{"id":3847,"date":"2022-12-03T14:42:16","date_gmt":"2022-12-03T05:42:16","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/?p=3847"},"modified":"2025-07-11T09:45:25","modified_gmt":"2025-07-11T00:45:25","slug":"%e7%89%b9%e7%99%ba%e6%80%a7%e3%83%8d%e3%83%95%e3%83%ad%e3%83%bc%e3%82%bc%e3%82%92%e7%99%ba%e7%97%87%e3%81%99%e3%82%8b%e5%8b%95%e7%89%a9%e3%83%a2%e3%83%87%e3%83%ab%e3%82%92%e5%88%9d%e3%82%81%e3%81%a6","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/archive\/3847\/","title":{"rendered":"\u7279\u767a\u6027\u30cd\u30d5\u30ed\u30fc\u30bc\u3092\u767a\u75c7\u3059\u308b\u52d5\u7269\u30e2\u30c7\u30eb\u3092\u521d\u3081\u3066\u958b\u767a \u301c\u65b0\u6cbb\u7642\u85ac\u306e\u958b\u767a\u306b\u8ca2\u732e\u3059\u308b\u671f\u5f85"},"content":{"rendered":"<div align=\"right\">\r\n<p><b>\r\n\u6210\u7530\u3000\u96c5\u7f8e\u3000\uff08\u5c0f\u5150\u79d1\u5b66\u6559\u5ba4\u3000\u6559\u6388\uff09<br 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\/>\r\n\r\n<h5>\u6982\u8981<\/h5>\r\n<p>\u7279\u767a\u6027\u30cd\u30d5\u30ed\u30fc\u30bc\u306f\u5c0f\u5150\u3068\u6210\u4eba\u306e\u3044\u305a\u308c\u306b\u3082\u767a\u75c7\u3057\u3001\u7cd6\u8cea\u30b9\u30c6\u30ed\u30a4\u30c9\u4f9d\u5b58\u6027\u306e\u56de\u907f\u3084\u672b\u671f\u814e\u4e0d\u5168\u3078\u306e\u79fb\u884c\u306e\u963b\u6b62\u304c\u81e8\u5e8a\u4e0a\u306e\u5927\u304d\u306a\u8ab2\u984c\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u5c0f\u5150\u79d1\u5b66\u6559\u5ba4\u306e\u7fbd\u7530 \u4f0a\u77e5\u90ce \u5c02\u4fee\u533b\u3001\u694a \u570b\u660c \u5ba2\u54e1\u6559\u6388\u306a\u3069\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u814e\u81d3\u306e\u7cf8\u7403\u4f53\u4e0a\u76ae\u7d30\u80de\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u7d30\u80de\u819c\u8cab\u901a\u5206\u5b50Crb2\u3092\u7d30\u80de\u5916\u304b\u3089\u523a\u6fc0\u3059\u308b\u3053\u3068\u3067\u3001\u30d2\u30c8\u7279\u767a\u6027\u30cd\u30d5\u30ed\u30fc\u30bc\u3068\u540c\u69d8\u306e\u75c5\u7406\u50cf\u3092\u793a\u3059\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u6210\u679c\u306f\u30012022\u5e748\u670819\u65e5\u306bJournal of The American Society of Nephrology\uff08\u7c73\u56fd\u814e\u81d3\u5b66\u4f1a\u96d1\u8a8c\uff09\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u901f\u5831\u7248\u3068\u3057\u3066\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\r\n<br \/>\r\n\u7fbd\u7530 \u4f0a\u77e5\u90ce 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\/>\r\n\r\n<figure id=\"Fig.1\" style=\"text-align: center;\">\r\n<a href=\"\/univ\/faculty\/medicine\/uploads\/2022\/11\/Fig1.png\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/2022\/11\/Fig1.png\" width=\"60%\" vspace=\"20\" alt=\"\u56f31\" border=\"0\"><\/a>\r\n<figcaption style=\"text-align: left; text-indent: -1em; padding-left: 2em;\">\u56f31.\u3000C3H\/HeN\u30de\u30a6\u30b9\u306b\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8Crb2\u3092\u76ae\u4e0b\u6ce8\u5c04\u3057\u305f\u3002\u514d\u75ab4\u9031\u5f8c\u304b\u3089\u3001\u30de\u30a6\u30b9\u306f\u7cf8\u7403\u4f53\u4e0a\u76ae\u7d30\u80de\u8db3\u7a81\u8d77\u306e\u7652\u5408\u3092\u4f34\u3046\u30cd\u30d5\u30ed\u30fc\u30bc\u30ec\u30d9\u30eb\u306e\u86cb\u767d\u5c3f\u3092\u767a\u75c7\u3057\u305f\u3002\u4e2d\u7b49\u5ea6\u86cb\u767d\u5c3f\u3092\u793a\u3057\u305f\u30de\u30a6\u30b9\u306e\u814e\u7d44\u7e54\u50cf\u306f\u5fae\u5c0f\u5909\u5316\u578b\u3067\u3042\u308a\u3001\u9ad8\u5ea6\u86cb\u767d\u5c3f\u3092\u793a\u3059\u30de\u30a6\u30b9\u306f\u5fc5\u305a\u8840\u5c3f\u3092\u4f34\u3044\u3001\u305d\u306e\u75c5\u7406\u50cf\u306f\u5de3\u72b6\u7cf8\u7403\u4f53\u786c\u5316\u578b\u3067\u3042\u3063\u305f\u3002\u30cd\u30d5\u30ed\u30fc\u30bc\u30de\u30a6\u30b9\u306e\u7cf8\u7403\u4f53\u4e0a\u76ae\u7d30\u80de\u306e\u7d30\u80de\u819c\u4e0a\u306b\u3001Crb2\u3068IgG\u306e\u540c\u5c40\u5728\u304c\u307f\u3089\u308c\u305f\u3002\u3055\u3089\u306b\u3001\u57f9\u990a\u7cf8\u7403\u4f53\u4e0a\u76ae\u7d30\u80de\u3092\u7528\u3044\u305fin vitro\u3067\u306e\u518d\u73fe\u5b9f\u9a13\u306b\u3088\u308a\u3001\u6297Crb2\u6297\u4f53\u306e\u7d50\u5408\u306b\u3088\u308bCrb2\u81ea\u8eab\u306e\u51dd\u96c6\u3068\u30a2\u30af\u30c1\u30f3\u306e\u504f\u501a\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3002<\/figcaption>\r\n<\/figure>\r\n\r\n<br \/ class=\"fig0\">\r\n\r\n<h5>\u63b2\u8f09\u8ad6\u6587<\/h5>\r\n\r\n<table class=\"citation\">\r\n <tr>\r\n  <td width=93>\u767a\u8868\u96d1\u8a8c\uff1a<\/td><td width=560>Journal of The American Society of Nephrology [2022 Nov 33(11):2008].<\/td>\r\n <\/tr>\r\n<tr>\r\n  <td>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1a<\/td><td><a href=\"http:\/\/doi.org\/10.1681\/ASN.2022010070\" target=\"_blank\" rel=\"noopener\">A Novel Mouse Model of Idiopathic Nephrotic Syndrome Induced by Immunization with the Podocyte Protein Crb2<\/a><\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>\u7b46\u3000\u8005\uff1a<\/td><td>Ichiro Hada<sup>1<\/sup>, Akira Shimizu<sup>21<\/sup>, Hiromu Takematsu<sup>3<\/sup>, Yukino Nishibori<sup>1<\/sup>, Toru Kimura<sup>4<\/sup>, Toshiyuki Fukutomi<sup>4<\/sup>, Akihiko Kudo<sup>5<\/sup>, Noriko Ito-Nitta<sup>1<\/sup>, Zentaro Kiuchi<sup>1<\/sup>, Jaakko Patrakka<sup>6<\/sup>, Naoaki Mikami<sup>1<\/sup>, Simon Leclerc<sup>7<\/sup>, Yoshihiro Akimoto<sup>5<\/sup>, Yoshiaki Hirayama<sup>8<\/sup>, Satoka Mori<sup>9<\/sup>, Tomoko Takano<sup>7<\/sup>, and Kunimasa Yan<sup>1<\/sup><br \/>\r\n(1.\u5c0f\u5150\u79d1\u5b66, 2.\u65e5\u672c\u533b\u79d1\u5927\u5b66, 3.\u85e4\u7530\u4fdd\u5065\u885b\u751f\u5927\u5b66, 4.\u85ac\u7406\u5b66, 5.\u9855\u5fae\u89e3\u5256\u5b66, 6.\u30ab\u30ed\u30ea\u30f3\u30b9\u30ab\u533b\u79d1\u5927\u5b66, 7.\u30de\u30ae\u30eb\u5927\u5b66\u30d8\u30eb\u30b9\u30bb\u30f3\u30bf\u30fc, 8.\u30c7\u30f3\u30ab\u682a\u5f0f\u4f1a\u793e, 9.\u30c7\u30f3\u30ab\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u30bb\u30f3\u30bf\u30fc)<\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>DOI:<\/td>  <td>10.1681\/ASN.2022010070<\/td>\r\n <\/tr>\r\n<\/table>\r\n<br \/>\r\n<div>\r\n<p>\u5c0f\u5150\u79d1\u5b66\u6559\u5ba4\u306e\u8a73\u7d30\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/pediatrics\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002\r\n<p>\u5c0f\u5150\u79d1\u5b66\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u8a73\u7d30\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/graduate\/medicine\/education\/departments\/pediatrics\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002\r\n<\/div>\r\n<br \/>\r\n<h5>\u554f\u3044\u5408\u308f\u305b\u5148<\/h5>\r\n<p class=\"noIndmt10\">\u674f\u6797\u5b66\u5712\u5e83\u5831\u5ba4<br \/>\r\n\u3000\u3000\u5e83\u5831\u5ba4\u3078\u306e\u304a\u554f\u3044\u5408\u308f\u305b\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/contact\/\">\u3053\u3061\u3089<\/a>\u307e\u3067<br \/>\r\n<\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>\u6210\u7530\u3000\u96c5\u7f8e\u3000\uff08\u5c0f\u5150\u79d1\u5b66\u6559\u5ba4\u3000\u6559\u6388\uff09 \u6728\u5185\u5584\u592a\u90ce\u3000\uff08\u5c0f\u5150\u79d1\u5b66\u6559\u5ba4\u3000\u52a9\u6559\uff09 \u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8 \u814e\u306e\u7cf8\u7403\u4f53\u4e0a\u76ae\u7d30\u80de\u819c\u4e0a\u306b\u767a\u73fe\u3059\u308b\u5206\u5b50Crb2\u3078\u306e\u523a\u6fc0\u306b\u3088\u308boutside-in signaling \u304c\u30de\u30a6\u30b9\u30cd\u30d5\u30ed\u30fc\u30bc\u3092\u767a\u75c7\u3055\u305b\u305f 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