{"id":150,"date":"2011-03-29T14:14:18","date_gmt":"2011-03-29T05:14:18","guid":{"rendered":"http:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/?p=150"},"modified":"2011-03-29T14:14:18","modified_gmt":"2011-03-29T05:14:18","slug":"2009%e5%b9%b4%e5%ba%a6%e6%a5%ad%e7%b8%be","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/archives\/150","title":{"rendered":"2009\u5e74\u5ea6\u696d\u7e3e"},"content":{"rendered":"<p><!--more--><\/p>\n<h1>\u3010\u53e3\u3000\u6f14\u3011 <\/h1>\n<ol>\n<li>Shiohara T<sup>\uff11<\/sup>(<sup>1<\/sup> Department of Dermatology): Viral reactivations in drug-induced hypersensitivity syndrome. 4th Joint Meeting of Japanese Dermatological Association and Australasian College of Dermatologists, Sapporo, 2009 July 10.<\/li>\n<li>Akira Ishih<sup>\uff11<\/sup>, Fumie Kobayashi <sup>2<\/sup>(<sup>\uff11<\/sup>Dept. Infect. Dis., Hamamatsu Univ. Schl. Med., <sup>2<\/sup>Dept. Infect. Dis.): Outcome of chloroquine treatment on Plasmodium yoelii 17XL infection in mice. \u7b2c69\u56de\u65e5\u672c\u5bc4\u751f\u866b\u5b66\u4f1a\u6771\u65e5\u672c\u5927\u4f1a, \u6771\u4eac, \u5e73\u621021\u5e7410\u67083\u65e5.<\/li>\n<li>\u5c0f\u6797\u5bcc\u7f8e\u60e0<sup>\uff11<\/sup>\uff08<sup>\uff11<\/sup>\u611f\u67d3\u75c7\u5b66\u8b1b\u5ea7\uff08\u5bc4\u751f\u866b\u5b66\u90e8\u9580\uff09)\uff1a\u8d64\u5185\u578b\u30de\u30e9\u30ea\u30a2\u30ef\u30af\u30c1\u30f3\u5019\u88dc\u6297\u539fMSP1\u306b\u5bfe\u3059\u308b\u5bbf\u4e3b\u514d\u75ab\u5fdc\u7b54\u6a5f\u69cb\u306e\u89e3\u660e\uff0e\u7b2c38\u56de\u674f\u6797\u533b\u5b66\u4f1a\u7dcf\u4f1a\uff0c\u6771\u4eac\uff0c\u5e73\u621021\u5e7411\u670821\u65e5\uff0e<\/li>\n<li>\u5869\u539f\u54f2\u592b<sup>1<\/sup>\uff08\u76ae\u819a\u79d1\uff09\uff1a\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0I. \u76ae\u819a\u3068\u514d\u75ab\uff0e\u514d\u75ab\u518d\u69cb\u7bc9\u75c7\u5019\u7fa4\u3068regulatory T \u7d30\u80de. \u7b2c73\u56de\u65e5\u672c\u76ae\u819a\u79d1\u5b66\u4f1a\u6771\u90e8\u652f\u90e8\u5b66\u8853\u5927\u4f1a\uff0e\u7532\u5e9c\u3001\u5e73\u621021\u5e749\u670826\u65e5.<\/li>\n<li>\u6176\u91ce\u535a<sup>1<\/sup>\u3001\u65b0\u5009\u4fdd<sup>2<\/sup>\u3001Yumiko Wada<sup>3<\/sup>\u3001\u5ca1\u7530\u30a2\u30ca\u30d9\u30eb\u3042\u3084\u3081<sup>1<\/sup> (<sup>1<\/sup>\u773c\u79d1\u5b66, <sup>2<\/sup>\u5b9f\u9a13\u52d5\u7269\u65bd\u8a2d, <sup>3<\/sup> Synta Pharmaceuticals corporation, Boston, MA), Therapeutic effect of a potent IL-12\/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis \u7b2c37\u56de\u65e5\u672c\u81e8\u5e8a\u514d\u75ab\u5b66\u4f1a\u3000\u6771\u4eac\u3000\u5e73\u621021\u5e7411\u670813\u65e5-14\u65e5<\/li>\n<li>Takahashi R, and Shiohara T<sup>1<\/sup> (<sup>1<\/sup>Dept. of Dermatology): Mycoplasma pneumoniae infection predisposes individuals to severe drug eruptions by chronically abrogating regulatory T cell function, The International Investigative Dermatology 2009, Fukuoka, Dec 4-5, 2009.<\/li>\n<li>Yohei Sato<sup>1<\/sup>, Maiko Kurata<sup>1<\/sup>, Momoko Kimishima<sup>1<\/sup>, Takahashi R, Tetsuo Shiohara<sup>1<\/sup> (<sup>1<\/sup>Dept. of Dermatology): Pathological role of regulatory T cells in the initiation and maintenance of Kaposi\\&#8217;s varicelliform eruption lesions, The International Investigative Dermatology 2009, Fukuoka, Dec 4-5, 2009.<\/li>\n<li>\u5c0f\u6797\u5bcc\u7f8e\u60e0<sup>\uff11<\/sup>\uff08<sup>\uff11<\/sup>\u611f\u67d3\u75c7\u5b66\u8b1b\u5ea7\uff08\u5bc4\u751f\u866b\u5b66\u90e8\u9580\uff09)\uff1a\u30de\u30e9\u30ea\u30a2\u514d\u75ab\u306e\u5999\u3000\u301c\u5982\u4f55\u306b\u5bbf\u4e3b\u306f\u30de\u30e9\u30ea\u30a2\u539f\u866b\u3092\u653b\u3081\uff0c\u5982\u4f55\u306b\u539f\u866b\u306f\u305d\u308c\u3092\u56de\u907f\u3059\u308b\u306e\u304b\u301c\uff0e\u3000\u7b2c\uff14\u56de\u9ebb\u5e03\u5927\u5b66\u751f\u7269\u79d1\u5b66\u7dcf\u5408\u7814\u7a76\u6240\u30bb\u30df\u30ca\u30fc\uff0e\u6771\u4eac\uff0c\u5e73\u621021\u5e7412\u670810\u65e5\uff0e<\/li>\n<li>\u5c0f\u6797\u5bcc\u7f8e\u60e0<sup>\uff11<\/sup>\uff08<sup>\uff11<\/sup>\u611f\u67d3\u75c7\u5b66\u8b1b\u5ea7\uff08\u5bc4\u751f\u866b\u5b66\u90e8\u9580\uff09)\uff1a\u611f\u67d3\u75c7\u3001\u5bc4\u751f\u866b\u75be\u60a3\u306e\u6700\u8fd1\u306e\u8a71\u984c\u3000\u301c\u73fe\u72b6\uff0c\u5bfe\u7b56\uff0c\u4e88\u9632\u306b\u3064\u3044\u3066\u301c\uff0e\u300c\u7b2c\uff11\u56de\uff1a\u8eab\u8fd1\u306b\u8feb\u308b\u5bc4\u751f\u866b\u300d\uff0e\u4e09\u9df9\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u5927\u5b66\uff0c\u4e09\u9df9\uff0c\u5e73\u621022\u5e743\u67082\u65e5\uff0e<\/li>\n<li>\u65b0\u5009\u3000\u4fdd<sup>1<\/sup>\uff0c\u5c0f\u6797\u5bcc\u7f8e\u60e0<sup>2<\/sup>\uff08<sup>\uff11<\/sup>\u5b9f\u9a13\u52d5\u7269\u3001<sup>2<\/sup>\u611f\u67d3\u75c7\u5b66\u8b1b\u5ea7\uff08\u5bc4\u751f\u866b\u5b66\u90e8\u9580\uff09\uff09\uff1a\u30de\u30a6\u30b9\u30de\u30e9\u30ea\u30a2\u539f\u866b\u8907\u5408\u611f\u67d3\u306b\u304a\u3051\u308b\u813e\u81d3\u306e\u5f79\u5272\uff0e \u7b2c3\u56de\u539f\u866b\u611f\u67d3\u514d\u75ab\u7814\u7a76\u4f1a,\u00a0 \u9577\u5d0e, \u5e73\u621022\u5e743\u670826\u65e5-27\u65e5<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h1>\u3010\u8ad6\u3000\u6587\u3011 <\/h1>\n<ol>\n<li>Takahashi R., Kano Y<sup>1<\/sup> ,Yamazaki Y<sup>1<\/sup>, Kimishima M<sup>1<\/sup>, Mizukawa Y<sup>1<\/sup>, and Shiohara T<sup>1<\/sup> (<sup>1<\/sup> Department of Dermatology). Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome:\u00a0 The Journal of Immunology 182:8071-79, 2009.<\/li>\n<li>Aota N<sup>1<\/sup>, Shiohara T<sup>1<\/sup> (<sup>1<\/sup> Department of Dermatology). Viral connection between drug rashes and autoimmune diseases: How autoimmune responses are generated after resolution of drug rashes. Autoimm Rev 8: 488-494, 2009.<\/li>\n<li>Shiohara T<sup>1<\/sup>, Kano Y<sup>1<\/sup>, and Takahashi R (<sup>1<\/sup> Department of Dermatology). Current concepts on the diagnosis and pathogenesis of drug-induced hypersensitivity syndrome: JMAJ 52:347-352, 2009.<\/li>\n<li>Shiohara T<sup>1<\/sup>(<sup>1<\/sup> Department of Dermatology). Fixed drug eruption: pathogenesis and diagnostic tests.\u00a0 Curr Opin Allergy Clin Immunol\u00a0 9 (4); 316-321, 2009<\/li>\n<li>Asano Y<sup>1<\/sup>, Kagawa H<sup>1<\/sup>, Kano Y<sup>1<\/sup>, Shiohara T(<sup>1<\/sup> Department of Dermatology). Cytomegalovirus disease during severe drug eruptions: Report of 2cases and retrospective study of 18 patients with drug-induced hypersensitivity syndrome. Arch Dermatol 145 (9 ), 1030- 1036, 2009.<\/li>\n<li>Niikura M<sup>\uff11,2<\/sup>, Kamiya S<sup>3<\/sup>, Nakane A<sup>4<\/sup>, Kita K<sup>2<\/sup>, Kobayashi <sup>3<\/sup>(<sup>1<\/sup>Inst. Lab. Anim., <sup>2<\/sup>Univ. of Tokyo, <sup>3<\/sup>Dept. Inf. Dis., <sup>4<\/sup>Hirosaki Univ.,): IL-10 plays a crucial role for the protection of experimental cerebral malaria by coinfection with nonlethal malaria parasites.\u00a0 Int. J. Parasitol., 40: 101-108, 2010.<\/li>\n<li>Hirahara K<sup>\uff11<\/sup>, Kano Y<sup>\uff11<\/sup>, Mitsuyama Y<sup>\uff11<\/sup>, Takahashi R, Kimishima M<sup>\uff11<\/sup>, Shiohara T<sup>\uff11<\/sup>(<sup>1<\/sup> Department of Dermatology):\u3000Differences in immunological alterations and underlying viral infections in two well defined severe drug eruptions. Clin Exp Dermatol (in press).<\/li>\n<li>Shiohara T<sup>\uff11<\/sup>, Mizukawa Y<sup>\uff11<\/sup>, Kano Y<sup>\uff11<\/sup>(<sup>1<\/sup> Department of Dermatology).: Editorial.\u00a0 The skin is a site of lomg-term viral persistence\u00a0 associated with retention of antiviral memory T cells. Dermatology (in press).<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h1>\u3010\u8457\u3000\u66f8\u3011 <\/h1>\n<ol>\n<li>Hashimoto K<sup>1<\/sup>, Tohyama M<sup>2<\/sup>, Shiohara T<sup>3<\/sup> (<sup>1<\/sup> Ehime Univ, <sup>2<\/sup>Keio Univ. <sup>3<\/sup> Department of Dermatology). Drug reactions with eosiniphilia and systemic symptoms (DRESS\/DIHS) Life-threatening dermatoses and emergencies in dermatology.\u00a0 Revuz J, Roujeau J-C, Kerdel FA, Valeyrie-Allanore L. eds. Springer-Verlag, Berlin, 2009., p.97-102.<\/li>\n<li>Shiohara T<sup>1<\/sup>, Mizukawa Y<sup>1<\/sup>, Kano Y<sup>1<\/sup>(<sup>1<\/sup> Department of Dermatology). Lichen planus.\u00a0 Therapy of skin diseases.\u00a0 Krieg T. ed.\u00a0 Springer Verlag, Berlin, 2010., p.213-222.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h1>\u3010\u305d\u306e\u4ed6\u3011 <\/h1>\n<ol>\n<li>\u7814\u7a76\u6210\u679c\u3000\u9ad8\u6a4b\u826f\uff1a\u85ac\u5264\u6027\u904e\u654f\u75c7\u75c7\u5019\u7fa4\u306b\u304a\u3051\u308b\u5236\u5fa1\u6027\uff34\u30ea\u30f3\u30d1\u7403\u306e\u6a5f\u80fd\u89e3\u6790\uff0e \u5e73\u621021\u5e74\u5ea6\u79d1\u5b66\u7814\u7a76\u8cbb\u88dc\u52a9\u91d1 \u82e5\u624b\u7814\u7a76\uff08B\uff09\u7814\u7a76\u4ee3\u8868\u8005&nbsp; <\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-150","post","type-post","status-publish","format-standard","hentry","category-archive"],"yoast_head":"<!-- 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