{"id":272,"date":"2024-02-07T21:05:59","date_gmt":"2024-02-07T12:05:59","guid":{"rendered":"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/pathology\/?page_id=272"},"modified":"2025-06-08T09:10:23","modified_gmt":"2025-06-08T00:10:23","slug":"braintumor","status":"publish","type":"page","link":"https:\/\/www.kyorin-u.ac.jp\/univ\/user\/medicine\/pathology\/braintumor\/","title":{"rendered":"\u8133\u816b\u760d\u75c5\u7406
\u8133\u816b\u760d\u9023\u643a\u7814\u7a76"},"content":{"rendered":"\n

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<\/p>\n\n\n\n

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\u8133\u816b\u760d\u8a3a\u65ad\u306e\u30d1\u30e9\u30c0\u30a4\u30e0\u30b7\u30d5\u30c8<\/h4>\n\n\n\n

\u982d\u84cb\u9aa8\u3084\u8840\u6db2\u8133\u95a2\u9580\u3068\u3044\u3063\u305f\u89e3\u5256\u5b66\u7684\u5236\u7d04\u3084\u3001\u305d\u306e\u4f4e\u3044\u767a\u751f\u983b\u5ea6\u306b\u3088\u308a\u3001\u6cbb\u7642\u306b\u96e3\u6e0b\u3059\u308b\u75c7\u4f8b\u304c\u591a\u304f\u3001\u8133\u816b\u760d\u306f\u6700\u3082\u4e88\u5f8c\u4e0d\u826f\u306a\u816b\u760d\u306e\u4e00\u3064\u3067\u3059\u3002\u65b0\u898f\u6cbb\u7642\u958b\u767a\u306b\u304a\u3044\u3066\u306f\u3001\u6cbb\u7642\u5bfe\u8c61\u3092\u7279\u5b9a\u3057\u3001\u305d\u306e\u672c\u8cea\u3092\u6349\u3048\u308b\u305f\u3081\u306b\u3001\u9811\u5065\u306b\u3057\u3066\u9069\u5207\u306a\u5206\u985e\u4f53\u7cfb\u3092\u5fc5\u8981\u3068\u3057\u3066\u304a\u308a\u3001\u8133\u816b\u760d\u5206\u985e\u306f1926\u5e74\u306bBailey\u3068Cushing\u304c\u795e\u7d4c\u4e0a\u76ae\u306e\u767a\u751f\u904e\u7a0b\u3068\u306e\u5f62\u614b\u5b66\u7684\u985e\u4f3c\u6027\u306b\u3082\u3068\u3065\u304d\u3001\u305d\u306e\u539f\u578b\u3092\u4f5c\u308a3<\/a><\/sup>\u30012007\u5e74\u306b\u51fa\u7248\u3055\u308c\u305f\u4e16\u754c\u4fdd\u5065\u6a5f\u69cb (World Health Organization: WHO)\u304c\u767a\u520a\u3059\u308bWHO\u5206\u985e\u7b2c4\u7248\u307e\u3067\u3001\u5f62\u614b\u5b66\u7684\u306a\u7279\u5fb4\u306b\u57fa\u3065\u3044\u305f\u5206\u985e\u304c\u63a1\u7528\u3055\u308c\u3066\u304d\u307e\u3057\u305f4<\/a><\/sup>\u3002\u3088\u308a\u53b3\u683c\u3067\u5ba2\u89b3\u7684\u306a\u816b\u760d\u306e\u5b9a\u7fa9\u3092\u76ee\u6307\u3057\u3001WHO\u5206\u985e\u6539\u8a02\u7b2c4\u7248\uff082016\u5e74\uff09\u3067\u306f\u907a\u4f1d\u5b50\u2015\u5f62\u614b\u7d71\u5408\u8a3a\u65ad\u304c\u5c0e\u5165\u3055\u308c5<\/a><\/sup> \u3001\u3055\u3089\u306bWHO\u5206\u985e\u7b2c\uff15\u7248\u3067\u306fDNA\u30e1\u30c1\u30eb\u5316\u5206\u985e\u3082\u7d71\u5408\u3055\u308c\u307e\u3057\u305f6<\/a><\/sup>\u3002\u73fe\u5728\u3001\u8133\u816b\u760d\u8a3a\u65ad\u306f\u3001\u5f62\u614b\u30fc\u30b2\u30ce\u30e0\u30fc\u30a8\u30d4\u30b2\u30ce\u30e0\uff08DNA\u30e1\u30c1\u30eb\u5316\uff09\u306e\u30de\u30eb\u30c1\u30e2\u30fc\u30c0\u30eb\u306a\u5206\u985e\u4f53\u7cfb\u306b\u57fa\u3065\u304f\u3001\u5206\u5b50\u2015\u5f62\u614b\u7d71\u5408\u8a3a\u65ad\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u5206\u5b50\u2015\u5f62\u614b\u7d71\u5408\u8a3a\u65ad\u306f\u3001\u5f62\u614b\u5b66\u7684\u6240\u898b\u306b\u52a0\u3048\u3001\u816b\u760d\u3092\u7279\u5fb4\u3065\u3051\u308b\u907a\u4f1d\u5b50\u7570\u5e38\u3084\u67d3\u8272\u4f53\u7570\u5e38\u3092\u8003\u616e\u3059\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3042\u308a\u3001\u3088\u308a\u53b3\u683c\u306b\u3001\u518d\u73fe\u6027\u9ad8\u304f\u5206\u985e\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u30597<\/a><\/sup>\u3002\u4f8b\u3048\u3070\u3001\u6700\u3082\u983b\u5ea6\u306e\u9ad8\u3044\u539f\u767a\u6027\u8133\u816b\u760d\u3067\u3042\u308b\u6210\u4eba\u578b\u6d78\u6f64\u6027\u81a0\u816b\u306f\u3001IDH\uff08IDH1, IDH2\uff09\u5909\u7570\u30681\u756a\u67d3\u8272\u4f53\u77ed\u8155\u306819\u756a\u67d3\u8272\u4f53\u9577\u8155\u306e\u30d8\u30c6\u30ed\u63a5\u5408\u6027\u6b20\u5931\uff081p\/19q\u5171\u6b20\u5931\uff09\u306e\u6709\u7121\u306b\u57fa\u3065\u304d\u3001Astrocytoma, IDH-mutant\uff08\u661f\u7d30\u80de\u816b, IDH\u5909\u7570\uff09\u3001Oligodendroglioma, IDH-mutant and 1p\/19q-codeleted\uff08\u4e4f\u7a81\u8d77\u81a0\u816b, IDH\u5909\u7570\u304a\u3088\u30731p\/19q\u5171\u6b20\u5931\uff09\u3001\u304a\u3088\u3073Glioblastoma, IDH-wildtype\uff08\u81a0\u82bd\u816b, IDH\u91ce\u751f\u578b\uff09\u306e\uff13\u3064\u306b\u5206\u985e\u3055\u308c\u307e\u3059\uff08\u4e0b\u56f3\u3000cBioPortal\u3088\u308a\u6539\u5909\uff09\u3002<\/p>\n\n\n

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\"\"<\/figure>\n<\/div>\n\n\n

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\"\"<\/figure>\n<\/div>\n\n\n

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\"\"<\/figure>\n<\/div>\n\n\n

DNA\u30e1\u30c1\u30eb\u5316\u5206\u985e<\/strong><\/h4>\n\n\n\n

\u8133\u816b\u760d\u5206\u985e\u306e\u4e16\u754c\u6a19\u6e96\u3067\u3042\u308bWHO\u5206\u985e\u7b2c5\u7248\u304b\u3089\u65b0\u305f\u306b\u5c0e\u5165\u3055\u308c\u305fDNA\u30e1\u30c1\u30eb\u5316\u5206\u985e9<\/a><\/sup>\u306f\u3001\u7d71\u5408\u8a3a\u65ad\u7cbe\u5ea6\u306e\u6539\u5584\u306b\u5bc4\u4e0e\u3057\u3001Bailey\u3068Cushing\u4ee5\u6765\u306e\u3082\u3063\u3068\u3082\u91cd\u8981\u306a\u6539\u9769\u3068\u8a55\u3055\u308c\u3066\u3044\u307e\u305910<\/a><\/sup> \u3002DNA\u30e1\u30c1\u30eb\u5316\u306f\u3001\u30b7\u30c8\u30b7\u30f3\u3068\u30b0\u30a2\u30cb\u30f3\u304c\u4e26\u3076CpG\u306e\u30b7\u30c8\u30b7\u30f3\u6b8b\u57fa\u306e5\u4f4d\u306e\u70ad\u7d20\u539f\u5b50\u306b\u30e1\u30c1\u30eb\u57fa\u4fee\u98fe\u304c\u4ed8\u52a0\u3055\u308c\u308b\u5316\u5b66\u53cd\u5fdc\u3067\u3042\u308a\u3001\u7a2e\u3005\u306e\u6a5f\u5e8f\u306b\u3088\u308a\u907a\u4f1d\u5b50\u767a\u73fe\u8abf\u7bc0\u3092\u4ecb\u3057\u3066\u751f\u547d\u73fe\u8c61\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u306aDNA\u30e1\u30c1\u30eb\u5316\u72b6\u614b\u3001\u3059\u306a\u308f\u3061DNA\u30e1\u30c1\u30ed\u30fc\u30e0\u306f\u500b\u4f53\u767a\u751f\u306b\u304a\u3044\u3066\u7d30\u80de\u5206\u5316\u3092\u5236\u5fa1\u3059\u308b\u307b\u304b\u3001\u816b\u760d\u767a\u751f\u306b\u304a\u3044\u3066\u3082\u7d30\u80de\u8d77\u6e90\u3092\u53cd\u6620\u3057\u305f\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u5448\u3059\u308b\u3053\u3068\u3092\u5229\u7528\u3057\u3066\u3001Capper\u3089\u306f\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9DNA\u30e1\u30c1\u30eb\u5316\u30a2\u30ec\u30a4[Infinium HumanMethylation450 BeadChip (450k) array (Illumina, San Diego, USA), Infinium HumanMethylationEPIC BeadChip (EPIC) array]\u3092\u7528\u3044\u305f\u3001\u8133\u816b\u760d\u306eDNA\u30e1\u30c1\u30eb\u5316\u5206\u985e\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002\u975e\u7dda\u5f62\u6b21\u5143\u524a\u6e1b\u6cd5\u3067\u3042\u308bt-distributed stochastic neighbor embedding (tSNE)\u306b\u3088\u3063\u3066\u3001\u8133\u816b\u760d\u306f\u72ec\u7acb\u3057\u305f\u30af\u30e9\u30b9\u30bf\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u3001\u3055\u3089\u306b\u305d\u306e\u591a\u304f\u306f\u7d71\u5408\u8a3a\u65ad\u306b\u3088\u3063\u3066\u78ba\u7acb\u3055\u308c\u3066\u304d\u305f\u816b\u760d\u578b\u306b\u307b\u307c\u5408\u81f4\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3001DNA\u30e1\u30c1\u30ed\u30fc\u30e0\u3092\u30e9\u30f3\u30c0\u30e0\u30d5\u30a9\u30ec\u30b9\u30c8\u6cd5\u306b\u3088\u3063\u306610,000\u306e\u5206\u5c90\u3092\u7d4c\u3066DNA\u30e1\u30c1\u30eb\u5316\u5206\u985e\u3092\u63a8\u5b9a\u53ef\u80fd\u306a\u6a5f\u68b0\u5b66\u7fd2\u6cd5\u3001\u3044\u308f\u3086\u308bAI\u306b\u3088\u3063\u3066\u4f5c\u6210\u3057\u3001\u30c9\u30a4\u30c4\u304c\u3093\u30bb\u30f3\u30bf\u30fc\uff08Deutsches Krebsforschungszentrum, DKFZ\uff09\u306e\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u306b\u3088\u3063\u3066\u30a6\u30a7\u30d6\u30c4\u30fc\u30eb\u3068\u3057\u3066\u516c\u958b\u3057\u3066\u3044\u307e\u3059 (DKFZ classifier, https:\/\/www.molecularneuropathology.org\/mnp\/<\/a>) \uff08\u6587\u732e9\u3088\u308a\u6539\u5909\uff09\u3002<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

\u305d\u306e\u539f\u7406\u3067\u3042\u308btSNE\u306b\u3064\u3044\u3066\u3001\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002DNA\u30e1\u30c1\u30eb\u5316\u30a2\u30ec\u30a4\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u308b\u8133\u816b\u760d\u306eDNA\u30e1\u30c1\u30ed\u30fc\u30e0\u306f\u3001\u30d7\u30ed\u30fc\u30d6\u6570\uff0885\u4e07\u306a\u3044\u305795\u4e07\uff09\u306e\u6b21\u5143\u6570\u3092\u6709\u3059\u308b\u9ad8\u6b21\u5143\u30c7\u30fc\u30bf\u3067\u3042\u308b\u305f\u3081\u3001\u305d\u306e\u307e\u307e\u3067\u306f\u30c7\u30fc\u30bf\u7279\u6027\u3092\u4eba\u9593\u306e\u8a8d\u77e5\u80fd\u3067\u306f\u628a\u63e1\u3067\u304d\u307e\u305b\u3093\u3002\u305d\u3053\u3067\u3001\u9069\u5207\u306a\u6b21\u5143\u524a\u6e1b\u6cd5\u306b\u3088\u308b\u53ef\u8996\u5316\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059\u3002\u5f93\u6765\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u6b21\u5143\u524a\u6e1b\u6cd5\u306e\u3046\u3061\u3001\u7dda\u5f62\u6b21\u5143\u524a\u6e1b\u6cd5\u3067\u3042\u308bPrincipal component analysis (PCA)11<\/a><\/sup>\u306f\u3001\u8133\u816b\u760d\u306eDNA\u30e1\u30c1\u30ed\u30fc\u30e0\u3092\u6b21\u5143\u524a\u6e1b\u3057\u3066\u3082\u307c\u3093\u3084\u308a\u3068\u30af\u30e9\u30b9\u30bf\u3057\u304b\u898b\u3044\u3060\u305b\u306a\u3044\u4e00\u65b9\u3001\u975e\u7dda\u5f62\u6b21\u5143\u524a\u6e1b\u6cd5\u3067\u3042\u308btSNE12<\/a><\/sup>\u3084\u3001Uniform Manifold Approximation and Projection (UMAP)13<\/a><\/sup>\u3067\u3042\u308c\u3070\u3001\u660e\u78ba\u306a\u30af\u30e9\u30b9\u30bf\u304c\u5f62\u6210\u3055\u308c\u307e\u3059\uff08\u4e0b\u56f3\u3001\u6587\u732e8\u3088\u308a\u6539\u5909\uff09\u3002<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

tSNE\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u540c\u58eb\u306e\u985e\u4f3c\u5ea6\uff08Local structure\uff09\u3092\u512a\u5148\u3057\u30662\u6b21\u5143\u5e73\u9762\uff08\u306a\u3044\u30573\u6b21\u5143\u7a7a\u9593\uff09\u306b\u30d7\u30ed\u30c3\u30c8\u3059\u308b\u305f\u3081\u3001\u4f4e\u6b21\u5143\u7a7a\u9593\u3067\u306f\u76f4\u611f\u7684\u306a\u30e6\u30fc\u30af\u30ea\u30c3\u30c9\u8ddd\u96e2\u306b\u3088\u308b\u6bd4\u8f03\u306f\u56f0\u96e3\u3067\u3001\u30d7\u30ed\u30c3\u30c8\u306e\u96c6\u5408\u3067\u3042\u308b\u5404\u30af\u30e9\u30b9\u30bf\u3092\u3001\u3069\u3053\u307e\u3067\u3092\u540c\u4e00\u30af\u30e9\u30b9\u30bf\u3068\u307f\u306a\u3059\u304b\u65ad\u5b9a\u306f\u56f0\u96e3\u3067\u3042\u308b\u307b\u304b\u3001\u30af\u30e9\u30b9\u30bf\u540c\u58eb\u306e\u8ddd\u96e2\u3092\u3082\u3063\u3066\u30af\u30e9\u30b9\u30bf\u9593\u306e\u985e\u4f3c\u6027\uff08Global structure\uff09\u3092\u8b70\u8ad6\u3059\u308b\u3053\u3068\u3082\u56f0\u96e3\u3067\u3059\u304c\u3001\u8133\u816b\u760d\u306eDNA\u30e1\u30c1\u30ed\u30fc\u30e0\u306e\u7279\u6027\u306e\u53ef\u8996\u5316\u306b\u306f\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u5f53\u6559\u5ba4\u3067\u306f\u3001\u8133\u816b\u760d14<\/a><\/sup>\u3060\u3051\u3067\u306a\u304f\u8edf\u90e8\u8089\u816b\u306b\u304a\u3044\u3066\u3082DKFZ classifier\u306e\u5b9f\u81e8\u5e8a\u4e0a\u306e\u9650\u754c\u3068\u3001tSNE\u304c\u7d71\u5408\u8a3a\u65ad\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a15<\/a><\/sup>\u3001DKFZ classifier\u3060\u3051\u306b\u983c\u3089\u306a\u3044DNA\u30e1\u30c1\u30eb\u5316\u89e3\u6790\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u306a\u304a\u3001UMAP\u306f\u3001\u57cb\u3081\u8fbc\u307f\u6b21\u5143\u6570\u306b\u3088\u3089\u305a\u5b9f\u884c\u6642\u9593\u304c\u307b\u307c\u4e00\u5b9a\u3067\u3001\u65e2\u5b58\u306e\u5b66\u7fd2\u7a7a\u9593\u306b\u65b0\u898f\u30b5\u30f3\u30d7\u30eb\u3092\u57cb\u3081\u8fbc\u307f\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u306b\u52a0\u3048\u3001Global structure\u304c\u4fdd\u305f\u308c\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u305916<\/a><\/sup>\u3002UMAP\u306f\u3001\u89b3\u6e2c\u3055\u308c\u308b\u30c7\u30fc\u30bf\u304c\u30ea\u30fc\u30de\u30f3\u591a\u69d8\u4f53\u306e\u4e0a\u306b\u4e00\u69d8\u5206\u5e03\u3059\u308b\u3068\u4eee\u5b9a\u3057\u3001\u305d\u308c\u3092fuzzy topological\u8868\u73fe\u306b\u3088\u308a\u3001\u6211\u3005\u304c\u8a8d\u77e5\u53ef\u80fd\u306a\u4f4e\u6b21\u5143\u30e6\u30fc\u30af\u30ea\u30c3\u30c9\u7a7a\u9593\u306b\u30de\u30c3\u30d4\u30f3\u30b0\u3059\u308b\u624b\u6cd5\u3067\u3059\u3002Fuzzy topological\u8868\u73fe\u306f\u3001\u539f\u8457\u8ad6\u6587\u306b\u304a\u3044\u3066\u306f\u570f\u8ad6 (Category Theory) \u306e\u624b\u6cd5\u3067\u8aac\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u816b\u760d\u5206\u985e\u3068\u306f\u3001class discovery\uff08\u75be\u60a3\u306e\u65b0\u305f\u306a\u30ab\u30c6\u30b4\u30ea\u30fc\u3092\u6b63\u78ba\u306b\u8a8d\u8b58\u3059\u308b\u904e\u7a0b\uff09\u3068class prediction\uff08\u500b\u3005\u306e\u75c7\u4f8b\u304c\u65e2\u77e5\u306e\u3069\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u5c5e\u3059\u308b\u304b\u3092\u6c7a\u3081\u308b\u904e\u7a0b\uff09\u3044\u3046\u660e\u77ad\u306b\u7570\u306a\u308b\u4e8c\u3064\u306e\u30d7\u30ed\u30bb\u30b9\u304c\u5305\u542b\u3055\u308c\u3066\u304a\u308a\u3001\u75c5\u7406\u5b66\u306f\u6700\u521d\u304b\u3089\u75be\u60a3\u6982\u5ff5\u305d\u306e\u3082\u306e\u3092\u6a19\u7684\u3068\u3057\u3001\u672a\u77e5\u306e\u75be\u60a3\u3092\u3082\u6a19\u7684\u3068\u3059\u308b\u5b66\u554f\u5206\u91ce\u3067\u3042\u308b\u3068\u3055\u308c17<\/a><\/sup>\u3001\u5bfe\u8c61\u3068\u305d\u306e\u9593\u306e\u5c04\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u300c\u570f\u300d\u3092\u8003\u5bdf\u306e\u5bfe\u8c61\u3068\u3059\u308b\u570f\u8ad6\u304c\u3001\u5bfe\u8c61\u306e\u985e\u4f3c\u6027\u3084\u95a2\u4fc2\u6027\u3092\u62bd\u8c61\u7684\u306b\u6349\u3048\u308b\u305f\u3081\u306e\u65b9\u6cd5\u3060\u3068\u3059\u308c\u307018<\/a><\/sup>\u3001UMAP\u306b\u3088\u308b\u8133\u816b\u760d\u306eDNA\u30e1\u30c1\u30ed\u30fc\u30e0\u306e\u53ef\u8996\u5316\u306f\u3001\u8133\u816b\u760d\u306b\u304a\u3051\u308b\u672a\u77e5\u306e\u751f\u7269\u5b66\u7684\u672c\u8cea\u3092\u3064\u304f\u3088\u3046\u3067\u8208\u5473\u6df1\u304f\u601d\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3055\u3089\u306b\u3001DNA\u30e1\u30c1\u30ed\u30fc\u30e0\u89e3\u6790\u304b\u3089\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u306a\u30b3\u30d4\u30fc\u6570\u89e3\u6790\u304c\u53ef\u80fd\u3067\u3059\u3002\u4f8b\u3048\u3070\u30011p\/19q\u5171\u6b20\u5931, CDKN2A\/B<\/em>\u30db\u30e2\u63a5\u5408\u6027\u6b20\u5931, EGFR<\/em>\u5897\u5e45, \u67d3\u8272\u4f537\u756again\/10\u756aloss\u7b49\u306f\u3001\u7d71\u5408\u8a3a\u65ad\u306b\u304a\u3051\u308b\u6709\u7528\u306a\u652f\u63f4\u30c4\u30fc\u30eb\u3068\u306a\u308b\u3002\u3055\u3089\u306b\u3001KIAA1549<\/em>::BRAF<\/em>\u3084FGFR3<\/em>::TACC3<\/em>\u306e\u3088\u3046\u306a\u3001\u91cd\u8907\u9818\u57df\u3092\u4f34\u3046\u878d\u5408\u907a\u4f1d\u5b50\u306e\u63a8\u5b9a\u3082\u53ef\u80fd\u3067\u3059\u3002DNA\u30e1\u30c1\u30ed\u30fc\u30e0\u304b\u3089\u7b97\u51fa\u3055\u308c\u308b\u30b3\u30d4\u30fc\u6570\u306f\u3001\u6b63\u5e38\u5bfe\u7167\u30b5\u30f3\u30d7\u30eb\u3068\u306e\u76f8\u5bfe\u6bd4\u3067\u3042\u308a\u3001SNP\u30a2\u30ec\u30a4\u7b49\u3068\u306f\u7570\u306a\u308a\u3001\u4e21\u30a2\u30ea\u30eb\u306e\u5e73\u5747\u5024\u3067\u3042\u308b\u3002R\u3092\u7528\u3044\u305f\u3001\u30b3\u30d4\u30fc\u6570\u3092\u7b97\u51fa\u3059\u308b\u305f\u3081\u306e\u30d1\u30c3\u30b1\u30fc\u30b8\u306f\u8907\u6570\u516c\u958b\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u306bconumee\u306fDKFZ classifier\u306e\u5831\u544a\u66f8\u306b\u304a\u3051\u308b\u30b3\u30d4\u30fc\u6570\u30d7\u30ed\u30c3\u30c8\u3067\u3082\u7528\u3044\u3089\u308c\u308b\u30d1\u30c3\u30b1\u30fc\u30b8\u3067\u3059\u3002EPIC\u30a2\u30ec\u30a4\u306e\u30a2\u30ce\u30c6\u30fc\u30b7\u30e7\u30f3\u30d5\u30a1\u30a4\u30eb\u306b\u8a18\u8ff0\u3055\u308c\u3066\u3044\u308b\u3001\u30b2\u30ce\u30e0\u4e0a\u306e\u30d7\u30ed\u30fc\u30d6\u4f4d\u7f6e\u306e\u60c5\u5831\u3068\u7a81\u5408\u3055\u305b\u308c\u3070\u3001\u67d3\u8272\u4f53\u8155\u3054\u306819<\/a><\/sup>\u3001\u907a\u4f1d\u5b50\u3054\u306820<\/a><\/sup>\u306e\u30b3\u30d4\u30fc\u6570\u306e\u5e73\u5747\u3082\u7b97\u51fa\u53ef\u80fd\u3067\u3042\u308a\u3001\u7814\u7a76\u624b\u6cd5\u3068\u3057\u3066\u3082\u6709\u7528\u3067\u3059\u3002<\/p>\n\n\n\n

\u8133\u816b\u760d\u8a3a\u65ad\u306e\u3053\u308c\u304b\u3089<\/h4>\n\n\n\n

\u672c\u90a6\u3067\u306f\u3001\u75c5\u7406\u8a3a\u65ad\u306e\u305f\u3081\u306e\u5206\u5b50\u907a\u4f1d\u5b66\u7684\u89e3\u6790\u3067\u3042\u3063\u3066\u3082\u4fdd\u967a\u53ce\u8f09\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u305d\u306e\u307b\u3068\u3093\u3069\u306f\u7814\u7a76\u5ba4\u30ec\u30d9\u30eb\u3067\u306e\u89e3\u6790\u3067\u5bfe\u5fdc\u3057\u3066\u3044\u308b\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002\u3057\u304b\u3057\u3053\u308c\u3089\u306e\u691c\u7d22\u306f\u3059\u3079\u3066\u306e\u65bd\u8a2d\u3067\u884c\u3048\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u5168\u56fd\u5747\u3066\u3093\u5316\u306f\u56f0\u96e3\u3067\u3042\u308a\u3001\u533b\u7642\u306e\u5148\u9032\u6027\u3068\u73fe\u5b9f\u6027\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u53d6\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002DNA\u30e1\u30c1\u30eb\u5316\u5206\u985e\u306f\u8133\u816b\u760d\u306e\u7d71\u5408\u8a3a\u65ad\u306b\u5927\u304d\u306a\u529b\u3092\u767a\u63ee\u3057\u3001\u672c\u90a6\u3067\u3082\u4e8b\u5b9f\u4e0a\u306e\u6a19\u6e96\u6280\u8853\u3068\u3057\u3066\u8a8d\u77e5\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u304c\u3001\u6280\u8853\u7684\u3001\u8cbb\u7528\u7684\u5236\u7d04\u304b\u3089\u5bb9\u6613\u306b\u884c\u3048\u308b\u89e3\u6790\u3067\u306f\u306a\u304f\u3001\u305d\u306e\u75c5\u7406\u8a3a\u65ad\u306b\u304a\u3051\u308b\u53d6\u308a\u6271\u3044\u3082\u53b3\u5bc6\u306b\u306f\u5b9a\u307e\u3063\u3066\u3044\u307e\u305b\u309321<\/a><\/sup>\u3002\u73fe\u72b6\u3067\u306f\u5206\u5b50\u907a\u4f1d\u5b66\u7684\u89e3\u6790\u306e\u54c1\u8cea\u3084\u89e3\u91c8\u306f\u3001\u5404\u75c5\u7406\u533b\u304c\u5168\u8cac\u4efb\u3092\u8ca0\u3044\u3001\u7d71\u5408\u8a3a\u65ad\u3068\u3057\u3066\u75c5\u7406\u8a3a\u65ad\u5831\u544a\u66f8\u306b\u8a18\u8f09\u3057\u3066\u3044\u307e\u3059\u3002WHO\u5206\u985e\u306b\u53b3\u683c\u306b\u5f93\u304a\u3046\u3068\u3059\u308c\u3070\u3001\u5206\u5b50\u907a\u4f1d\u5b66\u7684\u691c\u7d22\u306a\u3057\u306b\u78ba\u5b9a\u8a3a\u65ad\u304c\u3067\u304d\u306a\u304f\u306a\u3063\u305f\u73fe\u5728\u3001\u6700\u4f4e\u9650\u306e\u5206\u5b50\u907a\u4f1d\u5b66\u7684\u89e3\u6790\u306f\u81e8\u5e8a\u691c\u67fb\u3068\u3057\u3066\u4fdd\u967a\u8a3a\u7642\u4e0b\u306b\u884c\u308f\u308c\u308b\u3079\u304d\u3068\u8003\u3048\u307e\u3059\u3002<\/p>\n\n\n\n

\u8133\u816b\u760d\u5206\u985e\u306f\u4eca\u5f8c\u3082\u3055\u3089\u306b\u30b2\u30ce\u30e0\u30fb\u30a8\u30d4\u30b2\u30ce\u30e0\u60c5\u5831\u3092\u7d71\u5408\u3057\u3066\u767a\u5c55\u3057\u3066\u3044\u304f\u3053\u3068\u306f\u78ba\u5b9f\u3067\u3001\u7cbe\u7d30\u306a\u8133\u816b\u760d\u5206\u985e\u306e\u8ffd\u6c42\u306f\u7d76\u5bfe\u7684\u306b\u5fc5\u8981\u4e0d\u53ef\u6b20\u306a\u8a3a\u7642\u4e0a\u306e\u8981\u8acb\u3067\u3059\u3002\u5f53\u6559\u5ba4\u3067\u306f\u3001\u3053\u308c\u304b\u3089\u3082\u8133\u816b\u760d\u8a3a\u7642\u306e\u767a\u5c55\u306b\u5bc4\u4e0e\u3067\u304d\u308b\u3088\u3046\u6d3b\u52d5\u3092\u7d9a\u3051\u3066\u307e\u3044\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n\n\n\n

<\/p>\n\n\n

  1. Virchow. \u7d30\u80de\u75c5\u7406\u5b66. \uff08\u5ddd\u68b6\u662d\u7ffb\u8a33\uff09. \u6771\u4eac: \u671d\u65e5\u51fa\u7248\u793e; 1988.\u00a0 \u21a9\ufe0e<\/a><\/li>
  2. \u30b7\u30c3\u30c0\u30fc\u30eb\u30bf\u30fb\u30e0\u30ab\u30b8\u30fc. \u304c\u3093\u25004000\u5e74\u306e\u6b74\u53f2\u2500. (\u7530\u4e2d\u6587\u7ffb\u8a33): \u65e9\u5ddd\u66f8\u623f; 2016.\u00a0 \u21a9\ufe0e<\/a><\/li>
  3. Bailey P Cushing H. A Classification of Tumors of the Glioma Group on a Histogenetic Basis with a Correlated Study of Prognosis. Philadelphia: JB Lippincott; 1926. \u21a9\ufe0e<\/a><\/li>
  4. WHO Classification of Tumours of the Central Nervous System. Louis DN OH, Wiestler OD, Cavenee WK, editor. Lyon: International Agency for Research on Cancer; 2007.\u00a0 \u21a9\ufe0e<\/a><\/li>
  5. WHO Classification of Tumours of the Central Nervous System. Louis DN OH, Wiestler OD, Cavenee WK, editor. Lyon: IARC; 2016.\u00a0 \u21a9\ufe0e<\/a><\/li>
  6. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021;23(8):1231-51.\u00a0 \u21a9\ufe0e<\/a><\/li>
  7. \u91cc\u898b\u4ecb\u53f2\u3001\u5e02\u6751\u5e78\u4e00. \u8133\u816b\u760d.\u00a0 \u75c5\u7406\u3068\u81e8\u5e8a. \u3010\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\u6642\u4ee3\u306e\u5206\u5b50\u816b\u760d\u5b66\u3011(\u7b2c3\u90e8)\u304c\u3093\u306e\u5206\u5b50\u75c5\u7406\u5b66(\u5404\u8ad6)\u3000\u81d3\u5668\u304c\u3093\u300040. \u6771\u4eac: \u6587\u5149\u5802; 2022. p. 168-77.\u00a0 \u21a9\ufe0e<\/a><\/li>
  8. \u91cc\u898b\u4ecb\u53f2\u3001\u67f4\u539f\u7d14\u4e8c. \u304c\u3093\u75c5\u7406\u8a3a\u65ad\u306e\u6f6e\u6d41\u3000\u5f62\u614b\u8a3a\u65ad\u304b\u3089\u30b2\u30ce\u30e0\u30fb\u30a8\u30d4\u30b2\u30ce\u30e0\u7d71\u5408\u8a3a\u65ad\u3078. \u674f\u6797\u533b\u5b66\u4f1a\u96d1\u8a8c 2023;54(4):227-234.<\/a> \u21a9\ufe0e<\/a><\/li>
  9. Capper D et al. Nature. 2018;555(7697):469-74.<\/a> \u21a9\ufe0e<\/a><\/li>
  10. Paulus W. Acta Neuropathol. 2018;136(2):177-9.\u00a0<\/a> \u21a9\ufe0e<\/a><\/li>
  11. Stewart S et al. Chem Soc Rev. 2014;43(1):70-84.<\/a> \u21a9\ufe0e<\/a><\/li>
  12. LaurensvanderMaaten G. VisualizingDatausingt-SNE. Journal of Machine Learning Research. 2008;9:2579-605. \u21a9\ufe0e<\/a><\/li>
  13. Leland McInnes JH, James Melville. UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction. ArXiv e-prints. 2018;1802.03426. \u21a9\ufe0e<\/a><\/li>
  14. Satomi et al. Pathol Int. 2023 73(10):523-526.<\/a> \u21a9\ufe0e<\/a><\/li>
  15. Shibayama T et al. BMC Pulm Med. 2023;23(1):324.<\/a> \u21a9\ufe0e<\/a><\/li>
  16. \u91cc\u898b\u4ecb\u53f2. WHO2021\u306b\u304a\u3051\u308bDNA\u30e1\u30c1\u30ed\u30fc\u30e0\u89e3\u6790. Clinical Neuroscience. 2023;41(4):463-7. \u21a9\ufe0e<\/a><\/li>
  17. \u7af9\u5185\u8ce2\u543e. \u5faa\u74b0\u30d7\u30ed\u30bb\u30b9\u3068\u3057\u3066\u306e\u75c5\u7406\u5b66. \u75c5\u7406\u3068\u81e8\u5e8a. 2017;35(12):1170-1. \u21a9\ufe0e<\/a><\/li>
  18. Samuel Eilenberg SM. General Theory of Natural Equivalences. Transactions of the American Mathematical Society. 1945;58(2):231-94. \u21a9\ufe0e<\/a><\/li>
  19. Satomi et al. Neuro Oncol. 2022;24(5):834-46.<\/a> \u21a9\ufe0e<\/a><\/li>
  20. Nagane M et al. Cancers (Basel). 2022;14<\/a>(22). \u21a9\ufe0e<\/a><\/li>
  21. Satomi K, Ichimura K, Shibahara J. Pathol Int. 2024 74(2):51-67.<\/a> \u21a9\ufe0e<\/a><\/li><\/ol>","protected":false},"excerpt":{"rendered":"

    \u8133\u816b\u760d\u306e\u30b2\u30ce\u30e0\u30fb\u30a8\u30d4\u30b2\u30ce\u30e0\u7d71\u5408\u8a3a\u65ad\u3068\u306f \u306f\u3058\u3081\u306b \u304c\u3093\u306f\u3001\u7d00\u5143\u524d\u304b\u3089\u8a8d\u8b58\u3055\u308c\u3066\u304a\u308a\u3001\u300c\u3059\u3079\u3066\u306e\u7d30\u80de\u306f\u7d30\u80de\u304b\u3089\uff08omnis cellula e cellula\uff09\u300d\u3068\u3044\u3046\u7bb4\u8a00\u3092\u5531\u3048\u305f\u30c9\u30a4\u30c4\u306e\u75c5\u7406\u5b66\u8005Rudolf Vircho […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"[{\"content\":\"Virchow. \u7d30\u80de\u75c5\u7406\u5b66. \uff08\u5ddd\u68b6\u662d\u7ffb\u8a33\uff09. \u6771\u4eac: \u671d\u65e5\u51fa\u7248\u793e; 1988.\u00a0\",\"id\":\"ab7c6811-a184-45bb-a466-7cf4a5f561ca\"},{\"content\":\"\u30b7\u30c3\u30c0\u30fc\u30eb\u30bf\u30fb\u30e0\u30ab\u30b8\u30fc. \u304c\u3093\u25004000\u5e74\u306e\u6b74\u53f2\u2500. (\u7530\u4e2d\u6587\u7ffb\u8a33): \u65e9\u5ddd\u66f8\u623f; 2016.\u00a0\",\"id\":\"e8f0492d-8883-4203-a8c7-532cec3ea1f0\"},{\"content\":\"Bailey P Cushing H. A Classification of Tumors of the Glioma Group on a Histogenetic Basis with a Correlated Study of Prognosis. Philadelphia: JB Lippincott; 1926.\",\"id\":\"650b17e5-2da1-47a0-8eeb-6b1331475e73\"},{\"content\":\"WHO Classification of Tumours of the Central Nervous System. Louis DN OH, Wiestler OD, Cavenee WK, editor. Lyon: International Agency for Research on Cancer; 2007.\u00a0\",\"id\":\"6e1eb8f6-2b75-43c0-9980-a01c01a6d91b\"},{\"content\":\"WHO Classification of Tumours of the Central Nervous System. Louis DN OH, Wiestler OD, Cavenee WK, editor. Lyon: IARC; 2016.\u00a0\",\"id\":\"e4e04277-d8da-4795-b60c-44c0e403a686\"},{\"content\":\"Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021;23(8):1231-51.\u00a0\",\"id\":\"7a2ee179-ef36-447f-9865-f4f9a9718e53\"},{\"content\":\"\u91cc\u898b\u4ecb\u53f2\u3001\u5e02\u6751\u5e78\u4e00. \u8133\u816b\u760d.\u00a0 \u75c5\u7406\u3068\u81e8\u5e8a. \u3010\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\u6642\u4ee3\u306e\u5206\u5b50\u816b\u760d\u5b66\u3011(\u7b2c3\u90e8)\u304c\u3093\u306e\u5206\u5b50\u75c5\u7406\u5b66(\u5404\u8ad6)\u3000\u81d3\u5668\u304c\u3093\u300040. \u6771\u4eac: \u6587\u5149\u5802; 2022. p. 168-77.\u00a0\",\"id\":\"ce575ef2-cfa5-4b5e-a5a2-8222932a9043\"},{\"content\":\"\u91cc\u898b\u4ecb\u53f2\u3001\u67f4\u539f\u7d14\u4e8c. \u304c\u3093\u75c5\u7406\u8a3a\u65ad\u306e\u6f6e\u6d41\u3000\u5f62\u614b\u8a3a\u65ad\u304b\u3089\u30b2\u30ce\u30e0\u30fb\u30a8\u30d4\u30b2\u30ce\u30e0\u7d71\u5408\u8a3a\u65ad\u3078. \u674f\u6797\u533b\u5b66\u4f1a\u96d1\u8a8c 2023;54(4):227-234.<\/a>\",\"id\":\"0e955146-a523-499b-8e5f-35e2b28733a9\"},{\"content\":\"Capper D et al. Nature. 2018;555(7697):469-74.<\/a>\",\"id\":\"43cec3f2-e96c-4a37-b19a-b7a82b2edd36\"},{\"content\":\"Paulus W. Acta Neuropathol. 2018;136(2):177-9.\u00a0<\/a>\",\"id\":\"fa815dd2-50c1-4312-9de4-2ae70eb9777d\"},{\"content\":\"Stewart S et al. Chem Soc Rev. 2014;43(1):70-84.<\/a>\",\"id\":\"f1200df6-e58c-4adf-8f86-58f18206b5e4\"},{\"content\":\"LaurensvanderMaaten G. VisualizingDatausingt-SNE. Journal of Machine Learning Research. 2008;9:2579-605.\",\"id\":\"4515dc3a-0008-4d4c-8094-98b8e95ac02e\"},{\"content\":\"Leland McInnes JH, James Melville. UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction. ArXiv e-prints. 2018;1802.03426.\",\"id\":\"1b3a738c-ab14-440a-936e-38543658976a\"},{\"content\":\"Satomi et al. Pathol Int. 2023 73(10):523-526.<\/a> \",\"id\":\"6698d08e-ba3b-4c8d-8ee1-70334ee2cc3e\"},{\"content\":\"Shibayama T et al. BMC Pulm Med. 2023;23(1):324.<\/a>\",\"id\":\"6cbfaac6-1667-4169-8a63-40ee709389a2\"},{\"content\":\"\u91cc\u898b\u4ecb\u53f2. 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