{"id":5489,"date":"2024-07-24T17:06:01","date_gmt":"2024-07-24T08:06:01","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/?p=5489"},"modified":"2025-12-26T19:32:32","modified_gmt":"2025-12-26T10:32:32","slug":"%e7%b4%b0%e8%83%9e%e9%9a%9c%e5%ae%b3%e6%80%a7cd8%e9%99%bd%e6%80%a7temra%e7%b4%b0%e8%83%9e%e3%81%af%e9%87%8d%e7%97%87%e5%86%86%e5%bd%a2%e8%84%b1%e6%af%9b%e7%97%87%e3%81%ae%e9%9b%a3%e6%b2%bb%e6%80%a7","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/archive\/5489\/","title":{"rendered":"\u7d30\u80de\u969c\u5bb3\u6027CD8\u967d\u6027TEMRA\u7d30\u80de\u306f\u91cd\u75c7\u5186\u5f62\u8131\u6bdb\u75c7\u306e\u96e3\u6cbb\u6027\u306b\u95a2\u9023\u3059\u308b"},"content":{"rendered":"<div align=\"right\">\r\n<p><b>\u9ad8\u6a4b\u3000\u826f\u3000\uff08\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u90e8\u9580\u3000\u8b1b\u5e2b\uff09<\/b><\/p>\r\n<\/div>\r\n\r\n<h3>\u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8<\/h3>\r\n<div style=\u201dmargin-left: 1em; text-indent: -1em;\u201d>\r\n<ul>\r\n<li>\u91cd\u75c7\u5186\u5f62\u8131\u6bdb\u75c7\u306f\u3001NKG2D\u967d\u6027CD8\u967d\u6027T\u7d30\u80de\u304c\u6bdb\u306e\u6bdb\u7403\u90e8\u306e\u81ea\u5df1\u6297\u539f\u3092\u6a19\u7684\u306b\u3057\u3066\u3001\u6025\u901f\u306b\u8131\u6bdb\u304c\u8d77\u3053\u308b\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u3042\u308b\u3002\u672c\u75c7\u306e\u6cbb\u7642\u306b\u306f\u30b9\u30c6\u30ed\u30a4\u30c9\u30d1\u30eb\u30b9\u7642\u6cd5\u304c\u884c\u308f\u308c\u3066\u3044\u308b\u304c\u3001\u305d\u306e\u6cbb\u7642\u53cd\u5fdc\u6027\u3092\u4e88\u6e2c\u3059\u308b\u7814\u7a76\u306f\u5341\u5206\u306b\u306a\u3055\u308c\u3066\u3044\u306a\u3044\u3002\r\n<\/li>\r\n<li>\u672c\u7814\u7a76\u3067\u306f\u3001\u60a3\u8005\u672b\u68a2\u8840\u6db2\u4e2d\u306b\u5b58\u5728\u3059\u308bCD8\u967d\u6027T\u7d30\u80de\u306e\u7279\u6b8a\u306a\u30b5\u30d6\u30bb\u30c3\u30c8\u306eTEMRA\uff08Terminally differentiated effector memory T cells re-expressing CD45RA\uff09\u304c\u3001\u6cbb\u7642\u62b5\u6297\u6027\u3092\u793a\u3059\u60a3\u8005\u3055\u3093\u306e\u672b\u68a2\u8840\u4e2d\u3067\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u66f4\u306b\u6bdb\u7403\u90e8\u306b\u767a\u73fe\u3059\u308b\u81ea\u5df1\u6297\u539f\u306e\u30c8\u30ea\u30b3\u30d2\u30a2\u30ea\u30f3\u306b\u7279\u7570\u7684\u306b\u53cd\u5fdc\u3059\u308b\u3053\u3068\u3092\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u660e\u3089\u304b\u306b\u3057\u305f\u3002\r\n<\/li>\r\n<li>\u75c5\u5909\u7d44\u7e54\u3067\u3082CD8\u967d\u6027TEMRA\u304c\u96c6\u7a4d\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u3001\u672b\u68a2\u8840\u6db2\u3068\u6b63\u306e\u76f8\u95a2\u6027\u304c\u307f\u3089\u308c\u305f\u3002<\/li>\r\n<li>\u672c\u7814\u7a76\u306f\u3001\u30d1\u30eb\u30b9\u7642\u6cd5\u6cbb\u7642\u524d\u306b\u672b\u68a2\u8840\u6db2\u691c\u67fb\u3067CD8\u967d\u6027TEMRA\u306e\u983b\u5ea6\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u6cbb\u7642\u53cd\u5fdc\u6027\u306e\u5ba2\u89b3\u7684\u306a\u4e88\u6e2c\u304c\u53ef\u80fd\u306b\u306a\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/li>\r\n<\/ul>\r\n<\/div>\r\n\r\n<br \/>\r\n\r\n<h3>\u6982\u8981<\/h3>\r\n<p> \u91cd\u75c7\u5186\u5f62\u8131\u6bdb\u75c7\u306f\u3001\u4e3b\u306b\u514d\u75ab\u7d30\u80de\u306e\u3046\u3061natural killer group 2 member D\uff08NKG2D\uff09\u967d\u6027CD8\u967d\u6027T\u7d30\u80de\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3057\u3001\u6210\u9577\u671f\u6bdb\u306e\u6bdb\u7403\u90e8\u306b\u767a\u73fe\u3059\u308b\u81ea\u5df1\u6297\u539f\u3092\u6a19\u7684\u306b\u3057\u3066\u3001\u6025\u901f\u306b\u8131\u6bdb\u304c\u8d77\u3053\u308b\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u3059\u3002\u672c\u75c7\u306e\u6cbb\u7642\u306f\u81ea\u5df1\u514d\u75ab\u53cd\u5fdc\u306e\u6291\u5236\u306e\u70ba\u306b\u30b9\u30c6\u30ed\u30a4\u30c9\u7b49\u304c\u4f7f\u308f\u308c\u3066\u304a\u308a\u3001\u7279\u306b\u6025\u901f\u9032\u884c\u6027\u306e\u5e83\u6c4e\u6027\u5186\u5f62\u8131\u6bdb\u75c7\u3067\u306f\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u77ed\u671f\u9593\u306b\u70b9\u6ef4\u9759\u6ce8\u3059\u308b\u30d1\u30eb\u30b9\u7642\u6cd5\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u30d1\u30eb\u30b9\u6cbb\u7642\u306e\u6cbb\u7642\u53cd\u5fdc\u6027\u3092\u4e88\u6e2c\u3059\u308b\u7814\u7a76\u306f\u5341\u5206\u306b\u306a\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002<br \/>\r\n\u3000\u672c\u7814\u7a76\u3067\u306f\u3001\u672b\u68a2\u8840\u4e2d\u306eT\u7d30\u80de\u306e\u91cf\u7684\u30fb\u8cea\u7684\u306a\u5909\u5316\u3092\u3001\u7814\u7a76\u4ee3\u8868\u8005\u304c\u6240\u5c5e\u3057\u7ba1\u7406\u904b\u55b6\u3092\u884c\u3063\u3066\u3044\u308b\u300c\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u300d\u3068\u547c\u3070\u308c\u308b\u6700\u5148\u7aef\u306e\u7d30\u80de\u89e3\u6790\u88c5\u7f6e\u3067\u8a73\u7d30\u306b\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001\u60a3\u8005\u672b\u68a2\u8840\u6db2\u4e2d\u306b\u5b58\u5728\u3059\u308bCD8\u967d\u6027T\u7d30\u80de\u306e\u7279\u6b8a\u306a\u30b5\u30d6\u30bb\u30c3\u30c8\u306eTEMRA\uff08Terminally differentiated effector memory T cells re-expressing CD45RA\uff09\u304c\u3001\u30d1\u30eb\u30b9\u7642\u6cd5\u306b\u5bfe\u3057\u3066\u62b5\u6297\u6027\u3092\u793a\u3059\u96e3\u6cbb\u6027\u306e\u5e83\u6c4e\u6027\u5186\u5f62\u8131\u6bdb\u75c7\u60a3\u8005\u3055\u3093\u306e\u672b\u68a2\u8840\u4e2d\u3067\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<br \/>\r\n\u3000CD8\u967d\u6027TEMRA\u306f\u3001\u6700\u7d42\u5206\u5316\u3057\u305fT\u7d30\u80de\u3067\u3001\u7d30\u80de\u819c\u306b\u5b54\u3092\u958b\u3051\u308b\u30d1\u30fc\u30d5\u30a9\u30ea\u30f3\u3084\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306e\u30b0\u30e9\u30f3\u30b6\u30a4\u30e0B\u3068\u3044\u3063\u305f\u7d30\u80de\u6eb6\u89e3\u305f\u3093\u3071\u304f\u8cea\u3092\u4fdd\u6301\u3057\u3066\u3044\u308b\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\uff08CTL: Cytotoxic T-Lymphocyte\uff09\u306e\u3072\u3068\u3064\u3067\u3059\u3002\u30d1\u30eb\u30b9\u7642\u6cd5\u62b5\u6297\u7fa4\u3067\u5897\u52a0\u3057\u3066\u3044\u308bCD8\u967d\u6027TEMRA\u306f\u3001\u6bdb\u7403\u90e8\u306b\u767a\u73fe\u3059\u308b\u81ea\u5df1\u6297\u539f\u306e\u30c8\u30ea\u30b3\u30d2\u30a2\u30ea\u30f3\u306b\u7279\u7570\u7684\u306b\u53cd\u5fdc\u3059\u308b\u3053\u3068\u304c\u6a5f\u80fd\u89e3\u6790\u3067\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u30d1\u30eb\u30b9\u7642\u6cd5\u62b5\u6297\u7fa4\u306e\u75c5\u5909\u7d44\u7e54\u3067\u3082CD8\u967d\u6027TEMRA\u304c\u96c6\u7a4d\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u3001\u672b\u68a2\u8840\u6db2\u3068\u6b63\u306e\u76f8\u95a2\u6027\u304c\u307f\u3089\u308c\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u306f\u3001\u30d1\u30eb\u30b9\u6cbb\u7642\u524d\u306b\u672b\u68a2\u8840\u6db2\u691c\u67fb\u3067CD8\u967d\u6027TEMRA\u306e\u983b\u5ea6\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u6cbb\u7642\u53cd\u5fdc\u6027\u306e\u5ba2\u89b3\u7684\u306a\u4e88\u6e2c\u304c\u53ef\u80fd\u306b\u306a\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\r\n\r\n<figure style=\"text-align: center;\">\r\n<a href=\"\/univ\/faculty\/medicine\/uploads\/2024\/07\/Fig1.png\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/2024\/07\/Fig1.png\" width=\"60%\" vspace=\"20\" alt=\"\u6982\u5ff5\u56f31\" border=\"0\"><\/a>\r\n<figcaption style=\"text-align: left; text-indent: -1em; padding-left: 2em;\">\r\n<b>\u56f31 \u30d1\u30eb\u30b9\u7642\u6cd5\u62b5\u6297\u7fa4\u60a3\u8005\u672b\u68a2\u8840\u304a\u3088\u3073\u75c5\u5909\u7d44\u7e54\u3067TEMRA\u304c\u5897\u52a0\u3057\u3066\u3044\u308b<\/b><br \/>\r\n<b>A: \u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u6e2c\u5b9a\u3057\u305f\u60a3\u8005\u672b\u68a2\u8840CD8\u967d\u6027T\u7d30\u80de\u4e2d\u306eTEMRA\u306e\u983b\u5ea6<\/b><br \/>\r\n\u30d1\u30eb\u30b9\u7642\u6cd5\u958b\u59cb\u524d\u304b\u3089\u6cbb\u7642\u7d4c\u904e\u4e2d\u306b\u308f\u305f\u3063\u3066TEMRA\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u3066\u3044\u305f\u3002\u3000*P < .005, **P < .05<br \/>\r\n<b>B:\u30d1\u30eb\u30b9\u7642\u6cd5\u62b5\u6297\u7fa4\u60a3\u8005\u75c5\u5909\u7d44\u7e54\u306b\u96c6\u7a4d\u3057\u3066\u3044\u308bTEMRA\uff08<font color=\"#ff0000\">\u25b2<\/font>\uff09<\/b><br \/>\r\n\u9752\uff1aCD8\u967d\u6027\u7d30\u80de\u3000\u8d64\uff1aNKG2\u967d\u6027\u7d30\u80de\uff08TEMRA\uff09\r\n<\/figcaption>\r\n<\/figure>\r\n\r\n<figure style=\"text-align: center;\">\r\n<a href=\"\/univ\/faculty\/medicine\/uploads\/2024\/07\/Fig2.png\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/2024\/07\/Fig2.png\" width=\"60%\" vspace=\"20\" alt=\"\u6982\u5ff5\u56f31\" border=\"0\"><\/a>\r\n<figcaption style=\"text-align: left; text-indent: -1em; padding-left: 2em;\">\r\n<b>\u56f32  \u30de\u30eb\u30c1\u30ab\u30e9\u30fc\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3092\u7528\u3044\u305fTEMRA\u306et-SNE\u89e3\u6790\u306e\u4e00\u4f8b<\/b><br \/>\r\n\u30d1\u30eb\u30b9\u7642\u6cd5\u5fdc\u7b54\u7fa4\u3068\u62b5\u6297\u7fa4\u3067TEMRA\u306e\u30af\u30e9\u30b9\u30bf\u30fc\u5206\u5e03\u304c\u5927\u304d\u304f\u7570\u306a\u3063\u3066\u3044\u308b\u3002\u5f53\u90e8\u9580\u3067\u904b\u55b6\u3057\u3066\u3044\u308b\u65e5\u672cBD FACSCanto II\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u6e2c\u5b9a\u3057\u3001FlowJo \u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3067\u89e3\u6790\u3057\u305f\u3002\r\n<\/figcaption>\r\n<\/figure>\r\n\r\n<br \/ class=\"fig0\">\r\n\r\n<h3>\u7528\u8a9e\u89e3\u8aac<\/h3>\r\n<p><b>\u6025\u901f\u9032\u884c\u6027\u5e83\u6c4e\u6027\u5186\u5f62\u8131\u6bdb\u75c7\uff1a<\/b><br \/>\r\n\u5f8c\u5929\u6027\u306b\u985e\u5186\u5f62\u306e\u8131\u6bdb\u6591\u3092\u751f\u3058\u308b\u75be\u60a3\u3067\u3001\u91cd\u75c7\u4f8b\u3067\u306f\u5897\u60aa\u30fb\u8efd\u5feb\u3092\u7e70\u308a\u8fd4\u3057\u306a\u304c\u3089\u8131\u6bdb\u6591\u304c\u62e1\u5927\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3002\u533b\u7642\u6a5f\u95a2\u306e\u76ae\u819a\u79d1\u3092\u53d7\u8a3a\u3059\u308b\u8131\u6bdb\u75be\u60a3\u306e\u4e2d\u3067\u306f\u6700\u3082\u983b\u5ea6\u304c\u9ad8\u304f\u3001\u6cbb\u7642\u306b\u96e3\u6e0b\u3059\u308b.\u6bdb\u5305\u3068\u722a\u7532\u4ee5\u5916\u306e\u81d3\u5668\u306f\u4fb5\u3055\u306a\u3044\u304c\u3001\u5916\u898b\u4e0a\u306e\u5370\u8c61\u3092\u5927\u304d\u304f\u5de6\u53f3\u3059\u308b\u306e\u3067\u60a3\u8005\u81ea\u8eab\u306e\u60a9\u307f\u306f\u6df1\u304f\u3001\u751f\u6d3b\u306e\u8cea(QOL)\u306b\u3082\u5927\u304d\u304f\u5f71\u97ff\u3059\u308b\u3002<\/p>\r\n\r\n<p><b>\u70b9\u6ef4\u9759\u6ce8\u30b9\u30c6\u30ed\u30a4\u30c9\u30d1\u30eb\u30b9\u7642\u6cd5\uff1a<\/b><br \/>\r\n\u70b9\u6ef4\u9759\u6ce8\u30b9\u30c6\u30ed\u30a4\u30c9\u30d1\u30eb\u30b9\u7642\u6cd5\u306f\u3001\u767a\u75c7\u5f8c6\u30ab\u6708\u4ee5\u5185\u3067\u3001\u6025\u901f\u9032\u884c\u4e2d\u306e\u982d\u90e8\u5168\u4f53\u306e\u9762\u7a4d\u306b\u5360\u3081\u308b\u8131\u6bdb\u5de3\u9762\u7a4d\u306e\u5272\u5408\u304c25\uff05\u4ee5\u4e0a\u301c\u5168\u982d\u307e\u3067\u81f3\u3063\u3066\u3044\u306a\u3044\u75c7\u4f8b\u306b\u9069\u7528\u3055\u308c\u308b\u304c\u3001\u518d\u767a\u4f8b\u304c\u591a\u304f\u9577\u671f\u7684\u306a\u4e88\u5f8c\u306e\u6539\u5584\u3084\u518d\u767a\u4f8b\u3078\u306e\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u7121\u3044\u3002<\/p>\r\n\r\n<p><b>CD8\u967d\u6027TEMRA:<\/b><br \/>\r\nCD8\u967d\u6027\u30bf\u30fc\u30df\u30ca\u30eb\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u30e1\u30e2\u30ea\u30fcCD45RA\u967d\u6027T\u7d30\u80de\uff08Terminally differentiated effector memory T cells re-expressing CD45RA\uff09\u306f\u3001\u751f\u6765\u306e\u30b7\u30b0\u30ca\u30eb\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u306e\u5897\u52a0\u3001T\u7d30\u80de\u53d7\u5bb9\u4f53\uff08TCR\uff09\u4f9d\u5b58\u6027\u6d3b\u6027\u5316\u306e\u4f4e\u4e0b\u3001\u304a\u3088\u3073TCR\u30af\u30ed\u30fc\u30f3\u591a\u69d8\u6027\u306e\u4f4e\u4e0b\u3092\u7279\u5fb4\u3068\u3057\u3001\u7279\u306b\u9ad8\u9f62\u8005\u3067\u5897\u52a0\u3057\u3066\u3044\u308b\u3002 CD8\u967d\u6027TEMRA\u7d30\u80de\u96c6\u56e3\u306b\u304a\u3051\u308b\u819c\u53d7\u5bb9\u4f53CD28\u3001CD27\u3001CD127\u306e\u55aa\u5931\u3001CD45RA\u306e\u518d\u767a\u73fe\u3001\u304a\u3088\u3073\u75b2\u5f0a\u30de\u30fc\u30ab\u30fcPD1\u306e\u767a\u73fe\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u8981\u56e0\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\r\n\r\n<p><b>\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de\uff1a<\/b><br \/>\r\nCD8\u967d\u6027\u30ea\u30f3\u30d1\u7403T\u7d30\u80de\u306e\u3046\u3061\u306e\u3072\u3068\u3064\u3067\u3001\u5bbf\u4e3b\u306b\u3068\u3063\u3066\u7570\u7269\u306b\u306a\u308b\u79fb\u690d\u7d30\u80de\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u7d30\u80de\u3001\u764c\u7d30\u80de\u306a\u3069\u3092\u8a8d\u8b58\u3057\u3066\u7834\u58ca\u3059\u308b\u3002<\/p>\r\n\r\n\r\n\r\n<h3>\u63b2\u8f09\u8ad6\u6587<\/h3>\r\n\r\n<table class=\"citation\">\r\n <tr>\r\n  <td width=93>\u767a\u8868\u96d1\u8a8c\uff1a<\/td><td width=560>Journal of Investigative Dermatology 144: 1654-1657.E7.<\/td>\r\n <\/tr>\r\n<tr>\r\n  <td>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1a<\/td><td><a href=\"http:\/\/doi.org\/10.1016\/j.jid.2024.01.006\" target=\"_blank\" rel=\"noopener\">Increase in CD8<sup>+<\/sup> Effector Memory T Cells Re-Expressing CD45RA Correlates with Intractability of Severe Alopecia Areata<\/a><\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>\u7b46\u3000\u8005\uff1a<\/td><td>R.Takahashi<sup>1<\/sup>, M.Kinoshita-Ise<sup>2<\/sup>, Y.Yamazaki<sup>2<\/sup> M.Fukuyama<sup>2<\/sup>, M.Ohyama<sup>1,2<\/sup><br \/>\uff08\u9ad8\u6a4b \u826f<sup>1<\/sup>, \u6728\u4e0b \u7f8e\u54b2<sup>2<\/sup>, \u5c71\u5d0e \u597d\u7f8e<sup>2<\/sup>, \u798f\u5c71 \u96c5\u5927<sup>2<\/sup>, \u5927\u5c71 \u5b66<sup>1,2<\/sup>\uff081.\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u90e8\u9580, 2.\u533b\u5b66\u90e8\u76ae\u819a\u79d1\u5b66\u6559\u5ba4\uff09\uff09<\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>DOI:<\/td>  <td>10.1016\/j.jid.2024.01.006<\/td>\r\n <\/tr>\r\n<\/table>\r\n<br \/>\r\n<div>\r\n<p>\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u90e8\u9580\u306e\u8a73\u7d30\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002\r\n<\/div>\r\n<br \/>\r\n<h5>\u554f\u3044\u5408\u308f\u305b\u5148<\/h5>\r\n<p class=\"noIndmt10\">\u674f\u6797\u5b66\u5712\u5e83\u5831\u5ba4<br \/>\r\n\u3000\u3000\u5e83\u5831\u5ba4\u3078\u306e\u304a\u554f\u3044\u5408\u308f\u305b\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/contact\/\">\u3053\u3061\u3089<\/a>\u307e\u3067<br \/>\r\n<\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>\u9ad8\u6a4b\u3000\u826f\u3000\uff08\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u90e8\u9580\u3000\u8b1b\u5e2b\uff09 \u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8 \u91cd\u75c7\u5186\u5f62\u8131\u6bdb\u75c7\u306f\u3001NKG2D\u967d\u6027CD8\u967d\u6027T\u7d30\u80de\u304c\u6bdb\u306e\u6bdb\u7403\u90e8\u306e\u81ea\u5df1\u6297\u539f\u3092\u6a19\u7684\u306b\u3057\u3066\u3001\u6025\u901f\u306b\u8131\u6bdb\u304c\u8d77\u3053\u308b\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u3042\u308b\u3002\u672c\u75c7\u306e\u6cbb\u7642\u306b\u306f\u30b9\u30c6\u30ed\u30a4 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":5487,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-5489","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/5489","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/comments?post=5489"}],"version-history":[{"count":32,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/5489\/revisions"}],"predecessor-version":[{"id":7724,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/5489\/revisions\/7724"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media\/5487"}],"wp:attachment":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media?parent=5489"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/categories?post=5489"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/tags?post=5489"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}