{"id":7885,"date":"2026-03-18T09:28:57","date_gmt":"2026-03-18T00:28:57","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/?p=7885"},"modified":"2026-03-23T08:54:35","modified_gmt":"2026-03-22T23:54:35","slug":"%e5%ae%b6%e6%97%8f%e6%80%a7%e7%ad%8b%e8%90%8e%e7%b8%ae%e6%80%a7%e5%81%b4%e7%b4%a2%e7%a1%ac%e5%8c%96%e7%97%87als%e3%81%ae%e6%96%b0%e3%81%9f%e3%81%aa%e5%8e%9f%e5%9b%a0%e9%81%ba%e4%bc%9d%e2%bc%a6","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/archive\/7885\/","title":{"rendered":"\u5bb6\u65cf\u6027\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7(ALS)\u306e\u65b0\u305f\u306a\u539f\u56e0\u907a\u4f1d\u2f26\u5909\u7570\u3092\u767a\u2f92\u2015 SOD1\u907a\u4f1d\u2f26\u306e\u65b0\u898f\u5909\u7570\u304c\u2f70\u3059\u75c5\u614b\u7406\u89e3\u3068\u500b\u5225\u5316\u533b\u7642\u3078\u306e\u53ef\u80fd\u6027\uff08\u533b\u5b66\u90e8\u8133\u795e\u7d4c\u5185\u79d1\u5b66\u6559\u5ba4\u5e02\u5ddd\u6559\u6388\u3089\u306e\u30b0\u30eb\u30fc\u30d7\uff09"},"content":{"rendered":"<style type=\"text\/css\">\r\n <!-- .fig1 {float:left;} .fig2 {float:right;} .fig0 {clear:both;} figure { margin: 1em 0; \/* \u4e0a\u4e0b\u306e\u9699\u9593\u306e\u307f\u6b8b\u3059 *\/ padding: .5em; text-align: center; \/* \u753b\u50cf\u3068\u6ce8\u91c8\u3092\u4e2d\u592e\u5bc4\u305b *\/ border: solid 1px silver; \/* \u5468\u308a\u3092\u7dda\u3067\u56f2\u3046 *\/ } figcaption { margin-top: .5em; \/* \u753b\u50cf\u3068\u6ce8\u91c8\u306e\u9699\u9593 *\/ font-size: .9em; } --><br \/>\r\n <\/style>\r\n\r\n&nbsp;\r\n<div align=\"right\">\r\n<p>\r\n<b>\r\n\u5e02\u5ddd \u5f25\u2f63\u5b50\uff08\u8133\u795e\u7d4c\u5185\u79d1\u5b66\u30fb\u6559\u6388\uff09\r\n<\/b>\r\n<\/p>\r\n<\/div>\r\n<h3>\u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8<\/h3>\r\n<div>\r\n<ul>\r\n \t<li>\u2f47\u672c\u2f08\u306e\u5bb6\u65cf\u6027ALS\u306e1\u5bb6\u7cfb\u304b\u3089\u3001<i>SOD1<\/i>\u907a\u4f1d\u2f26\u306e\u65b0\u305f\u306a\u5909\u7570\u3092\u767a\u2f92\u3057\u307e\u3057\u305f\u3002<\/li>\r\n \t<li>\u3053\u306e\u5909\u7570\u306f\u4e16\u754c\u7684\u306b\u3082\u6975\u3081\u3066\u307e\u308c\u306a\u300c\u30a4\u30f3\u30d5\u30ec\u30fc\u30e0\u91cd\u8907\u578b\u300d\u306e<i>SOD1<\/i>\u907a\u4f1d\u2f26\u5909\u7570\u3067\u3059\u3002<\/li>\r\n \t<li>SOD1\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e09\u6b21\u5143\uff083D\uff09\u69cb\u9020\u4e88\u6e2c\u304b\u3089\u306f\uff0c\u672c\u5909\u7570\u306b\u3088\u3063\u3066\u69cb\u9020\u5909\u5316\u304c\u2f63\u3058\u308b\u53ef\u80fd\u6027\u304c\u2f70\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\r\n \t<li>\u907a\u4f1d\u5f62\u5f0f\u3001\u795e\u7d4c\u75c5\u7406\u304a\u3088\u3073\u907a\u4f1d\u2f26\u767a\u73fe\u89e3\u6790\u306e\u4e21\u2faf\u304b\u3089\u3001\u75c5\u539f\u6027\u6a5f\u80fd\u7372\u5f97\uff08gain of function\uff09\u306b\u3088\u308bALS\u767a\u75c7\u6a5f\u5e8f\u304c\u2f70\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\r\n \t<li>ALS\u306e\u500b\u5225\u5316\u533b\u7642\u3001\u907a\u4f1d\u2f26\u6cbb\u7642\u85ac\u958b\u767a\u3078\u306e\u8ca2\u732e\u304c\u671f\u5f85\u3055\u308c\u308b\u7814\u7a76\u6210\u679c\u3067\u3059\u3002<\/li>\r\n<\/ul>\r\n<\/div>\r\n&nbsp;\r\n<h3>\u6982\u8981<\/h3>\r\n<p>\r\n\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u306f\u3001\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u969c\u5bb3\u306b\u3088\u308a\u2f3f\u2f9c\u3084\u306e\u3069\u306e\u7b4b\u2f81\u304c\u5f90\u3005\u306b\u3084\u305b\u3066\u3044\u304f\u9032\u2f8f\u6027\u306e\u795e\u7d4c\u96e3\u75c5\u3067\u3059\u3002ALS\u306e\u7d04\r\n5-10\uff05\u306f\u907a\u4f1d\u304c\u95a2\u4e0e\u3059\u308b\u5bb6\u65cf\u6027ALS\u3067\u3059\u3002\u306a\u304b\u3067\u3082\u2f47\u672c\u2f08\u3067\u306f\u3001<i>SOD1<\/i>\u907a\u4f1d\u2f26\u306e\u5909\u7570\u306b\u3088\u308a\u767a\u75c7\u3059\u308b\u300cSOD1\u95a2\u9023ALS\u300d\u304c\u6700\u3082\u591a\u304f\u3001\u305d\u306e\r\n\u591a\u304f\u306f\u4e21\u89aa\u306e\u3044\u305a\u308c\u304b\u304b\u3089\u5909\u7570\u3092\u53d7\u3051\u7d99\u3050\u5e38\u67d3\u2f8a\u4f53\u9855\u6027\uff08\u512a\u6027\uff09\u907a\u4f1d\u5f62\u5f0f\u3092\u3068\u308a\u307e\u3059\u3002\r\n\u674f\u6797\u2f24\u5b66\u533b\u5b66\u90e8\u8133\u795e\u7d4c\u5185\u79d1\u5b66\u6559\u5ba4\u3067\u306f\u3001\u6771\u4eac\u2f24\u5b66\u30fb\u2f24\u962a\u533b\u79d1\u85ac\u79d1\u2f24\u5b66\u30fb\u611b\u77e5\u533b\u79d1\u2f24\u5b66\u30fb\u6ecb\u8cc0\u533b\u79d1\u2f24\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001\u5e38\u67d3\u2f8a\u4f53\u9855\u6027(\u512a\r\n\u6027)\u907a\u4f1d\u5f62\u5f0f\u3092\u3068\u308b\u5bb6\u65cf\u6027ALS\u306e\u2f47\u672c\u2f081\u5bb6\u7cfb\u306b\u304a\u3044\u3066\u3001<i>SOD1<\/i>\u907a\u4f1d\u2f26\u306e\u300c\u30a4\u30f3\u30d5\u30ec\u30fc\u30e0\u91cd\u8907\u300d\u578b\u306e\u65b0\u3057\u3044\u5909\u7570\uff08\u30a4\u30f3\u30d5\u30ec\u30fc\u30e0\u91cd\u8907\u5909\u7570\uff1a\r\np.Val120dup\uff09\u3092\u540c\u5b9a\u3057\u3001\u305d\u306e\u75c5\u7684\u610f\u7fa9\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u30a4\u30f3\u30d5\u30ec\u30fc\u30e0\u91cd\u8907\u5909\u7570\u306f\u3001\u907a\u4f1d\u2f26\u306e\u8aad\u307f\u67a0\u3092\u4fdd\u3063\u305f\u307e\u307e\u30bf\u30f3\u30d1\u30af\u914d\u5217\u306e\u2f00\r\n\u90e8\u304c\u91cd\u8907\u3059\u308b\u3068\u3044\u3046\u7279\u6b8a\u306a\u30bf\u30a4\u30d7\u306e\u5909\u7570\u3067\u3059\u3002<i>SOD1<\/i>\u907a\u4f1d\u2f26\u306b\u304a\u3051\u308b\u30a4\u30f3\u30d5\u30ec\u30fc\u30e0\u91cd\u8907\u5909\u7570\u306f\u3001ALS\u3067\u306f\u3053\u308c\u307e\u3067\u306b2\u5bb6\u7cfb\u3057\u304b\u5831\u544a\u3055\u308c\u3066\r\n\u304a\u3089\u305a\u3001\u4e16\u754c\u7684\u306b\u3082\u6975\u3081\u3066\u307e\u308c\u306a\u3082\u306e\u3067\u3059\u3002\r\n\u672c\u7814\u7a76\u6210\u679c\u306f\u3001<i>SOD1<\/i>\u907a\u4f1d\u2f26\u5909\u7570\u306e\u591a\u69d8\u6027\u3068ALS\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u7406\u89e3\u3092\u6df1\u3081\u308b\u3068\u3068\u3082\u306b\u3001\u907a\u4f1d\u2f26\u5909\u7570\u306b\u57fa\u3065\u304fALS\u306e\u500b\u5225\u5316\u533b\u7642\u3084\u3001\r\n\u5c06\u6765\u7684\u306a\u907a\u4f1d\u2f26\u6cbb\u7642\u85ac\u306e\u958b\u767a\u306b\u8ca2\u732e\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\r\n<\/p>\r\n<h3>\uff11\uff0e<i>SOD1<\/i>\u907a\u4f1d\u2f26\u306e\u65b0\u3057\u3044\u5909\u7570\uff08\u30a4\u30f3\u30d5\u30ec\u30fc\u30e0\u91cd\u8907\u5909\u7570\uff09<\/h3>\r\n<p>\r\n\u672c\u7814\u7a76\u3067\u306f\u3001<i>SOD1<\/i>\u907a\u4f1d\u2f26\u89e3\u6790\u3092\u2f8f\u3044\u3001\u65b0\u3057\u3044\u5909\u7570\uff08\u30a4\u30f3\u30d5\u30ec\u30fc\u30e0\u91cd\u8907\u5909\u7570\uff1ap.Val120dup\uff09\u3092\u540c\u5b9a\u3057\u3001\u5bb6\u65cf\u6027ALS\u306e\u539f\u56e0\u89e3\u660e\u306b\u65b0\u305f\u306a\u77e5\r\n\u2f92\u3092\u52a0\u3048\u307e\u3057\u305f\u3002\u672c\u5909\u7570\u306f\u3001\u907a\u4f1d\u2f26\u306e\u8aad\u307f\u67a0\u3092\u4fdd\u3063\u305f\u307e\u307e\u3001SOD1\u30bf\u30f3\u30d1\u30af\u8cea\u306e120\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u3067\u3042\u308b\u30d0\u30ea\u30f3\uff08Val\uff09\u304c\u91cd\u8907\u3059\u308b\u3068\u3044\r\n\u3046\u7279\u6b8a\u306a\u5909\u7570\u3067\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u672c\u6765121\u756a\u76ee\u306b\u4f4d\u7f6e\u3057\u3066\u3044\u308b\u30d2\u30b9\u30c1\u30b8\u30f3\uff08H121\uff09\u306f122\u756a\u76ee\uff08H122\uff09\u3078\u3068\u305a\u308c\u308b\u3053\u3068\u304c\u4e88\u6e2c\u3055\u308c\u307e\u3059\u3002\r\n\uff08\u56f3A\uff09\u3002\r\nSOD1\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u4f53\u5185\u3067\u2f63\u3058\u308b\u6709\u5bb3\u306a\u6d3b\u6027\u9178\u7d20\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u3067\u3042\u308a\u3001\u305d\u306e\u6a5f\u80fd\u306b\u306f\u9285\u30a4\u30aa\u30f3\u304c\u6d3b\u6027\u4e2d\u2f3c\u306b\u6b63\u3057\u304f\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u4e0d\r\n\u53ef\u2f4b\u3067\u3059\u3002\u7279\u306b121\u756a\u76ee\u306e\u30d2\u30b9\u30c1\u30b8\u30f3\uff08H121\uff09\u306f\u3001\u9285\u30a4\u30aa\u30f3\u3092\u5b89\u5b9a\u3057\u3066\u7d50\u5408\u3055\u305b\u308b\u305f\u3081\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u672c\u5909\r\n\u7570\u306b\u3088\u308b\u30a2\u30df\u30ce\u9178\u914d\u5217\u306e\u308f\u305a\u304b\u306a\u5909\u5316\u3067\u3042\u3063\u3066\u3082\u3001SOD1\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u2f74\u4f53\u69cb\u9020\u3084\u6a5f\u80fd\u306b\u2f24\u304d\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\r\n<\/p>\r\n<figure id=\"Fig.1\" style=\"text-align: center;\"><a href=\"\/univ\/faculty\/medicine\/uploads\/2024\/04\/Fig1.jpg\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"1100\" height=\"753\" class=\"alignnone size-medium wp-image-7893\" src=\"\/univ\/faculty\/medicine\/uploads\/2026\/03\/zuA.jpg\" alt=\"\" srcset=\"\/univ\/faculty\/medicine\/uploads\/2026\/03\/zuA.jpg 1100w, \/univ\/faculty\/medicine\/uploads\/2026\/03\/zuA-300x205.jpg 300w, \/univ\/faculty\/medicine\/uploads\/2026\/03\/zuA-1024x701.jpg 1024w, \/univ\/faculty\/medicine\/uploads\/2026\/03\/zuA-768x526.jpg 768w, \/univ\/faculty\/medicine\/uploads\/2026\/03\/zuA-500x342.jpg 500w, \/univ\/faculty\/medicine\/uploads\/2026\/03\/zuA-470x322.jpg 470w, \/univ\/faculty\/medicine\/uploads\/2026\/03\/zuA-367x251.jpg 367w\" sizes=\"auto, (max-width: 1100px) 100vw, 1100px\" \/><\/a><figcaption style=\"text-align: left; text-indent: -1em; padding-left: 2em;\"><b>\u56f3A\uff1a<i>SOD1<\/i>\u907a\u4f1d\u2f26\u89e3\u6790\u7d50\u679c\uff1a\u300c\u30a4\u30f3\u30d5\u30ec\u30fc\u30e0\u91cd\u8907\u578b\u300d\u306e<i>SOD1<\/i>\u907a\u4f1d\u2f26\u5909\u7570 (p.Val120dup)<\/b><br>\r\n\u56f3\u306b\u2f70\u3057\u305f\u6ce2\u5f62\u306f\u3001\u767a\u75c7\u8005\u306e<i>SOD1<\/i>\u907a\u4f1d\u2f26cDNA\u914d\u5217\u306e\u89e3\u6790\u7d50\u679c\u3092\u2f70\u3057\u3066\u3044\u307e\u3059\u3002\u5909\u7570\u578b\u3067\u306fcDNA\u914d\u5217\u306e\u2f00\u90e8\u306b\u300cGTG\u300d\u306e\u91cd\u8907\u304c\u8a8d\u3081\u3089\r\n\u308c\u3001\u8aad\u307f\u67a0\u306f\u4fdd\u305f\u308c\u305f\u307e\u307e\u3001SOD1\u30bf\u30f3\u30d1\u30af\u8cea\u306e120\u756a\u76ee\u306b\u30d0\u30ea\u30f3\uff08Val\uff09\u304c1\u3064\u633f\u2f0a\u3055\u308c\u307e\u3059\uff08\u30a4\u30f3\u30d5\u30ec\u30fc\u30e0\u91cd\u8907\uff09\u3002\u305d\u306e\u7d50\u679c\u3001\u672c\u6765121\r\n\u756a\u76ee\u306b\u4f4d\u7f6e\u3059\u308b\u30d2\u30b9\u30c1\u30b8\u30f3\uff08His\uff09\u306f122\u756a\u76ee\u3078\u3068\u305a\u308c\u3066\u3044\u307e\u3059\uff08\uff0a\uff09\u3002<\/figcaption><\/figure>\r\n<h3>\uff12\uff0eSOD1\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e09\u6b21\u5143\uff083D\uff09\u69cb\u9020\u5909\u5316\u306e\u4e88\u6e2c<\/h3>\r\n<p>\r\nSOD1\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u2f63\u3058\u308b\u69cb\u9020\u5909\u5316\u3092\u691c\u8a0e\u3059\u308b\u305f\u3081\u3001\u4e09\u6b21\u5143\uff083D\uff09\u69cb\u9020\u89e3\u6790\u306e\u4e88\u6e2c\uff08in silico\u89e3\u6790\uff09\u3092\u2f8f\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u672c\u5909\u7570\u306b\r\n\u3088\u3063\u3066\u65b0\u305f\u306b\u2f63\u3058\u305f\u30d2\u30b9\u30c1\u30b8\u30f3\uff08H122\uff09\u306f\u3001\u9285\u30a4\u30aa\u30f3\uff08Cu\u00b2\u207a\uff09\u306e\u7d50\u5408\u90e8\u4f4d\u304b\u3089\u96e2\u308c\u305f\u5834\u6240\u306b\u4f4d\u7f6e\u3059\u308b\u3053\u3068\u304c\u4e88\u6e2c\u3055\u308c\u307e\u3057\u305f\uff08\u56f3B\uff09\u3002\u3053\r\n\u306e\u3053\u3068\u304b\u3089\u3001SOD1\u306e\u6d3b\u6027\u4e2d\u2f3c\u306b\u304a\u3044\u3066\u3001\u9285\u30a4\u30aa\u30f3\u304c\u9069\u5207\u306b\u7d50\u5408\u3067\u304d\u306a\u304f\u306a\u308b\u69cb\u9020\u5909\u5316\u304c\u2f63\u3058\u308b\u53ef\u80fd\u6027\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\r\n\u9285\u30a4\u30aa\u30f3\u306f\u3001SOD1\u306e\u9175\u7d20\u6d3b\u6027\u306e\u4e2d\u2f3c\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u5168\u4f53\u306e\u2f74\u4f53\u69cb\u9020\u3092\u5b89\u5b9a\u5316\u3055\u305b\u308b\u91cd\u8981\u306a\u5f79\u5272\u3082\u62c5\u3063\u3066\u3044\u307e\r\n\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u672c\u5909\u7570\u306b\u3088\u308a\u9285\u30a4\u30aa\u30f3\u7d50\u5408\u304c\u969c\u5bb3\u3055\u308c\u308b\u3053\u3068\u3067\u3001SOD1\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6b63\u3057\u3044\u2f74\u4f53\u69cb\u9020\u3092\u5f62\u6210\u3067\u304d\u305a\u3001\u7570\u5e38\u306a\u5f62\u306b\u306a\u308b\r\n\u300c\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\uff08\u6b63\u3057\u3044\u5f62\u306b\u6298\u308a\u305f\u305f\u3081\u306a\u3044\u72b6\u614b\uff09\u300d\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u2f70\u5506\u3055\u308c\u307e\u3057\u305f\u3002\r\n<\/p>\r\n<figure id=\"Fig.1\" style=\"text-align: center;\"><a href=\"\/univ\/faculty\/medicine\/uploads\/2024\/04\/Fig1.jpg\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" class=\"alignnone size-medium wp-image-7893\" src=\"\/univ\/faculty\/medicine\/uploads\/2026\/03\/zuB.jpg\" alt=\"\" \/><\/a><figcaption style=\"text-align: left; text-indent: -1em; padding-left: 2em;\"><b>\u56f3B\uff1aSOD1\u306e\u9285\u30a4\u30aa\u30f3\uff08Cu\u00b2\u207a\uff09\u7d50\u5408\u90e8\u8fd1\u508d\u306b\u304a\u3051\u308b\u69cb\u9020\u5909\u5316\u4e88\u6e2c<\/b><br>\r\nSOD1\u304c\u6b63\u5e38\u306b\u50cd\u304f\u305f\u3081\u306b\u306f\u3001\u6d3b\u6027\u4e2d\u2f3c\u306b\u9285\u30a4\u30aa\u30f3\uff08Cu\u00b2\u207a\uff09\u304c\u7d50\u5408\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u56f3\u4e2d\u3067\u306f\u3001\u9285\u30a4\u30aa\u30f3\u3092\u2ee9\u2f8a\u306e\u7403\u3067\u2f70\u3057\u3066\u3044\u307e\u3059\u3002\u91ce\u2f63\u578b\u3067\u306f\u30014\u3064\u306e\u30d2\u30b9\u30c1\u30b8\u30f3\uff08H47\u3001H49\u3001H64\u3001H121\uff09\u304c\u9285\u30a4\u30aa\u30f3\u3092\u53d6\u308a\u56f2\u3080\u3088\u3046\u306b\u914d\u7f6e\u3055\u308c\u3001\u9285\u30a4\u30aa\u30f3\u3092\u3057\u3063\u304b\u308a\u3068\u7d50\u5408\u3057\u307e\u3059\u3002\u2f00\u2f45\u3001\u5909\u7570\u578bSOD1\u3067\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u914d\u5217\u306e\u305a\u308c\u306b\u3088\u3063\u3066\u672c\u6765121\u756a\u76ee\u306b\u3042\u3063\u305f\u30d2\u30b9\u30c1\u30b8\u30f3\u304c122\u756a\u76ee\uff08H122\uff09\u306b\u5909\u5316\u3057\u307e\u3059\u3002\u3053\u306e\u65b0\u305f\u306b\u2f63\u3058\u305fH122\u306f\u3001\u9285\u30a4\u30aa\u30f3\u304b\u3089\u96e2\u308c\u305f\u5834\u6240\u306b\u4f4d\u7f6e\u3059\u308b\u305f\u3081\u3001SOD1\u306e\u6d3b\u6027\u4e2d\u2f3c\u306b\u9285\u30a4\u30aa\u30f3\u304c\u7d50\u5408\u3067\u304d\u306a\u304f\u306a\u308b\u3068\u3044\u3046\u69cb\u9020\u5909\u5316\u304c\u2f63\u3058\u308b\u3068\u4e88\u6e2c\u3055\u308c\u307e\u3059\u3002<\/figcaption><\/figure>\r\n&nbsp;\r\n<h3>\uff13\uff0e\u75c5\u539f\u6027\u6a5f\u80fd\u7372\u5f97\uff08gain of function\uff09\u306b\u3088\u308bALS\u767a\u75c7\u6a5f\u5e8f\u306e\u691c\u8a3c<\/h3>\r\n<p>\r\n\u5b9f\u969b\u3001\u795e\u7d4c\u75c5\u7406\u5b66\u7684\u89e3\u6790\u306b\u304a\u3044\u3066\u3001\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u72b6\u614b\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7279\u7570\u7684\u306b\u691c\u51fa\u3067\u304d\u308b\u6297\u4f53\u3092\u2f64\u3044\u305f\u514d\u75ab\u67d3\u2f8a\u306b\u3088\u308a\u3001\u672c\u5bb6\u7cfb\r\n\u767a\u75c7\u8005\u306e\u795e\u7d4c\u7d30\u80de\u5185\u306b\u7570\u5e38\u306aSOD1\u306e\u51dd\u96c6\u4f53\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u4eca\u56de\u540c\u5b9a\u3057\u305f\u5909\u7570\uff08p.Val120dup\uff09\u304cSOD1\u30bf\u30f3\u30d1\r\n\u30af\u8cea\u306e\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001ALS\u306e\u75c5\u614b\u5f62\u6210\u306b\u76f4\u63a5\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u2f70\u3059\u91cd\u8981\u306a\u8a3c\u62e0\u3067\u3059\u3002<br>\r\n\u3055\u3089\u306b\u3001\u30c7\u30b8\u30bf\u30ebPCR\u306b\u3088\u308b\u89e3\u6790\u3067\u306f\u3001<i>SOD1<\/i>\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\u306e\u767a\u73fe\u91cf\u306b\u306f\u767a\u75c7\u8005\u3068\u5065\u5e38\u5bfe\u7167\u8005\u3067\u5909\u5316\u304c\u306a\u3044\u3053\u3068\u3082\u78ba\u8a8d\u3055\u308c\u307e\u3057\r\n\u305f\u3002\u3053\u308c\u306b\u52a0\u3048\u3066\u3001SOD1\u95a2\u9023ALS\u304c\u2f5a\u89aa\u306e\u307f\u304b\u3089\u907a\u4f1d\u2f26\u5909\u7570\u3092\u53d7\u3051\u7d99\u3050\u3053\u3068\u3067\u767a\u75c7\u3059\u308b\u5e38\u67d3\u2f8a\u4f53\u9855\u6027\uff08\u512a\u6027\uff09\u907a\u4f1d\u5f62\u5f0f\u3067\u3042\u308b\u3053\u3068\u3092\u8e0f\r\n\u307e\u3048\u308b\u3068\u3001\u4eca\u56de\u306ep.Val120dup\u5909\u7570\u578bSOD1\u306f\u3001\u767a\u73fe\u91cf\u306e\u5909\u5316\u306b\u3088\u3063\u3066ALS\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u3067\u306f\u306a\u304f\u3001\u75c5\u6c17\u3092\u5f15\u304d\u8d77\u3053\u3059\u6a5f\u80fd\u3092\u65b0\u305f\u306b\u7372\u5f97\r\n\u3059\u308b\u3053\u3068\uff08gain of function\uff09\u3067ALS\u306e\u767a\u75c7\u306b\u2f84\u308b\u3053\u3068\u304c\u2f70\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\r\n<h3>\uff14\uff0eALS\u306e\u65b0\u898f\u6cbb\u7642\u85ac\u30c8\u30d5\u30a7\u30eb\u30bb\u30f3\u3068\u500b\u5225\u5316\u533b\u7642<\/h3>\r\n<p>\r\nSOD1\u95a2\u9023ALS\u3067\u306f\u3001SOD1\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u6838\u9178\u6cbb\u7642\u85ac\u300c\u30c8\u30d5\u30a7\u30eb\u30bb\u30f3\u300d\u304c\u3001\u2f47\u672c\u3067\u3082\u7d041\u5e74\u524d\u306b\u627f\u8a8d\u3055\u308c\u3001\u5b9f\u969b\u306e\u6cbb\u7642\u306b\r\n\u2f64\u3044\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u30c8\u30d5\u30a7\u30eb\u30bb\u30f3\u306f\u3001<i>SOD1<\/i>\u907a\u4f1d\u2f26\u304b\u3089\u4f5c\u3089\u308c\u308bSOD1\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u5909\u7570\u578b\u3092\u542b\u3080\uff09\u306e\u91cf\u3092\u6e1b\u3089\u3059\u3053\u3068\u3067\u3001\u795e\r\n\u7d4c\u7d30\u80de\u306e\u5909\u6027\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u85ac\u3067\u3059\u3002\u672c\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3001SOD1\u306e\u69cb\u9020\u5909\u5316\u3084\u3001\u65b0\u305f\u306a\u75c5\u539f\u6027\u6a5f\u80fd\u306e\u7372\u5f97(gain of\r\nfunction\uff09\u3068\u3044\u3063\u305f\u75c5\u614b\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u30c8\u30d5\u30a7\u30eb\u30bb\u30f3\u6cbb\u7642\u306e\u9069\u5fdc\u5bfe\u8c61\u306b\u306a\u308b\u3053\u3068\u3092\u2f70\u3057\u3066\u3044\u307e\u3059 \u3002\u3055\u3089\u306b\u3001\u672c\u7814\u7a76\u306f\u3001\u60a3\u8005\u3055\u3093\u3054\u3068\u306b\u7570\r\n\u306a\u308b<i>SOD1<\/i>\u907a\u4f1d\u2f26\u306e\u5909\u7570\u306b\u5fdc\u3058\u3066\u6700\u9069\u306a\u6cbb\u7642\u3092\u9078\u3076\u300c\u500b\u5225\u5316\u533b\u7642\u300d\u306e\u91cd\u8981\u6027\u3092\u2f70\u3057\u3066\u3044\u307e\u3059\u3002\r\n<\/p>\r\n<h3>\u307e\u3068\u3081<\/h3>\r\n<p>\r\n\u672c\u7814\u7a76\u3067\u306f\u3001SOD1\u95a2\u9023ALS\u306e\u2f47\u672c\u2f081\u5bb6\u7cfb\u306b\u304a\u3044\u3066\u3001\u4e16\u754c\u7684\u306b\u7a00\u5c11\u306a\u65b0\u3057\u3044<i>SOD1<\/i>\u907a\u4f1d\u2f26\u5909\u7570\uff08\u30a4\u30f3\u30d5\u30ec\u30fc\u30e0\u91cd\u8907\u5909\u7570\uff09\u3092\u540c\u5b9a\u3057\u3001\u4e88\u6e2c\r\n\u3055\u308c\u308bSOD1\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u5909\u5316\u304a\u3088\u3073\u75c5\u614b\u6a5f\u5e8f\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u4eca\u56de\u306e\u6210\u679c\u306f\u3001SOD1\u95a2\u9023ALS\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u7406\u89e3\u3092\u6df1\u3081\u308b\u3068\r\n\u3068\u3082\u306b\u3001ALS\u306e\u500b\u5225\u5316\u6cbb\u7642\u3084\u5c06\u6765\u7684\u306a\u907a\u4f1d\u2f26\u6cbb\u7642\u306e\u767a\u5c55\u306b\u8ca2\u732e\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\r\n<\/p>\r\n<h3>\u2f64\u8a9e\u89e3\u8aac<\/h3>\r\n<p>\r\n<b>\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\uff1a<\/b><br>\r\nALS\u306f\u3001\u4f53\u3092\u52d5\u304b\u3059\u6307\u4ee4\u3092\u51fa\u3059\u795e\u7d4c\uff08\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\uff09\u304c\u5f90\u3005\u306b\u969c\u5bb3\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u2f3f\u2f9c\u3084\u306e\u3069\u3001\u547c\u5438\u306b\r\n\u95a2\u308f\u308b\u7b4b\u2f81\u304c\u6b21\u7b2c\u306b\u3084\u305b\u3066\u5f31\u304f\u306a\u3063\u3066\u3044\u304f\u9032\u2f8f\u6027\u306e\u75c5\u6c17\u3067\u3059\u3002ALS\u306e\u591a\u304f\u306f\u907a\u4f1d\u3068\u306f\u95a2\u4fc2\u306a\u304f\u767a\u75c7\u3057\u307e\u3059\u304c\u3001\u5168\u4f53\u306e\u7d045\u301c10\uff05\u306f\u907a\u4f1d\u2f26\r\n\u306e\u5909\u5316\uff08\u5909\u7570\uff09\u304c\u539f\u56e0\u3067\u8d77\u3053\u308a\u3001\u300c\u5bb6\u65cf\u6027ALS\u300d\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u2f47\u672c\u2f08\u3067\u306f\u3001<i>SOD1<\/i>\u907a\u4f1d\u2f26\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u2f63\u3058\u308b\u300cSOD1\u95a2\u9023ALS\u300d\u304c\u5bb6\r\n\u65cf\u6027ALS\u306e\u4e2d\u3067\u6700\u3082\u591a\u304f\u3001\u7d0440\uff05\u3092\u5360\u3081\u3066\u3044\u307e\u3059<sup>1)<\/sup> \u3002SOD1\u95a2\u9023ALS\u306e\u591a\u304f\u306f\u3001\u5e38\u67d3\u2f8a\u4f53\u9855\u6027\uff08\u512a\u6027\uff09\u907a\u4f1d\u5f62\u5f0f\u3092\u3068\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u4e21\u89aa\r\n\u306e\u3046\u3061\u3069\u3061\u3089\u304b\u2f00\u2f45\u304b\u3089\u75c5\u6c17\u306e\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u2f26\u5909\u7570\u3092\u53d7\u3051\u7d99\u3050\u3053\u3068\u3067\u767a\u75c7\u3059\u308b\u30bf\u30a4\u30d7\u3067\u3059\u3002<\/p>\r\n<p>\r\n<b>SOD1\uff1a<\/b><br>\r\n\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30b8\u30b9\u30e0\u30bf\u30fc\u30bc1\uff08SOD1\uff09\u306f\u3001\u4f53\u5185\u3067\u767a\u2f63\u3059\u308b\u6d3b\u6027\u9178\u7d20\u306e\u2f00\u7a2e\u300c\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u300d\u3092\u904e\u9178\u5316\u2f54\u7d20\u3078\u5909\u63db\u3059\u308b\u9175\r\n\u7d20\u3067\u3042\u308a\u3001\u7d30\u80de\u3092\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u5b88\u308b\u50cd\u304d\u3092\u3082\u3064\u6297\u9178\u5316\u9175\u7d20\u3067\u3059\u3002\u307e\u305f\u3001<i>SOD1<\/i>\u907a\u4f1d\u2f26\u306e\u5909\u7570\u306f\u3001\u5bb6\u65cf\u6027ALS\u306e\u539f\u56e0\u306e\u2f00\u3064\u3068\u3055\u308c\u3066\u3044\r\n\u307e\u3059\u3002<br>\r\n<\/p>\r\n<H4>\u91ce\u2f63\u578b\u3068\u5909\u7570\u578b<\/H4><p>\r\n<b>\u91ce\u2f63\u578b\uff1a<\/b>\u591a\u304f\u306e\u2f08\u306b\u5171\u901a\u3057\u3066\u307f\u3089\u308c\u308b\u6a19\u6e96\u7684\u907a\u4f1d\u2f26\u914d\u5217\u3092\u6301\u3061\u3001\u7814\u7a76\u306b\u304a\u3051\u308b\u2f50\u8f03\u306e\u57fa\u6e96\u3068\u306a\u308b\u907a\u4f1d\u2f26\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u72b6\u614b\u3092\u6307\u3057\u307e\u3059\u3002<br>\r\n<b>\u5909\u7570\u578b\uff1a<\/b>\u907a\u4f1d\u2f26\u914d\u5217\u306b\u5909\u5316\uff08\u5909\u7570\uff09\u304c\u2f63\u3058\u305f\u72b6\u614b\u3092\u6307\u3057\u307e\u3059\u3002\u5909\u7570\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u306f\u3001\u4f5c\u3089\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u3084\u6a5f\u80fd\u304c\u5909\u5316\u3059\u308b\u3053\u3068\r\n\u304c\u3042\u308a\u307e\u3059\u3002<br>\r\n<\/p>\r\n<p>\r\n<b>\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\uff1a<\/b><br>\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u4f53\u306e\u4e2d\u3067\u50cd\u304f\u305f\u3081\u306b\u3001\u6b63\u3057\u3044\u2f74\u4f53\u69cb\u9020\u306b\u6298\u308a\u305f\u305f\u307e\u308c\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\r\n\u9020\u306b\u5909\u5316\u304c\u2f63\u3058\u308b\u3068\u3001\u6b63\u3057\u304f\u6298\u308a\u305f\u305f\u3081\u305a\u3001\u7570\u5e38\u306a\u5f62\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3092\u300c\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u300d\u3068\u547c\u3073\u307e\u3059\u3002<br>\r\n<\/p><p>\r\n<b>\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u6838\u9178\u6cbb\u7642\uff1a<\/b><br>\u7279\u5b9a\u306e\u907a\u4f1d\u2f26\u306e\u60c5\u5831\u3092\u3082\u3068\u306b\u4f5c\u3089\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u91cf\u3092\u6e1b\u3089\u3059\u6cbb\u7642\u6cd5\u3067\u3059\u3002ALS\u306e\u6cbb\u7642\u3067\u306f\u3001SOD1\u30bf\u30f3\u30d1\u30af\u8cea\r\n\u306e\u91cf\u3092\u6e1b\u3089\u3059\u85ac\u300c\u30c8\u30d5\u30a7\u30eb\u30bb\u30f3\u300d\u304c\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002\r\n<\/p>\r\n<h3>\u53c2\u8003\u2f42\u732e<\/h3>\r\n<p>\r\n1) Hiroya Naruse et al., Molecular epidemiological study of familial amyotrophic lateral sclerosis in Japanese population by wholeexome\r\nsequencing and identification of novel HNRNPA1 mutation, Neurobiology of Aging, Volume 61, 2018, Pages 255.e9-255.e16\r\n<a href=\"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.08.030\">https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.08.030<\/a>\r\n<\/p>\r\n<h5>\u63b2\u8f09\u8ad6\u6587<\/h5>\r\n<table class=\"citation\">\r\n<tbody>\r\n<tr>\r\n<td width=\"93\">\u767a\u8868\u96d1\u8a8c\uff1a<\/td>\r\n<td>Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2025 Dec 3:1-11.<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1a<\/td>\r\n<td><a href=\"https:\/\/doi.org\/10.1080\/21678421.2025.2593302\">Novel in-frame duplication variant of SOD1 in a Japanese family with familial amyotrophic lateral sclerosis<\/a><\/td>\r\n<\/tr>\r\n<tr>\r\n<td>\u7b46\u3000\u8005\uff1a<\/td>\r\n<td>Masanori Nakajima*, Hiroya Naruse*, Yuichi Riku, Kunihiro Ueda, Takashi Matsukawa, Jun Mitsui, Yoshitsugu Nakamura,\r\nShimon Ishida, Takashi Yamada, Naoki Moro, Naoki Kotsuki, Kentaro Nagai, Shin-ichi Tokushige, Ayumi Uchibori, Chizuko Oishi,\r\nHiroyuki Yabata, Makoto Urushitani, Yasushi Iwasaki, Hiroyuki Ishiura, Tatsushi Toda, Shoji Tsuji, Yaeko Ichikawa\r\n*These authors contributed equally to this work.\r\n\uff08\u4e2d\u5cf6 \u660c\u5178<sup>1<\/sup>, \u6210\u702c \u7d18\u4e5f<sup>2<\/sup>, \u9678 \u96c4\u2f00<sup>3<\/sup>, \u4e0a\u2f65 \u6d32\u88d5<sup>2<\/sup>, \u677e\u5ddd \u656c\u5fd7<sup>2<\/sup>, \u4e09\u4e95 \u7d14<sup>2,4<\/sup>, \u4e2d\u6751 \u5584\u80e4<sup>5<\/sup>, \u2f6f\u2f65 \u5fd7\u9580<sup>5<\/sup>, \u2f2d\u2f65 \u9686\u53f8<sup>6<\/sup>, \u8302\u5442 \u76f4\u7d00<sup>1<\/sup>, \u4e0a\u2f49 \u76f4\u6a39<sup>1<\/sup>, \u6c38\u4e95 \u5065\u592a\u90ce<sup>1<\/sup>, \u5fb3\u91cd \u771f\u2f00<sup>1<\/sup>, \u5185\u5800 \u6b69<sup>1<\/sup>, \u2f24\u2f6f \u77e5\u745e\u2f26<sup>1<\/sup>, \u2f6e\u7aef \u535a\u2f8f<sup>7<\/sup>, \u6f06\u2f95 \u771f<sup>7<\/sup>, \u5ca9\u5d0e \u9756<sup>3<\/sup>, \u2f6f\u6d66 \u6d69\u4e4b<sup>2,8<\/sup>, \u2f3e\u2f65 \u9054\u53f2<sup>2,9<\/sup>, \u8fbb \u7701\u6b21<sup>2,10<\/sup>, \u5e02\u5ddd \u5f25\u2f63\u2f26<sup>1<\/sup>\uff08\uff11\u8133\u795e\u7d4c\u5185\u79d1\u5b66, \uff12\u6771\u4eac\u2f24\u5b66\u2f24\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u795e\u7d4c\u5185\u79d1\u5b66, \uff13\u611b\u77e5\u533b\u79d1\u2f24\u5b66\u52a0\u9f62\u533b\u79d1\u5b66\u7814\u7a76\u6240\u795e\u7d4c\u75c5\u7406\u90e8\u9580, \uff14\u6771\u4eac\u2f24\u5b66\u2f24\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u30d7\u30ec\u30b7\r\n\u30b8\u30e7\u30f3\u30e1\u30c7\u30a3\u30b7\u30f3\u795e\u7d4c\u5b66, 5\u2f24\u962a\u533b\u79d1\u85ac\u79d1\u2f24\u5b66\u8133\u795e\u7d4c\u5185\u79d1, 6\u2f24\u962a\u533b\u79d1\u85ac\u79d1\u2f24\u5b66\u75c5\u7406\u5b66, 7\u6ecb\u8cc0\u533b\u79d1\u2f24\u5b66\u8133\u795e\u7d4c\u5185\u79d1\u5b66, 8\u5ca1\u2f2d\u2f24\u5b66\u2f24\u5b66\u9662\u533b\u2eed\r\n\u85ac\u5b66\u7dcf\u5408\u7814\u7a76\u79d1\u8133\u795e\u7d4c\u5185\u79d1\u5b66, 9\u56fd\u2f74\u7cbe\u795e\u30fb\u795e\u7d4c\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u75c5\u9662, 10 \u56fd\u969b\u533b\u7642\u798f\u7949\u2f24\u5b66\u30b2\u30ce\u30e0\u533b\u5b66\u7814\u7a76\u6240)\uff09<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>DOI:<\/td>\r\n<td><a href=\"https:\/\/doi.org\/10.1080\/21678421.2025.2593302\">10.1080\/21678421.2025.2593302<\/a><\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n&nbsp;\r\n\r\n\r\n<h3>\u554f\u3044\u5408\u308f\u305b\u5148<\/h3>\r\n\r\n\r\n<p class=\"noIndmt10\">\u674f\u6797\u5b66\u5712\u5e83\u5831\u5ba4\r\n\u5e83\u5831\u5ba4\u3078\u306e\u304a\u554f\u3044\u5408\u308f\u305b\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/contact\/\">\u3053\u3061\u3089<\/a>\u307e\u3067<\/p>","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u5e02\u5ddd \u5f25\u2f63\u5b50\uff08\u8133\u795e\u7d4c\u5185\u79d1\u5b66\u30fb\u6559\u6388\uff09 \u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8 \u2f47\u672c\u2f08\u306e\u5bb6\u65cf\u6027ALS\u306e1\u5bb6\u7cfb\u304b\u3089\u3001SOD1\u907a\u4f1d\u2f26\u306e\u65b0\u305f\u306a\u5909\u7570\u3092\u767a\u2f92\u3057\u307e\u3057\u305f\u3002 \u3053\u306e\u5909\u7570\u306f\u4e16\u754c\u7684\u306b\u3082\u6975\u3081\u3066\u307e\u308c\u306a\u300c\u30a4\u30f3\u30d5\u30ec\u30fc\u30e0\u91cd\u8907\u578b\u300d\u306eSOD1\u907a\u4f1d\u2f26\u5909\u7570 [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-7885","post","type-post","status-publish","format-standard","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/7885","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/comments?post=7885"}],"version-history":[{"count":61,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/7885\/revisions"}],"predecessor-version":[{"id":8004,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/7885\/revisions\/8004"}],"wp:attachment":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media?parent=7885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/categories?post=7885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/tags?post=7885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}