{"id":2926,"date":"2025-12-25T17:51:21","date_gmt":"2025-12-25T08:51:21","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/?p=2926"},"modified":"2025-12-25T17:59:24","modified_gmt":"2025-12-25T08:59:24","slug":"%e9%9b%a3%e6%b2%bb%e6%80%a7%e5%86%86%e5%bd%a2%e8%84%b1%e6%af%9b%e7%97%87%e3%81%ae%e6%b2%bb%e7%99%82%e6%8a%b5%e6%8a%97%e6%80%a7%e3%81%ab%e9%96%a2%e3%82%8f%e3%82%8bt%e7%b4%b0%e8%83%9e%e3%81%ae%e7%89%b9","status":"publish","type":"post","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/archives\/2926","title":{"rendered":"\u96e3\u6cbb\u6027\u5186\u5f62\u8131\u6bdb\u75c7\u306e\u6cbb\u7642\u62b5\u6297\u6027\u306b\u95a2\u308f\u308bT\u7d30\u80de\u306e\u7279\u6027\u3092\u89e3\u660e"},"content":{"rendered":"<h2><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"2930\" data-permalink=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/archives\/2926\/g6itfv6wcaavads\" data-orig-file=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/G6iTFv6WcAAVadS.jpeg\" data-orig-size=\"583,768\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"G6iTFv6WcAAVadS\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/G6iTFv6WcAAVadS.jpeg\" class=\"alignnone wp-image-2930 size-medium\" src=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/G6iTFv6WcAAVadS-228x300.jpeg\" alt=\"\" width=\"228\" height=\"300\" srcset=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/G6iTFv6WcAAVadS-228x300.jpeg 228w, https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/G6iTFv6WcAAVadS.jpeg 583w\" sizes=\"auto, (max-width: 228px) 100vw, 228px\" \/><\/h2>\n<h2 style=\"font-weight: 400;\">\u9ad8\u6a4b\u3000\u826f\u3000\u526f\u90e8\u9580\u9577\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u7814\u7a76\u6210\u679c\u304cJournal of Investigative Dermatology\u306b\u63b2\u8f09<\/h2>\n<p>\u672c\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u90e8\u9580\u3000\u526f\u90e8\u9580\u9577\u3000\u9ad8\u6a4b\u3000\u826f\u3000\u8b1b\u5e2b\u3001\u540c\u90e8\u9580\u9577\u30fb\u76ae\u819a\u79d1\u5b66\u6559\u5ba4\u4e3b\u4efb\u3000\u5927\u5c71\u3000\u5b66\u3000\u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u7814\u7a76\u6210\u679c\u304c\u3001\u76ae\u819a\u79d1\u5b66\u7814\u7a76\u9818\u57df\u306e\u30c8\u30c3\u30d7\u30b8\u30e3\u30fc\u30ca\u30eb\u3067\u3042\u308bJournal of Investigative Dermatology\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p style=\"font-weight: 400;\"><strong>\u3010\u7814\u7a76\u306e\u30cf\u30a4\u30e9\u30a4\u30c8\u3011<\/strong><\/p>\n<ul>\n<li>\u91cd\u75c7\u306e\u5186\u5f62\u8131\u6bdb\u75c7\u306f\u3001\u672c\u6765\u306f\u4f53\u3092\u5b88\u308b\u306f\u305a\u306e\u514d\u75ab\u7d30\u80de\u304c\u3001\u6210\u9577\u4e2d\u306e\u6bdb\u6839\u3092\u8aa4\u3063\u3066\u653b\u6483\u3057\u3066\u3057\u307e\u3046\u3053\u3068\u3067\u3001\u77ed\u671f\u9593\u306e\u3046\u3061\u306b\u5f37\u3044\u8131\u6bdb\u304c\u8d77\u3053\u308b\u75c5\u6c17\u3067\u3059\u3002\u7279\u306b\u6025\u901f\u306b\u75c7\u72b6\u304c\u9032\u884c\u3059\u308b\u75c7\u4f8b\u306e\u6cbb\u7642\u306b\u306f\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u70b9\u6ef4\u3067\u6295\u4e0e\u3059\u308b\u300c\u30b9\u30c6\u30ed\u30a4\u30c9\u30d1\u30eb\u30b9\u7642\u6cd5\u300d\u304c\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8ab0\u306b\u52b9\u679c\u304c\u51fa\u308b\u306e\u304b\u3092\u4e8b\u524d\u306b\u4e88\u6e2c\u3059\u308b\u65b9\u6cd5\u306f\u3001\u3053\u308c\u307e\u3067\u5341\u5206\u306b\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/li>\n<li>\u79c1\u305f\u3061\u306f\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u3001\u8840\u6db2\u4e2d\u306b\u5b58\u5728\u3059\u308b\u514d\u75ab\u7d30\u80de\u306e\u4e00\u90e8\uff08TEMRA\u7d30\u80de\uff09\u304c\u3001\u6cbb\u7642\u304c\u52b9\u304d\u306b\u304f\u3044\u60a3\u8005\u3055\u3093\u3067\u5897\u3048\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u7d30\u80de\u304c\u591a\u3044\u3060\u3051\u3067\u306f\u3001\u6cbb\u7642\u306e\u52b9\u304d\u306b\u304f\u3055\u3092\u5b8c\u5168\u306b\u306f\u8aac\u660e\u3067\u304d\u306a\u3044\u3053\u3068\u3082\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/li>\n<li>\u672c\u7814\u7a76\u3067\u306f\u3001\u6cbb\u7642\u304c\u52b9\u304d\u306b\u304f\u3044\u60a3\u8005\u3055\u3093\u3067\u306f\u3001TEMRA\u7d30\u80de\u306e\u4e2d\u3067\u3082\u7279\u306b\u653b\u6483\u6027\u306e\u5f37\u3044\u30bf\u30a4\u30d7\u306e\u7d30\u80de\u304c\u591a\u304f\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u7d30\u80de\u306e\u300c\u6570\u300d\u3060\u3051\u3067\u306a\u304f\u3001\u300c\u6027\u8cea\u306e\u9055\u3044\u300d\u304c\u6cbb\u7642\u7d50\u679c\u306b\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n<li>\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u6cbb\u7642\u524d\u306b\u8840\u6db2\u4e2d\u306e\u514d\u75ab\u7d30\u80de\u306e\u7279\u5fb4\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u30d1\u30eb\u30b9\u7642\u6cd5\u304c\u52b9\u304d\u3084\u3059\u3044\u304b\u3069\u3046\u304b\u3092\u65e9\u3044\u6bb5\u968e\u3067\u4e88\u6e2c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u60a3\u8005\u3055\u3093\u4e00\u4eba\u3072\u3068\u308a\u306b\u5408\u3063\u305f\u6cbb\u7642\u3092\u9078\u3076\u305f\u3081\u306e\u65b0\u3057\u3044\u624b\u304c\u304b\u308a\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\"><strong>\u3010\u6982\u8981\u3011<\/strong><\/p>\n<p style=\"font-weight: 400;\"><strong>\uff5e\u65e9\u671f\u306e\u6cbb\u7642\u52b9\u679c\u4e88\u6e2c\u306b\u8ca2\u732e\u3059\u308b\u53ef\u80fd\u6027\uff5e<\/strong><\/p>\n<p style=\"font-weight: 400;\">\u5186\u5f62\u8131\u6bdb\u75c7\uff08Alopecia Areata: AA\uff09\u306f\u3001\u81ea\u8eab\u306e\u514d\u75ab\u304c\u8aa4\u3063\u3066\u6210\u9577\u671f\u6bdb\u306e\u6bdb\u7403\u90e8\u306b\u767a\u73fe\u3059\u308b\u81ea\u5df1\u6297\u539f\u3092\u653b\u6483\u3057\u3001\u8131\u6bdb\u3092\u5f15\u304d\u8d77\u3053\u3059\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u4e00\u3064\u3067\u3059\u3002\u306a\u304b\u3067\u3082\u3001\u982d\u90e8\u5168\u4f53\u306b\u8131\u6bdb\u304c\u6025\u901f\u306b\u9032\u884c\u3059\u308b\u6025\u901f\u9032\u884c\u6027\u306e\u5e83\u6c4e\u6027\u5186\u5f62\u8131\u6bdb\u75c7\uff08Rapidly Progressive Alopecia Areata: RP\u2212AA\uff09\u306f\u91cd\u75c7\u578b\u3068\u3055\u308c\u3001\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u77ed\u671f\u9593\u306b\u70b9\u6ef4\u9759\u6ce8\u3059\u308b\u30b9\u30c6\u30ed\u30a4\u30c9\u30d1\u30eb\u30b9\u7642\u6cd5\uff08\u30d1\u30eb\u30b9\u7642\u6cd5\uff09\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"font-weight: 400;\">\u3057\u304b\u3057\u3001\u30d1\u30eb\u30b9\u7642\u6cd5\u306e\u52b9\u679c\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u6700\u7d42\u7684\u306a\u6cbb\u7642\u52b9\u679c\u306e\u8a55\u4fa1\u306b\u306f\u7d046\u304b\u6708\u3092\u8981\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u6cbb\u7642\u53cd\u5fdc\u6027\u3092\u65e9\u671f\u306b\u4e88\u6e2c\u3067\u304d\u308b\u6307\u6a19\u306e\u78ba\u7acb\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p style=\"font-weight: 400;\"><strong>T<\/strong><strong>\u7d30\u80de\u306e\u30b5\u30d6\u30bb\u30c3\u30c8\u306b\u7740\u76ee\u3057\u305f\u7814\u7a76<\/strong><\/p>\n<p style=\"font-weight: 400;\">\u79c1\u305f\u3061\u306f\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u3001\u30d1\u30eb\u30b9\u7642\u6cd5\u306b\u53cd\u5fdc\u3057\u306a\u3044\u975e\u5fdc\u7b54\u8005\u306e\u60a3\u8005\u3055\u3093\u306e\u8840\u6db2\u4e2d\u306b\u3001\u514d\u75ab\u7d30\u80de\u306e\u4e00\u7a2e\u3067\u3042\u308bCD8<sup>+<\/sup> TEMRA\uff08effector memory T cells re-expressing CD45RA\uff09\u7d30\u80de\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f<\/p>\n<p style=\"font-weight: 400;\">\uff08<a href=\"https:\/\/www.jidonline.org\/article\/S0022-202X(24)00025-3\/fulltext\" target=\"_blank\" rel=\"noopener\">Journal of Investigative Dermatology 144: 1654\u20131657.e7, 2024<\/a>\uff0f\u30ea\u30f3\u30af\uff1a<a href=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/archives\/2512\" target=\"_blank\" rel=\"noopener\">FCM NEW\u8a18\u4e8b<\/a>\uff09\u3002\u4e00\u65b9\u3067\u3001TEMRA\u7d30\u80de\u306e\u5897\u52a0\u3068\u6cbb\u7642\u52b9\u679c\u306f\u5fc5\u305a\u3057\u3082\u76f8\u95a2\u305b\u305a\u3001\u7d30\u80de\u306e\u300c\u6027\u8cea\u300d\u306e\u9055\u3044\u304c\u6cbb\u7642\u53cd\u5fdc\u6027\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p style=\"font-weight: 400;\">\u305d\u3053\u3067\u672c\u7814\u7a76\u3067\u306f\u3001\u6cbb\u7642\u5fdc\u7b54\u8005\u3068\u975e\u5fdc\u7b54\u8005\u306e\u9593\u3067\u3001TEMRA\u7d30\u80de\u306e\u300c\u8cea\u300d\u306b\u9055\u3044\u304c\u3042\u308b\u306e\u304b\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u7814\u7a76\u4ee3\u8868\u8005\u304c\u6240\u5c5e\u3057\u7ba1\u7406\u904b\u55b6\u3092\u884c\u3063\u3066\u3044\u308b\u300c\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u300d\u306b\u3088\u308b\u6700\u5148\u7aef\u306e\u7d30\u80de\u89e3\u6790\u6280\u8853\u3092\u7528\u3044\u3001T\u7d30\u80de\u306e\u6210\u719f\u3084\u6a5f\u80fd\u306b\u95a2\u4e0e\u3059\u308bCD27\u3084\u3001\u514d\u75ab\u306e\u30d6\u30ec\u30fc\u30ad\u5f79\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u5206\u5b50PD\u22121\u306e\u767a\u73fe\u72b6\u6cc1\u3092\u8a73\u3057\u304f\u8abf\u3079\u307e\u3057\u305f\u3002<\/p>\n<p style=\"font-weight: 400;\"><strong>\u6cbb\u7642\u62b5\u6297\u6027\u306b\u95a2\u308f\u308b\u300cCD27<sup>\u2212<\/sup>PD\u22121<sup>\u2212<\/sup> TEMRA\u300d\u306e\u512a\u4f4d\u6027<\/strong><\/p>\n<p style=\"font-weight: 400;\">\u305d\u306e\u7d50\u679c\u3001\u30d1\u30eb\u30b9\u7642\u6cd5\u975e\u5fdc\u7b54\u8005\u3067\u306f\u3001TEMRA\u7d30\u80de\u306e\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u3046\u3061\u3001CD27\u304a\u3088\u3073PD\u22121\u306e\u3044\u305a\u308c\u3082\u767a\u73fe\u3057\u306a\u3044\uff08CD27<sup>\u2212<\/sup>PD\u22121<sup>\u2212<\/sup>\uff09TEMRA\u7d30\u80de\u304c\u3001\u5fdc\u7b54\u8005\u3068\u6bd4\u3079\u3066\u6709\u610f\u306b\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08<strong>\u56f3<\/strong><strong>a<\/strong><strong>\u3001<\/strong><strong>b<\/strong>\uff09\u3002<\/p>\n<p style=\"font-weight: 400;\">\u3053\u306eCD27<sup>\u2212<\/sup>PD\u22121<sup>\u2212<\/sup> TEMRA\u7d30\u80de\u306f\u3001\u7d30\u80de\u50b7\u5bb3\u6d3b\u6027\uff08\u30b0\u30e9\u30f3\u30b6\u30a4\u30e0B\u304a\u3088\u3073\u30d1\u30fc\u30d5\u30a9\u30ea\u30f3\u306e\u767a\u73fe\uff09\u304c\u975e\u5e38\u306b\u9ad8\u304f\uff08<strong>\u56f3<\/strong><strong>c<\/strong>\uff09\u3001\u6cbb\u7642\u62b5\u6297\u6027\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001PD\u22121<sup>\u2212<\/sup> TEMRA\u7d30\u80de\u306f\u8840\u6db2\u4e2d\u3060\u3051\u3067\u306a\u304f\u3001\u6cbb\u7642\u524d\u306e\u75c5\u5909\u982d\u76ae\u306b\u304a\u3051\u308b\u6bdb\u5305\u5468\u56f2\u3067\u3082\u6709\u610f\u306b\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\uff08<strong>\u56f3<\/strong><strong>d<\/strong><strong>\u3001<\/strong><strong>e<\/strong>\uff09\u3002\u4e00\u65b9\u3001PD-1\u3068\u7d50\u5408\u3057\u3066\u514d\u75ab\u30d6\u30ec\u30fc\u30ad\u3092\u4f5c\u52d5\u3055\u305b\u308bPD-L1\u306e\u3001\u6bdb\u7403\u90e8\u306b\u304a\u3051\u308b\u767a\u73fe\u3092\u8abf\u3079\u307e\u3057\u305f\u304c\u3001\u5fdc\u7b54\u7fa4\u3068\u975e\u5fdc\u7b54\u7fa4\u306e\u9593\u306b\u5927\u304d\u306a\u5dee\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p style=\"font-weight: 400;\"><strong>\u6cbb\u7642\u53cd\u5fdc\u6027\u3068\u7279\u5b9a\u306eTEMRA\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u3068\u306e\u76f8\u95a2<\/strong><\/p>\n<p style=\"font-weight: 400;\">\u6cbb\u7642\u5f8c\u306e\u6bdb\u9aea\u518d\u751f\u7387\u3068\u5404TEMRA\u30b5\u30d6\u30bb\u30c3\u30c8\u306e\u983b\u5ea6\u306e\u76f8\u95a2\u3092\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001\u6cbb\u7642\u524d\u306bCD27\u3068PD\u22121\u306e\u4e21\u65b9\u3092\u767a\u73fe\u3057\u3066\u3044\u308b\uff08CD27<sup>+<\/sup>PD\u22121<sup>+<\/sup>\uff09TEMRA\u7d30\u80de\u306e\u5272\u5408\u304c\u9ad8\u3044\u60a3\u8005\u3055\u3093\u307b\u3069\u3001\u6bdb\u9aea\u518d\u751f\u7387\u304c\u826f\u597d\u3067\u3042\u308b\u3068\u3044\u3046\u6b63\u306e\u76f8\u95a2\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u306f\u3001\u514d\u75ab\u306e\u30d6\u30ec\u30fc\u30ad\u6a5f\u69cb\u306b\u3088\u3063\u3066\u5236\u5fa1\u53ef\u80fd\u306aT\u7d30\u80de\u304c\u591a\u3044\u307b\u3069\u3001\u30d1\u30eb\u30b9\u7642\u6cd5\u304c\u6709\u52b9\u306b\u50cd\u304d\u3084\u3059\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3><strong>\u307e\u3068\u3081<\/strong><\/h3>\n<p style=\"font-weight: 400;\">\u672c\u7814\u7a76\u306b\u3088\u308a\u3001RP\u2212AA\u306b\u5bfe\u3059\u308b\u30d1\u30eb\u30b9\u7642\u6cd5\u306e\u6cbb\u7642\u52b9\u679c\u306b\u306f\u3001TEMRA\u7d30\u80de\u306e\u91cf\u7684\u306a\u9055\u3044\u3060\u3051\u3067\u306a\u304f\u3001\u305d\u306e\u8cea\u7684\u306a\u9055\u3044\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u60a3\u8005\u3055\u3093\u306e\u8840\u6db2\u4e2d\u306b\u5b58\u5728\u3059\u308bCD8<sup>+<\/sup> TEMRA\u7d30\u80de\u306b\u304a\u3051\u308bCD27\u304a\u3088\u3073PD\u22121\u306e\u767a\u73fe\u72b6\u614b\u3092\u8abf\u3079\u308b\u3053\u3068\u306f\u3001RP\u2212AA\u306b\u304a\u3044\u3066\u30d1\u30eb\u30b9\u7642\u6cd5\u306e\u6cbb\u7642\u52b9\u679c\u3092\u65e9\u671f\u306b\u4e88\u6e2c\u3059\u308b\u65b0\u305f\u306a\u6307\u6a19\uff08\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff09\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p style=\"font-weight: 400;\"><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"2927\" data-permalink=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/archives\/2926\/figure\" data-orig-file=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/figure-scaled.png\" data-orig-size=\"1772,2560\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"figure\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/figure-709x1024.png\" class=\"alignnone size-large wp-image-2927 aligncenter\" src=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/figure-709x1024.png\" alt=\"\" width=\"640\" height=\"924\" srcset=\"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/figure-709x1024.png 709w, https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/figure-208x300.png 208w, https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/figure-768x1109.png 768w, https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/figure-1063x1536.png 1063w, https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/figure-1418x2048.png 1418w, https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/fcm\/wordpress\/wp-content\/uploads\/2025\/12\/figure-scaled.png 1772w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/p>\n<p style=\"font-weight: 400;\"><strong>\u3010\u56f3\u306e\u89e3\u8aac\u3011<\/strong><\/p>\n<p style=\"font-weight: 400;\"><strong>\u30d1\u30eb\u30b9\u7642\u6cd5\u975e\u5fdc\u7b54\u7fa4\u3067\u5897\u52a0\u3059\u308b\u30b0\u30e9\u30f3\u30b6\u30a4\u30e0B<sup>+<\/sup>\u30d1\u30fc\u30d5\u30a9\u30ea\u30f3<sup>+<\/sup>CD27<sup>\u2212<\/sup>PD\u22121<sup>\u2212<\/sup> CD8<sup>+<\/sup> TEMRA<\/strong><\/p>\n<p style=\"font-weight: 400;\"><strong>a:<\/strong> \u60a3\u8005\u672b\u68a2\u8840CD8<sup>+<\/sup> TEMRA\u7d30\u80de\u306b\u304a\u3051\u308bCD27<sup>+<\/sup>PD\u22121<sup>+<\/sup>\u3068CD27<sup>\u2212<\/sup>PD\u22121<sup>\u2212<\/sup>\u306e\u983b\u5ea6\u306e\u7d4c\u6642\u7684\u5909\u5316\u3002<\/p>\n<p style=\"font-weight: 400;\"><strong>b:<\/strong> \u30b0\u30e9\u30f3\u30b6\u30a4\u30e0B\/\u30d1\u30fc\u30d5\u30a9\u30ea\u30f3\u3092\u767a\u73fe\u3057CD27\u304a\u3088\u3073PD\u22121\u3092\u5171\u767a\u73fe\u3059\u308b\u5404\u30b5\u30d6\u30bb\u30c3\u30c8\uff08\uff14\u7fa4\uff09\u306e\u4ee3\u8868\u7684\u306at\u5206\u5e03\u578b\u78ba\u7387\u7684\u8fd1\u508d\u57cb\u3081\u8fbc\u307f\u6cd5\uff08t\u2212Distributed Stochastic Neighbor Embedding\u3001t-SNE\uff09\u89e3\u6790<\/p>\n<p style=\"font-weight: 400;\"><strong>c: <\/strong>CD27\u304a\u3088\u3073PD\u22121\u3092\u5171\u767a\u73fe\u3059\u308b\u5404\u30b5\u30d6\u30bb\u30c3\u30c8\uff08\uff14\u7fa4\uff09\u306b\u304a\u3051\u308b\u30b0\u30e9\u30f3\u30b6\u30a4\u30e0B\u3068\u30d1\u30fc\u30d5\u30a9\u30ea\u30f3\u306e\u767a\u73fe\u983b\u5ea6\u3002<\/p>\n<p style=\"font-weight: 400;\"><strong>d:<\/strong> \u6bdb\u5305\u5468\u56f2\u306eTEMRA\u3068PD\u22121\u306e\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u4e8c\u91cd\u67d3\u8272\u50cf\u3002TEMRA\u306fNKG7 \u3067\u691c\u51fa\u3057\u3066\u3044\u308b\u3002\u8d64\u77e2\u5370\u306fPD\u22121<sup>+<\/sup>NKG7<sup>+<\/sup>\u7d30\u80de\u3001\u9ed2\u77e2\u5370\u306fPD\u22121\u207bNKG7<sup>+<\/sup>\u7d30\u80de\u3092\u793a\u3059\u3002<\/p>\n<p style=\"font-weight: 400;\"><strong>e:<\/strong> \u6bdb\u5305\u5468\u56f2\u306eTEMRA\u306ePD\u22121<sup>+<\/sup>\u7d30\u80de\u306e\u983b\u5ea6\u306e\u6bd4\u8f03\u3002<\/p>\n<p style=\"font-weight: 400;\">mean \u00b1 S.E.M. *: P &lt; 0.001, **: P &lt; 0.01, ***: P &lt; 0.05\u3002<\/p>\n<p style=\"font-weight: 400;\">\u203b\u51fa\u7248\u793eElsevier\u793e\u306e\u8a31\u53ef\u3092\u5f97\u3066\u8ee2\u8f09<\/p>\n<h3><strong>\u3010\u7528\u8a9e\u89e3\u8aac\u3011<\/strong><\/h3>\n<ul>\n<li>\u5186\u5f62\u8131\u6bdb\u75c7\uff08AA\uff09: \u81ea\u5206\u306e\u514d\u75ab\u7d30\u80de\u304c\u6bdb\u6839\u3092\u653b\u6483\u3059\u308b\u3053\u3068\u3067\u3001\u6bdb\u304c\u629c\u3051\u3066\u3057\u307e\u3046\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3002<\/li>\n<li>\u6025\u901f\u9032\u884c\u6027\u5186\u5f62\u8131\u6bdb\u75c7\uff08RP-AA\uff09: \u8131\u6bdb\u304c\u6025\u901f\u306b\u9032\u884c\u3057\u3001\u5e83\u7bc4\u56f2\u306b\u53ca\u3076\u91cd\u75c7\u306a\u30bf\u30a4\u30d7\u3002<\/li>\n<li>CD8<sup>+<\/sup> T\u7d30\u80de: \u7570\u7269\u3084\u7570\u5e38\u306a\u7d30\u80de\u3092\u8a8d\u8b58\u3057\u3001\u653b\u6483\u30fb\u6392\u9664\u3059\u308b\u514d\u75ab\u7d30\u80de\u3002\u5186\u5f62\u8131\u6bdb\u75c7\u3067\u306f\u3001\u3053\u306e\u7d30\u80de\u304c\u6bdb\u5305\u3092\u653b\u6483\u3057\u307e\u3059\u3002<\/li>\n<li>TEMRA\u7d30\u80de: \u904e\u53bb\u306b\u6297\u539f\u3092\u8a8d\u8b58\u3057\u305f\u8a18\u61b6\u3092\u6301\u3064CD8<sup>+<\/sup> T\u7d30\u80de\u306e\u4e00\u7a2e\u3067\u3001\u9ad8\u3044\u7d30\u80de\u50b7\u5bb3\u80fd\u529b\u3092\u6301\u3061\u307e\u3059\u3002<\/li>\n<li>\u30b9\u30c6\u30ed\u30a4\u30c9\u30d1\u30eb\u30b9\u7642\u6cd5\uff08\u30d1\u30eb\u30b9\u7642\u6cd5\uff09: \u5927\u91cf\u306e\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u70b9\u6ef4\u3067\u77ed\u671f\u9593\u6295\u4e0e\u3059\u308b\u6cbb\u7642\u6cd5\u3002<\/li>\n<li>CD27 \/ PD\u22121: T\u7d30\u80de\u306e\u8868\u9762\u306b\u3042\u308b\u5206\u5b50\uff08\u30de\u30fc\u30ab\u30fc\uff09\u3067\u3001\u7d30\u80de\u306e\u5206\u5316\u3084\u514d\u75ab\u306e\u5236\u5fa1\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002PD-1\u306f\u7279\u306b\u514d\u75ab\u306e\u30d6\u30ec\u30fc\u30ad\u5f79\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\uff08\u514d\u5f79\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\uff09\u3002<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\"><strong>\u3010\u63b2\u8f09\u8ad6\u6587\u3011<\/strong><\/p>\n<p style=\"font-weight: 400;\">\u30fb\u767a\u8868\u96d1\u8a8c\uff1a<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022202X25005615?via%3Dihub\" target=\"_blank\" rel=\"noopener\">Journal of Investigative Dermatology. 145: 3195-3199.e6. 2025<\/a><\/p>\n<p style=\"font-weight: 400;\">\u30fb\u8ad6\u2f42\u30bf\u30a4\u30c8\u30eb\uff1aPredominance of CD27<sup>&#8211;<\/sup>PD-1<sup>&#8211;<\/sup> effector memory T cells re-expressing CD45RA characterizes treatment-resistant severe alopecia areata<\/p>\n<p style=\"font-weight: 400;\">\u30fb\u7b46\u8005\uff1aTakahashi R, Kinoshita-Ise M, Yamazaki Y, Fukuyama M, and Ohyama M.<\/p>\n<p style=\"font-weight: 400;\">\u9ad8\u6a4b \u826f<sup>1<\/sup>, \u6728\u4e0b \u7f8e\u54b2<sup>2<\/sup>, \u5c71\u5d0e \u597d\u7f8e<sup>2<\/sup>, \u798f\u5c71 \u96c5\u5927<sup>2<\/sup>, \u5927\u5c71 \u5b66<sup>1,2<\/sup><\/p>\n<p style=\"font-weight: 400;\"><sup>1.<\/sup>\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u90e8\u9580, <sup>2.<\/sup>\u533b\u5b66\u90e8\u76ae\u819a\u79d1\u5b66\u6559\u5ba4<\/p>\n<p style=\"font-weight: 400;\">\u30fbDOI \uff1a<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022202X25005615?via%3Dihub\" target=\"_blank\" rel=\"noopener\">doi.org\/10.1016\/j.jid.2025.05.034<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u9ad8\u6a4b\u3000\u826f\u3000\u526f\u90e8\u9580\u9577\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u7814\u7a76\u6210\u679c\u304cJournal of Investigative Dermatology\u306b\u63b2\u8f09 \u672c\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u5171\u540c\u7814\u7a76\u65bd\u8a2d\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u90e8\u9580\u3000\u526f\u90e8\u9580\u9577\u3000\u9ad8\u6a4b\u3000\u826f\u3000\u8b1b\u5e2b\u3001\u540c\u90e8\u9580\u9577\u30fb\u76ae [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[6,45],"tags":[111],"class_list":["post-2926","post","type-post","status-publish","format-standard","hentry","category-fcm-news","category-ryotakahashiphd","tag-111"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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