u308c\u3066\u3044\u305f\u30ec\u30cb\u30f3\u7523\u751f\u7d30\u80de\u306e\u30e1\u30ab\u30ce\u30bb\u30f3\u30b7\u30f3\u30b0\u6a5f\u69cb\u306bPiezo2\u304c\u95a2\u308f\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3001\u4e16\u754c\u521d\u306e\u7814\u7a76\u3067\u3059\u3002\u4eca\u5f8c\u3055\u3089\u306b\u7814\u7a76\u3092\u9032\u3081\u3001\u9ad8\u8840\u5727\u3084\u7cd6\u5c3f\u75c5\u306b\u4f34\u3046\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u3001\u6551\u6025\u533b\u7642\u3068\u5bc6\u63a5\u306b\u95a2\u308f\u308b\u6025\u6027\u814e\u969c\u5bb3\uff08AKI\uff09\u306e\u75c5\u614b\u89e3\u660e\u3092\u76ee\u6307\u3059\u6240\u5b58\u3067\u3059\u3002<\/p>\r\n\r\n<p>\u306a\u304a\u3001\u3053\u306e\u7814\u7a76\u306f\u3001\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb(AMED)\u9769\u65b0\u7684\u5148\u7aef\u7814\u7a76\u958b\u767a\u652f\u63f4\u4e8b\u696d PRIME \u30e1\u30ab\u30ce\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u6a5f\u69cb\u306e\u89e3\u660e\u306b\u3088\u308b\u9769\u65b0\u7684\u533b\u7642\u6a5f\u5668\u53ca\u3073\u533b\u7642\u6280\u8853\u306e\u5275\u51fa\u3001\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d\uff08\u57fa\u76e4\u7814\u7a76C\uff09\u306e\u52a9\u6210\u3092\u53d7\u3051\u3066\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\r\n\r\n<figure id=\"Fig.1\" style=\"text-align: center;\"><a href=\"\/univ\/faculty\/medicine\/uploads\/assets\/news\/2022\/03\/30\/Fig1.png\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/assets\/news\/2022\/03\/30\/Fig1.png\" alt=\"\u6982\u5ff5\u56f31\" width=\"60%\" border=\"0\" vspace=\"\u4e0a\u4e0b\u30de\u30fc\u30b8\u30f320\"><\/a>\r\n<figcaption style=\"text-align: left; text-indent: -1em; padding-left: 2em;\">\u56f3\uff11\uff1a\u30de\u30a6\u30b9\u814e\u81d3\u306b\u304a\u3051\u308bPiezo2\u306e\u767a\u73fe\u90e8\u4f4d\u3092\u793a\u3059\u6a21\u5f0f\u56f3\u3002\u30de\u30a6\u30b9\u814e\u81d3\u3067\u306f\u3001Piezo2\uff08\u8d64\uff09\u306f\u7cf8\u7403\u4f53\u306e\u30e1\u30b5\u30f3\u30ae\u30a6\u30e0\u7d30\u80de\u3068\u508d\u7cf8\u7403\u4f53\u88c5\u7f6e\u306e\u30ec\u30cb\u30f3\u7523\u751f\u7d30\u80de\uff08\u9846\u7c92\u7d30\u80de\u3001\u508d\u7cf8\u7403\u4f53\u7d30\u80de\u3068\u3082\u3044\u3046\uff09\u306b\u767a\u73fe\u3057\u3066\u3044\u305f\u3002<\/figcaption>\r\n<\/figure>\r\n\r\n<figure id=\"Fig.2\" class=\"fig2\"><a href=\"\/univ\/faculty\/medicine\/uploads\/assets\/news\/2022\/03\/30\/Fig2.jpg\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/assets\/news\/2022\/03\/30\/Fig2.jpg\" alt=\"\u6982\u5ff5\u56f32\" width=\"80%\" border=\"0\" vspace=\"\u4e0a\u4e0b\u30de\u30fc\u30b8\u30f320\"><\/a>&nbsp;\r\n\r\n<figcaption style=\"text-align: left; text-indent: -1em; padding-left: 2em;\">\u56f3\uff12\uff1a\u30de\u30a6\u30b9\u814e\u81d3\u306b\u304a\u3051\u308bPiezo2\u306e\u767a\u73fe\u90e8\u4f4d\u3068\u8131\u6c34\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u5909\u5316\u3002a. RNAscope in situ hybridization\u6cd5\u306b\u3088\u308bPiezo2\u767a\u73fe\u90e8\u4f4d\u3002Piezo2 \uff08\u8d64\uff09\u306fPdgfrb\u967d\u6027\u30e1\u30b5\u30f3\u30ae\u30a6\u30e0\u7d30\u80de\uff08\u7dd1\uff09\u3068\u3001Ren1\u967d\u6027\u30ec\u30cb\u30f3\u7523\u751f\u7d30\u80de\uff08\u7dd1\uff09\u306b\u767a\u73fe\u3057\u3066\u3044\u305f\u3002b. \u30ec\u30cb\u30f3\u7523\u751f\u7d30\u80de\uff08\u7dd1\uff09\u306b\u304a\u3051\u308bPiezo2\u767a\u73fe\uff08\u8d64\uff09\u306f\u8131\u6c34\u306b\u3088\u308a\u5897\u52a0\u3057\u305f\u3002\u753b\u50cf\u306f\u5171\u7126\u70b9\u30ec\u30fc\u30b6\u30fc\u9855\u5fae\u93e1LSM980\u3092\u7528\u3044\u3066\u64ae\u5f71\u3057\u305f\u3002<\/figcaption>\r\n\r\n<\/figure>\r\n\r\n\u3000<br \/>\r\n\u3000<br \/>\r\n\r\n<h5>\u63b2\u8f09\u8ad6\u6587<\/h5>\r\n<table class=\"citation\">\r\n<tbody>\r\n<tr>\r\n<td width=\"93\">\u767a\u8868\u96d1\u8a8c\uff1a<\/td>\r\n<td width=\"560\">Scientific Reports [ vol.12, 4197 (2022) ]<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1a<\/td>\r\n<td><a href=\"http:\/\/doi.org\/10.1038\/s41598-022-07987-7\" target=\"_blank\" rel=\"noopener\">Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells<\/a><\/td>\r\n<\/tr>\r\n<tr>\r\n<td>\u7b46\u3000\u8005\uff1a<\/td>\r\n<td>Yuki Mochida, Koji Ochiai, Takashi Nagase, Keiko Nonomura, Yoshihiro Akimoto5, Hiroshi Fukuhara, Tatsuo Sakai, George Matsumura, Yoshihiro Yamaguchi &amp; Miki Nagase\r\n\uff08\u6301\u7530\u52c7\u5e0c<sup>1,2<\/sup>\uff0c\u843d\u5408\u525b\u4e8c<sup>1,2<\/sup>\uff0c\u9577\u702c\u656c<sup>3<\/sup>\uff0c\u91ce\u3005\u6751\u6075\u5b50<sup>4<\/sup>\uff0c\u79cb\u5143\u7fa9\u5f18<sup>5<\/sup>\uff0e\u798f\u539f\u6d69<sup>6<\/sup>\uff0c\u5742\u4e95\u5efa\u96c4<sup>7<\/sup>\uff0c\u677e\u6751\u8b93\u5152<sup>1<\/sup>\uff0c\u5c71\u53e3\u82b3\u88d5<sup>2<\/sup>\uff0c\u9577\u702c\u7f8e\u6a39<sup>1,7<\/sup>\uff081\u8089\u773c\u89e3\u5256\u5b66\u30012\u6551\u6025\u533b\u5b66\u30013\u56fd\u7acb\u3042\u304a\u3084\u304e\u82d1\u7acb\u5ddd\u30014\u57fa\u790e\u751f\u7269\u5b66\u7814\u7a76\u6240\u30015\u9855\u5fae\u89e3\u5256\u5b66\u30016\u6ccc\u5c3f\u5668\u79d1\u5b66\u30017\u9806\u5929\u5802\u5927\u5b66\uff09\uff09<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>DOI:<\/td>\r\n<td>10.1038\/s41598-022-07987-7<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<div>\r\n\r\n<p>\u8089\u773c\u89e3\u5256\u5b66\u6559\u5ba4\u306e\u8a73\u7d30\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/macro-anat\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002<\/p>\r\n\r\n<p>\u8089\u773c\u89e3\u5256\u5b66\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u8a73\u7d30\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/graduate\/medicine\/education\/departments\/macro-anat\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002<\/p>\r\n\r\n<\/div>\r\n<h5>\u554f\u3044\u5408\u308f\u305b\u5148<\/h5>\r\n<p class=\"noIndmt10\">\u674f\u6797\u5b66\u5712\u5e83\u5831\u5ba4<br \/>\r\n\u3000\u3000\u5e83\u5831\u5ba4\u3078\u306e\u304a\u554f\u3044\u5408\u308f\u305b\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/contact\/\">\u3053\u3061\u3089<\/a>\u307e\u3067<br \/>\r\n<\/p>","protected":false},"excerpt":{"rendered":"<p>\u9577\u702c\u3000\u7f8e\u6a39\uff08\u8089\u773c\u89e3\u5256\u5b66\u30fb\u6559\u6388\uff09 \u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8 \u30de\u30a6\u30b9\u814e\u81d3\u306b\u304a\u3044\u3066\u3001Piezo2\u306f\u7cf8\u7403\u4f53\u9818\u57df\u306b\u9650\u5c40\u3057\u3066\u767a\u73fe\u3057\u3066\u3044\u305f\u3002 Piezo2\u306f\u30e1\u30b5\u30f3\u30ae\u30a6\u30e0\u7d30\u80de\u3068\u3001\u8f38\u5165\u7d30\u52d5\u8108\u4e2d\u819c\u306b\u5b58\u5728\u3059\u308b\u30ec\u30cb\u30f3\u7523\u751f\u7d30\u80de\uff08\u9846\u7c92\u7d30\u80de\u3001\u508d\u7cf8\u7403\u4f53\u7d30\u80de\u3068\u3082 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2356,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-2329","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/2329","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/comments?post=2329"}],"version-history":[{"count":10,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/2329\/revisions"}],"predecessor-version":[{"id":7289,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/2329\/revisions\/7289"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media\/2356"}],"wp:attachment":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media?parent=2329"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/categories?post=2329"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/tags?post=2329"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}