{"id":8790,"date":"2026-10-16T16:25:04","date_gmt":"2026-10-16T07:25:04","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/?p=8790"},"modified":"2026-10-16T16:25:04","modified_gmt":"2026-10-16T07:25:04","slug":"%e3%82%b0%e3%83%aa%e3%82%aa%e3%83%bc%e3%83%9e%e3%81%ab%e5%8f%96%e3%82%8a%e5%9b%b2%e3%81%be%e3%82%8c%e3%81%9f%e7%a5%9e%e7%b5%8c%e7%b4%b0%e8%83%9e%e3%81%a7%e3%81%af%e3%80%81%e4%bd%95%e3%81%8c%e8%b5%b7","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/archive\/8790\/","title":{"rendered":"\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u53d6\u308a\u56f2\u307e\u308c\u305f\u795e\u7d4c\u7d30\u80de\u3067\u306f\u3001\u4f55\u304c\u8d77\u304d\u3066\u3044\u308b\u306e\u304b\uff1f<br \/> \u2015\u7a7a\u9593\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u3067\u898b\u3048\u3066\u304d\u305f\u65b0\u305f\u306a\u30b0\u30ea\u30aa\u30fc\u30de-\u795e\u7d4c\u76f8\u4e92\u4f5c\u7528\u2015"},"content":{"rendered":"<head>\r\n <style type=\"text\/css\">\r\n <!--\r\n        .fig1 {float:left;}\r\n        .fig2 {float:right;}\r\n        .fig0 {clear:both;}\r\n\r\nfigure {\r\n  margin: 1em 0; \/* \u4e0a\u4e0b\u306e\u9699\u9593\u306e\u307f\u6b8b\u3059 *\/\r\n  padding: .5em;\r\n  text-align: center; \/* \u753b\u50cf\u3068\u6ce8\u91c8\u3092\u4e2d\u592e\u5bc4\u305b *\/\r\n  border: solid 0px silver; \/* \u5468\u308a\u3092\u7dda\u3067\u56f2\u3046 1px\u4ee5\u4e0a\u306b\u3059\u308b\u3068\u7dda\u304c\u8868\u793a\u3055\u308c\u308b*\/\r\n}\r\n\r\nfigcaption {\r\n  margin-top: .5em; \/* \u753b\u50cf\u3068\u6ce8\u91c8\u306e\u9699\u9593 *\/\r\n  font-size: .9em;\r\n}\r\n\r\n-->\r\n <\/style>\r\n <\/head>\r\n \r\n <!-- <h2 style=\"text-align: left;\">\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u53d6\u308a\u56f2\u307e\u308c\u305f\u795e\u7d4c\u7d30\u80de\u3067\u306f\u3001\u4f55\u304c\u8d77\u304d\u3066\u3044\u308b\u306e\u304b\uff1f<br \/>\r\n\u2015\u7a7a\u9593\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u3067\u898b\u3048\u3066\u304d\u305f\u65b0\u305f\u306a\u30b0\u30ea\u30aa\u30fc\u30de-\u795e\u7d4c\u76f8\u4e92\u4f5c\u7528\u2015<\/h2> -->\r\n \r\n<div align=\"right\">\r\n\t<p><b>\u91cc\u898b \u4ecb\u53f2\uff08\u75c5\u7406\u5b66\u6559\u5ba4\u30fb\u51c6\u6559\u6388\uff09<\/b><\/p>\r\n<\/div>\r\n\r\n<h3>\u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8<\/h3>\r\n<div style=\u201dmargin-left: 1em; text-indent: -1em;\u201d>\r\n<ul>\r\n<li>\u8fd1\u5e74\u3001\u6b63\u5e38\u795e\u7d4c\u7d30\u80de\u306e\u6d3b\u52d5\u304c\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u9032\u5c55\u30fb\u5897\u6b96\u3092\u4fc3\u3059\u3053\u3068\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u795e\u7d4c\u7d30\u80de\u81ea\u4f53\u304c\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3059\u308b\u306e\u304b\u306f\u5341\u5206\u306b\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/li>\r\n<li>\u672c\u7814\u7a76\u3067\u306f\u3001\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6d78\u6f64\u5148\u9032\u90e8\u306b\u6b8b\u5b58\u3059\u308b\u795e\u7d4c\u7d30\u80de\u306b\u7740\u76ee\u3057\u3001\u75c5\u7406\u7d44\u7e54\u5207\u7247\u4e0a\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u89e3\u6790\u3067\u304d\u308b\u7a7a\u9593\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/li>\r\n<li>\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u306b\u56f2\u307e\u308c\u305f\u795e\u7d4c\u7d30\u80de\u3067\u306fIGFBP5\u306e\u767a\u73fe\u4e0a\u6607\u304c\u307f\u3089\u308c\u3001\u540c\u3058\u9818\u57df\u306e\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u3067\u306fTGF-\u03b2\u95a2\u9023\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u3092\u793a\u5506\u3059\u308bpSMAD2\u967d\u6027\u50cf\u3092\u8a8d\u3081\u307e\u3057\u305f\u3002<\/li>\r\n<li>IGFBP5\u306f\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306e\u5909\u5316\u3084\u7dda\u7dad\u5316\u306b\u95a2\u9023\u3059\u308b\u5206\u5b50\u3067\u3042\u308a\u3001\u795e\u7d4c\u7d30\u80de\u306e\u72b6\u614b\u5909\u5316\u306bTGF-\u03b2\u95a2\u9023\u30b7\u30b0\u30ca\u30eb\u304c\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\r\n<li>\u672c\u7814\u7a76\u306f\u3001\u300c\u795e\u7d4c\u7d30\u80de\u304c\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u300d\u3060\u3051\u3067\u306a\u304f\u3001\u300c\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u795e\u7d4c\u7d30\u80de\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u300d\u3068\u3044\u3046\u9006\u65b9\u5411\u304b\u3089\u3082\u6349\u3048\u308b\u3001\u65b0\u305f\u306a\u7814\u7a76\u306e\u65b9\u5411\u6027\u3092\u63d0\u793a\u3057\u307e\u3057\u305f\u3002<\/li>\r\n<\/ul>\r\n<\/div>\r\n\r\n<br \/>\r\n\r\n<h3>\u6982\u8981<\/h3>\r\n<p><b>\u795e\u7d4c\u7d30\u80de\u304c\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u9032\u5c55\u30fb\u5897\u6b96\u3092\u52a9\u3051\u308b<\/b><\/p>\r\n<p>\u30b0\u30ea\u30aa\u30fc\u30de\u306f\u3001\u5468\u56f2\u306e\u6b63\u5e38\u306a\u8133\u7d44\u7e54\u306b\u3057\u307f\u8fbc\u3080\u3088\u3046\u306b\u5e83\u304c\u308b\u8133\u816b\u760d\u3067\u3059\u3002\u8fd1\u5e74\u3001\u795e\u7d4c\u7d30\u80de\u3068\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u306e\u9593\u306b\u30b7\u30ca\u30d7\u30b9\u69d8\u306e\u7d50\u5408\u304c\u5f62\u6210\u3055\u308c\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6d3b\u52d5\u304c\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u306b\u4f1d\u308f\u308b\u3053\u3068\u3067\u3001\u305d\u306e\u9032\u5c55\u30fb\u5897\u6b96\u3092\u52a9\u3051\u308b\u3053\u3068\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u795e\u7d4c\u7d30\u80de\u3068\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u306e\u7d50\u5408\u306f\u300c\u30cb\u30e5\u30fc\u30ed\u30f3\uff0d\u30b0\u30ea\u30aa\u30fc\u30de\u30b7\u30ca\u30d7\u30b9\u300d\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u9006\u306b\u3001\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u306b\u56f2\u307e\u308c\u305f\u795e\u7d4c\u7d30\u80de\u81ea\u4f53\u304c\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3059\u308b\u306e\u304b\u306f\u5341\u5206\u306b\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\r\n\r\n<p><b>\u30b0\u30ea\u30aa\u30fc\u30de\u6d78\u6f64\u90e8\u3067\u306f\u795e\u7d4c\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u72b6\u614b\u304c\u5909\u5316\u3059\u308b<\/b><\/p>\r\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u75c5\u7406\u7d44\u7e54\u5207\u7247\u4e0a\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u89e3\u6790\u3067\u304d\u308b\u7a7a\u9593\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\uff08Xenium In Situ\uff09\u3092\u7528\u3044\u3066\u3001\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u3084\u795e\u7d4c\u7d30\u80de\u304c\u816b\u760d\u5185\u306e\u4f4d\u7f6e\u306b\u3088\u3063\u3066\u3069\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u72b6\u614b\u3092\u793a\u3059\u306e\u304b\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u306b\u306f\u8907\u6570\u306e\u7570\u306a\u308b\u7d30\u80de\u72b6\u614b\u304c\u5b58\u5728\u3057\u3001POSTN\u3092\u9ad8\u304f\u767a\u73fe\u3059\u308b\u96c6\u56e3\u3068\u3001TGFB2\u3092\u542b\u3080TGF-\u03b2\u95a2\u9023\u30b7\u30b0\u30ca\u30eb\u304c\u76ee\u7acb\u3064\u96c6\u56e3\u304c\u3001\u7a7a\u9593\u7684\u306b\u7570\u306a\u308b\u5206\u5e03\u3092\u793a\u3059\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\r\n\u3055\u3089\u306b\u3001\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u306b\u56f2\u307e\u308c\u305f\u795e\u7d4c\u7d30\u80de\u3067\u306f\u3001\u816b\u760d\u304b\u3089\u96e2\u308c\u305f\u975e\u6d78\u6f64\u90e8\u306e\u795e\u7d4c\u7d30\u80de\u3068\u6bd4\u3079\u3066\u3001IGFBP5\u3068\u3044\u3046\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306e\u5909\u5316\u3084\u7dda\u7dad\u5316\u306b\u95a2\u9023\u3059\u308b\u5206\u5b50\u306e\u767a\u73fe\u304c\u9ad8\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\r\n\r\n<p><b>TGF-\u03b2\u95a2\u9023\u30b7\u30b0\u30ca\u30eb\u304c\u795e\u7d4c\u7d30\u80de\u306e\u5909\u5316\u306b\u95a2\u4e0e\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044<\/b><\/p>\r\n<p>\u305d\u3053\u3067\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u306b\u3088\u308a\u30b0\u30ea\u30aa\u30fc\u30de\u6d78\u6f64\u9818\u57df\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u795e\u7d4c\u7d30\u80de\u306bTGF-\u03b2\u95a2\u9023\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u3092\u793a\u3059pSMAD2\u967d\u6027\u50cf\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u304b\u3089\u3001\u30b0\u30ea\u30aa\u30fc\u30de\u6d78\u6f64\u90e8\u306b\u304a\u3051\u308b\u795e\u7d4c\u7d30\u80de\u306e\u72b6\u614b\u5909\u5316\u306b\u3001TGF-\u03b2\u95a2\u9023\u30b7\u30b0\u30ca\u30eb\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\r\n\u672c\u7814\u7a76\u306f\u5358\u4e00\u75c7\u4f8b\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u63a2\u7d22\u7684\u691c\u8a0e\u3067\u3059\u304c\u3001\u300c\u795e\u7d4c\u7d30\u80de\u304c\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u300d\u3060\u3051\u3067\u306a\u304f\u3001\u300c\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u795e\u7d4c\u7d30\u80de\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u300d\u3068\u3044\u3046\u9006\u65b9\u5411\u304b\u3089\u3082\u4e21\u8005\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u6349\u3048\u308b\u3001\u65b0\u305f\u306a\u7814\u7a76\u306e\u65b9\u5411\u6027\u3092\u63d0\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\r\n\r\n<p><b>\u4eca\u5f8c\u306e\u5c55\u671b<\/b><\/p>\r\n<p>\u30b0\u30ea\u30aa\u30fc\u30de\u3092\u542b\u3080\u304c\u3093\uff08\u60aa\u6027\u816b\u760d\uff09\u306e\u8a3a\u65ad\u306b\u306f\u3001\u9855\u5fae\u93e1\u3067\u7d44\u7e54\u306e\u5f62\u3092\u89b3\u5bdf\u3059\u308b\u75c5\u7406\u8a3a\u65ad\u304c\u6b20\u304b\u305b\u307e\u305b\u3093\u3002\u79c1\u305f\u3061\u306f\u300c\u5f62\u614b\u3068\u3044\u3046\u66f8\u7269\u306f\u5206\u5b50\u306e\u8a00\u8449\u3067\u66f8\u304b\u308c\u3066\u3044\u308b\u300d\u3092\u4e00\u3064\u306e\u5408\u8a00\u8449\u3068\u3057\u3066\u3001\u3053\u308c\u304b\u3089\u3082\u5f62\u614b\u5b66\u306b\u6839\u5dee\u3057\u305f\u5206\u5b50\u751f\u7269\u5b66\u7684\u89e3\u6790\u3092\u901a\u3058\u3066\u3001\u304c\u3093\u306e\u7406\u89e3\u3092\u6df1\u3081\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\r\n\r\n<!-- class\u3092\u4f7f\u308f\u306a\u3044\u5834\u5408\u3000-->\r\n<figure id=\"Fig.1\" style=\"text-align: center;\"> \r\n<a href=\"\/univ\/faculty\/medicine\/uploads\/2026\/10\/Figure1.jpg\" target=\"_blank\"><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/2026\/10\/Figure1.jpg\" style=\"margin: 20px; width: 80%; border-width: 0px;\" alt=\"\u6982\u5ff5\u56f31\"><\/a>\r\n<figcaption style=\"text-align: left; text-indent: -1em; padding-left: 2em; padding-right: 2em;\"><b>\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u795e\u7d4c\u7d30\u80de\u306e\u76f8\u4e92\u4f5c\u7528<\/b>\r\n<br \/>\r\n\u8fd1\u5e74\u3001\u795e\u7d4c\u7d30\u80de\u304b\u3089\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u3078\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304c\u816b\u760d\u306e\u9032\u5c55\u30fb\u5897\u6b96\u3092\u4fc3\u3059\u300c\u30cb\u30e5\u30fc\u30ed\u30f3\uff0d\u30b0\u30ea\u30aa\u30fc\u30de\u30b7\u30ca\u30d7\u30b9\u300d\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u9006\u306b\u3001\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u306b\u56f2\u307e\u308c\u305f\u795e\u7d4c\u7d30\u80de\u306e\u5909\u5316\u306b\u7740\u76ee\u3057\u305f\u3068\u3053\u308d\u3001IGFBP5\u306e\u767a\u73fe\u4e0a\u6607\u3068pSMAD2\u306e\u967d\u6027\u50cf\u3092\u8a8d\u3081\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u304b\u3089\u3001\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u6d78\u6f64\u90e8\u306b\u6b8b\u5b58\u3059\u308b\u795e\u7d4c\u7d30\u80de\u306e\u72b6\u614b\u5909\u5316\u306b\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/figcaption>\r\n<\/figure>\r\n\r\n<!--class\u3092\u4f7f\u3046\u5834\u5408\r\n<figure id=\"Fig.2\" class=\"fig2\">\u3000\r\n\r\n<a href=\"\/univ\/faculty\/medicine\/uploads\/2026\/10\/Figure1.jpg\" target=\"_blank\"><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/2026\/10\/Figure1.jpg\" style=\"margin: \u4e0a\u4e0b\u5de6\u53f3\u30de\u30fc\u30b8\u30f320px; width: \u5e45\u306b\u5bfe\u3059\u308b\u5272\u5408 60%; border-width: 0px;\" alt=\"\u6982\u5ff5\u56f32\"><\/a>\r\n<figcaption><b>\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u795e\u7d4c\u7d30\u80de\u306e\u76f8\u4e92\u4f5c\u7528<\/b><br>\r\n\u8fd1\u5e74\u3001\u795e\u7d4c\u7d30\u80de\u304b\u3089\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u3078\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304c\u816b\u760d\u306e\u9032\u5c55\u30fb\u5897\u6b96\u3092\u4fc3\u3059\u300c\u30cb\u30e5\u30fc\u30ed\u30f3\uff0d\u30b0\u30ea\u30aa\u30fc\u30de\u30b7\u30ca\u30d7\u30b9\u300d\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u9006\u306b\u3001\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u306b\u56f2\u307e\u308c\u305f\u795e\u7d4c\u7d30\u80de\u306e\u5909\u5316\u306b\u7740\u76ee\u3057\u305f\u3068\u3053\u308d\u3001IGFBP5\u306e\u767a\u73fe\u4e0a\u6607\u3068pSMAD2\u306e\u967d\u6027\u50cf\u3092\u8a8d\u3081\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u304b\u3089\u3001\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u6d78\u6f64\u90e8\u306b\u6b8b\u5b58\u3059\u308b\u795e\u7d4c\u7d30\u80de\u306e\u72b6\u614b\u5909\u5316\u306b\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/figcaption>\r\n<\/figure> \u3000-->\r\n\r\n\r\n<br \/ class=\"fig0\">\r\n\r\n<h3>\u7528\u8a9e\u89e3\u8aac<\/h3>\r\n<div style=\"padding-left: 10em; text-indent: -10em;\">\r\n\t<p><b>\u7a7a\u9593\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\uff1a<\/b><br \/>\u75c5\u7406\u7d44\u7e54\u5207\u7247\u4e0a\u3067\u7d44\u7e54\u306e\u5f62\u3092\u4fdd\u3063\u305f\u307e\u307e\u3001\u3069\u306e\u7d30\u80de\u3067\u3069\u306e\u907a\u4f1d\u5b50\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u304b\u3092\u53ef\u8996\u5316\u3067\u304d\u308b\u65b0\u3057\u3044\u89e3\u6790\u6cd5\u3067\u3059\u3002<\/p>\r\n\t<p><b>\u30b0\u30ea\u30aa\u30fc\u30de\uff08\u795e\u7d4c\u81a0\u816b\uff09\uff1a<\/b><br \/>\u8133\u3092\u69cb\u6210\u3059\u308b\u30b0\u30ea\u30a2\u7cfb\u7d30\u80de\u306e\u7279\u5fb4\u3092\u793a\u3059\u8133\u816b\u760d\u306e\u7dcf\u79f0\u3067\u3001\u7279\u306b\u60aa\u6027\u5ea6\u306e\u9ad8\u3044\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u306f\u5468\u56f2\u306e\u6b63\u5e38\u306a\u8133\u7d44\u7e54\u306b\u6d78\u6f64\u3057\u3066\u5e83\u304c\u308b\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\r\n\t<p><b>\u514d\u75ab\u7d44\u7e54\u5316\u5b66\uff1a<\/b><br \/>\u75c5\u7406\u7d44\u7e54\u5207\u7247\u4e0a\u3067\u3001\u6297\u539f\u6297\u4f53\u53cd\u5fdc\u3092\u5229\u7528\u3057\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5c40\u5728\u3092\u53ef\u8996\u5316\u3059\u308b\u5f62\u614b\u5b66\u7684\u6280\u8853\u3067\u3059\u3002<\/p>\r\n\t<p><b>pSMAD2\uff08\u30ea\u30f3\u9178\u5316SMAD2\uff09\uff1a<\/b><br \/>TGF-\u03b2\u304b\u3089\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u53d7\u3051\u3066\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001TGF-\u03b2\u95a2\u9023\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u3092\u8a55\u4fa1\u3059\u308b\u6307\u6a19\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u307e\u3059\u3002<\/p>\r\n<\/div>\r\n\r\n<h3>\u63b2\u8f09\u8ad6\u6587<\/h3>\r\n\r\n<table class=\"citation\">\r\n <tr>\r\n  <td width=93>\u767a\u8868\u96d1\u8a8c\uff1a<\/td><td width=860>Brain Pathology [ 2026 Sep 29:e70154 ]<\/td>\r\n <\/tr>\r\n<tr>\r\n  <td>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1a<\/td><td><a href=\"http:\/\/doi.org\/10.1111\/bpa.70154\"  target=\"_blank\">Spatial transcriptomic analysis of neurons at the glioma infiltration front: a case study<\/a><\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>\u7b46\u3000\u8005\uff1a<\/td><td>Satomi K, Takami H, Onizuka H, Saito K, Yoshioka T, Nagane M, Suzuki Y, Ichimura K, Shibahara J\r\n<br \/>\uff08\u91cc\u898b\u4ecb\u53f2\uff0c\u9ad9\u898b\u6d69\u6570\uff0c\u9b3c\u585a\u88d5\u7f8e\uff0c\u9f4a\u85e4\u90a6\u662d\uff0c\u7fa9\u5ca1\u5b5d\u5b50\uff0c\u6c38\u6839\u57fa\u96c4\uff0c\u9234\u6728\u7a63\uff0c\u5e02\u6751\u5e78\u4e00\uff0c\u67f4\u539f\u7d14\u4e8c\uff09<\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>DOI:<\/td>  <td>10.1111\/bpa.70154<\/td>\r\n <\/tr>\r\n<\/table>\r\n<br \/>\r\n<div>\r\n<p>\u75c5\u7406\u5b66\u6559\u5ba4\u306e\u8a73\u7d30\u306f<a href=\"http:\/\/https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/pathology\/\" target=\"_blank\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002<\/p>\r\n<\/div>\r\n<br \/>\r\n<h5>\u554f\u3044\u5408\u308f\u305b\u5148<\/h5>\r\n<p class=\"noIndmt10\">\u674f\u6797\u5b66\u5712\u5e83\u5831\u5ba4<br \/>\r\n\u3000\u3000\u5e83\u5831\u5ba4\u3078\u306e\u304a\u554f\u3044\u5408\u308f\u305b\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/contact\/\">\u3053\u3061\u3089<\/a>\u307e\u3067<br \/>\r\nTel: 0422-44-0611<br \/>\r\n<\/p>","protected":false},"excerpt":{"rendered":"<p>\u91cc\u898b \u4ecb\u53f2\uff08\u75c5\u7406\u5b66\u6559\u5ba4\u30fb\u51c6\u6559\u6388\uff09 \u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8 \u8fd1\u5e74\u3001\u6b63\u5e38\u795e\u7d4c\u7d30\u80de\u306e\u6d3b\u52d5\u304c\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u9032\u5c55\u30fb\u5897\u6b96\u3092\u4fc3\u3059\u3053\u3068\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u795e\u7d4c\u7d30\u80de\u81ea\u4f53\u304c\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3059\u308b\u306e\u304b\u306f\u5341\u5206\u306b\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002 \u672c\u7814\u7a76\u3067\u306f\u3001 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":8862,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-8790","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/8790","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/comments?post=8790"}],"version-history":[{"count":9,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/8790\/revisions"}],"predecessor-version":[{"id":8861,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/8790\/revisions\/8861"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media\/8862"}],"wp:attachment":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media?parent=8790"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/categories?post=8790"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/tags?post=8790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}