{"id":124,"date":"2009-05-08T11:31:32","date_gmt":"2009-05-08T02:31:32","guid":{"rendered":"http:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/?p=124"},"modified":"2009-05-08T11:31:32","modified_gmt":"2009-05-08T02:31:32","slug":"2008%e5%b9%b4%e5%ba%a6%e6%a5%ad%e7%b8%be","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/archives\/124","title":{"rendered":"2008\u5e74\u5ea6\u696d\u7e3e"},"content":{"rendered":"<p><!--more--><\/p>\n<h1>\u3010\u53e3\u3000\u6f14\u3011 <\/h1>\n<ol>\n<li>Keino H1, Watanabe T1, Sato Y2, Niikura M3, Wada Y4, Okada AA1 \uff081Department of Ophthalmology, 2Division of Radioisotope Research, 3Laboratory of Animals, Kyorin Univerisity School of Medicine, 4Synta Pharmaceuticals Corporation, MA, USA\uff09\uff1a Therapeutic effect of the potent IL-12\/IL-23 inhibitor STA-5326 in experimental autoimmune uveoretinitis.&nbsp; ARVO \uff08Association for Research in Vision and Ophthalmology\uff09 Fort. Lauderdale FL, Apr. 2, 2008.<\/li>\n<li>\u65b0\u5009\u4fdd1,2, \u5317\u6f542, \u5c0f\u6797\u5bcc\u7f8e\u60e03\uff081\u674f\u6797\u5927\u30fb\u9662\u30fb\u533b\u30fb\u5b9f\u9a13\u52d5\u7269, 2\u6771\u5927\u30fb\u9662\u30fb\u533b\u30fb\u56fd\u969b\u4fdd\u5065, 3\u674f\u6797\u5927\u30fb\u533b\u30fb\u611f\u67d3\u75c7\uff09\uff1a \u30de\u30a6\u30b9\u30de\u30e9\u30ea\u30a2\u539f\u866b\u5f31\u6bd2\u682a\u3068\u306e\u8907\u5408\u611f\u67d3\u306fPlasmodium berghei NK65\u5f37\u6bd2\u682a\u611f\u67d3\u306b\u3088\u308b\u809d\u50b7\u5bb3\u3092\u6291\u5236\u3059\u308b. \u7b2c77\u56de\u65e5\u672c\u5bc4\u751f\u866b\u5b66\u4f1a\u5927\u4f1a, \u9577\u5d0e, \u5e73\u621020\u5e744\u67082-4\u65e5. <\/li>\n<li>\u7530\u908a\u5c07\u4fe11\uff0c\u6df1\u5c3e\u592a\u90ce1\uff0c\u6c38\u7530\u535a\u53f82\uff0c\u95a2\u585a\u6c38\u4e003\uff0c\u5bae\u5d0e\u8015\u53f83\uff0c\u5c0f\u6797\u5bcc\u7f8e\u60e04\uff0c\u7af9\u5185\u52e41\uff081\u6176\u61c9\u5927\u30fb\u533b\u30fb\u71b1\u5e2f\u5bc4\u751f\u866b\uff0c\uff12\u3051\u3044\u3086\u3046\u75c5\u9662\u30fb\u5185\u79d1\uff0c3\u56fd\u7acb\u57fc\u7389\u30fb\u5185\u79d1, 4\u674f\u6797\u5927\u30fb\u611f\u67d3\u75c7\u5b66\uff09\uff1a \u6162\u6027\u30de\u30f3\u30bd\u30f3\u4f4f\u8840\u5438\u866b\u611f\u67d3\u30de\u30a6\u30b9\u306fPseudomonas aeruginosa \u81f4\u6b7b\u611f\u67d3\u306b\u5bfe\u3057\u62b5\u6297\u6027\u3067\u3042\u308b\uff0e\u7b2c77\u56de\u65e5\u672c\u5bc4\u751f\u866b\u5b66\u4f1a\u5927\u4f1a, \u9577\u5d0e, \u5e73\u621020\u5e744\u67084\u65e5.<\/li>\n<li>\u85e4\u91ce\u9686\u5fd71, \u677e\u5c3e\u667a\u82f11, \u4eca\u4e0a\u7d75\u74062, \u5c0f\u6797\u5bcc\u7f8e\u60e01, \u677e\u4e95\u5229\u535a1\uff081\u674f\u6797\u5927\u30fb\u611f\u67d3\u75c7\u5b66,2\u674f\u6797\u5927\u30fb\u4fdd\u5065\u5b66\u90e8\uff09\uff1a Eimeria krijgsmanni\u611f\u67d3\u30de\u30a6\u30b9\u306b\u5bfe\u3059\u308b\u6570\u7a2e\u30b5\u30eb\u30d5\u30a1\u5264\u306e\u52b9\u679c\uff0e\u7b2c77\u56de\u65e5\u672c\u5bc4\u751f\u866b\u5b66\u4f1a\u5927\u4f1a, \u9577\u5d0e, \u5e73\u621020\u5e744\u67084\u65e5.<\/li>\n<li>Ishii A1 and Kobayashi F2\uff081Dept. Inf. Dis., Hamamatsu Univ. Sch. Med., 2Dept. Inf. Dis., Kyorin Univ.\uff09\uff1a Effects of chloroquine treatment on Plasmodium yoelii 17XL infection in IFN-gamma KO mice\uff0e\u7b2c77\u56de\u65e5\u672c\u5bc4\u751f\u866b\u5b66\u4f1a\u5927\u4f1a, \u9577\u5d0e, \u5e73\u621020\u5e744\u67084\u65e5\uff0e <\/li>\n<li>Shiohara T1, Kano Y1, Takahashi R \uff081 Department of Dermatology\uff09\uff1a&nbsp; Update on regulators\uff1a&nbsp; regulatory T cells in DIHS\/DRESS and SJS\/TEN. 3rd International drug hypersensitivity meeting. Paris, Apr. 2, 2008.<\/li>\n<li>Kano Y1, Hirahara K1, Asano Y1, Mitsuyama Y1, Takahashi R, Shiohara T1 \uff081 Department of Dermatology\uff09\uff1a&nbsp; Association between drug and human herpesvirus in drug-induced hypersensitivity syndrome\/drug rash with eosinophilia and systemic symptoms. 3rd International drug hypersensitivity meeting, Paris, Apr. 2, 2008.<\/li>\n<li>Takahashi R and Shiohara T1 \uff081Dept. of Dermatology\uff09\uff1a&nbsp; Trafficking receptor expression on regulatory t cells in severe drug eruptions, 3rd International drug hypersensitivity meeting, Paris, Apr. 11-13, 2008.<\/li>\n<li>Mitsuyama Y1, Kano Y1, Hirahara K1, Mizukawa Y1, Shiohara T1 \uff081 Department of Dermatology\uff09\uff1a&nbsp; Usefulness of monitoring of cytokine expression to evaluate therapeutic efficacy of plasmapheresis in patients with toxic epidermal necrolysis. 3rd International drug hypersensitivity meeting, Paris, Apr. 2, 2008.<\/li>\n<li>Takahashi R, Kimisima M1, Yamazaki Y1, and Shiohara T1 \uff081Dept. of Dermatology\uff09\uff1a&nbsp; Severe drug hypersensitivity disorders is induced by dysfunctional Tregs, The International Investigative Dermatology 2008, Kyoto, May. 14-17, 2008.<\/li>\n<li>Aota N1, Fukuhara M1, Hirahara K1, Kano Y1, Shiohara T1 \uff081 Department of Dermatology\uff09\uff1a&nbsp; Autoimmune disease as sequelae of drug-induced hypersensitivity syndrome. 2nd International conference on cutaneous lupus erythematosus, Kyoto, May. 12, 2008.<\/li>\n<li>Kano Y1, Asano Y1, Hirahara T1, Shiohara T1 \uff081 Department of Dermatology\uff09\uff1a&nbsp; Autoimmune diseases occurring after drug-induced hypersensitivity syndrome. 6th International conference on HHV-6 &amp; 7, Baltimore, Jun. 21, 2008.&nbsp; <\/li>\n<li>\u5c0f\u6797\u5bcc\u7f8e\u60e01 \uff081\u674f\u6797\u5927\u30fb\u611f\u67d3\u75c7\u5b66\uff09\uff1a \u30de\u30a6\u30b9\u30de\u30e9\u30ea\u30a2\u30e2\u30c7\u30eb\u306e\u529f\u7f6a\uff1a \u7b2c16\u56de\u5206\u5b50\u5bc4\u751f\u866b\u30ef\u30fc\u30af\u30b7\u30e7\u30c3\u30d7,&nbsp; \u7fa4\u99ac, \u5e73\u621020\u5e748\u67083-6\u65e5. <\/li>\n<li>\u65b0\u5009\u4fdd1,2, \u5317\u6f542, \u5c0f\u6797\u5bcc\u7f8e\u60e03\uff08 1\u674f\u6797\u5927\u30fb\u9662\u30fb\u533b\u30fb\u5b9f\u9a13\u52d5\u7269, 2\u6771\u5927\u30fb\u9662\u30fb\u533b\u30fb\u56fd\u969b\u4fdd\u5065, 3\u674f\u6797\u5927\u30fb\u533b\u30fb\u611f\u67d3\u75c7\uff09 \uff1a Plasmodium berghei ANKA\u5f37\u6bd2\u682a\u611f\u67d3\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u8133\u30de\u30e9\u30ea\u30a2\u69d8\u75c7\u72b6\u306f\u30de\u30a6\u30b9\u30de\u30e9\u30ea\u30a2\u539f\u866b\u5f31\u6bd2\u682a\u3068\u306e\u8907\u5408\u611f\u67d3\u306b\u3088\u3063\u3066\u6291\u5236\u3055\u308c\u308b. \u7b2c16\u56de\u5206\u5b50\u5bc4\u751f\u866b\u30ef\u30fc\u30af\u30b7\u30e7\u30c3\u30d7, \u7fa4\u99ac, \u5e73\u621020\u5e748\u67083-6\u65e5. <\/li>\n<li>Mamoru Niikura1,3, Shigeru Kamiya\u30002, Kiyoshi Kita\u30003, Fumie Kobayashi\u30002 \uff081\u3000Institute of Laboratory Animals, Graduate School of Medicine 2\u3000Department of Infectious Diseases, Faculty of Medicine, Kyorin University, 3\u3000Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo.\uff09 \uff1a Liver injury caused by Plasmodium berghei NK65 is suppressed by coinfection with nonlethal murine malaria parasites. 16th Japanese-German Cooperative Symposium on Protozoan Diseases. Goettingen, Sep. 24-29, 2008.<\/li>\n<li>Niikura M1,2, Kamiya S3, Kita K2 and Kobayashi F3 \uff081Inst. Lab. Anim., Kyorin Univ. Schl. Med., 2Dept. Biomed. Chem., Grad. Sch. Med., Univ of Tokyo, 3Dept. Inf. Dis., Kyorin Univ.\uff09\uff1a&nbsp; Liver injury caused by Plasmodium berghei NK65 is suppressed by coinfection with nonlethal murine malaria parasites. The 16th Japanese-German Cooperative Symposium on Protozoan Diseases. Goettingen, Sep. 24-29, 2008.<\/li>\n<li>\u65b0\u5009\u4fdd1,2, \u5317\u6f542, \u5c0f\u6797\u5bcc\u7f8e\u60e03 \uff08 1\u674f\u6797\u5927\u30fb\u9662\u30fb\u533b\u30fb\u5b9f\u9a13\u52d5\u7269, 2\u6771\u5927\u30fb\u9662\u30fb\u533b\u30fb\u56fd\u969b\u4fdd\u5065, 3\u674f\u6797\u5927\u30fb\u533b\u30fb\u611f\u67d3\u75c7\uff09 \uff1a \u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u8133\u30de\u30e9\u30ea\u30a2\u69d8\u75c7\u72b6\u306f\u5f31\u6bd2\u682a\u30de\u30e9\u30ea\u30a2\u539f\u866b\u3068\u306e\u8907\u5408\u611f\u67d3\u306b\u3088\u3063\u3066\u6291\u5236\u3055\u308c\u308b. \u7b2c7\u56de\u5206\u5b50\u5bc4\u751f\u866b\u30fb\u30de\u30e9\u30ea\u30a2\u7814\u7a76\u30d5\u30a9\u30fc\u30e9\u30e0, \u677e\u5c71, \u5e73\u621020\u5e7410\u670810-11\u65e5.<\/li>\n<li>Niikura M1,2 and Kobayashi F3 \uff081Inst. Lab. Anim., Kyorin Univ. Schl. Med., 2Dept. Biomed. Chem., Grad. Sch. Med., Univ of Tokyo, 3Dept. Inf. Dis., Kyorin Univ.\uff09\uff1a&nbsp; IL-10 plays a crucial role for the suppression of experimental cerebral malaria by coinfection with nonlethal murine malaria parasites. The 38th Annual Meeting of Japanese Society of Immunologists, Kyoto, Dec. 1-3, 2008.<\/li>\n<li>Mamoru Niikura1,2, Fumie Kobayashi3 \uff081Institute of Laboratory Animals, Graduate School of Medicine, Kyorin University, 2 Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 3Department of Infectious Diseases, Faculty of Medicine, Kyorin University.\uff09 \uff1a IL-10 plays a crucial role for the protection of experimental cerebral malaria by coinfection with nonlethal malaria parasites. \u7b2c38\u56de\u65e5\u672c\u514d\u75ab\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u96c6\u4f1a, \u4eac\u90fd, \u5e73\u621020\u5e7412\u67081-3\u65e5.<\/li>\n<li>Kobayashi F1, Niikura M2,3 and Kita K3 \uff081Dept. Inf. Dis., Kyorin Univ.,2Inst. Lab. Anim., Kyorin Univ., 3Dept. Biomed. Chem., Grad. Sch. Med., Univ of Tokyo\uff09\uff1a&nbsp; Supression of severe pathogenisis during coinfection with lethal and nonlethal mararia parasites\uff1a&nbsp; A consideration of possible mechanisms by using murine malaria models. JSPS Seminar, 2009\uff1a&nbsp; Strategies for controlling emerging and re-emerging infectious diseases in Southeast Asia in JSPS Core University Program, Tokyo, Jan. 20, 2009.<\/li>\n<li>\u65b0\u5009\u4fdd1, 2\uff0c\u5317\u6f541\uff0c\u5c0f\u6797\u5bcc\u7f8e\u60e03\uff08\uff11\u6771\u5927\u30fb\u9662\u30fb\u533b\u30fb\u751f\u7269\u533b\u5316\u5b66\uff0c\uff12\u674f\u6797\u5927\u30fb\u9662\u30fb\u533b\u30fb\u5b9f\u9a13\u52d5\u7269, 3\u674f\u6797\u5927\u30fb\u611f\u67d3\u75c7\uff09\uff1a \u30de\u30a6\u30b9\u30de\u30e9\u30ea\u30a2\u539f\u866b\u8907\u5408\u611f\u67d3\u306b\u304a\u3051\u308bIL-10\u306e\u610f\u7fa9\u3068\u5f79\u5272\uff0e \u7b2c2\u56de\u539f\u866b\u611f\u67d3\u514d\u75ab\u7814\u7a76\u4f1a,&nbsp; \u4f50\u8cc0\u5e02, \u5e73\u621021\u5e742\u670821-22\u65e5.<\/li>\n<li>Mamoru Niikura1,2, Kiyoshi Kita2, Fumie Kobayashi3 \uff081Institute of Laboratory Animals, Graduate School of Medicine, Kyorin University, 2 Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 3Department of Infectious Diseases, Faculty of Medicine, Kyorin University.\uff09 \uff1a Coinfection with nonlethal malaria parasites suppresses experimental cerebral malaria in IL-10 dependent-manner. \u7b2c78\u56de\u65e5\u672c\u5bc4\u751f\u866b\u5b66\u4f1a\u5927\u4f1a, \u6771\u4eac, \u5e73\u621021\u5e743\u670827-28\u65e5.<\/li>\n<li>Niikura M1,2, Kita K2, Kobayashi F3 \uff081Inst. Lab. Anim., Kyorin Univ., 2Dept. Biomed. Chem., Grad. Sch. Med., Univ of Tokyo, 3Dept. Inf. Dis., Kyorin Univ.\uff09\uff1a&nbsp; Coinfection with nonlethal malaria parasites suppresses experimental cerebral malaria in IL-10-dependent manner. \u7b2c\uff12\u56de\u65e5\u672c\u5bc4\u751f\u866b\u5b66\u4f1a\u5927\u4f1a, \u6771\u4eac, \u5e73\u621021\u5e743\u670827-28\u65e5.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h1>\u3010\u8ad6\u3000\u6587\u3011 <\/h1>\n<ol>\n<li>Keino H1, Watanabe T1, Sato Y2, Niikura M3, Wada Y4, Okada AA1 \uff081Department of Ophthalmology, 2Division of Radioisotope Research, 3Laboratory of Animals, Kyorin Univerisity School of Medicine, 4Synta Pharmaceuticals Corporation, MA, USA\uff09\uff1a Therapeutic effect of the potent IL-12\/IL-23 inhibitor STA-5326 in experimental autoimmune uveoretinitis.&nbsp;&nbsp;&nbsp; Arthritis Res Ther 10\uff1a R122, 2008.<\/li>\n<li>Shiohara T1, Mizukawa Y1, Takahashi R, Kano Y1 \uff081 Department of Dermatology\uff09\uff1a&nbsp; Pathomechanisms of lichen planus autoimmunity elicited by cross-reactive T cells. Curr Dir Autoimmun 10\uff1a 206-226, 2008.<\/li>\n<li>Sirirat Amonpatumrat1,3, Hiroyuki Sakurai1, Pattama Wiriyasermkul12, Narakorn Khunweeraphong1,2, Shushi Nagamori2, Hidekazu Tanaka2, Pawinee Piyachaturawat3,4 and Yoshikatsu Kanai2 \uff081 Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan, 2 Division of Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Japan 3 Toxicology Graduate Program, Faculty of Science, Mahidol University, Thailand,4 Department of Physiology, Faculty of Science, Mahidol University, Thailand\uff09\uff1a L-Glutamate Enhances Methylmercury Toxicity by Synergistically Increasing Oxidative Stress. J Pharmacol Sci&nbsp; 108\uff1a 280-289. 2008<\/li>\n<li>Mamoru Niikura1,3, Shigeru Kamiya2, Kiyoshi Kita3, Fumie Kobayashi2 \uff081Institute of Laboratory Animals, Graduate School of Medicine 2Department of Infectious Diseases, Faculty of Medicine, Kyorin University, 3Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo.\uff09\uff1a&nbsp; Coinfection with nonlethal murine malaria parasites suppresses pathogenesis caused by Plasmodium berghei NK65. J Immunol 180\uff1a&nbsp; 6877-6884. 2008. <\/li>\n<li>Hiroshi Keino1, Takayo Watanabe1, Yasuhiko Sato2, Mamoru Niikura3, Yumiko Wada4, and Annabelle A Okada1 \uff081Department of Ophthalmology, 2Division of Radioisotope Research, Faculty of Medicine,&nbsp; 3Laboratory of Animals, Graduate School of Medicine, Kyorin University, 4Synta Pharmaceuticals Corporation, 45 Hartwell Ave. Lexington, MA 02421, USA.\uff09 \uff1a Therapeutic effect of a potent IL-12\/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis. Arthritis Res Ther 10\uff1aR122,&nbsp; 2008.<\/li>\n<li>Ishih A1, Nagata T1, Kobayashi F2, Muregi F.W1, Ohori K1, and Miyase T1\uff081Dept. Inf. Dis., Hamamatsu Univ. Sch. Med., 2Dept. Inf. Dis., Kyorin Univ.\uff09\uff1a&nbsp; Possible involvement of IFN-g in earlier mortality of Plasmodium berghei NK65-infected BALB\/c mice after febrifugine treatment. Southeast Asian J Trop Med Public Health 39\uff1a 949-956, 2008. <\/li>\n<li>Aota N1, Hirahara K1, Kano Y1, Fukuoka T1, Yamada A1, Shiohara T1 \uff081 Department of Dermatology\uff09\uff1a&nbsp; Systemic lupus erythematosus presenting with Kikuchi-Fujimoto\u2019s disease as a long-term sequele of drug-induced hypersensitivity syndrome, a possible role of Epstein-Barr virus reactivation. Dermatology 218\uff1a275-7, 2009.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h1>\u3010\u8457\u3000\u66f8\u3011 <\/h1>\n<ol>\n<li>Shiohara T1, Mizukawa Y1, Takahashi R, Kano Y1 \uff081 Department of Dermatology\uff09\uff1a&nbsp; Pathomechanisms of lichen planus autoimmunity elicited by cross-reactive T cells. In\uff1a&nbsp; Dermatologic Immunity. Nickoloff BJ, Nestle FO \uff08Ed.\uff09 Basel, Karger, 2008. p. 206-226.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h1>\u3010\u305d\u306e\u4ed6\u3011 <\/h1>\n<ol>\n<li>\u7814\u7a76\u6210\u679c\u3000\u9ad8\u6a4b\u826f\uff1a\u85ac\u5264\u6027\u904e\u654f\u75c7\u75c7\u5019\u7fa4\u306b\u304a\u3051\u308b\u5236\u5fa1\u6027\uff34\u30ea\u30f3\u30d1\u7403\u306e\u6a5f\u80fd\u89e3\u6790\uff0e \u5e73\u621020\u5e74\u5ea6\u79d1\u5b66\u7814\u7a76\u8cbb\u88dc\u52a9\u91d1 \u82e5\u624b\u7814\u7a76\uff08B\uff09\u7814\u7a76\u4ee3\u8868\u8005&nbsp; <\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-124","post","type-post","status-publish","format-standard","hentry","category-archive"],"yoast_head":"<!-- This site is optimized with the Yoast SEO 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