高橋 良 <教員業績>

Takahashi Ryo Ph.D.(専任講師)

2024.2.17現在

第33回日本サイトメトリー学会学術集会 会長

oViceバーチャル会場・ZOOM配信で開催

【受賞学術賞】

  1. 杏林大学医学部 研究奨励賞(2016年)
  2. BioLegend/Tomy Digital Biology “Travel Award2013”(2013年3月期)
  3. 杏林大学医学部研究奨励賞(2012年)
  4. 第11回ガルデルマ賞(2010年)
  5. 日本臨床衛生検査技師会 会長賞(1998年)
  6. 日本研究皮膚科学会プレナリー口演(第26・27・29・30・31・32回年次学術大会)
  7. Good poster design 1998, IAMLT, 23rd World Congress in Singapore(1998年)

【主要研究業績およびメディア】

h-index: 17 by scopus

 

in press

Takahashi R, Kinoshita-Ise M, Yamazaki Y, Fukuyama M, and Ohyama M: Increase in CD8+ Effector Memory T Cells Re-Expressing CD45RA Correlates with Intractability of Severe Alopecia Areata: Journal of Investigative Dermatology (in press), DOI:https://doi.org/10.1016/j.jid.2024.01.006
Takahashi R, Shiohara T, and Mizukawa Y: Monocyte-Independent and -Dependent Regulation of Regulatory T-Cell Development in Mycoplasma Infection: The Journal of Infectious Diseases 223:1724-1732, 2021.

被引用数:2(via Google Scholar)

Takahashi R, Sato Y, Kimishima M, Shiohara T, and Ohyama M:Intracellular accumulation of PD-1 molecules in circulating T lymphocytes in advanced malignant melanoma: an implication for immune evasion mechanism. Int J Clin Oncol (10):1861-1869: doi: 10.1007/s10147-020-01732-8, 2020.

被引用数:3(via Google Scholar)

Takahashi R, Sato Y, Kurata M, Yamazaki Y, Kimishima M, and Shiohara T: Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions. The Journal of Immunology 192: 969-978. 2014.

被引用数:23(via Google Scholar)

cover.gif Takahashi R, Kano Y ,Yamazaki Y, Kimishima M, Mizukawa Y, and Shiohara T: Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome. The Journal of Immunology 182:8071-79, 2009.

被引用数:306(via Google Scholar)

jimmunol_cover.jpg Takahashi R, Mizukawa Y, Yamazaki Y, Hayakawa K, Hayakawa J, Kudo A and Shiohara T: In Vitro Differentiation from Naive to Mature E-Selectin Binding CD4 T Cells: Acquisition of Skin-Homing Properties Occurs Independently of Cutaneous Lymphocyte Antigen Expression. The Journal of Immunology, 171: 5769-5777, 2003.

被引用数:24(via Google Scholar)

blood_cover.jpg Takahashi R, Sekine N, and Nakatake T: Influence of monoclonal antiplatelet glyco-protein antibodies on in vitro human megakaryocyte colony formation and proplatelet formation. Blood, 93 (6): 1951-1958, 1999, および表紙

被引用数:132(via Google Scholar)

Keynote_cover.jpg Keynote 2プレゼンテーション入門 ビギナーからPowerPointユーザーまで 秀潤社
Snapz%20Pro%20X001.jpg Keynote 2およびKeynote 3:アップルコンピュータ株式会社

【論 文】

  1. 高橋 良:第 33 回日本サイトメトリー学術総会奮闘記 -前編-:サイトメトリーリサーチ2024 年 33 巻 2 号 p. 17-28.
  2. Takahashi R, Kinoshita-Ise M, Yamazaki Y, Fukuyama M, and Ohyama M: Increase in CD8+ Effector Memory T Cells Re-Expressing CD45RA Correlates with Intractability of Severe Alopecia Areata: Journal of Investigative Dermatology (in press), DOI:https://doi.org/10.1016/j.jid.2024.01.006
  3. Mizukawa Y1, Aoyama Y2, Takahashi H3, Takahashi R, and Shiohara T1 (1Department of Dermatology, 2Department of Dermatology, Kawasaki Medical School, 3Department of Dermatology, Keio University School of Medicine): Risk of Progression to Autoimmune Disease in Severe Drug Eruption: Risk Factors and the Factor-Guided Stratification: Journal of Investigative Dermatology 142:960-968.e9, 2021.
  4. Takahashi R, Shiohara T1, and Mizukawa Y1 (1Department of Dermatology): Monocyte-Independent and -Dependent Regulation of Regulatory T-Cell Development in Mycoplasma Infection: The Journal of Infectious Diseases 223:1724-1732, 2021.
  5. Takahashi R, Sato Y1, Kimishima M1, Shiohara T1 (1Department of Dermatology), and Ohyama M: Intracellular accumulation of PD-1 molecules in circulating T lymphocytes in advanced malignant melanoma: an implication for immune evasion mechanism. Int J Clin Oncol 12: doi: 10.1007/s10147-020-01732-8, 2020.
  6. Moro Y1, Kogashiwa Y2, Sakurai H3, Takahashi R, Kimura T3, Hirasaki M4, Matsumoto Y1, Sugasawa M2, Kohno N1,5(1Department of Otolaryngology, 2Department of Head and Neck Surgery, Otolaryngology, Saitama Medical University International Medical Center, 3Department of Pharmacology and Toxicology, 4Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, 5Department of Otolaryngology, Kosei Hospital) : In Vitro Study of the Anti-cancer Effect of Alternate-day 5-Fluorouracil in Head and Neck Cancer Cells. Anticancer Res 39:6041-6047, 2019.
  7. Ushigome Y1, Mizukawa Y1, Kimishima M1, Yamazaki Y1, Takahashi R, Kano Y1, Shiohara T1 (1Department of Dermatology): Monocytes are involved in the balance between regulatory T cells and Th17 cells in severe drug eruptions. Clin Exp Allergy 48:1453-1463, 2018
  8. Shimoda-Komatsu Y1, Sato Y1, Yamazaki Y1, Takahashi R, Shiohara T1 (1Department of Dermatology): A novel method to assess the potential role of sweating abnormalities in the pathogenesis of atopic dermatitis. Exp Dermatol 27:386-392, 2018
  9. Shiohara T1, Ushigome Y1, Kano Y1, Takahashi R (1Department of Dermatology): Crucial role of viral reactivation in the development of severe drug eruptions: a comprehensive review. Clin Rev Allergy Immunol 49:192-202, 2015.
  10. Shiohara T1, Takahashi R, Ushigome Y1, and Kano Y1 (1Department of Dermatology): Regulatory T Cells in Severe Drug Eruptions. Current Immunology Reviews 10: 41-50, 2014
  11. Shiohara T1, Ushigome Y1, Kano Y1, and Takahashi R (1Department of Dermatology): Crucial Role of Viral Reactivation in the Development of Severe Drug Eruptions: a Comprehensive Review. Clinical Reviews in Allergy & Immunology (Published online: 16 Apr 2014).
  12. Takahashi
    R
    , Sato Y1, Kurata M1, Yamazaki Y1, Kimishima M1, and Shiohara T1 (1Department of Dermatology):
    Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions. The Journal of Immunology 192: 969-978. 2014.
  13. Shiohara T1, Takahashi R, Yukiko Ushigome1, and Kano,Y1 (1Department of Dermatology): Regulatory
    T cells in severe drug eruption. Current Immunology Review 2014, 10, 41-50.
  14. Shiohara T1, Kano Y1, Takahashi R, Ishida T1, Mizukawa Y1 (1Department of Dermatology): Drug-induced
    hypersensitivity syndrome: recent advances in the diagnosis, pathogenesis and management: Chem
    Immunol Allergy. 97:122-38, 2012
    .
  15. 石田正1, 高橋良, 塩原哲夫1(1皮膚科), 制御性T細胞と重症薬疹:日本皮膚科学会雑誌 121巻: 2682〜2685, 2011.
  16. Hirahara K1, Kano Y1, Mitsuyama Y1, Takahashi R, Kimishima M1, Shiohara T1(1Department of Dermatology): Differences in immunological alterations and underlying viral infections in two well-defined severe drug eruptions. Clin Exp Dermatol 35: 863-868, 2010.
  17. 高橋 良, 重症薬疹とレギュラトリー T 細胞:臨床免疫・アレルギー科 54巻: 90〜96,2010.
  18. Shiohara T1, Kano Y1, and Takahashi R (1Department of Dermatology). Current concepts on the
    diagnosis and pathogenesis of drug-induced hypersensitivity syndrome: JMAJ 52:347-352, 2009.
  19. Takahashi R, Kano Y1 ,Yamazaki Y1, Kimishima M1, Mizukawa Y1, and Shiohara T1 (1Department of Dermatology). Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome: The Journal of Immunology 182:8071-79, 2009.
  20. Shiohara T1, Mizukawa Y1, Takahashi R, Kano Y1 (1Department of Dermatology). Pathomechanisms of lichen planus autoimmunity elicited by cross-reactive T cells: Curr Dir Autoimmun 10:206-26. Review, 2008.
  21. Mizukawa Y1, Takahashi R, Yamazaki Y1, Kimishima M1, and Shiohara T1 (1Department of Dermatology): Fucosyltransferase VII positive, skin-homing T cells in the blood and skin lesions of atopic dermatitis patients: Exp Dermatol 17:170-6, 2008.
  22. Kano Y1, Hirahara K1, Mitsuyama Y1, Takahashi R, Shiohara T1 (1Department of Dermatology): Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption: Allergy 62: 1439-1444, 2007.
  23. Hasannejad H1, Takahashi R (Corresponding author), Kimishima M1, Hayakawa K1, Shiohara T1 (1Department of Dermatology): Selective impairment of Toll-like receptor 2-mediated proinflammatory cytokine production by monocytes from patients with atopic dermatitis: J Allergy Clin Immunol,120, 69-75,2007.
  24. Inaoka M1, Kimishima M1, Takahashi R, Shiohara T1 (1Department of Dermatology): Non-steroidal anti-inflammatory drugs
    selectively inhibit cytokine production by NK cells and gamma delta T cells: Exp Dermatol 15:981-990, 2006.
  25. Katsuta M1, Takigawa Y1, Kimishima M1, Inaoka M1, Takahashi R, Shiohara T1 (1Department of Dermatology): NK cells and
    gamma delta+ T cells are phenotypically and functionally defective due to preferential apoptosis in patients with atopic dermatitis: The Journal of Immunology, 176:7736-7744, 2006.
  26. 高橋良:特集 I リンパ球の動態とケモカイン・接着分子.皮膚へのリンパ球のホーミングとケモカイン・接着分子.臨床免疫 45巻:147〜152,2006.< /li>
  27. 高橋良bossa mac ジョブズのプレゼンに学べ!.MacPeople 12巻4号:99頁,2006.
  28. 高橋良:bossa macノートとデスクトップ, どう使い分けています?.MacPeople 12巻5号:96頁,2006.
  29. 高橋良:bossa macノートとデスクトップ, どう使い分けています?.MacFan 14巻10号特別付録「iWork\’06仕事と生活得本」:18ー32,58ー96頁,2006.
  30. 高橋良:Apple特集#7 「Keynote-プレゼンに差をつけたいユーザーへ-」:32~33頁:PC-Webzine12月号 vol.178.
  31. Shiohara1, Mizukawa Y1, Takahashi R, Jun Hayakawa1 & Kazuhito Hayakawa1 (1Department of Dermatology): T-cell
    dynamics of inflammatory skin diseases: Expert Review of Clinical Immunology 1:357-368,2005.
  32. Takahashi R, Mizukawa Y1, Yamazaki Y1, Hayakawa K1, Hayakawa J1, Kudo A2 and Shiohara T1 (1Department of Dermatology, 2Department of Anatomy): In Vitro Differentiation from Naive to Mature E-Selectin Binding CD4 T Cells: Acquisition of Skin-Homing Properties Occurs Independently of Cutaneous Lymphocyte Antigen Expression: The Journal of Immunology, 171: 5769-5777, 2003.
  33. 塩原哲夫, 水川良子, 高橋良, Cutaneous lymphocyte-associated antigenとfucosyltransferase VII.アレルギー科 14巻5号: 2002.
  34. Mizukawa Y1, Shitara K2, Yamazaki Y1, Teraki Y1, Takahashi R, Narimatsu H3 & Shiohra T1 (1Departments of Dermatology, 2Research Laboratories, Kyowa Hakko Kogyo Company, Ltd., 3Institute of Life Science, Soka University), Development and characterization of a monoclonal antibody specific for fucosyltransferase VII (Fuc-T VII): Discordant expression of CLA and Fuc-T VII in peripheral CD4+ and CD8+ T cells: J Invest Dermatol 117: 743-747, 2001.
  35. Kawano TA, Aoki N, Homori M, Kawano K, Maki A, Kimura M, Yanagisawa A, Ohsaki T, Takahashi R, Shiohara T, Ishikawa K, Yoshino H, Mental stress and physical exercise increase platelet-dependent thrombin generation: Heart Vessels. 2000;15(6):280-8.
  36. 中竹 俊彦, 高橋良, 関根 名里子, 出血時間測定後の瘢痕化予防の発想とその実践指導: 医学検査 49(10), 1427-1430. 2000.
  37. 中竹 俊彦, 高橋良, 関根 名里子, 骨髄像の解析学を特色ある臨床細胞学教育として位置づける方法と実践論: 医学検査 49(9), 1328-1331. 2000.
  38. Takahashi R, Sekine N, and Nakatake T, Influence of monoclonal antiplatelet glyco-protein antibodies on in vitro human megakaryocyte colony formation and proplatelet formation: Blood, 93 (6): 1951-1958, 1999 特記事項1:本論文の図がBlood 93 (6), 1999の表紙に採用された. 特記事項2:本論文要旨の学会発表「International Association of Medical Laboratory Technologists (IAMLT), 23rd World Congress of Medical Technology, Singapore, June 28 – July 3, 19」は,「GOOD POSTER DESIGN AWARD 1998 IAMLT」を受賞.
  39. 高橋良, 臨床検査でのデジタルカメラの活用法  低価格デジタルカメラを使用した顕微鏡写真撮影のテクニックとプロフェッショナル用最新デジタルカメラの紹介: 都臨技会誌, 27 (2), 19 – 28. 1999.
  40. 高橋良, 関根名里子, 中竹俊彦, ヒト末梢血単核細胞からの巨核球系コロニー形成における遺伝子組換え型ヒトトロンボポエチンの効果 ‐無血清培養によ 検討‐: 医学検査, 46 (7), 1064 – 1067. 1997.特記事項:本論文は、日本臨床衛生検査技師会 会長賞を受賞した(1998年).
  41. 中竹 俊彦, 田中 薫, 高橋良, 関根 名里子, 村上 映治, 佐久間 孝志, マルチメディア骨髄像判読トレーニングシステム『マルクマスター』の開発: 医学検査, 47(1), 50-53. 1997.
  42. 高橋良, 関根名里子, 中竹俊彦, 特発性血小板減少性紫斑病の巨核球細胞質空胞の血液学的意義:臨床病理, 45 (1): 67 – 71. 1997.

【著 書】

  1. Shiohara T1, Sato Y1, Takahashi R, Kurata M1, Mizukawa Y1 (1Department of Dermatology): Increased susceptibility to cutaneous viral infections in atopic dermatitis: the roles of regulatory T cells and innate immune defects. In: Current Problems in Dermatology, vol. 41. Pathomechanisms, diagnosis and management of atopic dermatitis. Shiohara T, ed. Karger AG, Basel. 2011.
  2. Shiohara T1, Kano Y1, Takahashi R, Ishida T1, Mizukawa Y1 (1Department of Dermatology): Drug-induced hypersensitivity syndrome (DIHS): Recent advances in the diagnosis, pathogenesis and management. In: Adverse Cutaneous Drug Eruptions. French LE, ed. Karger AG, Basel. 2011
  3. Shiohara T1, Mizukawa Y1,Takahashi R, and Kano Y1 (1Department of Dermatology): Pathomechanisms of lichen planus. Autoimmunity elicited by cross-reactive T cells. In Current Directions in Autoimmunity: Dermatologic Autoimmunity. Nickoloff, B.J. and Nestle, F., eds. Basel, Karger Press, 206-226, 2008.
  4. Shiohara T1,Takahashi R, and Kano Y1 (1Department of Dermatology): Drug-Induced Hypersensitivity Syndrome and Viral Reactivation. Drug Hypersensitivity. Basel, Karger, 224-239, 2007.
  5. 高橋良:Keynote 2プレゼンテーション入門—ビギナーからPowerPointユーザーまで.東京都,秀潤社,2005.
  6. 高橋良:Medical Technology別冊 臨床検査Web活用術, 井口健・木村聡 編著,(血液・凝固検査,フローサイトメトリー), 医歯薬出版

【学会発表】

  1. Takahashi R, Kinoshita-Ise M, Sato Y, Kimishima M, Ohyama M: Increase in CD8+ effector memory cells re-expressing CD45RA (TEMRA) reflects disease activity and enables early prediction of therapeutic outcome in rapidly progressive alopecia areata. International Societies for Investigative Dermatology Meeting 2023, Tokyo, May 10th-13th, 2023.
  2. 高橋 良.シンポジウム2【ラウンドテーブル「座談会:共同研究施設の実情とこれから」】.第33回日本サイトメトリー学会学術集会 会長講演、金沢市(オンライン)、 2023年7月22日.
  3. 高橋 良、大山 学.ワイヤレス温度ロガーとクラウドサービスを用いたFCM機器モニタリングシステムの開発.第33回日本サイトメトリー学会学術集会 会長講演、金沢市(オンライン)、 2023年7月22日.
  4. 高橋 良. 日本サイトメトリー学会初のバーチャル会場開催は成功したのか?.第33回日本サイトメトリー学会学術集会 会長講演、金沢市(オンライン)、 2023年7月23日.
  5. Takahashi R, Sato Y, Kimishima M, Ohyama M: Changes in peripheral blood mononuclear cell subsets putatively predict response to i.v. steroid pulse therapy to severe alopecia areata. The 47th Annual Meeting of the Japanese Society for Investigative Dermatology, Nagasaki, December 2nd-4th, 2022.
  6. Takahashi R, Sato Y, Kimishima M, Ohyama M: Time course changes in peripheral blood mononuclear cell subsets during intravenous corticosteroid pulse therapy for severe alopecia areata. The 46th Annual Meeting of the Japanese Society for Investigative Dermatology, Kyoto (Web), December 3rd-5th, 2021.
  7. Takahashi R, Sato Y, Kimishima M, Ohyama M: Increse in melanoma antigen-specific intracellular PD-1+ cells in advanced melanoma patients. The 45th Annual Meeting of the Japanese Society for Investigative Dermatology, Nagoya (Web), December 11th-13th, 2020.
  8. Takahashi R, Sato Y, Kimishima M, Ohyama M: Restoration of cell surface PD-1 expression in intracellular PD-1 positive T cell subset in nivolumab-treated advanced melanoma patients. The 44th Annual Meeting of the Japanese Society for Investigative Dermatology, Aomori, Nov 8th 2019.
  9. Takahashi R, Sato Y, Kimishima M, and M Ohyama. Enhanced recovery of PD-1 expression the cell surface of PD-1 negative T cells in nivolumab-treated advanced melanoma patients. Society for Investigative Dermatology 2019, Chicago, USA, May 8th-11th, 2019.
  10. 高橋 良, 大山 学: 免疫チェック・ポイント阻害薬および分子標的薬で皮膚障害を認められた進行期悪性黒色腫患者における免疫担当細胞プロファイルの変化とサイトカイン産生の評価,免疫アレルギー疾患等実用化研究事業(免疫アレルギー疾患実用化研究分野)「新規分子標的薬による皮膚障害の調査および重症化予防の研究, 平成30年度 第1回班会議、東京, 2018年9月21日.
  11. Sato Y, Takahashi R, Kimishima M, Yamazaki Y, Ohyama M. Developmetn of a scoring system for the prediction of the outcome of intravenous corticosteroid pulse therapy in rapidly-progressive alopecia areata. Internatioanl Investigative Dermatology 2018, Orlaondo, USA, May 16th-19th, 2018.
  12. Takahashi R, Sato Y, Kimishima M, Shiohara T, Ohyama M: Characterization of the influence of PD-1 blockade on IFN-γ, granzyme B and IL-9 production by T cells in advanced melanoma patients. The 42st Annual meeting of the Japanese society for investigative dermatology, Kochi, Japan, December 16th-17th, 2017.
  13. Sato Y, Takahashi R, Yamazaki Y, Ohyama M: Quantitative clinicopathological analyses identify poor prognostic factors for systemic steroid pulse therapy in acute slopecia areata. 10th World Congress for Hair Research, Kyoto, Japan, November 2nd, 2017.
  14. Takahashi R Sato Y, Kimishima M, Shiohara T, Ohyama M: Influence of programmed cell death-1 immune checkpoint blockade on T cell profile and resposen to melanoma-associated antigen in advanced malignant melanoma patients. 47th Annual European Society for Dermatological Research Meeting, Salzburg, Autria, September 30th, 2017.
  15. Sato Y, Takahashi R, Kimishima M, Yamaszaki Y, Shiohara T, Ohyama M. Identification of early predictors of the efficacy of intravenous corticosteroid pulse therapy in rapidly-progessive diffuse alopecia areata patients. 76th Annual Meeting of of the Society for Investigative Dermatology, Portland, USA, April 27th, 2017.
  16. Takahashi R, Sato Y, Kimishima M, Shiohara T, and Ohyama M: Change in lymphocyte subsets during the nivolumab treatment in advanced melanoma patients. 「難治性疾患等政策研究事業(難治性疾患政策研究事業):重症多形滲出性紅斑に関する調査研究(H26-難治等(難)-一般-081)」平成28 年度第2回班会議プログラム, 東京,2017年1月7日
  17. Takahashi R Sato Y, Kimishima M, Shiohara T, and Ohyama M: Impact of therapeutic PD-1 blockade on T cell profile in advanced malignant melanoma: a possible link between PD-1+CD4+ cell and prognosis,41st JSID.Dec 9-10, 2016.Sendai,Japan
  18. Sato Y, Takahashi R, Kimishima M, Yamasaki Y, Shiohara T, Ohyama M: Search for early predictive factors for recovery from rapidlu-progressive alopecia areata after intravenous corticosteroid pulse therapy. 41st JSID.Dec 9-10, 2016.Sendai,Japan
  19. Sato Y, Takahashi R, Hayakawa J, Ohyama M. Attempt to identify predictors for outcomes of intravenous corticosteroid pulse therapy for rapidly progressive alopecia areata. The 4th Eastern Asia Dermatology Congress, Nov 16-18, 2016. Urayasu, Japan.
  20. Takahashi R Sato Y, Kimishima M, Shiohara T, and Ohyama M: Flowcytometric analysis of lymphocyte subset in an advanced melanoma patient during vemurafenib-associated toxic rash after nivolumab treatment. 「難治性疾患等政策研究事業(難治性疾患政策研究事業):重症多形滲出性紅斑に関する調査研究(H26-難治等(難)-一般-081)」平成28 年度第1回班会議プログラム, 東京,2016年7月30日
  21. Ryo Takahashi, Yukiko Ushigome, Tetsuo Shiohara: An unfavorable shift from Treg to Th17 development can be preventable by selective depletion of IL-6-producing proinflammatory monocytes. 40th Annual Meeting of the Japanese Society for Investigative Dermatology, Okayama, December 11-13th, 2015.
  22. Ryo
    Takahashi
    , Yukiko Ushigome1, and Tetsuo Shiohara1 (1Dept. of Dermatology): Monocytes are crucial for a shift away from a Treg to Th17 response in mycoplasma pneumoniae infection and SJS/TEN, The 39th Annual Meeting of the Japanese Society for Investigative Dermatology, Osaka, Dec 12-14, 2014.
  23. Takahashi R, Yukiko Ushigome1, Tetsuo Shiohara1 (1Dept. of Dermatology): Mycoplasma Pneumoniae Infections Serve To Enhance The Risk Of Subsequently Developing Severe Allergic Diseases By Chronically Abrogating Treg-mediated Suppression, The 6th drug hypersensitivity meeting (DHM6), Bern, Switzerland, April 9-12, 2014.
  24. Tetsuo Shiohara1, Takahashi R, Yoko Kano, Yukiko Ushigome1 (1Dept. of Dermatology): Monocytes control Treg in severe drug eruption, The 6th drug hypersensitivity meeting (DHM6), Bern, Switzerland, April 9-12, 2014.
  25. Yukiko Ushigome1, Takahashi R, Tetsuo Shiohara1 (1Dept. of Dermatology): Patrolling monocytes sensing herpes simplex virus in severe drug eruption, The 6th drug hypersensitivity meeting (DHM6), Bern, Switzerland, April 9-12, 2014.
  26. Yoshiko Mizukawa1, Takahashi R, Yoko Kano1, Tetsuo Shiohara1 (1Dept. of Dermatology): Mycoplasma infection as an inhibitory factor for developing DIHS/DRESS, The 6th drug hypersensitivity meeting (DHM6), Bern, Switzerland, April 9-12, 2014.
  27. 高橋 良:
    アトピー性皮膚炎患者におけるヘルペスウィルスの再活性化と制御性 T 細胞の動態. 第23回日本サイトメトリー学会 シンポジウム, 東京, 2013年6月22日.
  28. Takahashi R and Shiohara T1 (1Dept. of Dermatology):  Suppressive CD14dimCD16+ monocytes contribute defective anti-viral immune responses in eczema herpeticum, International Investigative Dermatology 2013, Edinburgh, Scotland, May 8-11, 2013.
  29. Ushigome Y1, Takahashi R, Shiohara T1: CD16+ patrolling monocytes (pMO) sensing HSV negatively control regulatory T cell (Treg) responses in severe drug eruptions, International Investigative Dermatology 2013, Edinburgh, Scotland, May
    8-11, 2013.
  30. Takahashi R and Shiohara T1 (1Dept. of Dermatology):  Increased expression of PILRα on patrolling monocytes sensing HSV is the mechanism by which HSV evades immune attack, The International Investigative Dermatology 2012, Okinawa, Dec 7-8, 2012.
  31. Ushigome Y1, Takahashi R, Shiohara T1: Preferential elimination of patrolling monocytes sensing herpesvirus in drug-induced hypersensitivity syndrome, The International Investigative Dermatology 2012, Okinawa, Dec 7-8, 2012.
  32. 高橋 良, 塩原哲夫: Googleカレンダーを利用したFCM機器予約システムの構築: 第21回日本サイトメトリー学会学術集会,大阪,平成24年6 25日
  33. 高橋 良, 塩原哲夫: Evolving FACS Technology サーバー監視ソフトウェアと温度ロガーを用いたFCM機器モニタリングシステムの開発:第21回日本サイトメトリー学会学術集会,大阪,平成24年6月25日
  34. 高橋 良:制御性T細胞とは?, 血液形態学の自己研修プログラム支援塾, 八王子市, 平成24年2月25日
  35. Takahashi R, Yohei Sato1, and Shiohara T1 (1Dept. of Dermatology): Defective anti-viral immune responses and alternative activation of monocytes are triggered by expansions of Treg in eczema herpeticum, The International Investigative Dermatology 2011, Kyoto, Dec 9-10, 2011.
  36. 水川良子1, 狩野葉子1, 高橋 良, 塩原哲夫1(1皮膚科):マイコプラズマ感染はDIHS発症を抑制する,日本皮膚科学会
    愛媛地方会 橋本公二教授退職記念 第53回学術大会・総会,平 成23年3月19日,松山
  37. Takahashi R, Yohei Sato1, and Shiohara T1 (1Dept. of Dermatology): Defective regulatory T cell function in HSV-seronegative atopic dermatitis patients, The International Investigative Dermatology 2010, Wakayama, Dec 3-5, 2010.
  38. Takahashi R, and Shiohara T1 (1Dept. of Dermatology): Mycoplasma pneumoniae infection predisposes individuals to severe drug eruptions by chronically abrogating regulatory T cell function, The International Investigative Dermatology 2009, Fukuoka, Dec 4-5, 2009.
  39. Yohei Sato1, Maiko Kurata1, Momoko Kimishima1, Takahashi R, Tetsuo Shiohara1 (1Dept. of Dermatology): Pathological role of regulatory T cells in the initiation and maintenance of Kaposi’s varicelliform eruption lesions, The International Investigative Dermatology 2009, Fukuoka, Dec 4-5, 2009.
  40. Takahashi R, Kimisima M1, Yamazaki Y1, and Shiohara T1 (1Dept. of Dermatology): Severe drug hypersensitivity disorders is induced by dysfunctional Tregs, The International Investigative Dermatology 2008, Kyoto, May 14-17, 2008.
  41. Takahashi R and Shiohara T1 (1Dept. of Dermatology): Trafficking receptor expression on regulatory t cells in severe drug eruptions, 3rd International drug hypersensitivity meeting (DHM3), Paris, France, Apr 11-13, 2008.
  42. Kano Y1, Hirahara K1, Asano Y1, Mitsuyama Y1, Takahashi R, Shiohara T1 (1Department of Dermatology): Association
    between drug and human herpesvirus in drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms. 3rd International drug hypersensitivity meeting (DHM3), Paris, France, Apr 12, 2008.
  43. Shiohara T1, Kano Y1, Takahashi R(1Department of Dermatology): Update on regulators: regulatory T cells in DIHS/DRESS and SJS/TEN. 3rd International drug hypersensitivity meeting. Paris, France, Apr 12, 2008.
  44. Takahashi R and Shiohara T1 (1Dept. of Dermatology): Dramatic expansion of Tregs with skin-homing potential followed by sequential reactivations of herpesviruses. The 32st annual meeting of the Japanese Society for Investigative Dermatology (プレナリー口演), Yokohama, Apr 18-20, 2007.
  45. Takahashi R: Recent flow cytometric analysis; cytometric beads array (CBA). Lunch Talk in International College (招待口演), Mahidol University, Bangkok, Thailand, Feb 20, 2007.
  46. 高橋良,塩原哲夫1(1皮膚科): MacOS X環境におけるFACSデーターマネージメント,第16回日本サイトメトリー学会学術集会,長崎,平成18年7月7日.
  47. Takahashi R, Mizukawa Y1, and Shiohara T1 (Dept. of Dermatology): Dynamic balance between Fuc T- IV and Fuc T- VII is a major check point for the regulation of skin-homing CD4+T cell differentiation. The 31st annual meeting of the Japanese Society for Investigative Dermatology (プレナリー口演), Kyoto, May 31-June 2, 2006.
  48. Takahashi R, Mizukawa Y1, and Shiohara T1 (1Department of Dermatology) :Direct visualization of the expression of E-selectin ligands on human CD4 skin-homing T cells. Strategies for controlling emerging and reemerging infectious diseases in Southeast Asia in JSPS Core University Program (招待口演), Bangkok Thailand, Mar 27,
    2006.
  49. 高橋良:インターネットの最新トピックス,東京都臨床検査技師会 臨床検査情報システム研究班,東京 , 平成18年2月10日
  50. Takahashi R, Mizukawa Y1, and Shiohara T1 (1Department of Dermatology) :Coordinate and Ssequential expression of fucosyltransferases, FucT-4 and FucT-7, regulates skin-homing CD4+ T cell differentiation. European Immunodermatology Society Satellite Meeting, Tubingen Germany, Sep 21 – 24, 2005.
  51. 高橋良水川良子1, 塩原哲夫1 (1杏林大・医・皮膚科):ヒトCD4+T細胞のE-selectin ligand発現におけるFucT-4の補助的役割,第30回日本研究皮膚科学会年次学術大会(プレナリー口演) ,横浜,平成17年4月20- 22日
  52. 高橋良, 塩原哲夫1 (1杏林大・医・皮膚科) :ヒトTh1/Th2細胞の皮膚ホーミングレセプタ発現の違い. 第34回日本免疫学会総会, 札幌,平成16年12月1- 3日
  53. 高橋良, 水川良子1, 塩原哲夫1(1杏林大・医・皮膚科):ヒトTh1/Th2細胞の皮膚への選択的ホーミングはE-セレクチンリガンドとCCR4の協調的な発現によって決定される.第29回日本研究皮膚科学会年次学術大会 (プレナリー口演),京都,平成16年4月14- 16日
  54. 高橋良, 水川良子1, 塩原哲夫1(1杏林大・医・皮膚科):皮膚ホーミングTh1細胞はサイトカイン環境によりホーミングレセプターの発現経路を使いわける. 第27回日本研究皮膚科学会年次学術大会(プレナリー口演),京都,平成14年8月2- 3日
  55. 水川良子1,高橋良,塩原哲夫1(1杏林大・医・皮膚科):アトピー性皮膚炎ではTh2細胞の皮膚への遊走が障害されている. 第27回日本研究皮膚科学会総会,京都,平成14年8月2- 3日.
  56. 高橋良, 水川良子1,寺木祐一1,塩原哲夫1(1杏林大・医・皮膚科):T細胞におけるCLAとFucT-VII発現のkineticsの違い(ワークショップ),第100回日本皮膚科学会総会,東京,平成13年4月6−8日.
  57. 高橋良, 稲岡峰幸1, 塩原哲夫1,滝川幸生2(1杏林大・医・皮膚科,1東京都立府中病院・歯科口腔外科):ニッケルイオンが抗原提示細胞へ与える影響の基礎的検討(1)〜抗原提示細胞からのサイトカイン産生〜,第50回日本医学検査学会,東京,平成13年5月24−26日.
  58. 高橋良, 稲岡峰幸1, 塩原哲夫1, 滝川幸生2(1杏林大・医・皮膚科,1東京都立府中病院・歯科口腔外科):ニッケルイオンが抗原提示細胞へ与える影響の基礎的検討(2)〜細胞分化に関する検討〜,第50回日本医学検査学会,東京,平成13年5月24−26日.
  59. 高橋良, 水川良子1,寺木祐一1,塩原哲夫1(1杏林大・医・皮膚科):ヒト皮膚ホーミングCD4T細胞のEセレクチンリガンド発現を直接検出する,第26回日本研究皮膚科学会年次学術大会 (プレナリー口演),愛媛,平成13年9月7−8日.
  60. 水川良子1,高橋良,寺木祐一1,塩原哲夫1(1杏林大・医・皮膚科):末梢血中の皮膚ホーミングT細胞の増加は皮膚への浸潤の程度を反映しない. 第26回日本研究皮膚科学会総会,愛媛,平成13年9月7−8日.
  61. 寺木祐一1,高橋良,水川良子1,塩原哲夫1(1杏林大・医・皮膚科):炎症性疾患におけるcutaneous lymphocyte-associated antigen (CLA)とfucosyltransferase (FucT)-VIIの発現と調節. 第100回日本皮膚科学会総会,東京,平成13年4月6−8日. 日皮会誌 111:519,2001.
  62. 稲岡峰幸1, 塩原哲夫1,高橋良(1杏林大・医・皮膚科):水銀はB細胞,ニッケルはNK細胞の早期活性化を引き起こす,第26回日本研究皮膚科学会総会,愛媛,平成13年9月7−8日.

【その他】

  1. 高橋 良:第33回日本サイトメトリー学会学術集会会長,オンライン(配信会場:石川県金沢市), 2023年7月22日〜23日
  2. 高橋 良:FM軽井沢「KARUIZAWA Twilight Hour」出演, FM軽井沢(長野県軽井沢市),2023年7月10日
  3. 高橋 良:フローサイトメトリー入門講座, 情報機構,オンライン, 2022年7月11日〜12日
  4. 高橋 良:第28回日本サイトメトリー学会技術講習会主催, 東京, 2018年2月16日.
  5. 高橋良: Keynote 3でより簡単に,さらに向上したプレゼンテーションの表現力. アップルコンピュータ株式会社Web Site (http://www.apple.com/jp/medical/takahashi/keynote3/), 2006. →PDFで見る ファイルをダウンロード
  6. 高橋良:学会発表で説得力のあるプレゼンを可能にするKeynote 2. アップルコンピュータ株式会社Web Site,(http://www.apple.com/jp/articles/medical/takahashi/), 2005. →PDFで見る ファイルをダウンロード

【研究交流】

  1. 2006年〜2008年「拠点大学方式による学術交流事業」(日本学術振興会)タイ王国マヒドン大学熱帯医学部(Faculty of Tropical Medicine – Mahidol University, Bangkok, Thailand)への技術移転および研究交流

【助成金】

  1. 高橋 良: 平成30〜32年度科学研究費補助金 基盤研究(C) 研究代表者
  2. 高橋 良: 平成27〜29年度科学研究費補助金 基盤研究(C) 研究代表者
  3. 高橋 良: 平成24〜26年度科学研究費補助金 基盤研究(C) 研究代表者
  4. 高橋 良:平成22〜23年度科学研究費補助金 若手研究(B) 研究代表者
  5. 高橋 良:平成20〜21年度科学研究費補助金 若手研究(B) 研究代表者
  6. 高橋 良:平成17〜18年度科学研究費補助金 若手研究(B) 研究代表者
  7. 高橋 良:平成15〜16年度科学研究費補助金 若手研究(B) 研究代表者
  8. 高橋 良:平成13〜14年度科学研究費補助金 若手研究(B) 研究代表者