最近の研究業績 Recent Publications

  • USP40 gene knockdown disrupts glomerular permeability in zebrafish
    Takagi H, Nishibori Y, Katayama K, Katada T, Takahashi S, Kiuchi Z, Takahashi SI, Kamei H, Kawakami H, Akimoto Y, Kudo A, Asanuma K, Takematsu H, Yan K.
    Am J Physiol Renal Physiol. 312, F702-F715 (2017)
  • Involvement of cross-reactive carbohydrate determinants-specific IgE in pollen allergy testing.
    Yokoi H, Yoshitake H, Matsumoto Y, Kawada M, Takato Y, Shinagawa K, Sakurai H, Saito K.
    Asia Pac Allergy. 7, 29-36 (2017)
  • Inhibition of epithelial-mesenchymal transition by cetuximab via the EGFR-GEP100-Arf6-AMAP1 pathway in head and neck cancer.
    Matsumoto Y, Sakurai H, Kogashiwa Y, Kimura T, Matsumoto Y, Shionome T, Asano M, Saito K, Kohno N.
    Head Neck. 39, 476-485 (2017)
  • Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression.
    Ito Y, Katayama K, Nishibori Y, Akimoto Y, Kudo A, Kurayama R, Hada I, Takahashi S, Kimura T, Fukutomi T, Katada T, Suehiro J, Beltcheva O, Tryggvason K, Yan K.
    Am J Physiol Renal Physiol. in press. 2017
  • Prostate Cancer Cells in Different Androgen Receptor Status Employ Different Leucine Transporters.
    Otsuki H, Kimura T, Yamaga T, Kosaka T, Suehiro JI, Sakurai H.
    Prostate. 77, 222-233 (2017)
  • Visualizing dynamics of angiogenic sprouting from a three-dimensional microvasculature model using stage-top optical coherence tomography.
    Takahashi H, Kato K, Ueyama K, Kobayashi M, Baik G, Yukawa Y, Suehiro JI, Matsunaga YT.
    Sci Rep. in press. 2017
  • A Vascular Permeability Assay Using an In Vitro Human Microvessel Model Mimicking the Inflammatory Condition.
    Pauty J, Usuba R, Takahashi H, Suehiro J, Fujisawa K, Yano K, Nishizawa T, Matsunaga YT.
    Nanotheranostics 1, 103-113 (2017)
  • Diversification of the AlpB outer membrane protein of Helicobacter pylori affects biofilm formation and cellular adhesion.
    Yonezawa H, Osaki T, Fukutomi T, Hanawa T, Kurata S, Zaman C, Hojo F, Kamiya S.
    J Bacteriol. in press. 2017
  • Identification of novel inhibitors of human SPCA2.
    Yamamoto S, Takehara M, Kabashima Y, Fukutomi T, Ushimaru M.
    Biochem Biophys Res Commun. 477, 266-270 (2016)
  • Comprehensive proteome analysis of brush border membrane fraction of ileum of ezrin knockdown mice.
    Yoshida S, Fukutomi T, Kimura T, Sakurai H, Hatano R, Yamamoto H, Mukaisho K, Hattori T, Sugihara H, Asano S.
    Biomed Res. 37, 127-139 (2016)
  • Metformin enhances anti-tumor effect of L-type amino acid transporter 1 (LAT1) inhibitor.
    Ueno S, Kimura T, Yamaga T, Kawada A, Ochiai T, Endou H, Sakurai H.
    J Pharmacol Sci. 131, 110-117 (2016)
  • Proper Notch activity is necessary for the establishment of proximal cells and differentiation of intermediate, distal, and connecting tubule in Xenopus pronephros development.
    Katada T, Sakurai H.
    Dev Dyn. 245, 472-482 (2016)
  • Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells.
    Xu M, Sakamoto S, Matsushima J, Kimura T, Ueda T, Mizokami A, Kanai Y, Ichikawa T.
    J Urol. 195, 1588-1597 (2015)
  • Glutamate Limitation, BvgAS Activation, and (p)ppGpp Regulate the Expression of the Bordetella pertussis Type 3 Secretion System.
    Hanawa T, Kamachi K, Yonezawa H, Fukutomi T, Kawakami H, Kamiya S.
    J Bacteriol. 198, 343-351 (2015)
  • Sentinel Node Biopsy for the Head and Neck Using Contrast-Enhanced Ultrasonography Combined with Indocyanine Green Fluorescence in Animal Models: A Feasibility Study.
    Kogashiwa Y, Sakurai H, Akimoto Y, Sato D, Ikeda T, Matsumoto Y, Moro Y, Kimura T, Hamanoue Y, Nakamura T, Yamauchi K, Saito K, Sugasawa M, Kohno N.
    PLoS One 10, e0132511 (2015)
  • Feasibility Study of Alternate-day S-1 as Adjuvant Chemotherapy for Head and Neck Cancer.
    Moro Y, Kogashiwa Y, Sato D, Matsumoto Y, Nakamura T, Yamauchi K, Sakurai H, Kohno N.
    Anticancer Res. 35, 977-981 (2015)
  • Diabetes Induces Aberrant DNA Methylation in the Proximal Tubules of the Kidney.
    Marumo T, Yagi S, Kawarazaki W, Nishimoto M, Ayuzawa N, Watanabe A, Ueda K, Hirahashi J, Hishikawa K, Sakurai H, Shiota K, Fujita T.
    J. Am. Soc. Nephrol. 26, 2388-2397 (2015)
  • Single adult kidney stem/progenitor cells reconstitute three-dimensional nephron structures in vitro.
    Kitamura S, Sakurai H, Makino H.
    Stem Cells 33, 774-784 (2015)
  • Expression of L-type amino acid transporter 1 in various skin lesions.
    Hirano K, Uno K, Kuwabara H, Kojima K, Ohno S, Sakurai H, Kamma H, Kurata A.
    Pathol. Res. Pract. 210, 634-639 (2014)
  • Expression analysis of amino acid transporter LAT1 in mouse development.
    Katada T, Kanai-Azuma M, Kanai Y, Endou H, Sakurai H.
    J. Pharmacol. Sci. 124, 145 (2014)
  • Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements.
    Inoue T, Kohro T, Tanaka T, Kanki Y, Li G, Poh HM, Mimura I, Kobayashi M, Taguchi A, Maejima T, Suehiro JI, Sugiyama A, Kaneki K, Aruga H, Dong S, Stevens JF, Yamamoto S, Tsutsumi S, Fujita T, Ruan X, Aburatani H, Nangaku M, Ruan Y, Kodama T, Wada Y.
    Genome Biol. 15, R63 (2014)
  • Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells.
    Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, Shibata H, Yoshinaka Y, Doi T, Asanuma A, Tanabe S, Tanaka T, Minami T, Hamakubo T, Sakai J, Nozaki N, Aburatani H, Nangaku M, Ruan X, Tanabe H, Ruan Y, Ihara S, Endo A, Kodama T, Wada Y.
    PLoS One 9, e96005 (2014)
  • Genome-wide approaches reveal functional vascular endothelial growth factor (VEGF)-inducible nuclear factor of activated T cells (NFAT) c1 binding to angiogenesis-related genes in the endothelium.
    Suehiro J, Kanki Y, Makihara C, Schadler K, Miura M, Manabe Y, Aburatani H, Kodama T, Minami T.
    J. Biol. Chem. 289, 29044-29059 (2014)
  • Controlling leucine-zipper partner recognition in cells through modification of a-g interactions.
    Azuma Y, Kükenshöner T, Ma G, Yasunaga J, Imanishi M, Tanaka G, Nakase I, Maruno T, Kobayashi Y, Arndt KM, Matsuoka M, Futaki S.
    Chem. Commun. (Camb) 50, 6364-6367 (2014)
  • Molecular interplays involved in the cellular uptake of octaarginine on cell surfaces and the importance of syndecan-4 cytoplasmic V domain for the activation of protein kinase Cα.
    Nakase I, Osaki K, Tanaka G, Utani A, Futaki S.
    Biochem. Biophys. Res. Commun. 446, 857-862 (2014)
  • Paracellular route is the major urate transport pathway across the blood-placental barrier.
    Uehara I, Kimura T, Tanigaki S, Fukutomi T, Sakai K, Shinohara Y, Ichida K, Iwashita M, Sakurai H.
    Physiol. Rep. 2, e12013 (2014)
  • Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.
    Ikari A, Tonegawa C, Sanada A, Kimura T, Sakai H, Hayashi H, Hasegawa H, Yamaguchi M, Yamazaki Y, Endo S, Matsunaga T, Sugatani J.
    J. Biol. Chem. 289, 13112-13123 (2014)
  • Expression of SLC2A9 Isoforms in the Kidney and Their Localization in Polarized Epithelial Cells.
    Kimura T, Takahashi M, Yan K, Sakurai H.
    PLoS One 9, e84996 (2014)
  • Urate transporters in the genomic era.
    Sakurai H.
    Curr. Opin. Nephrol. Hypertens. 22, 545-550 (2013)
  • 妊娠時における母体・胎児間の尿酸代謝解析
    木村徹, 上原一朗, 谷垣伸治, 岩下光利, 安西尚彦, 櫻井裕之
    発達腎研究会誌 21, 7-11 (2013)
  • Cell-penetrating peptides (CPPs) as a vector for the delivery of siRNAs into cells.
    Nakase I, Tanaka G, Futaki S
    Molecular Biosystems 9, 855-861 (2013)
  • Role of (p)ppGpp in biofilm formation and expression of filamentous structures in Bordetella pertussis.
    Sugisaki K, Hanawa T, Yonezawa H, Osaki T, Fukutomi T, Kawakami H, Yamamoto T, Kamiya S.
    Microbiology 159, 1379-1389 (2013)
  • Identification of cellular proteins interacting with octaarginine (R8) cell-penetrating peptide by photo-crosslinking.
    Kawaguchi Y, Tanaka G, Nakase I, Imanishi M, Chiba J, Hatanaka Y, Futaki S.
    Bioorganic & Medicinal Chemistry Letters 23, 3738-3740 (2013)
  • The Calcineurin-NFAT-Angiopoietin-2 Signaling Axis in Lung Endothelium Is Critical for the Establishment of Lung Metastases.
    Minami T, Jiang S, Schadler K, Suehiro J, Osawa T, Oike Y, Miura M, Naito M, Kodama T, Ryeom S.
    Cell Reports 4, 709-723 (2013)
  • Recent advances in renal urate transport: characterization of candidate transporter indicated by genome-wide association studies.
    Anzai N, Amonpatumrat-Takahashi S, Sakurai H.
    Clin. Exp. Nephrol.16, 89-95 (2012)
  • The Involvement of L-Type Amino Acid Transporters in Theanine Transport.
    Yamamoto S, Kimura T, Tachiki T, Anzai N, Sakurai T, Ushimaru M.
    Biosci. Biotechnol. Biochem. 76, 2230-2235 (2012)
  • Protein phosphatase 2A interacts with the Na+,K+-ATPase and modulates its trafficking by inhibition of its association with arrestin.
    Kimura T, Han W, Pagel P, Nairn AC and Caplan MJ.
    PLoS One 6, e29269 (2011)
  • The role of Notch signaling in Xenopus pronephros development.
    Katada T, Sakurai H.
    J. Dev. Nephrol. 19, 25-29 (2011)
  • Apical voltage-driven urate efflux transporter NPT4 in renal proximal tubule.
    Jutabha P, Anzai N, Wempe MF, Wakui S, Endou H, Sakurai H.
    Nucleosides Nucleotides Nucleic Acids 30, 1302-1311 (2011)
  • Increased expression of SLC2A9 decreases urate excretion from the kidney.
    Kimura T, Amonpatumrat S, Tsukada A, Fukutomi T, Jutabha P, Thammapratip T, Lee EJ, Ichida K, Anzai N, Sakurai H.
    Nucleosides Nucleotides Nucleic Acids 30, 1295-1301 (2011)
  • A novel human organic anion transporter NPT4 mediates the transport of ochratoxin A.
    Jutabha P, Anzai N, Hayashi K, Domae M, Uchida K, Endou H, Sakurai H.
    J. Pharmacol. Sci. 116, 392-396 (2011)
  • Divergent expression of L-type amino acid transporter 1 during uterine cervical carcinogenesis.
    Uno K, Kuwabara H, Terado Y, Kojima K, Kawakami T, Kamma H, Sakurai H, Sakamoto A, Kurata A.
    Hum. Pathol. 42, 1660-1666 (2011)
  • Functional analysis of human sodium-phosphate transporter 4 (NPT4/SLC17A3) polymorphisms.
    Jutabha P, Anzai N, Kimura T, Taniguchi A, Urano W, Yamanaka H, Endou H, Sakurai H.
    J. Pharmacol. Sci. 115, 249-253 (2011)
  • Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate.
    Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, Katada T, Fukutomi T, Tomita K, Urano W, Yamanaka H, Seki G, Fujita T, Moriyama Y, Yamada A, Uchida S, Wempe MF, Endou H, Sakurai H.
    J. Biol. Chem. 285, 35123-35132 (2010)
  • Functional analysis of human organic cation transporter OCT3 (SLC22A3) polymorphisms.
    Sakata T, Anzai N, Kimura T, Miura D, Fukutomi T, Takeda M, Sakurai H, Endou H.
    J. Pharmacol. Sci. 113, 263-266 (2010)
  • A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules.
    Shiraya K, Hirata T, Hatano R, Nagamori S, Wiriyasermkul P, Jutabha P, Matsubara M, Muto S, Tanaka H, Asano S, Anzai N, Endou H, Yamada A, Sakurai H, Kanai Y.
    J. Biol. Chem. 285, 22141-22151 (2010)
  • Properties of L-type amino acid transporter 1 in epidermal ovarian cancer.
    Kaji M, Kabir-Salmani M, Anzai N, Jin CJ, Akimoto Y, Horita A, Sakamoto A, Kanai Y, Sakurai H, Iwashita M.
    Int. J. Gynecol Cancer. 20, 329-336 (2010)
  • Docetaxel suppresses invasiveness of head and neck cancer cells in vitro.
    Kogashiwa Y, Sakurai H, Kimura T, Kohno N.
    Cancer Sci. 20, 1382-1386 (2010)
  • Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney.
    Tsuchida H, Anzai N, Shin HJ, Wempe MF, Jutabha P, Enomoto A, Cha SH, Satoh T, Ishida M, Sakurai H, Endou H.
    Cell Physiol. Biochem. 25, 511-522 (2010)
  • System L amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell line.
    Yamauchi K, Sakurai H, Kimura T, Wiriyasermkul P, Nagamori S, Kanai Y, Kohno N.
    Cancer Lett. 276, 95-101 (2009)
  • L-glutamate enhances methylmercury toxicity by synergistically increasing oxidative stress.
    Amonpatumrat S, Sakurai H, Wiriyasermkul P, Khunweeraphong N, Nagamori S, Tanaka H, Piyachaturawat P, Kanai Y.
    J. Pharmacol. Sci. 108, 280-289 (2008)
  • Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans.
    Anzai N, Ichida K, Jutabha P, Kimura T, Babu E, Jin CJ, Srivastava S, Kitamura K, Hisatome I, Endou H, Sakurai H.
    J. Biol. Chem. 283, 26834-26838 (2008)