{"id":8867,"date":"2026-11-09T13:45:41","date_gmt":"2026-11-09T04:45:41","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/?p=8867"},"modified":"2026-11-09T13:47:56","modified_gmt":"2026-11-09T04:47:56","slug":"%e8%86%b5%e7%99%8c%e3%81%ae%e9%80%80%e5%bd%a2%e6%88%90%e5%a4%89%e5%8c%96%e3%82%92%e5%bd%a2%e6%85%8b%e3%81%a8%e5%88%86%e5%ad%90%e3%81%8b%e3%82%89%e8%aa%ad%e3%81%bf%e8%a7%a3%e3%81%8f","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/archive\/8867\/","title":{"rendered":"\u81b5\u764c\u306e\u9000\u5f62\u6210\u5909\u5316\u3092\u5f62\u614b\u3068\u5206\u5b50\u304b\u3089\u8aad\u307f\u89e3\u304f"},"content":{"rendered":"<head>\r\n <style type=\"text\/css\">\r\n <!--\r\n        .fig1 {float:left;}\r\n        .fig2 {float:right;}\r\n        .fig0 {clear:both;}\r\n\r\nfigure {\r\n  margin: 1em 0; \/* \u4e0a\u4e0b\u306e\u9699\u9593\u306e\u307f\u6b8b\u3059 *\/\r\n  padding: .5em;\r\n  text-align: center; \/* 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-1em;\u201d>\r\n<ul>\r\n<li>\u672c\u5b66\u75c5\u7406\u5b66\u6559\u5ba4\uff08\u67f4\u539f\u7d14\u4e8c\u6559\u6388\u3089\uff09\u304a\u3088\u3073\u7406\u5316\u5b66\u7814\u7a76\u6240\uff08\u304c\u3093\u30b2\u30ce\u30e0\u7814\u7a76\u30c1\u30fc\u30e0\u3001\u4e2d\u5ddd\u82f1\u5200\u30c7\u30a3\u30ec\u30af\u30bf\u30fc\u3089\uff09\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u7a7a\u9593\u7684\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306b\u3088\u308a\u3001\u9000\u5f62\u6210\u764c\u6210\u5206\u306b\u304a\u3051\u308b\u4e0a\u76ae\u9593\u8449\u8ee2\u63db\uff08EMT\uff09\u306e\u6d3b\u6027\u5316\u3068ELF3\u767a\u73fe\u306e\u4f4e\u4e0b\u3092\u8a8d\u3081\u307e\u3057\u305f\u3002<\/li>\r\n<li>\u30e1\u30e2\u30ea\u30a2\u30eb\u30fb\u30b9\u30ed\u30f3\u30b1\u30bf\u30ea\u30f3\u30b0\u304c\u3093\u30bb\u30f3\u30bf\u30fc\uff08MSK\u3001Iacobuzio-Donahue\u81b5\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u9577\u3089\uff09\u3068\u306e\u5171\u540c\u7814\u7a76\u3067MSK-IMPACT\u306e\u7d046,000\u4f8b\u306e\u901a\u5e38\u578b\u81b5\u764c\u306841\u4f8b\u306e\u9000\u5f62\u6210\u764c\uff08\u672a\u5206\u5316\u764c\uff09\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6bd4\u8f03\u3057\u3001\u9000\u5f62\u6210\u764c\u306b\u7279\u5fb4\u7684\u306a\u5909\u7570\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/li>\r\n<li>SMAD4\u3068ELF3\u306e\u767a\u73fe\u30fb\u6d3b\u6027\u306e\u95a2\u4fc2\u306b\u7740\u76ee\u3057\u3001\u81b5\u764c\u306e\u672a\u5206\u5316\u8ee2\u5316\u306b\u95a2\u308f\u308b\u5206\u5b50\u6a5f\u69cb\u306e\u4e00\u7aef\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/li>\r\n<\/ul>\r\n<\/div>\r\n\r\n<br \/>\r\n\r\n<h3>\u6982\u8981<\/h3>\r\n<p>\u81b5\u764c\u306f\u3001\u65e9\u671f\u767a\u898b\u304c\u96e3\u3057\u304f\u3001\u73fe\u5728\u3082\u6cbb\u7642\u304c\u56f0\u96e3\u306a\u60aa\u6027\u816b\u760d\u306e\u4e00\u3064\u3067\u3059\u3002\u306a\u304b\u3067\u3082\u9000\u5f62\u6210\u764c\uff08\u672a\u5206\u5316\u764c\uff09\u306f\u3001\u901a\u5e38\u306e\u81b5\u7ba1\u764c\u3068\u6bd4\u8f03\u3057\u3066\u7d30\u80de\u306e\u5f62\u614b\u304c\u8457\u3057\u304f\u7570\u306a\u308a\u3001\u6025\u901f\u306b\u9032\u884c\u3059\u308b\u7a00\u306a\u7d44\u7e54\u578b\u3067\u3059\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u4e00\u3064\u306e\u816b\u760d\u306e\u4e2d\u306b\u3001\u817a\u7ba1\u69cb\u9020\u3092\u4fdd\u3064\u901a\u5e38\u578b\u81b5\u764c\u3068\u3001\u817a\u7ba1\u69cb\u9020\u3092\u5931\u3063\u305f\u9000\u5f62\u6210\u764c\uff08\u672a\u5206\u5316\u764c\uff09\u304c\u6df7\u5728\u3059\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u6240\u898b\u306f\u3001\u81b5\u764c\u304c\u9032\u5c55\u306e\u904e\u7a0b\u3067\u7d30\u80de\u306e\u5f62\u614b\u3084\u6027\u8cea\u3092\u5909\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u5909\u5316\u3092\u751f\u307f\u51fa\u3059\u5206\u5b50\u6a5f\u69cb\u306f\u5341\u5206\u306b\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<br \/>\r\n\u672c\u7814\u7a76\u3067\u306f\u3001\u672c\u5b66\u75c5\u7406\u5b66\u6559\u5ba4\u304a\u3088\u3073\u7406\u5316\u5b66\u7814\u7a76\u6240\uff08\u304c\u3093\u30b2\u30ce\u30e0\u7814\u7a76\u30c1\u30fc\u30e0\uff09\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001\u674f\u6797\u5927\u5b66\u533b\u5b66\u90e8\u4ed8\u5c5e\u75c5\u9662\u3067\u5207\u9664\u3055\u308c\u305f\u81b5\u764c\u306e\u3046\u3061\u3001\u901a\u5e38\u578b\u306e\u817a\u764c\u6210\u5206\u3068\u9000\u5f62\u6210\u764c\u6210\u5206\u3092\u540c\u4e00\u816b\u760d\u5185\u306b\u8a8d\u3081\u305f4\u75c7\u4f8b\u3092\u5bfe\u8c61\u306b\u3001\u7a7a\u9593\u7684\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u75c5\u7406\u7d44\u7e54\u306e\u5f62\u614b\u3068\u4f4d\u7f6e\u95a2\u4fc2\u3092\u4fdd\u3061\u306a\u304c\u3089\u3001\u5404\u9818\u57df\u3067\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\u3092\u7db2\u7f85\u7684\u306b\u8abf\u3079\u308b\u6280\u8853\u3067\u3059\u3002\u52a0\u3048\u3066\u3001\u7c73\u56fd\u306eMemorial Sloan Kettering Cancer Center\uff08MSK\uff09\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001MSK-IMPACT\u30b3\u30db\u30fc\u30c8\u306b\u3042\u308b5,997\u4f8b\u306e\u901a\u5e38\u578b\u81b5\u764c\u306841\u4f8b\u306e\u672a\u5206\u5316\u764c\u306e\u907a\u4f1d\u5b50\u5909\u7570\u30c7\u30fc\u30bf\u3092\u6bd4\u8f03\u3057\u3001\u75c5\u7406\u5f62\u614b\u306e\u5909\u5316\u306b\u95a2\u308f\u308b\u5206\u5b50\u57fa\u76e4\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002<br \/>\r\n\u305d\u306e\u7d50\u679c\u3001\u9000\u5f62\u6210\u764c\u6210\u5206\u3067\u306f\u3001\u4e0a\u76ae\u7d30\u80de\u3068\u3057\u3066\u306e\u6027\u8cea\u3092\u5931\u3044\u3001\u3088\u308a\u9593\u8449\u7cfb\u306b\u8fd1\u3044\u6027\u8cea\u3092\u7372\u5f97\u3059\u308b\u4e0a\u76ae\u9593\u8449\u8ee2\u63db\uff08EMT\uff09\u306b\u95a2\u9023\u3057\u305f\u907a\u4f1d\u5b50\u7fa4\u304c\u6d3b\u6027\u5316\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3068\u304f\u306b\u3001\u4e0a\u76ae\u7d30\u80de\u306e\u6027\u8cea\u306e\u7dad\u6301\u306b\u95a2\u308f\u308b\u8ee2\u5199\u56e0\u5b50ELF3\u306e\u767a\u73fe\u306f\u3001\u89e3\u6790\u3057\u305f4\u75c7\u4f8b\u3059\u3079\u3066\u306e\u9000\u5f62\u6210\u764c\u6210\u5206\u3067\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001\u9000\u5f62\u6210\u764c\u3067\u306fSMAD4\u907a\u4f1d\u5b50\u306e\u5909\u7570\u983b\u5ea6\u304c\u901a\u5e38\u578b\u81b5\u764c\u3088\u308a\u3082\u4f4e\u304f\u3001\u7a7a\u9593\u7684\u306a\u89e3\u6790\u3067\u306f\u9000\u5f62\u6210\u764c\u6210\u5206\u3067SMAD4\u95a2\u9023\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u304c\u63a8\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3068\u516c\u958b\u30c7\u30fc\u30bf\u306e\u89e3\u6790\u304b\u3089\u3001SMAD4\u306e\u50cd\u304d\u3068ELF3\u306e\u767a\u73fe\u306e\u9593\u306b\u9006\u76f8\u95a2\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001SMAD4\u3068ELF3\u306e\u76f8\u4e92\u306b\u95a2\u9023\u3057\u305f\u5236\u5fa1\u304c\u3001\u81b5\u764c\u306e\u9000\u5f62\u6210\u5909\u5316\uff08\u672a\u5206\u5316\u8ee2\u5316\uff09\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\uff08\u4e0b\u56f3\u3082\u3054\u53c2\u7167\u4e0b\u3055\u3044\uff09\u3002<br \/>\r\n\u672c\u7814\u7a76\u306e\u7279\u5fb4\u306f\u3001\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3055\u308c\u308b\u5f62\u614b\u306e\u9055\u3044\u3092\u51fa\u767a\u70b9\u3068\u3057\u3066\u3001\u540c\u4e00\u816b\u760d\u5185\u306e\u9818\u57df\u3054\u3068\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u6bd4\u8f03\u3057\u3001\u3055\u3089\u306b\u5927\u898f\u6a21\u306a\u30b2\u30ce\u30e0\u60c5\u5831\u3068\u5b9f\u9a13\u30e2\u30c7\u30eb\u3067\u691c\u8a3c\u3057\u305f\u70b9\u306b\u3042\u308a\u307e\u3059\u3002\u4eca\u56de\u660e\u3089\u304b\u306b\u306a\u3063\u305fSMAD4\u3068ELF3\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u3001\u76f4\u63a5\u7684\u306a\u5236\u5fa1\u6a5f\u69cb\u3084\u816b\u760d\u9593\u8cea\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u4eca\u5f8c\u306e\u8ab2\u984c\u3067\u3059\u304c\u3001\u81b5\u764c\u306e\u591a\u69d8\u6027\u3068\u60aa\u6027\u5316\u3092\u7406\u89e3\u3059\u308b\u3046\u3048\u3067\u3001\u65b0\u305f\u306a\u8996\u70b9\u3092\u63d0\u4f9b\u3059\u308b\u6210\u679c\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\r\n\r\n<figure id=\"Fig.2\" class=\"fig2\">\u3000\r\n<a href=\"\/univ\/faculty\/medicine\/uploads\/2026\/11\/Fig1.png\" target=\"_blank\"><img decoding=\"async\" src=\"\/univ\/faculty\/medicine\/uploads\/2026\/11\/Fig1.png\" style=\"margin:20px; width:60%; border-width: 0px;\" alt=\"\u56f31\"><\/a>\r\n<\/figure>\r\n\r\n\r\n<br \/ class=\"fig0\">\r\n\r\n<h3>\u7528\u8a9e\u89e3\u8aac<\/h3>\r\n<div style=\"padding-left: 10em; text-indent: -10em;\">\r\n\t<p><b>\u9000\u5f62\u6210\u5909\u5316\uff1a<\/b><br \/>\u817a\u7ba1\u69cb\u9020\u306a\u3069\u306e\u5206\u5316\u3057\u305f\u5f62\u614b\u7684\u7279\u5fb4\u3092\u5931\u3044\u3001\u3088\u308a\u672a\u5206\u5316\u306a\u5f62\u614b\u3078\u5909\u5316\u3059\u308b\u3053\u3068<\/p>\r\n\t<p><b>\u7a7a\u9593\u7684\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\uff1a<\/b><br \/>\u7d44\u7e54\u5185\u306e\u4f4d\u7f6e\u60c5\u5831\u3092\u4fdd\u6301\u3057\u305f\u307e\u307e\u3001\u5404\u9818\u57df\u306b\u304a\u3051\u308b\u591a\u6570\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u89e3\u6790\u3059\u308b\u624b\u6cd5<\/p>\r\n\t<p><b>SMAD4\u30fbELF3\uff1a<\/b><br \/>SMAD4\u306f\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u95a2\u308f\u308b\u5206\u5b50\u3001ELF3\u306f\u4e0a\u76ae\u7d30\u80de\u306e\u6027\u8cea\u306e\u7dad\u6301\u306b\u95a2\u308f\u308b\u8ee2\u5199\u56e0\u5b50<\/p>\r\n<\/div>\r\n\r\n\r\n<h3>\u63b2\u8f09\u8ad6\u6587<\/h3>\r\n\r\n<table class=\"citation\">\r\n <tr>\r\n  <td width=93>\u767a\u8868\u96d1\u8a8c\uff1a<\/td><td width=860>The Journal of Pathology\uff082026\u5e7410\u670813\u65e5\u30aa\u30f3\u30e9\u30a4\u30f3\u516c\u958b\uff09<\/td>\r\n <\/tr>\r\n<tr>\r\n  <td>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1a<\/td><td><a href=\"http:\/\/doi.org\/10.1002\/path.70136\"  target=\"_blank\">Molecular landscape of anaplastic transformation in pancreatic ductal adenocarcinoma<\/a><\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>\u7b46\u3000\u8005\uff1a<\/td><td>Akimasa Hayashi, Shota Sasagawa, Takahiro Shibayama, Kaloyan M Tsanov, Shigeaki Umeda, Yu-Jui Ho, Kazunari Tanabe, Wungki Park, Kiyotaka Nagahama, Hiromi Onizuka, Takashi Hibiya, Kaishi Satomi, Jerry P Melchor, Yoshihiro Sakamoto, Scott W Lowe, Eileen M O\u2019Reilly, Christine A Iacobuzio-Donahue, Hidewaki Nakagawa, Junji Shibahara<br \/>\u8cac\u4efb\u8457\u8005\uff1a\u4e2d\u5ddd\u82f1\u5200\u3001\u67f4\u539f\u7d14\u4e8c\u3001\u6797\u73b2\u5321<\/td>\r\n <\/tr>\r\n <tr>\r\n  <td>DOI:<\/td>  <td>10.1002\/path.70136<\/td>\r\n <\/tr>\r\n<\/table>\r\n<br \/>\r\n<div>\r\n<p style=\"margin-left: 20px;\">\u75c5\u7406\u5b66\u6559\u5ba4\u306e\u8a73\u7d30\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/education\/labo\/pathology\/\" target=\"_blank\">\u3053\u3061\u3089<\/a>\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002\r\n<\/div>\r\n<br \/>\r\n<h4>\u554f\u3044\u5408\u308f\u305b\u5148<\/h4>\r\n<p class=\"noIndmt10\">\u674f\u6797\u5b66\u5712\u5e83\u5831\u5ba4<br \/>\r\n\u3000\u3000\u5e83\u5831\u5ba4\u3078\u306e\u304a\u554f\u3044\u5408\u308f\u305b\u306f<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/contact\/\">\u3053\u3061\u3089<\/a>\u307e\u3067<br \/>\r\nTel: 0422-44-0611<br \/>\r\n<\/p>\r\n\r\n<\/body>\r\n","protected":false},"excerpt":{"rendered":"<p>\u6797\u3000\u73b2\u5321\uff08\u7d71\u5408\u751f\u7406\u5b66\u6559\u5ba4\u3000\u6559\u6388\uff08\u524d \u75c5\u7406\u5b66\u6559\u5ba4\uff09\uff09 \u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8 \u672c\u5b66\u75c5\u7406\u5b66\u6559\u5ba4\uff08\u67f4\u539f\u7d14\u4e8c\u6559\u6388\u3089\uff09\u304a\u3088\u3073\u7406\u5316\u5b66\u7814\u7a76\u6240\uff08\u304c\u3093\u30b2\u30ce\u30e0\u7814\u7a76\u30c1\u30fc\u30e0\u3001\u4e2d\u5ddd\u82f1\u5200\u30c7\u30a3\u30ec\u30af\u30bf\u30fc\u3089\uff09\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u7a7a\u9593\u7684\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306b\u3088\u308a\u3001 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":8888,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-8867","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/8867","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/comments?post=8867"}],"version-history":[{"count":18,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/8867\/revisions"}],"predecessor-version":[{"id":8887,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/posts\/8867\/revisions\/8887"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media\/8888"}],"wp:attachment":[{"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/media?parent=8867"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/categories?post=8867"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kyorin-u.ac.jp\/univ\/faculty\/medicine\/wp-json\/wp\/v2\/tags?post=8867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}