{"id":2512,"date":"2024-07-10T15:00:08","date_gmt":"2024-07-10T06:00:08","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/?p=2512"},"modified":"2024-07-12T12:38:09","modified_gmt":"2024-07-12T03:38:09","slug":"%e9%ab%98%e6%a9%8b%e8%89%af%e5%89%af%e9%83%a8%e9%96%80%e9%95%b7%e3%81%ae%e7%a0%94%e7%a9%b6%e3%82%b0%e3%83%ab%e3%83%bc%e3%83%97%e3%81%ae%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e3%81%8cjournal-of-investiga","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/archives\/2512","title":{"rendered":"\u9ad8\u6a4b\u826f\u526f\u90e8\u9580\u9577\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u7814\u7a76\u6210\u679c\u304cJournal of Investigative Dermatology\u306b\u63b2\u8f09"},"content":{"rendered":"

\u3000\u672c\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u90e8\u9580\u3000\u526f\u90e8\u9580\u9577\u3000\u9ad8\u6a4b\u3000\u826f\u3000\u8b1b\u5e2b\u3001\u540c\u90e8\u9580\u9577\u30fb\u76ae\u819a\u79d1\u5b66\u6559\u5ba4\u4e3b\u4efb\u3000\u5927\u5c71\u3000\u5b66\u3000\u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u7814\u7a76\u6210\u679c\u304c\u3001\u76ae\u819a\u79d1\u5b66\u7814\u7a76\u9818\u57df\u306e\u30c8\u30c3\u30d7\u30b8\u30e3\u30fc\u30ca\u30eb\u3067\u3042\u308bJournal of Investigative Dermatology\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u6025\u901f\u9032\u884c\u6027\u5e83\u6c4e\u6027\u5186\u5f62\u8131\u6bdb\u75c7\u306b\u304a\u3051\u308b\u6cbb\u7642\uff08\u70b9\u6ef4\u9759\u6ce8\u30b9\u30c6\u30ed\u30a4\u30c9\u30d1\u30eb\u30b9\u7642\u6cd5\uff1a\u30d1\u30eb\u30b9\u7642\u6cd5\uff09\u3078\u306e\u62b5\u6297\u6027\u3068\u95a2\u9023\u3059\u308b\u30ea\u30f3\u30d1\u7403\u306e\u30b5\u30d6\u30bb\u30c3\u30c8\uff08\u96c6\u56e3\uff09\u3092\u65b0\u3057\u304f\u540c\u5b9a\u3057\u305f\u3068\u3044\u3046\u5185\u5bb9\u306e\u7814\u7a76\u3067\u3001\u5f97\u3089\u308c\u305f\u77e5\u898b\u306f\u3053\u308c\u304b\u3089\u306e\u91cd\u75c7\u5186\u5f62\u8131\u6bdb\u75c7\u306e\u8a3a\u7642\u3067\u306e\u6d3b\u7528\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u9ad8\u6a4b\u8b1b\u5e2b\u306f<\/p>\n

\n

\u300c\u3053\u308c\u307e\u3067CD8\u967d\u6027T\u7d30\u80de\u304c\u81ea\u5df1\u514d\u75ab\u6027\u306e\u5186\u5f62\u8131\u6bdb\u75c7\u306e\u75c5\u56e0\u3068\u3055\u308c\u3066\u3044\u305f\u304c\u3001\u672c\u7814\u7a76\u6210\u679c\u306b\u3088\u308a\u6cbb\u7642\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u3055\u3089\u306b\u7d5e\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306f\u3001\u6700\u8fd1\u91cd\u75c7\u5186\u5f62\u8131\u6bdb\u75c7\u306e\u6cbb\u7642\u85ac\u306b\u9069\u7528\u3055\u308c\u3066\u3044\u308b\u7d4c\u53e3JAK\u963b\u5bb3\u85ac\u306e\u6cbb\u7642\u5fdc\u7b54\u6027\u30fb\u4e88\u5f8c\u3068\u76f8\u95a2\u3059\u308b\u56e0\u5b50\u306e\u63a2\u7d22\u306b\u3082\u5f79\u7acb\u3066\u305f\u3044\u3067\u3059\u3002\u300d<\/p>\n<\/blockquote>\n

\u3068\u3053\u308c\u304b\u3089\u306e\u7814\u7a76\u3078\u306e\u62b1\u8ca0\u3092\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u9ad8\u6a4b\u8b1b\u5e2b\u306f<\/p>\n

\n

\u300c\u672c\u7814\u7a76\u306f\u79c1\u304c\u6240\u5c5e\u3059\u308b\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u90e8\u9580\u306e\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3092\u7528\u3044\u3066\u7814\u7a76\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u306f\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u30ec\u30d9\u30eb\u3067\u591a\u9805\u76ee\u306e\u60c5\u5831\u3092\u3001\u77ac\u6642\u306b\u5ba2\u89b3\u7684\u30fb\u7d71\u8a08\u5b66\u7684\u306b\u53d6\u5f97\u51fa\u6765\u307e\u3059\u3002\u591a\u304f\u306e\u5148\u751f\u306e\u3054\u7814\u7a76\u306b\u5f53\u90e8\u9580\u306e\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3092\u6d3b\u7528\u3057\u3066\u3044\u305f\u3060\u3051\u308c\u3070\u3068\u601d\u3044\u307e\u3059\u3002\u300d<\/p>\n<\/blockquote>\n

\u3068\u30b3\u30e1\u30f3\u30c8\u3057\u3066\u3044\u308b\u3002<\/p>\n

\n

\u7d30\u80de\u969c\u5bb3\u6027CD8\u967d\u6027TEMRA\u7d30\u80de\u306f\u91cd\u75c7\u5186\u5f62\u8131\u6bdb\u75c7\u306e\u96e3\u6cbb\u6027\u306b\u95a2\u9023\u3059\u308b<\/h1>\n

\u6982\u8981<\/h2>\n

\u3000\u5186\u5f62\u8131\u6bdb\u75c7\u306f\u3001\u4e3b\u306b\u514d\u75ab\u7d30\u80de\u306e\u3046\u3061natural killer group 2 member D\uff08NKG2D\uff09\u967d\u6027CD8\u967d\u6027T\u7d30\u80de\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3057\u3001\u6210\u9577\u671f\u6bdb\u306e\u6bdb\u7403\u90e8\u306b\u767a\u73fe\u3059\u308b\u81ea\u5df1\u6297\u539f\u3092\u6a19\u7684\u3068\u3059\u308b\u81ea\u5df1\u514d\u75ab\u5fdc\u7b54\u306b\u3088\u308a\u8131\u6bdb\u304c\u751f\u3058\u308b\u75be\u60a3\u3067\u3059\u3002\u6025\u901f\u306b\u8131\u6bdb\u75c7\u72b6\u304c\u5e83\u7bc4\u56f2\u306b\u751f\u3058\u308b\u91cd\u75c7\u4f8b\u3067\u306f\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u77ed\u671f\u9593\u306b\u70b9\u6ef4\u9759\u6ce8\u3059\u308b\u30d1\u30eb\u30b9\u7642\u6cd5\uff08\u4ee5\u4e0b\u30d1\u30eb\u30b9\u7642\u6cd5\uff09\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u30d1\u30eb\u30b9\u6cbb\u7642\u304c\u6709\u52b9\u3067\u3042\u3063\u305f\u304b\u3092\u8a55\u4fa1\u3059\u308b\u306b\u306f\u6570\u30f6\u6708\u3068\u9577\u3044\u671f\u9593\u3092\u8981\u3059\u308b\u305f\u3081\u3001\u7d4c\u904e\u89b3\u5bdf\u4e2d\u306e\u60a3\u8005\u3055\u3093\u306e\u4e0d\u5b89\u306f\u5927\u304d\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u63b2\u8f09\u8ad6\u6587<\/h2>\n

\"\"<\/a><\/p>\n

Journal of Investigative Dermatology 144: 1654-1657.E7.<\/span><\/a><\/p>\n

\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1aIncrease in CD8+<\/sup> Effector Memory T Cells Re-Expressing CD45RA Correlates with Intractability of Severe Alopecia Areata<\/span><\/p>\n

\u7b46\u3000\u8005\uff1aRyo Takahashi1<\/sup>, Misaki Kinoshita-Ise2<\/sup>, Yoshimi Yamazaki2<\/sup>, Masahiro Fukuyama2<\/sup>, Manabu Ohyama1,2<\/sup>
\n(1.<\/span>\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u90e8\u9580, 2.<\/span>\u533b\u5b66\u90e8\u76ae\u819a\u79d1\u5b66\u6559\u5ba4)<\/span><\/p>\n

DOI: <\/span>doi.org\/10.1016\/j.jid.2024.01.006<\/div>\n

 <\/p>\n

\u7814\u7a76\u6210\u679c<\/h2>\n

\u3000\u672c\u7814\u7a76\u3067\u306f\u3001\u672b\u68a2\u8840\u4e2d\u306eT\u7d30\u80de\u306e\u91cf\u7684\u30fb\u8cea\u7684\u306a\u5909\u5316\u3092\u3001\u7814\u7a76\u4ee3\u8868\u8005\u304c\u6240\u5c5e\u3057\u7ba1\u7406\u904b\u55b6\u3092\u884c\u3063\u3066\u3044\u308b\u300c\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u300d\u3068\u547c\u3070\u308c\u308b\u6700\u5148\u7aef\u306e\u7d30\u80de\u89e3\u6790\u88c5\u7f6e\u3067\u8a73\u7d30\u306b\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001\u60a3\u8005\u672b\u68a2\u8840\u6db2\u4e2d\u306b\u5b58\u5728\u3059\u308bCD8\u967d\u6027T\u7d30\u80de\u306e\u7279\u6b8a\u306a\u30b5\u30d6\u30bb\u30c3\u30c8\u306eTEMRA\uff08Terminally differentiated effector memory T cells re-expressing CD45RA\uff09\u304c\u3001\u30d1\u30eb\u30b9\u7642\u6cd5\u306b\u5bfe\u3057\u3066\u62b5\u6297\u6027\u3092\u793a\u3059\u96e3\u6cbb\u6027\u306e\u5186\u5f62\u8131\u6bdb\u75c7\u60a3\u8005\u3055\u3093\u306e\u672b\u68a2\u8840\u4e2d\u3067\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u3000CD8\u967d\u6027TEMRA\uff08\u4ee5\u5f8cTEMRA\uff09\u306f\u3001\u6700\u7d42\u5206\u5316\u3057\u305fT\u7d30\u80de\u3067\u3001\u7d30\u80de\u819c\u306b\u5b54\u3092\u958b\u3051\u308b\u30d1\u30fc\u30d5\u30a9\u30ea\u30f3\u3084\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306e\u30b0\u30e9\u30f3\u30b6\u30a4\u30e0B\u3068\u3044\u3063\u305f\u7d30\u80de\u6eb6\u89e3\u305f\u3093\u3071\u304f\u8cea\u3092\u4fdd\u6301\u3057\u3066\u3044\u308b\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de\u96c6\u56e3\uff08CTL: Cytotoxic T-Lymphocyte\uff09\u306e\u3072\u3068\u3064\u3067\u3059\u3002\u30d1\u30eb\u30b9\u7642\u6cd5\u62b5\u6297\u7fa4\u3067\u5897\u52a0\u3057\u3066\u3044\u308bTEMRA\u306f\u3001\u6bdb\u7403\u90e8\u306b\u767a\u73fe\u3059\u308b\u81ea\u5df1\u6297\u539f\u306e\u30c8\u30ea\u30b3\u30d2\u30a2\u30ea\u30f3\u306b\u7279\u7570\u7684\u306b\u53cd\u5fdc\u3059\u308b\u3053\u3068\u304c\u6a5f\u80fd\u89e3\u6790\u3067\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u30d1\u30eb\u30b9\u7642\u6cd5\u62b5\u6297\u7fa4\u306e\u75c5\u5909\u90e8\u306e\u7d44\u7e54\u6a19\u672c\u3092\u7528\u3044\u305f\u89e3\u6790\u3067\u3082TEMRA\u304c\u96c6\u7a4d\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u3001\u672b\u68a2\u8840\u6db2\u4e2d\u306e\u540c\u3058\u30ea\u30f3\u30d1\u7403\u306e\u96c6\u56e3\u306e\u6bd4\u7387\u3068\u6b63\u306e\u76f8\u95a2\u6027\u304c\u307f\u3089\u308c\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u306f\u3001\u30d1\u30eb\u30b9\u6cbb\u7642\u524d\u306b\u672b\u68a2\u8840\u6db2\u691c\u67fb\u3067TEMRA\u306e\u983b\u5ea6\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u6cbb\u7642\u53cd\u5fdc\u6027\u306e\u5ba2\u89b3\u7684\u306a\u4e88\u6e2c\u304c\u53ef\u80fd\u306b\u306a\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\"\u56f31<\/a><\/p>\n

\u56f31 \u30d1\u30eb\u30b9\u7642\u6cd5\u62b5\u6297\u7fa4\u60a3\u8005\u672b\u68a2\u8840\u304a\u3088\u3073\u75c5\u5909\u7d44\u7e54\u3067TEMRA\u304c\u5897\u52a0\u3057\u3066\u3044\u308b<\/h4>\n

A: <\/strong>\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u6e2c\u5b9a\u3057\u305f\u60a3\u8005\u672b\u68a2\u8840<\/strong>CD8<\/strong>\u967d\u6027<\/strong>T<\/strong>\u7d30\u80de\u4e2d\u306e<\/strong>TEMRA<\/strong>\u306e\u983b\u5ea6<\/strong><\/p>\n

\u30d1\u30eb\u30b9\u7642\u6cd5\u958b\u59cb\u524d\u304b\u3089\u6cbb\u7642\u7d4c\u904e\u4e2d\u306b\u308f\u305f\u3063\u3066TEMRA\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u3066\u3044\u305f\u3002<\/p>\n

\u3000*P<\/em> < .005, **P<\/em> < .05<\/p>\n

B:<\/strong>\u30d1\u30eb\u30b9\u7642\u6cd5\u62b5\u6297\u7fa4\u60a3\u8005\u75c5\u5909\u7d44\u7e54\u306b\u96c6\u7a4d\u3057\u3066\u3044\u308b<\/strong>TEMRA<\/strong>\uff08<\/strong>\u25b2<\/strong><\/span>\uff09<\/strong><\/p>\n

\u9752\uff1a<\/span>CD8<\/span>\u967d\u6027\u7d30\u80de\u3000\u8d64\uff1a<\/span>NKG2<\/span>\u967d\u6027\u7d30\u80de\uff08<\/span>TEMRA<\/span>\uff09<\/span><\/p>\n

\"\u56f32<\/a><\/p>\n

\u56f32 \u00a0\u30de\u30eb\u30c1\u30ab\u30e9\u30fc\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3092\u7528\u3044\u305fTEMRA\u306et-SNE\u89e3\u6790\u306e\u4e00\u4f8b<\/h4>\n

\u30d1\u30eb\u30b9\u7642\u6cd5\u5fdc\u7b54\u7fa4\u3068\u62b5\u6297\u7fa4\u3067<\/span>TEMRA<\/span>\u306e\u30af\u30e9\u30b9\u30bf\u30fc\u5206\u5e03\u304c\u5927\u304d\u304f\u7570\u306a\u3063\u3066\u3044\u308b\u3002\u5f53\u90e8\u9580\u3067\u904b\u55b6\u3057\u3066\u3044\u308b\u65e5\u672c<\/span>BD FACSCanto II<\/span><\/a>\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc<\/a>\u3067\u6e2c\u5b9a\u3057\u3001<\/span>FlowJo <\/span><\/a>\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3067\u89e3\u6790\u3057\u305f\u3002<\/span><\/p>\n

\n

\u7528\u8a9e\u89e3\u8aac<\/h2>\n

\u6025\u901f\u9032\u884c\u6027\u5e83\u6c4e\u6027\u5186\u5f62\u8131\u6bdb\u75c7\uff1a<\/strong><\/p>\n

\u5178\u578b\u7684\u306b\u306f\u5f8c\u5929\u6027\u306b\u985e\u5186\u5f62\u306e\u8131\u6bdb\u6591\u3092\u751f\u3057\u3099\u308b\u75be\u60a3\u304c\u5186\u5f62\u8131\u6bdb\u75c7\u3067\u3059\u304c\u3001\u305d\u306e\u91cd\u75c7\u578b\u306e\u3072\u3068\u3064\u3068\u3057\u6025\u901f\u306b\u307b\u307c\u5168\u982d\u306b\u8131\u6bdb\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u6025\u901f\u9032\u884c\u6027\u5e83\u6c4e\u6027\u5186\u5f62\u8131\u6bdb\u75c7\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u70b9\u6ef4\u9759\u6ce8\u30b9\u30c6\u30ed\u30a4\u30c9\u30d1\u30eb\u30b9\u7642\u6cd5\uff1a<\/strong><\/p>\n

\u70b9\u6ef4\u9759\u6ce8\u30b9\u30c6\u30ed\u30a4\u30c8\u3099\u30cf\u309a\u30eb\u30b9\u7642\u6cd5\u306f\u3001\u767a\u75c7\u5f8c 6 \u30ab\u6708\u4ee5\u5185\u3066\u3099\u3001\u6025\u901f\u9032\u884c\u4e2d\u306e\u982d\u90e8\u5168\u4f53\u306e\u9762\u7a4d\u306b\u5360\u3081\u308b\u8131\u6bdb\u5de3\u9762\u7a4d\u306e\u5272\u5408\u304b\u309925\uff05 \u4ee5\u4e0a\u301c\u5168\u982d\u307e\u3066\u3099\u81f3\u3063\u3066\u3044\u306a\u3044\u75c7\u4f8b\u306b\u306f\u6cbb\u7642\u306e\u9078\u629e\u80a2\u306e\u4e00\u3064\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

CD8<\/strong>\u967d\u6027<\/strong>TEMRA:<\/strong><\/p>\n

CD8\u967d\u6027\u30bf\u30fc\u30df\u30ca\u30eb\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u30e1\u30e2\u30ea\u30fcCD45RA\u967d\u6027T \u7d30\u80de (Terminally differentiated effector memory T cells re-expressing CD45RA)\u306f\u3001\u751f\u6765\u306e\u30b7\u30b0\u30ca\u30eb\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u306e\u5897\u52a0\u3001T \u7d30\u80de\u53d7\u5bb9\u4f53 (TCR) \u4f9d\u5b58\u6027\u6d3b\u6027\u5316\u306e\u4f4e\u4e0b\u3001\u304a\u3088\u3073 TCR \u30af\u30ed\u30fc\u30f3\u591a\u69d8\u6027\u306e\u4f4e\u4e0b\u3092\u7279\u5fb4\u3068\u3057\u3001\u7279\u306b\u9ad8\u9f62\u8005\u3067\u5897\u52a0\u3057\u3066\u3044\u308bCD\uff18\u967d\u6027T\u30ea\u30f3\u30d1\u7403\u306e\u96c6\u56e3\u3067\u3059\u3002 CD8\u967d\u6027TEMRA\u7d30\u80de\u96c6\u56e3\u306b\u304a\u3051\u308b\u819c\u53d7\u5bb9\u4f53CD28\u3001CD27\u3001CD127\u306e\u55aa\u5931\u3001CD45RA\u306e\u518d\u767a\u73fe\u3001\u304a\u3088\u3073\u75b2\u5f0a\u30de\u30fc\u30ab\u30fcPD1\u306e\u767a\u73fe\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u8981\u56e0\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u7d30\u80de\u969c\u5bb3\u6027<\/strong>T<\/strong>\u7d30\u80de\uff1a<\/strong><\/p>\n

CD8<\/span>\u967d\u6027<\/span>\u30ea\u30f3\u30d1\u7403<\/span>T<\/span>\u7d30\u80de\u306e\u3046\u3061\u306e\u3072\u3068\u3064\u3067\u3001\u5bbf\u4e3b\u306b\u3068\u3063\u3066\u7570\u7269\u306b\u306a\u308b\u79fb\u690d\u7d30\u80de\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u7d30\u80de\u3001\u764c\u7d30\u80de\u306a\u3069\u3092\u8a8d\u8b58\u3057\u3066\u7834\u58ca\u3057\u307e\u3059\u3002<\/span><\/p>\n

\u76ae\u819a\u79d1\u5b66\u6559\u5ba4\u306e\u8a73\u7d30\u306f\u3053\u3061\u3089\uff08https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/derma\/<\/a>\uff09\u3092\u3054\u89a7\u4e0b\u3055\u3044\u3002<\/div>\n","protected":false},"excerpt":{"rendered":"

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