{"id":211,"date":"2014-04-03T18:45:34","date_gmt":"2014-04-03T09:45:34","guid":{"rendered":"http:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/?p=211"},"modified":"2014-04-03T18:45:34","modified_gmt":"2014-04-03T09:45:34","slug":"2013%e5%b9%b4%e5%ba%a6%e6%a5%ad%e7%b8%be","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/archives\/211","title":{"rendered":"2013\u5e74\u5ea6\u696d\u7e3e"},"content":{"rendered":"


\n\u3010\u8ad6\u3000\u6587\u3011
\n1.\tTakahashi R, Sato Y, Kurata M, Yamazaki Y, Kimishima M, and Shiohara T: Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions.\u3000J Immunol 192: 969-978. 2014.
\n2.\tShiohara T, Takahashi R, and Kano,Y: Review. Regulatory T cells in severe drug eruption. Immune mechanisms of SCARs. In Current Immunology Review (Roujeau JC ed.) \u3000in press.
\n3.\tShiohara T, Ushigome U, Kano Y : Crucial role of viral reactivations in the development of severe drug eruptions. Clinical Reviews in Allergy & Immunology, in press
\n4.\tHirahara K, Kano Y, Sato Y, Horie C, Okazaki A, Ishida T, Aoyama Y, Shiohara T: Methylprednisolone pulse therapy for Stevens-Johnson syndrome\/toxic epidermal necrolysis:Clinical evaluation and analysis of biomarkers. J Am Acad Dermatol 69:496-498,2013.
\n5.\tShiohara T : Die rolle viraler infektionen bei schwerer arzneimittelreaktionen. Der Bayerische Internist 33:14-20,2013.
\n6.\tMineo S, Niikura M, Inoue S-I, Kuroda M, Kobayashi F: Development of severe pathology in immunized pregnant mice challenged with lethal malaria parasites. Inf Immun, 81(10): 3865-3871, 2013.
\n7.\tInoue S-I, Niikura M, Mineo S, Kobayashi F: Roles of IFN-\u03b3 and \u03b3\u03b4T cells in protective immunity against blood-stage malaria. Front Immunol, 4(258):1-9, 2013. (doi: 10.3389\/fimmu.2013.00258)
\n8.\t\u4e95\u4e0a\u4fe1\u4e00\uff08\u7dcf\u8aac\uff09\uff1a\u30de\u30e9\u30ea\u30a2\u539f\u866b\u611f\u67d3\u9632\u5fa1\u306b\u304a\u3051\u308b \u03b3\u03b4\uff08\u30ac\u30f3\u30de\u30c7\u30eb\u30bf\uff09T\u7d30\u80de\u306e\u5f79\u5272. \u674f\u6797\u533b\u5b66\u4f1a\u96d1\u8a8c 44 (4), s47-s48, 2013.
\n\u3010\u53e3\u3000\u6f14\u3011
\n1.\tTakahashi R and Shiohara T: \u3000 Suppressive CD14dimCD16+ monocytes contribute defective anti-viral immune responses in eczema herpeticum, International Investigative Dermatology 2013, Edinburgh, Scotland, May 8-11, 2013.
\n2.\tUshigome Y, Takahashi R, Shiohara T: CD16+ patrolling monocytes (pMO) sensing HSV negatively control regulatory T cell (Treg) responses in severe drug eruptions, International Investigative Dermatology 2013, Edinburgh, Scotland, May 8-11, 2013.
\n3.\t\u9ad8\u6a4b \u826f: \u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u60a3\u8005\u306b\u304a\u3051\u308b\u30d8\u30eb\u30da\u30b9\u30a6\u30a3\u30eb\u30b9\u306e\u518d\u6d3b\u6027\u5316\u3068\u5236\u5fa1\u6027 T \u7d30\u80de\u306e\u52d5\u614b. \u7b2c23\u56de\u65e5\u672c\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u5b66\u4f1a\u3000\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0,\u3000\u6771\u4eac, 2013\u5e746\u670822\u65e5.
\n4.\t\u4e95\u4e0a\u4fe1\u4e00,\u65b0\u5009\u3000\u4fdd,\u4e95\u4e0a\u611b\u7f8e,\u5cef\u5c3e\u677e\u4e00\u90ce,\u5c0f\u6797\u5bcc\u7f8e\u60e0: \u30de\u30e9\u30ea\u30a2\u539f\u866b\u611f\u67d3\u9632\u5fa1\u306b\u50cd\u304f\u813e\u81d3\u03b3\u03b4 T\u7d30\u80de\u306e\u30ec\u30d1\u30c8\u30a2\u89e3\u6790. \u7b2c24\u56de\u65e5\u672c\u751f\u4f53\u9632\u5fa1\u5b66\u4f1a\u5b66\u8853\u7dcf\u4f1a, \u718a\u672c, \u5e73\u621025\u5e747\u670810-12\u65e5.
\n5.\t\u4e95\u4e0a\u4fe1\u4e00\uff08\u5e73\u621025\u5e74\u5ea6\u751f\u4f53\u9632\u5fa1\u5b66\u4f1a\u5968\u52b1\u8cde\u53d7\u8cde\u8b1b\u6f14\uff09: \u30de\u30e9\u30ea\u30a2\u539f\u866b\u611f\u67d3\u9632\u5fa1\u306b\u304a\u3051\u308b\u03b3\u03b4 T\u7d30\u80de\u306e\u5f79\u5272\u306e\u89e3\u660e.\u7b2c24\u56de\u65e5\u672c\u751f\u4f53\u9632\u5fa1\u5b66\u4f1a\u5b66\u8853\u7dcf\u4f1a, \u718a\u672c, \u5e73\u621025\u5e747\u670810-12\u65e5.
\n6.\t\u6817\u7530\u660c\u548c, \u6c5f\u85e4\u3072\u3068\u307f, \u83c5\u6d69\u9686, \u591a\u4e45\u5d8b\u4eae\u5f66, \u6ce2\u5229\u4e95\u6e05\u7d00 \u76ae\u819a\u6f70\u760d\u4e0a\u76ae\u5316\u4fc3\u9032\u3092\u76ee\u7684\u3068\u3057\u305f\u7dda\u7dad\u82bd\u7d30\u80de\u304b\u3089\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3078\u306e\u76f4\u63a5\u8ee2\u63db\u306e\u3053\u3053\u308d\u307f \u30d1\u30cd\u30eb\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f31\u3000 \u5275\u50b7\u6cbb\u7652\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0 \u5e73\u621025\u5e747\u670811, 12\u65e5\u3000\u7b2c5\u56de\u65e5\u672c\u5275\u50b7\u5916\u79d1\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u96c6\u4f1a\u3000\u30db\u30c6\u30eb\u30b0\u30e9\u30f3\u30f4\u30a3\u30a2\u4eac\u90fd, \u4eac\u90fd\u5e9c
\n7.\tShin\u2013Ichi Inoue, Mamoru Niikura, Megumi Inoue, Shoichiro Mineo, Fumie Kobayashi: V\u03b31+ cells are the major subset of \u03b3\u03b4 T cells for protection against Plasmodium berghei XAT. Forum Cheju 16, Seoul, August 30th-September 1st, 2013.
\n8.\tMamoru Niikura, Shin\u2013Ichi Inoue, Shoichiro Mineo, Megumi Inoue, Fumie Kobayashi: Roles of
\nNT1 and PNP in the blood stages of Plasmodium berghei ANKA. Forum Cheju 16, Seoul, August 30th-September 1st, 2013.
\n9.\tMegumi Inoue, Jianxia Tang, Mana Miyakoda, Osamu Kaneko, Katsuyuki Yui, Richard Culleton: The specificity of immunity against the blood stages and pre-erythrocytic stages of Plasmodium yoelii. Forum Cheju 16, Seoul, August 30th-September 1st, 2013.
\n10.\t\u4e95\u4e0a\u4fe1\u4e00, \u65b0\u5009\u3000\u4fdd, \u4e95\u4e0a\u611b\u7f8e, \u5cef\u5c3e\u677e\u4e00\u90ce,\u5c0f\u6797\u5bcc\u7f8e\u60e0: Plasmodium berghei XAT\u611f\u67d3\u306b\u304a\u3051\u308b\u03b3\u03b4 T\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u6a5f\u80fd\u89e3\u6790. \u7b2c11\u56de\u5206\u5b50\u5bc4\u751f\u866b\u30fb\u30de\u30e9\u30ea\u30a2\u7814\u7a76\u30d5\u30a9\u30fc\u30e9\u30e0, \u9577\u5d0e, \u5e73\u621025\u5e7410\u67082-3\u65e5.
\n11.\t\u5cef\u5c3e\u677e\u4e00\u90ce, \u65b0\u5009\u3000\u4fdd, \u4e95\u4e0a\u4fe1\u4e00,\u4e95\u4e0a\u611b\u7f8e,\u9ed2\u7530\u96c5\u5f661,\u5c0f\u6797\u5bcc\u7f8e\u60e0\uff081\u6771\u4eac\u533b\u79d1\u5927\u5b66\u30fb\u5206\u5b50\u75c5\u7406\u5b66\u8b1b\u5ea7\uff09: \u598a\u5a20\u30de\u30e9\u30ea\u30a2\u306e\u75c5\u614b\u306b\u95a2\u308f\u308b\u65b0\u305f\u306a\u5bbf\u4e3b\u56e0\u5b50\u306e\u63a2\u7d22\uff0eDevelopment of liver dysfunction in immunized pregnant mice challenged with lethal malaria parasites. \u7b2c54\u56de\u65e5\u672c\u71b1\u5e2f\u533b\u5b66\u4f1a\u5927\u4f1a, \u9577\u5d0e, \u5e73\u621025\u5e7410\u67084-5\u65e5.
\n12.\t\u6817\u7530\u660c\u548c, \u6c5f\u85e4\u3072\u3068\u307f, \u4f50\u85e4\u5353\u5fd7, \u83c5\u6d69\u9686, \u591a\u4e45\u5d8b\u4eae\u5f66, \u6ce2\u5229\u4e95\u6e05\u7d00\u3000\u76ae\u819a\u6f70\u760d\u4e0a\u76ae\u5316\u4fc3\u9032\u3092\u76ee\u7684\u3068\u3057\u305f\u7dda\u7dad\u82bd\u7d30\u80de\u304b\u3089\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3078\u306e\u76f4\u63a5\u8ee2\u63db\u306e\u3053\u3053\u308d\u307f, \u7b2c22\u56de\u65e5\u672c\u5f62\u6210\u5916\u79d1\u5b66\u4f1a\u57fa\u790e\u5b66\u8853\u96c6\u4f1a\u3000\u6731\u9dfa\u30e1\u30c3\u30bb\u3000\u65b0\u6f5f\u30b3\u30f3\u30d9\u30f3\u30b7\u30e7\u30f3\u30bb\u30f3\u30bf\u30fc, \u65b0\u6f5f\u770c, \u5e73\u621025\u5e74\u300011\u67087, 8\u65e5.
\n13.\t\u6c5f\u85e4\u3072\u3068\u307f, \u6817\u7530\u660c\u548c, \u83c5\u6d69\u9686, \u591a\u4e45\u5d8b\u4eae\u5f66, \u6ce2\u5229\u4e95\u6e05\u7d00\u3000\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u3092\u7528\u3044\u305f\u771f\u76ae\u6d45\u5c64\u7dda\u7dad\u82bd\u7d30\u80de\u3068\u6df1\u5c64\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u6bd4\u8f03\u89e3\u6790, \u7b2c22\u56de\u65e5\u672c\u5f62\u6210\u5916\u79d1\u5b66\u4f1a\u57fa\u790e\u5b66\u8853\u96c6\u4f1a\u3000\u6731\u9dfa\u30e1\u30c3\u30bb\u3000\u65b0\u6f5f\u30b3\u30f3\u30d9\u30f3\u30b7\u30e7\u30f3\u30bb\u30f3\u30bf\u30fc, \u65b0\u6f5f\u770c, \u5e73\u621025\u5e7411\u67087, 8\u65e5.
\n14.\tHussein Abkallo1,\u4e95\u4e0a \u611b\u7f8e1, 2, Hunt Paul3, \u4e09\u9ad8 \u96bc\u4eba1, \u91d1\u5b50 \u4fee2,Illingworth Chris4, Martinelli Axel4, Shwen Ho Y5, Pain Arnab5, Culleton Richard1 \uff081\u9577\u5d0e\u5927\u5b66\u71b1\u5e2f\u533b\u5b66\u7814\u7a76\u6240\u5171\u540c\u7814\u7a76\u5ba4\u30de\u30e9\u30ea\u30a2\u30e6\u30cb\u30c3\u30c8, 2\u9577\u5d0e\u5927\u5b66\u71b1\u5e2f\u533b\u5b66\u7814\u7a76\u6240\u539f\u866b\u5b66\u5206\u91ce, 3\u30a8\u30b8\u30f3\u30d0\u30e9\u5927\u5b66\u611f\u67d3\u75c7\u7814\u7a76\u6240, 4\u30a6\u30a7\u30eb\u30ab\u30e0\u30c8\u30e9\u30b9\u30c8\u30b5\u30f3\u30ac\u30fc\u7814\u7a76\u6240 \u30b2\u30ce\u30e0\u30ad\u30e3\u30f3\u30d1\u30b9, 5\u30ad\u30f3\u30b0\u30a2\u30d6\u30c9\u30e9\u5de5\u79d1\u5927\u5b66 \u5316\u5b66\u751f\u547d\u79d1\u5b66\u5de5\u5b66\u90e8\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u751f\u7269\u79d1\u5b66\u7814\u7a76\u6240\uff09: Quantitative Whole Genome Resequencing and Genetic Linkage Analyses To Identify Genes Controlling Virulence in Malaria Parasites. \u7b2c54\u56de\u65e5\u672c\u71b1\u5e2f\u533b\u5b66\u4f1a\u5927\u4f1a, \u9577\u5d0e, \u5e73\u621025\u5e7410\u67084-5\u65e5.
\n15.\t\u77f3\u4e95\u3000\u660e, \u67f4\u7530\u3000\u6e05, \u5ca9\u6c38\u53f2\u6717, \u6cb9\u7530\u6b63\u592b \u65b0\u5009\u3000\u4fdd, \u5c0f\u6797\u5bcc\u7f8e\u60e0: \u30cd\u30ba\u30df\u30de\u30e9\u30ea\u30a2\u539f\u866b\uff12\u7a2e\u6df7\u5408\u611f\u67d3\u3067\u306e\u611f\u67d3\u52d5\u614b.\u7b2c73\u56de\u65e5\u672c\u5bc4\u751f\u866b\u5b66\u4f1a\u6771\u65e5\u672c\u652f\u90e8\u5927\u4f1a, \u6771\u4eac, \u5e73\u621025\u5e7410\u670812\u65e5.
\n16.\t\u6817\u7530\u6075\u91cc\u5948, \u83c5\u6d69\u9686, \u6817\u7530\u660c\u548c, \u6c5f\u85e4\u3072\u3068\u307f, \u4f50\u85e4\u5353\u58eb, \u6ce2\u5229\u4e95\u6e05\u7d00: \u5358\u7403\u30fb\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u7cfb\u7d30\u80de\u304c\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306e\u89e3\u660e, \u7b2c22\u56de\u65e5\u672c\u5f62\u6210\u5916\u79d1\u5b66\u4f1a\u57fa\u790e\u5b66\u8853\u96c6\u4f1a\u3000\u6731\u9dfa\u30e1\u30c3\u30bb\u3000\u65b0\u6f5f\u30b3\u30f3\u30d9\u30f3\u30b7\u30e7\u30f3\u30bb\u30f3\u30bf\u30fc, \u65b0\u6f5f\u770c, \u5e73\u621025\u5e7411\u67087, 8\u65e5.
\n17.\t\u4e95\u4e0a\u4fe1\u4e00\uff0c\u65b0\u5009\u3000\u4fdd\uff0c\u5927\u897f\u5b8f\u660e\uff0c\u6e21\u9089\u3000\u5353\uff0c\u5c0f\u6797\u5bcc\u7f8e\u60e0\uff0c\uff08\u5e73\u621025\u5e74\u5ea6\u674f\u6797\u5927\u5b66\u533b\u5b66\u90e8\u5171\u540c\u7814\u7a76\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u4e2d\u9593\u5831\u544a\uff09: \u30de\u30e9\u30ea\u30a2\u9632\u5fa1\u514d\u75ab\u306b\u304a\u3051\u308b\u03b3\u03b4 T\u7d30\u80de\u306e\u5f79\u5272\uff0e\u7b2c42\u56de\u674f\u6797\u533b\u5b66\u4f1a\u7dcf\u4f1a,\u6771\u4eac,\u5e73\u621025\u5e7411\u670816\u65e5.
\n18.\t\u4e95\u4e0a\u4fe1\u4e00, \u65b0\u5009\u3000\u4fdd, \u4e95\u4e0a\u611b\u7f8e\uff0c\u5cef\u5c3e\u677e\u4e00\u90ce,\u5c0f\u6797\u5bcc\u7f8e\u60e0: \u30de\u30e9\u30ea\u30a2\u539f\u866b\u611f\u67d3\u306b\u5bfe\u3059\u308b\u5bbf\u4e3b\u9632\u5fa1\u514d\u75ab\u3092\u4fc3\u9032\u3059\u308b\u03b3\u03b4 T\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u6a5f\u80fd\u89e3\u6790\uff0eCharacterzation of \u03b3\u03b4 T-cell subsets during Plasmodium berghei XAT infection. \u7b2c36\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a, \u795e\u6238, \u5e73\u621025\u5e7412\u67083-6\u65e5.
\n19.\tShin-Ichi Inoue, Mamoru Niikura, Megumi Inoue, Fumie Kobayashi: Protective effect of agonistic anti-CD40 monoclonal antibody is limited in the early phase of Plasmodium berghei XAT infection. \u7b2c42\u4f1a\u65e5\u672c\u514d\u75ab\u5b66\u4f1a\u5b66\u8853\u96c6\u4f1a, \u5e55\u5f35, \u5e73\u621025\u5e7412\u670811-13\u65e5.
\n20.\tKurita M, Eto H, Suga H, Takushima A, Harii K. Searching the way of direct conversion of fibroblasts into keratinocytes for the treatment of cutaneous ulcers. January 16, 17 and 18, 2014 Cira International Symposium 2014.Osaka, Japan. Center for Learning and Innovation (CLI), Takeda Pharmaceutical Company, Ltd., Osaka, Japan.
\n21.\tShin-Ichi Inoue, Mamoru Niikura, Megumi Inoue, Shoichiro Mineo, Fumie Kobayashi: The protective effect of CD40 ligand-CD40 signaling is limited during the early phase of Plasmodium infection. \u7b2c7\u56de\u5bc4\u751f\u866b\u611f\u67d3\u514d\u75ab\u7814\u7a76\u4f1a, \u9ad8\u5c71, \u5e73\u621026\u5e743\u670811-13\u65e5.
\n22.\t\u4e95\u4e0a\u4fe1\u4e00, \u65b0\u5009\u3000\u4fdd, \u4e95\u4e0a\u611b\u7f8e\uff0c\u5cef\u5c3e\u677e\u4e00\u90ce,\u5ddd\u4e0a\u3000\u6cf0, \u5185\u7530\u660e\u5f66, \u5c0f\u6797\u5bcc\u7f8e\u60e0: \u30de\u30e9\u30ea\u30a2\u9632\u5fa1\u514d\u75ab\u306b\u5fc5\u8981\u306aCD40\u30b7\u30b0\u30ca\u30eb\u3092\u4ecb\u3057\u305f\u6a39\u72b6\u7d30\u80de\u306e\u6d3b\u6027\u5316\u306f\u539f\u866b\u611f\u67d3\u521d\u671f\u3067\u91cd\u8981\u3067\u3042\u308b.\u7b2c83\u56de\u65e5\u672c\u5bc4\u751f\u866b\u5b66\u4f1a\u5927\u4f1a, \u611b\u5a9b, \u5e73\u621026\u5e743\u670827-28\u65e5.
\n23.\t\u65b0\u5009\u3000\u4fdd\uff0c\u5cef\u5c3e\u677e\u4e00\u90ce\uff0c\u4e95\u4e0a\u4fe1\u4e00\uff0c\u4e95\u4e0a\u611b\u7f8e, \u5c0f\u6797\u5bcc\u7f8e\u60e0: \u598a\u5a20\u306b\u3088\u308b\u30de\u30e9\u30ea\u30a2\u306e\u75c5\u614b\u91cd\u75c7\u5316\u6a5f\u69cb\u306e\u89e3\u660e\uff0eStudies on pathogenesis in immunized pregnant mice challenged with lethal malaria parasites. \u7b2c83\u56de\u65e5\u672c\u5bc4\u751f\u866b\u5b66\u4f1a\u5927\u4f1a, \u611b\u5a9b, \u5e73\u621026\u5e743\u670827-28\u65e5.
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