2015年度業績

【口演】

1. 鈴木重雄，彦坂健児，Balogun Emmanuel，小松谷啓介，新倉保，小林富美恵，高橋究，田中徹，中島元夫，北 潔：ALA/鉄化合物で治療したマラリア感染マウスに付与された防御免疫. 第５回ポルフィリン・ALA学会年会．東京（新宿区），2015年4月25-26日．
2. Tetsuo Shiohara: DRESS/DIHS-Pathogenesis–What’s new? and What’s next? International Severe Cutaneous Adverse Reaction 2015, Vancouver, June 8th, 2015.
3. Tetsuo Shiohara: Newly described drug eruptions. 23rd World Congress of Dermatology, Vancouver, June 11th, 2015.
4. Tetsuo Shiohara: Pathophysiology of fixed drug eruption. 23rd World Congress of Dermatology, Vancouver, June 12th, 2015.
5. 井上信一, 新倉　保, 朝日博子, 小林富美惠　(若手シンポジウム選択演題)：マラリア原虫感染防御においてγδ T細胞は抗原虫抗体産生能の維持に働く. γδ Tcells maintain humoral immunity against Plasmodium berghei XAT parasites.第26回日本生体防御学会学術総会, 東京（台東区）, 2015年7月10-12日.
6. Tetsuo Shiohara: Meet the Expert. Cutaneous drug eruptions. International Summer Academy, Munich, July 31th, 2015.
7. 新倉　保，井上信一，朝日博子，小林富美惠：マウスモデルを用いた妊娠中のマラリアの病態発症機序の解明. 第23回分子寄生虫学ワークショップ&第13回分子寄生虫マラリアフォーラム合同大会, 帯広, 2015年8月30 日-9月2日.
8. 井上信一，新倉　保，朝日博子，小林富美惠：　γδ T細胞を介したマラリア原虫感染防御の免疫機構を探る. 第23回分子寄生虫学ワークショップ&第13回分子寄生虫マラリアフォーラム合同大会, 帯広, 2015年8月30日-9月2日.
9. Tetsuo Shiohara: The physiological role of IgE and scratching in negatively regulating innate immune responses. 8th World Congress on Itch, Nara, September 29th, 2015.
10. Tetsuo Shiohara: Workshop「Severe Adverse Drug Reactions」Drug-induced hypersensitivity syndrome. 24th World Allergy Organization, Seoul, October 14th, 2015.
11. 井上信一：γδT細胞によるマラリア免疫防御機構. BioJapan 2015,　横浜, 2015年10月14-16日.
12. Mamoru Niikura, Shin-Ichi Inoue, Hiroko Asahi, Fumie Kobayashi: Maternal immune response to Plasmodiuminfection during pregnancy is associated with development of placental pathology. 第17回日韓寄生虫セミナー Forum Cheju, Osaka, November 13th, 2015.
13. Shin-Ichi Inoue, Mamoru Niikura, Hiroko Asahi, Fumie Kobayashi：Vg1⁺ gd T-cell subset preferentially responds to Plasmodium berghei XAT infection. 第17回日韓寄生虫セミナー Forum Cheju, Osaka, November 13th, 2015.
14. 中村 益夫, 和田 裕雄, 佐田 充, 乾 俊哉, 中本 啓太郎, 檜垣 学, 宮東 昭彦, 井上 信一, 花輪 智子, 小林 富美恵, 菅間 博, 滝澤 始：　IL-17A/F遺伝子欠損マウスは長期喫煙曝露による気腔開大が抑制される（Interleukin-17A/F regulates MMP-9 expression in the lung of mice after inhalation of cigarette smoke.）: 第38回日本分子生物学会年会/第88回日本生化学会大会,　神戸, 平成27年12月1-4日.
15. Ryo Takahashi, Yukiko Ushigome, Tetsuo Shiohara: An unfavorable shift from Treg to Th17 development can be preventable by selective depletion of IL-6-producing proinflammatory monocytes. 40th Annual Meeting of the Japanese Society for Investigative Dermatology, Okayama, December 11-13th, 2015.
16. Ise M, Kubo A, Sasaki T, Umegaki−Arano N, Amagai M, Ohyama M. Clinicopathological insights into the phenotypic variation of autosomal recessive hypotrichosis/wooly hair by c.736T>Amutation. The 40th Annual Meeting of the Japanese Society for Investigative Dermatology, Okayama, December 11th 2015.
17. Atsugi T, Yokouchi M, Hirabayashi A, Ohyama M, Amagai M, Kubo A. Functional tight junction barriers in sebaceous glands: detects in holocrine secretion in claudin-1 deficient mice. The 40th Annual Meeting of the Japanese Society for Investigative Dermatology, Okayama, December 12th 2015.
18. 末弘淳一, 田中弦, 木村徹, 櫻井裕之: アミノ酸トランスポーターLAT1阻害薬は血管内皮細胞増殖及び血管新生を抑制する. 第23回日本血管生物医学会学術集会, 神戸, 2015年12月11日.
19. 塩原哲夫: DiHSの病態と臨床. 第45回日本皮膚アレルギー・接触皮膚炎学会, 島根, 平成27年11月21日.
20. 井上信一，新倉　保，朝日博子，小林富美惠：マラリア原虫感染に対する宿主免疫防御を促進するγδ T細胞サブセットの解明. 第44回杏林医学会総会, 三鷹, 平成26年11月21日.
21. 兼松健也，井上信一，新倉　保，朝日博子，小林富美惠： LPS刺激はマラリア免疫記憶能を低下させる. 第44回杏林医学会総会, 三鷹, 平成27年11月21日.
22. Endo Y, Takahashi M, Obayashi Y, Aisawa N, Serizawa T, Murakoshi M, Ohyama M: The Ovariectomized mouse model mimics the pathophysiology of human female pattern hair loss. 9th World Congress of Hair Research, USA, November 18th-21st, 2015.
23. Ise M, Kubo A, Umegaki N, Amagai M, Ohyama M: Clinical, histological and genetic insights into the pathophysiology underlying phenotypic variation of autosomal recessive hypotrichosis/wooly hair caused by c.736T>A LIPH mutation. 9th World Congress of Hair Research, USA, November 18th-21st, 2015.
24. Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H: I2020T LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3beta signaling pathway. XXI World Congress on Parkinson’s Disease and Related Disorders, Italy, December 6th-9th, 2015.
25. 粟崎健, 加藤健太郎, 伊藤啓：ショウジョウバエ脳をモデルとしたグリアアセンブリ動作原理の解明．新学術領域研究「グリアアセンブリによる脳機能発現の制御と病態」第３回班会議, 平成28年1月９日．
26. Mamoru Niikura, Shin-Ichi Inoue, Hiroko Asahi, Fumie Kobayashi: Maternal immune response is associated with development of placental pathology during Plasmodium 第9回寄生虫感染免疫研究会，鹿児島，2016年2月11-12日．
27. Shin-Ichi Inoue, Mamoru Niikura, Hiroko Asahi, Fumie Kobayashi：Vg1⁺ gd T cells preferentially respond to Plasmodium 第9回寄生虫感染免疫研究会，鹿児島，2016年2月11-12日．
28. 塩原哲夫: シンポジウム「重症薬疹発症メカニズムから治療まで」.　薬剤性過敏症症候群(DiHS)の発症機序と治療. 日本皮膚科学会東京・東部支部合同学術大会, 新宿, 平成28年2月20日.
29. Fumie Kobayashi: Studies on malaria using mouse models of uncomplicated and fatal malaria. Scientific Symposium of Japan-India Research Exchange Projects within “Strategic International Research Cooperative Program (SICP)”, Tokyo, February 25, 2016.
30. Mamoru Niikura: Establishment of genetically attenuated rodent malaria parasites for predicting the severity. Scientific Symposium of Japan-India Research Exchange Projects within “Strategic International Research Cooperative Program (SICP)”, Tokyo, February 25, 2016.
31. Shin-Ichi Inoue: Protective immunity against a low virulent Plasmodium Scientific Symposium of Japan-India Research Exchange Projects within “Strategic International Research Cooperative Program (SICP)”, Tokyo, February 25, 2016.
32. 朝日博子, 救仁郷圭祐, 竹田美香, 矢幡一英, 井上信一, 新倉　保, Indah S. Tantular, Fumihiko Kawamoto, 中澤秀介, 小林富美惠, 金子　修, 鈴木 穣： Plasmodium falciparum ガメトサイト形成に伴って特異的に発現される分子の網羅的解析. 第85回日本寄生虫学会大会，宮崎，2016年3月19-20日．
33. 井上信一，新倉　保，朝日博子，小林富美惠：マラリア原虫感染防御において樹状細胞を活性化させるVγ１^＋γδ T細胞．第85回日本寄生虫学会大会，宮崎，2016年3月19-20日．
34. 北　潔，鈴木重雄，小松谷啓介，新倉　保，小林富美惠，田中　徹，中島元夫，高橋　究：新規抗マラリア薬としての5-アミノレブリン酸．第85回日本寄生虫学会大会，宮崎，2016年3月19-20日．
35. Mamoru Niikura, Shin-Ichi Inoue, Hiroko Asahi, Fumie Kobayashi: IFNGR1 signaling is involved in development of placental pathology during Plasmodium infection．（BPA候補採択演題）第85回日本寄生虫学会大会，宮崎，2016年3月19-20日．

【論　文】

1. Ise M, Funakoshi T, Furuichi Y, Honda H, Fujio Y, Amagai M, Ohyama M: A case of angiosarcoma on the abdominal wall, an extremely rare variant, putatively shared the pathogenesis with Stewart-Traves syndrome. J Dermatol 42: 426-427, 2015.
2. Kano Y, Tohyama M, Aihara M, Shiohara T, et al: Sequelae in 145 patients with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR). J Dermatol 42:276-282, 2015.
3. Andoh-Noda T, Akamatsu W, Miyake K, Matsumoto T, Yamaguchi R, Sanosaka T, Okada Y, Kobayashi T, Ohyama M, Nakashima K, Kurosawa H, Kubota T, Okano H: Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage. Molecualr Brain 27: 31, 2015.
4. 大山学：【再生医療－新たな医療を求めて－】 臨床応用を目指した基礎研究　多能性幹細胞とreprogramming技術　iPS細胞の毛包への誘導．日臨 73：193-198，2015
5. Ohyama M: Pump up the hair follicle. Br J Dermatol 172: 1479-1480, 2015.
6. Sotozono C, Ueta M, Nakatani E, Shiohara T, et al: Predictive factors associated with acute ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis. Am J Ophthalmol 160:228237, 2015.
7. Aihara M, Kano Y, Fujita H, Shiohara T, et al: Efficacy of additional i.v. immunoglobulin to sgteroid therapy in Stevens-Johnson syndrome and toxic epidermal necrolysis. J Dermatol 42:768-777, 2015.
8. Shiohara T, Mizukawa Y, Aoyama Y: Monitoring the acute response in severe hypersensitivity reactions to drugs. Curr Opin Allergy Clin Immunol 14:294-299, 2015.
9. Saito M, Ohyama M, Amagai M: Exploring the biology of the nail: An intriguing but less-investigated skin appendage. J Dermatol Sci 79: 187-193, 2015.
10. Kurata M, Horie, Kano Y, Shiohara T: Pompholyx as a clinical manifestation suggesting increased serum immunoglobulin G (IgG) levels in a patient with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS). Br J Dermatol 2015. doi: 10.1111/bjd.14200.
11. Horie C, Kano Y, Mitomo T, Shiohara T: Possible involvement of mycoplasma fermentans in the development of nonsexually acquired genital ulceration (Lipschütz Ulcers) in 3 young female patients. JAMA Dermatol 151:1388-1389, 2015.
12. Shiohara T, Ushigome Y, Kano Y, Takahashi R: Crucial role of viral reactivation in the development of severe drug eruptions: a comprehensive review. Clin Rev Allergy Immunol 49:192-202, 2015.
13. Kurata M, Kano Y, Sato Y, Hirahara K, Shiohara T: Synergistic effects of mycoplasma pneumoniae infection and drug reaction on the development of atypical Stevens-Johnson syndrome in adults. Acta Derm Venereol 96:111-113, 2016.
14. Funakoshi T, Sato T, Hosokawa R, Saito M, Amagai M, Ishiko A, Ohyama M: Application of electron microscopic analysis and fluorescent in situ hybridiazation technique for the successful diagnosis of extraskeletal Ewing’s sarcoma. J Dermatol 42: 893-896, 2015.
15. Ohta E, Nihira T, Uchino A, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Masafuchi R, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H: I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway. Hum Mol Genet 24: 4879-4900, 2015.
16. Iwabuchi T, Ideta T, Ehama R, Yamanishi H, Iino M, Nakazawa Y, Kobayashi T, Ohyama M, Kishimoto J: Topical adenosine increases the proportion of thick hair on Caucasian men with androgenetic alopecia. J Dermatol (Epub ahead of print) 2015.
17. Ise M, Tanese K, Adachi T, Du W, Amagai M, Ohyama M: Postherpetic Wolf’s isotopic response: Possible contribution of resident memory T cells to the pathogenesis of lichenoid reaction. Br J Dermatol 173: 1331-1334, 2015.
18. Shimojo D, Onodera K, Doi-Torii Y, Ishihara Y, Hattori C, Miwa Y, Tanaka S, Okada R, Ohyama M, Shoji M, Nakanishi A, Doyu M, Okano H, Okada Y: Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells. Mol Brain 8: 79, 2015.
19. Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, and Okano H: Functional neurons generated from T cell-derived iPSCs for neurological disease modeling. Stem Cell Reports (in press)
20. Sosuke Inokawa, Takayo Watanabe, Hiroshi Keino, Yasuhiko Sato,　Akito Hirakata, Annabelle A Okada, Ken Fukuda, Atsuki Fukushima & Kazuo Umezawa:  Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, reduces chemokines and adhesion molecule expression induced by IL-1β in human corneal fibroblasts. Graefes Arch Clin Exp Ophthalmol 253:557-563, 2015.
21. Asahi H, Kobayashi F, Niikura M, Inoue S-I, Yagita K, Tolba ME: Copper homeostasis for the developmental progression of intraerythrocytic malarial parasite. Current Topics in Medical Chemistry, 2015, in press.
22. Suzuki S, Hikosaka K, Balogun EO, Komatsuya K, Niikura M, Kobayashi F, Takahashi K, Tanaka T, Nakajima M, Kita K: In vivo curative and protective potential of orally administrated 5-aminolevulinic acid plus ferrous iron against malaria. Antimicrobial Agents and Chemotherapy, 59(11): 6960-6967, 2015.
23. Manabu Higaki, Hiroo Wada, Shin-ichiro Mikura, Tetsuo Yasutake, Masuo Nakamura, Mamoru Niikura, Fumie Kobayashi, Hiroshi Kamma, Shigeru Kamiya, Kazuhiro Ito, Peter Barnes, Hajime Goto, Hajime Takizawa: IL-10 modulates pulmonary neutrophilic inflammation induced by cigarette smoke exposure. Experimental Lung Research, 41(10): 525-534, 2015.
24. Furusawa J-I, Mizoguchi I, Chiba Y, Hisada M, Kobayashi F, Yoshida H, Nakae S, Tshuchida A, Matsumoto T, Ema H, Mizuguchi J, Yoshimoto T: Expansion and differentiation of hematopoietic stem cells by IL-27 into myeloid progenitors to control infection. PLOS Pathogens, in press.

【著　書】

1. 塩原哲夫: 皮膚疾患─薬疹. 極める副作用モニタリング. 飯島正文監修. 調剤と情報, 21:6(臨時増刊);61-67, 東京, じほう
2. 塩原哲夫: Stevens-Johnson症候群. 小児疾患診療のための病態生理 小児内科　47巻増刊号, p.886-890, 東京. 東京医学社, 2015年11月.
3. 塩原哲夫: 薬疹. 今日の診断指針第7版 金澤一郎, 永井良三編. 東京. 医学書院, p.1599-1602, 2015年11月25日.
4. 塩原哲夫: 薬剤アレルギー. 重症薬疹. 薬剤性過敏症症候群. 免疫症候群(第2版) その他の免疫疾患を含めて. II. 別冊日本臨床. 大阪. 日本臨床社, p.497-500, 2016年1月28日.
5. Tetsuo Shiohara, Yoshiko Mizukawa: Lichen planus and lichenoid dermatoses. Dermatology 4th Edition (Bolognia JL, et al. eds).  Elsevier, U.S.A. in press.
6. 小林　富美惠：随筆 「ぎょう虫検査」考． モダンメディア，2015．