{"id":7610,"date":"2025-11-27T11:35:54","date_gmt":"2025-11-27T02:35:54","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/?p=7610"},"modified":"2025-11-27T11:35:54","modified_gmt":"2025-11-27T02:35:54","slug":"%e8%9b%8b%e7%99%bd%e5%b0%bf%e7%99%ba%e7%97%87%e6%a9%9f%e5%ba%8f%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%a1%e3%82%ab%e3%83%8e%e3%83%81%e3%83%a3%e3%83%8d%e3%83%abpiezo1%e3%81%ae%e7%94%9f%e4%bd%93","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/archive\/7610\/","title":{"rendered":"\u86cb\u767d\u5c3f\u767a\u75c7\u6a5f\u5e8f\u306b\u304a\u3051\u308b\u30e1\u30ab\u30ce\u30c1\u30e3\u30cd\u30ebPiezo1\u306e\u751f\u4f53\u5185\u6a5f\u80fd\u306e\u89e3\u660e"},"content":{"rendered":"<head>\r\n <style type=\"text\/css\">\r\n <!--\r\n        .fig1 {float:left;}\r\n        .fig2 {float:right;}\r\n        .fig0 {clear:both;}\r\n\r\nfigure {\r\n  margin: 1em 0; \/* \u4e0a\u4e0b\u306e\u9699\u9593\u306e\u307f\u6b8b\u3059 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-1em;\u201d>\r\n\t<ul>\r\n\t\t<li>\u30dd\u30c9\u30b5\u30a4\u30c8\u7279\u7570\u7684Piezo1\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\uff08KO\uff09\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u3066\u751f\u4f53\u306b\u304a\u3051\u308b\u30dd\u30c9\u30b5\u30a4\u30c8Piezo1\u306e\u6a5f\u80fd\u3092\u89e3\u6790\u3057\u305f\u3002<\/li>\r\n\t\t<li>\u901a\u5e38\u98fc\u80b2\u4e0b\u3067\u306f\u814e\u306b\u7570\u5e38\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u304c\u3001\u9ad8\u8840\u5727\u4e0b\u3067\u306f\u3001Piezo1\u306e\u6b20\u5931\u306b\u3088\u308a\u86cb\u767d\u5c3f\u306f\u6539\u5584\u305b\u305a\u3001\u3080\u3057\u308d\u5897\u5f37\u3059\u308b\u3068\u3044\u3046\u4e88\u60f3\u5916\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u305f\u3002<\/li>\r\n\t\t<li>\u9ad8\u8840\u5727\u4e0b\u306ePiezo1 KO\u30de\u30a6\u30b9\u306e\u86cb\u767d\u5c3f\u3084\u30dd\u30c9\u30b5\u30a4\u30c8\u969c\u5bb3\u306f\u3001\u964d\u5727\u85ac\u3084Rho\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u85ac\u306e\u6295\u4e0e\u306b\u3088\u3063\u3066\u8efd\u6e1b\u3057\u305f\u3002<\/li>\r\n\t\t<li>Piezo1\u304c\u30dd\u30c9\u30b5\u30a4\u30c8\u306b\u304a\u3044\u3066\u3001\u72b6\u6cc1\u306b\u5fdc\u3058\u3066\u969c\u5bb3\u7684\u306b\u3082\u4fdd\u8b77\u7684\u306b\u3082\u50cd\u304f\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/li>\r\n\t\t<li>Piezo1\u306e\u4e0b\u6d41\u3067\u3001\u969c\u5bb3\u60f9\u8d77\u6642\u306b\u306fRac1\u7d4c\u8def\u304c\u3001\u4fdd\u8b77\u4f5c\u7528\u3067\u306fRhoA\u7d4c\u8def\u304c\u50cd\u304f\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/li>\r\n\t<\/ul>\r\n<\/div>\r\n\r\n<br \/>\r\n\r\n<h3>\u6982\u8981<\/h3>\r\n<p>\u814e\u81d3\u306e\u7cf8\u7403\u4f53\u306b\u306f\u3001\u4f53\u5185\u306e\u8001\u5ec3\u7269\u3092\u6392\u51fa\u3059\u308b\u305f\u3081\u306b\u5e38\u306b\u5927\u91cf\u306e\u8840\u6db2\u304c\u6d41\u308c\u8fbc\u3093\u3067\u3044\u307e\u3059\u3002\u7cf8\u7403\u4f53\u306e\u8868\u9762\u306b\u5b58\u5728\u3059\u308b\u30dd\u30c9\u30b5\u30a4\u30c8\u306f\u3001\u30bf\u30b3\u8db3\u306e\u3088\u3046\u306a\u7a81\u8d77\u3092\u591a\u6570\u4f38\u3070\u3057\u3001\u8840\u6db2\u4e2d\u306e\u86cb\u767d\u304c\u5c3f\u306b\u6f0f\u308c\u51fa\u306a\u3044\u3088\u3046\u30d0\u30ea\u30a2\u3068\u3057\u3066\u50cd\u3044\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u7cd6\u5c3f\u75c5\u3084\u9ad8\u8840\u5727\u306a\u3069\u3067\u814e\u969c\u5bb3\u304c\u9032\u884c\u3059\u308b\u3068\u30dd\u30c9\u30b5\u30a4\u30c8\u304c\u640d\u50b7\u3057\u3001\u5c3f\u691c\u67fb\u3067\u300c\u86cb\u767d\u5c3f\u300d\u3068\u5224\u5b9a\u3055\u308c\u307e\u3059\u3002\u30dd\u30c9\u30b5\u30a4\u30c8\u640d\u50b7\u306e\u539f\u56e0\u3068\u3057\u3066\u8840\u6d41\u306b\u4f34\u3046\u529b\u5b66\u7684\u306a\u529b\u304c\u6ce8\u76ee\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u5341\u5206\u306b\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<br \/>\r\n\u3000\u8fd1\u5e74\u3001\u5727\u529b\u3084\u305a\u308a\u5fdc\u529b\u3001\u632f\u52d5\u306a\u3069\u306e\u529b\u5b66\u7684\u523a\u6fc0\u306b\u5bfe\u3059\u308b\u751f\u4f53\u5fdc\u7b54\u3092\u7814\u7a76\u3059\u308b\u300c\u30e1\u30ab\u30ce\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u300d\u304c\u811a\u5149\u3092\u6d74\u3073\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u30e1\u30ab\u30ce\u30c1\u30e3\u30cd\u30ebPiezo1\u30fbPiezo2\uff082021\u5e74\u30ce\u30fc\u30d9\u30eb\u533b\u5b66\u751f\u7406\u5b66\u8cde\u306e\u5bfe\u8c61\u3068\u306a\u3063\u305f\u5206\u5b50\uff09\u306e\u814e\u81d3\u306b\u304a\u3051\u308b\u5f79\u5272\u3092\u4e16\u754c\u306b\u5148\u99c6\u3051\u3066\u7814\u7a76\u3057\u3066\u304d\u307e\u3057\u305f\u3002<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/archive\/2329\/\">\u6628\u5e74\u306e\u8ad6\u6587<\/a>\u3067\u306f\u3001\u9ad8\u8840\u5727\u30de\u30a6\u30b9\u3067\u86cb\u767d\u5c3f\u306e\u9032\u884c\u306b\u4f34\u3044\u30dd\u30c9\u30b5\u30a4\u30c8\u306ePiezo1\u767a\u73fe\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u3001\u57f9\u990a\u30dd\u30c9\u30b5\u30a4\u30c8\u306b\u529b\u5b66\u7684\u8ca0\u8377\u3092\u304b\u3051\u308b\u3068Piezo\uff11\u3092\u4ecb\u3057\u3066\u969c\u5bb3\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u306e\u7d50\u679c\u306f\u3001Piezo1\u306f\u81d3\u5668\u969c\u5bb3\u3092\u60aa\u5316\u3055\u305b\u308b\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3057\u305f\u304c\u3001\u751f\u4f53\u3067\u306e\u6a5f\u80fd\u306f\u672a\u691c\u8a3c\u3067\u3057\u305f\u3002<br \/>\r\n\u751f\u4f53\u5185\u3067\u306e\u907a\u4f1d\u5b50\u6a5f\u80fd\u3092\u691c\u8a3c\u3059\u308b\u306b\u306f\u3001\u751f\u304d\u305f\u30de\u30a6\u30b9\u3067\u305d\u306e\u907a\u4f1d\u5b50\u3092\u50cd\u304b\u305b\u306a\u304f\u3059\u308b\u3001\u3059\u306a\u308f\u3061KO\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3059\u308b\u3053\u3068\u304c\u9375\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u3053\u3067\u79c1\u305f\u3061\u306f\u3001\u30dd\u30c9\u30b5\u30a4\u30c8\u7279\u7570\u7684\u306bPiezo1\u3092\u6b20\u640d\u3055\u305b\u305fKO\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u3001\u305d\u306e\u5f79\u5272\u3092\u76f4\u63a5\u8abf\u3079\u307e\u3057\u305f\u3002\u4e88\u60f3\u3067\u306f\u969c\u5bb3\u304c\u8efd\u6e1b\u3055\u308c\u308b\u306f\u305a\u3067\u3057\u305f\u304c\u3001\u7d50\u679c\u306f\u9006\u3067\u3001KO\u30de\u30a6\u30b9\u3067\u306f\u9ad8\u8840\u5727\u4e0b\u3067\u5c3f\u86cb\u767d\u304c\u8457\u3057\u304f\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u3064\u307e\u308aPiezo1\u306f\u969c\u5bb3\u56e0\u5b50\u3067\u306f\u306a\u304f\u3001\u4fdd\u8b77\u7684\u306b\u50cd\u304f\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\u306e\u3067\u3059\u3002\u3055\u3089\u306b\u89e3\u6790\u3092\u9032\u3081\u308b\u3068\u3001\u969c\u5bb3\u6642\u306b\u306fRac1\u7d4c\u8def\u3001\u4fdd\u8b77\u4f5c\u7528\u6642\u306b\u306fRhoA\u7d4c\u8def\u304c\u50cd\u304f\u3053\u3068\u304c\u5206\u304b\u308a\u3001Rho\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u85ac\u306e\u6295\u4e0e\u3067KO\u30de\u30a6\u30b9\u306e\u969c\u5bb3\u304c\u6539\u5584\u3059\u308b\u3053\u3068\u3082\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002<br \/>\r\n<br \/>\r\n\u5b50\u4f9b\u306e\u9803\u306e\u590f\u4f11\u307f\u306e\u81ea\u7531\u7814\u7a76\u3067\u3001\u601d\u3063\u305f\u901a\u308a\u306e\u7d50\u679c\u304c\u51fa\u305a\u306b\u56f0\u3063\u305f\u7d4c\u9a13\u306f\u3042\u308a\u307e\u305b\u3093\u304b\uff1f <br \/>\r\n\u4eca\u56de\u306e\u6210\u679c\u306f\u3001Piezo1\u304c\u814e\u81d3\u3067\u72b6\u6cc1\u306b\u5fdc\u3058\u3066\u7570\u306a\u308b\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u3092\u793a\u3059\u91cd\u8981\u306a\u77e5\u898b\u3067\u3059\u3002\u907a\u4f1d\u5b50\u3084\u5206\u5b50\u306f\u3042\u308b\u81d3\u5668\u3067\u306f\u75c5\u6c17\u306e\u539f\u56e0\u3067\u3042\u3063\u3066\u3082\u3001\u5225\u306e\u81d3\u5668\u3067\u306f\u601d\u3044\u304c\u3051\u306a\u3044\u6a5f\u80fd\u3092\u62c5\u3046\u3053\u3068\u304c\u3042\u308a\u3001\u305d\u306e\u591a\u69d8\u6027\u3053\u305d\u79d1\u5b66\u306e\u918d\u9190\u5473\u3067\u3059\u3002\u75c5\u6c17\u306e\u7814\u7a76\u306f\u300c\u6cbb\u7642\u306b\u76f4\u7d50\u3059\u308b\u304b\u300d\u304c\u554f\u308f\u308c\u304c\u3061\u3067\u3059\u304c\u3001\u81ea\u7136\u73fe\u8c61\u306f\u5358\u7d14\u3067\u306f\u306a\u304f\u3001\u3082\u3084\u3082\u3084\u3057\u305f\u5fae\u5999\u7cbe\u5999\u306a\u8907\u96d1\u3055\u306e\u4e2d\u306b\u771f\u7406\u304c\u3042\u308a\u307e\u3059\u3002KO\u30de\u30a6\u30b9\u306e\u6280\u8853\u306f1990\u5e74\u4ee3\u304b\u3089\u767a\u5c55\u3057\u3001\u305d\u306e\u89e3\u6790\u306f\u300c\u3053\u306e\u907a\u4f1d\u5b50\u306b\u3053\u3093\u306a\u6a5f\u80fd\u304c\u3042\u3063\u305f\u306e\u304b\uff01\u300d\u3068\u3044\u3046\u9a5a\u304d\u3092\u3082\u305f\u3089\u3057\u3001\u610f\u5916\u306a\u7d50\u679c\u304c\u65b0\u3057\u3044\u767a\u898b\u3092\u751f\u307f\u7d9a\u3051\u3066\u3044\u307e\u3059\u3002\u4e88\u60f3\u5916\u306e\u7d50\u679c\u3092\u53d7\u3051\u6b62\u3081\u3066\u65b0\u305f\u306a\u30b9\u30c8\u30fc\u30ea\u30fc\u3092\u63cf\u304d\u76f4\u3059\u3053\u3068\u304c\u79d1\u5b66\u306e\u9032\u6b69\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u3082\u3001Piezo1\u306e\u591a\u9762\u7684\u306a\u5f79\u5272\u3092\u89e3\u304d\u660e\u304b\u3059\u3053\u3068\u3067\u814e\u81d3\u75c5\u306e\u7406\u89e3\u3068\u6cbb\u7642\u6cd5\u958b\u767a\u306b\u65b0\u3057\u3044\u8996\u70b9\u3092\u63d0\u4f9b\u3067\u304d\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u601d\u3044\u901a\u308a\u306e\u7d50\u679c\u304c\u51fa\u306a\u304b\u3063\u305f\u6642\u306b\u300c\u3080\u3057\u308d\u9762\u767d\u3044\u300d\u3068\u611f\u3058\u3089\u308c\u308b\u3053\u3068\u3053\u305d\u3001\u79d1\u5b66\u306e\u9b45\u529b\u306a\u306e\u3067\u3059\u3002\r\n<\/p>\r\n<br\/>\r\n\r\n<figure id=\"Fig.1\" style=\"text-align: center;\"> \r\n<a href=\"\/univ\/faculty\/medicine\/uploads\/2025\/11\/Fig1-scaled.jpg\" target=\"_blank\"><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/2025\/11\/Fig1-scaled.jpg\" width=\"50%\" vspace=\"20\" alt=\"\u6982\u5ff5\u56f3\" border=\"0\"><\/a>\r\n<figcaption style=\"text-align: left; padding-left: 2em; padding-right: 2em;\"> \u30dd\u30c9\u30b5\u30a4\u30c8\u7279\u7570\u7684 Piezo1 \u6b20\u640d\uff08KO\uff09\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u3001\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3II\u304a\u3088\u3073\u9ad8\u98df\u5869\u98df\u6295\u4e0e\u306b\u3088\u3063\u3066\u9ad8\u8840\u5727\u3092\u8a98\u5c0e\u3057\u305f\u3068\u3053\u308d\u3001\u9ad8\u8840\u5727\u306b\u5408\u4f75\u3059\u308b\u86cb\u767d\u5c3f\u3068\u30dd\u30c9\u30b5\u30a4\u30c8\u969c\u5bb3\u306f\u4e88\u60f3\u306b\u53cd\u3057\u3066 KO \u30de\u30a6\u30b9\u3067\u5897\u60aa\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306f\u964d\u5727\u85ac\u6cbb\u7642\u306b\u3088\u308a\u5b8c\u5168\u306b\u6539\u5584\u3057\u3001Rho \u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u85ac\u306b\u3088\u3063\u3066\u3082\u8efd\u6e1b\u3057\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u3088\u308a\u3001\u7cf8\u7403\u4f53\u9ad8\u8840\u5727\u6642\u306ePiezo1 \u306e\u4fdd\u8b77\u7684\u5f79\u5272\u3068 RhoA \u30b7\u30b0\u30ca\u30eb\u306e\u95a2\u4e0e\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/figcaption>\r\n<\/figure>\r\n\r\n<br \/ class=\"fig0\">\r\n\r\n<h3>\u7528\u8a9e\u89e3\u8aac<\/h3>\r\n<p>\r\n\t<b>\u30dd\u30c9\u30b5\u30a4\u30c8\uff08\u8db3\u7d30\u80de\uff09\uff1a<\/b><br \/>\r\n\u814e\u81d3\u306e\u7cf8\u7403\u4f53\u6bdb\u7d30\u8840\u7ba1\u306e\u6700\u5916\u5074\u306b\u3042\u308b\u4e0a\u76ae\u7d30\u80de\u3067\u3001\u7cf8\u7403\u4f53\u5185\u76ae\u7d30\u80de\u3084\u57fa\u5e95\u819c\u3068\u3068\u3082\u306b\u7cf8\u7403\u4f53\u6ffe\u904e\u30d0\u30ea\u30a2\u3092\u4f5c\u308b\u3000\u3002\u7d30\u80de\u304b\u3089\u4f38\u3073\u308b\u8db3\u7a81\u8d77\u306f\u3001\u96a3\u306e\u7d30\u80de\u306e\u8db3\u7a81\u8d77\u3068\u4ea4\u4e92\u306b\u4e26\u3073\u3001\u305d\u306e\u9593\u306b\u3067\u304d\u308b\u30b9\u30ea\u30c3\u30c8\u819c\u304c\u8840\u6db2\u4e2d\u306e\u86cb\u767d\u8cea\u306e\u5c3f\u3078\u306e\u6f0f\u51fa\u3092\u9632\u3044\u3067\u3044\u308b\u3002\u30a2\u30af\u30c1\u30f3\u7d30\u80de\u9aa8\u683c\u304c\u767a\u9054\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u8907\u96d1\u306a\u5f62\u614b\u306fRho\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4f4e\u5206\u5b50\u91cfG\u86cb\u767d\u8cea\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u308b\u3002\u969c\u5bb3\u3092\u53d7\u3051\u308b\u3068\u8db3\u7a81\u8d77\u304c\u9000\u7e2e\u3057\u3001\u30b9\u30ea\u30c3\u30c8\u819c\u304c\u58ca\u308c\u3066\u86cb\u767d\u5c3f\u3092\u751f\u3058\u308b\u3002<br \/>\r\n\t<b>Piezo1\uff1a<\/b><br \/>\r\n\u7d30\u80de\u819c\u306e\u4f38\u3073\u3084\u5727\u529b\u306a\u3069\u3001\u6a5f\u68b0\u7684\u306a\u523a\u6fc0\u306b\u3088\u308a\u958b\u9589\u304c\u8abf\u7bc0\u3055\u308c\u308b\u967d\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u3002\u30d2\u30c8\u3067\u306f2521\u500b\u306e\u30a2\u30df\u30ce\u9178\u304b\u3089\u306a\u308a\u300138\u500b\u306e\u819c\u8cab\u901a\u9818\u57df\u3092\u6301\u3064\u975e\u5e38\u306b\u5927\u304d\u306a\u86cb\u767d\u8cea\u3002\u4e09\u679a\u7fbd\u6839\u306e\u5de8\u5927\u306a\u30d7\u30ed\u30da\u30e9\u306e\u3088\u3046\u306a\u5f62\u3092\u3057\u3066\u304a\u308a\uff0c\u819c\u306b\u57cb\u3081\u8fbc\u307e\u308c\u305f\u30d7\u30ed\u30da\u30e9\u90e8\u5206\u304c\u7d30\u80de\u819c\u306e\u4f38\u5c55\u3092\u611f\u3058\u53d6\u308b\u3002\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3084\u8d64\u8840\u7403\u306a\u3069\u591a\u304f\u306e\u7d30\u80de\u306b\u5b58\u5728\u3057\u3001\u8840\u6d41\u3084\u5727\u529b\u306e\u5909\u5316\u3092\u611f\u77e5\u3057\u3066\u7d30\u80de\u306e\u50cd\u304d\u3092\u8abf\u6574\u3059\u308b\u3002\u300c\u30d4\u30a8\u30be\u300d\u3068\u306f\u30ae\u30ea\u30b7\u30e3\u8a9e\u306e\u300c\u5727\u529b\u3092\u304b\u3051\u308b\u300d\u306b\u7531\u6765\u3059\u308b\u3002<\/p>\r\n\r\n\r\n<h3>\u63b2\u8f09\u8ad6\u6587<\/h3>\r\n\r\n<table class=\"citation\">\r\n <tr>\r\n  <td width=93>\u767a\u8868\u96d1\u8a8c\uff1a<\/td><td width=560>Hypertension Research<\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1a<\/td><td><a href=\"http:\/\/doi.org\/10.1038\/s41440-025-02383-w\"  target=\"_blank\">Podocyte-specific deletion of mechanochannel Piezo1 exacerbates proteinuria and podocyte injury in mouse hypertensive nephropathy.<\/a><\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>\u7b46\u3000\u8005\uff1a<\/td><td>Kaori Mikami, Takashi Nagase, Hisaki Kishino, Nobuhiro Nakamura, Yoshiro Suzuki, Hiroshi Fukuhara, Taiji Matsusaka, Keiko Nonomura, Miki Nagase\r\n  <br \/>\u4e09\u4e0a\u9999\u7e54<sup>1<\/sup>\uff0c\u9577\u702c\u656c<sup>2<\/sup>\uff0c\u5cb8\u91ce\u65e5\u54b2<sup>3<\/sup>\uff0c\u4e2d\u6751\u4fe1\u5927<sup>4<\/sup>\uff0c\u9234\u6728\u559c\u90ce<sup>5<\/sup>\uff0c\u798f\u539f\u6d69<sup>6<\/sup>\uff0c\u677e\u962a\u6cf0\u4e8c<sup>7<\/sup>\uff0c\u91ce\u3005\u6751\u6075\u5b50<sup>8<\/sup>\uff0c\u9577\u702c\u7f8e\u6a39<sup>1<\/sup> \uff081\u8089\u773c\u89e3\u5256\u5b66\u30012\u56fd\u7acb\u3042\u304a\u3084\u304e\u82d1\u7acb\u5ddd\u30013\u533b\u5b66\u90e85\u5e74\u751f\u30014\u6771\u4eac\u79d1\u5b66\u5927\u5b66\u30015\u5ca9\u624b\u533b\u79d1\u5927\u5b66\u30016\u6ccc\u5c3f\u5668\u79d1\u5b66\u30017\u6771\u6d77\u5927\u5b66\u30018\u4eac\u90fd\u5927\u5b66\uff09<\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>DOI:<\/td>  <td>10.1038\/s41440-025-02383-w<\/td>\r\n <\/tr>\r\n<\/table>\r\n<br \/>\r\n\r\n<div>\r\n <p>\u8089\u773c\u89e3\u5256\u5b66\u6559\u5ba4\u306e\u8a73\u7d30\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/macro-anat\/\" target=\"_blank\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002\r\n<\/div>\r\n<br \/>\r\n\r\n<h5>\u554f\u3044\u5408\u308f\u305b\u5148<\/h5>\r\n<p class=\"noIndmt10\">\u674f\u6797\u5b66\u5712\u5e83\u5831\u5ba4<br \/>\r\n\u3000\u3000\u5e83\u5831\u5ba4\u3078\u306e\u304a\u554f\u3044\u5408\u308f\u305b\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/contact\/\">\u3053\u3061\u3089<\/a>\u307e\u3067<br \/>\r\nTel: 0422-44-0611<br \/>\r\n<\/p>","protected":false},"excerpt":{"rendered":"<p>\u9577\u702c\u3000\u7f8e\u6a39\uff08\u8089\u773c\u89e3\u5256\u5b66\u30fb\u6559\u6388\uff09 \u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8 \u30dd\u30c9\u30b5\u30a4\u30c8\u7279\u7570\u7684Piezo1\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\uff08KO\uff09\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u3066\u751f\u4f53\u306b\u304a\u3051\u308b\u30dd\u30c9\u30b5\u30a4\u30c8Piezo1\u306e\u6a5f\u80fd\u3092\u89e3\u6790\u3057\u305f\u3002 \u901a\u5e38\u98fc\u80b2\u4e0b\u3067\u306f\u814e\u306b\u7570\u5e38\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u304c\u3001\u9ad8\u8840\u5727\u4e0b [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":7612,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-7610","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/7610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/comments?post=7610"}],"version-history":[{"count":16,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/7610\/revisions"}],"predecessor-version":[{"id":7628,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/7610\/revisions\/7628"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media\/7612"}],"wp:attachment":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media?parent=7610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/categories?post=7610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/tags?post=7610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}