項 目 内 容
教員名 石井 さなえ
フリガナ イシイ サナエ
NAME Sanae Hasegawa-Ishii
職 位 准教授
所属研究室 病理学研究
研究テーマ・分野 鼻腔の炎症が脳及び腸内細菌叢にどのような影響を及ぼすか
担当科目(学部) 生化学
担当科目(大学院) 臨床検査・生命科学特別演習
略 歴 平成 7年 筑波大学附属高等学校 卒業
平成12年 東京大学理学部生物学科人類学 卒業
平成14年 東京大学大学院医学系研究科医科学専攻修士課程修了
平成18年 東京大学大学院医学系研究科機能生物学専攻博士課程修了
平成18年 名古屋大学大学院医学系研究科老年科学  技術補佐員
平成19年 愛知県心身障害者コロニー発達障害研究所 病理学部  
平成24年 日本学術振興会特別研究員 (RPD)
平成27年 中部大学現代教育学部 非常勤講師 静岡県立大学薬理学部 客員共同研究員
平成27年 ペンシルバニア州立大学医学校薬理学 リサーチアソシエイト
平成29年10月〜 杏林大学保健学部准教授
所有する学位等 博士(医学)
主要研究業績 1. 学術論文 代表的なもののみ抜粋
Asano H, Hasegawa-Ishii S*, Arae K, Obara A, Laumet G, Dantzer R and Shimada A. Infiltration of peripheral immune cells into the olfactory bulb in a mouse model of acute nasal inflammation. J. Neuroimmunol. In press

Kishimoto-Urata M, Urata S, Kagoya R, Imamura F, Nagayama S, Reyna RA, Maruyama J, Yamasoba T, Kondo K*, Hasegawa-Ishii S*, Paessler S.* Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit.
Sci Rep. 2022 Apr 6;12(1):5728. doi: 10.1038/s41598-022-09731-7.

Mishima Y, Osaki T , Shimada A, Kamiya S, Hasegawa-Ishii S*. Sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice. Sci Rep. 2021 Feb 25;11(1)4640. doi: 10.1038/s41598-021-83896-5.

Shimada A and Hasegawa-Ishii S. Increased cytokine expression in the choroid plexus stroma and epithelium in response to endotoxin-induced systemic inflammation in mice. Toxicol Rep. 2021 Mar 10;8:520-528. doi: 10.1016/j.toxrep.2021.03.002. eCollection 2021.PMID: 33747797

Hasegawa-Ishii S*, Imamura F, Nagayama S, Murata M, Shimada A. Differential effects of nasal inflammation and odor deprivation on layer-specific degeneration of the mouse olfactory bulb. eNeuro. 2020 Mar 20. pii: ENEURO.0403-19.2020. doi:10.1523/ENEURO.0403-19.2020.

Hasegawa-Ishii S, Inaba M, Shimada A. Widespread time-dependent changes in tissue cytokine concentrations in brain regions during the acute phase of endotoxemia in mice. Neurotoxicology 76:67-74. doi: 10.1016/j.neuro.2019.10.006

Morita-Takemura S, Nakahara K, Hasegawa-Ishii S, Isonishi A, Tatsumi K, Okuda H, Tanaka T, Kitabatake M, Ito T, Wanaka A. Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance. J Neuroinflammation. 2019 Feb 14;16:1:39. doi: 10.1186/s12974-019-1431-6.

Hasegawa-Ishii S, Shimada A, Imamura F. Neuroplastic changes in the olfactory bulb associated with nasal inflammation in mice. J Allergy Clin Immunol. 2019 Mar;143:3:978-989.e3. doi: 10.1016/j.jaci.2018.09.028. Epub 2018 Oct 10.

Zouikr I, Hasegawa-Ishii S, Shimada A. Editorial: Neuroimmune Interface in Health and Diseases. Front Immunol. 8:1315. doi: 10.3389/fimmu.2017.01315.

Imamura F, Cooper TK, Hasegawa-Ishii S, Sonobe T, Haouzi P. Hydrogen Sulfide Specifically Alters NADPH Quinone Dehydrogenase 1-NQO1- Olfactory Neurons in the Rat.Neuroscience. 366:105-112. doi: 10.1016/j.neuroscience.2017.10.014.

Hasegawa-Ishii S, Shimada A, Imamura F. Lipopolysaccharide-initiated persistent rhinitis causes gliosis and synaptic loss in the olfactory bulb. Sci Rep. 7:1:11605. doi: 10.1038/s41598-017-10229-w.

Hasegawa-Ishii S, Inaba M, Umegaki H, Unno K, Wakabayashi K, and Shimada A. Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain-immune interface. Sci. Rep. 6:25457. doi: 10.1038/srep25457

Hasegawa-Ishii S, Inaba M, Li M, Shi M, Umegaki H, Ikehara S and Shimada A. Increased recruitment of bone marrow-derived cells into the brain associated with altered brain cytokine profile in senescence-accelerated mice. Brain Struct. Funct. 221:3:1513-1531.

Hasegawa-Ishii S, Shimada A, Inaba M, Li M, Shi M, Kawamura N, Takei S, Chiba Y, Hosokawa M and Ikehara S. Selective localization of bone marrow-derived ramified cells in the brain adjacent to the attachments of choroid plexus. Brain Behav. Immun. 29:82-97.2013

Hasegawa-Ishii S, Takei S, Inaba M, Umegaki H, Chiba Y, Furukawa A, Kawamura N, Hosokawa M and Shimada A. Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse. Brain Behav. Immun. 25:1:83-100. 2011

Hasegawa-Ishii S, Takei S, Chiba Y, Furukawa A, Umegaki H, Iguchi A, Kawamura N, Yoshikawa K, Hosokawa M and Shimada A. Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice. Neuropathology 31: 20-28. 2011

Hasegawa S, Yamaguchi M, Nagao H, Mishina M, Mori K. Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus. J. Neuroimmunol. 186, 75-85. 2007

Hasegawa S, Yamaguchi M, Nagao H, Yoshihara Y, Mori K. Activated natural killer cells adhere to cultured hippocampal neurons and affect the dendritic morphology. J. Neuroimmunol. 151. 126-136. 2004

2. 総説 
Shimada, A. and Hasegawa-Ishii, S. Histological architecture underlying brain-immune cell-cell interactions and the cerebral response to systemic inflammation. Front. Immunol. 19;8:17. doi: 10.3389/fimmu.2017.00017. 2017

Imamura, F. and Hasegawa-Ishii, S. Environmental toxicans-induced immune responses in the olfactory mucosa. Front. Immunol. 7:475. doi: 10.3389/fimmu.2016.00475. 2016

Hasegawa-Ishii, S., Inaba, M., Li, M., Umegaki, H., Ikehara, S. and Shimada, A. Dynamics of bone marrow-derived cells relevant to the brain-immune cell-cell interactions under non-inflammatory conditions. Curr. Trends Neurol. 8:39-52. 2014

Shimada, A. and Hasegawa-Ishii, S. Senescence-accelerated mice –SAMs- as a model for brain aging and immunosenescence. Aging Dis. 2:5: 414-435. 2011

3. 著書 
Zouiker I, Hasegawa-Ishii S and Shimada A. Neuroimmune interface in health and diseases. Frontiers eBooks. 2017

Shimada A, Hasegawa-Ishii S and Furukawa A. SAMP10 strain as a model for the study of brain aging. In: The senescence-accelerated mouse –SAM-: Achievements and Future Directions. Takeda T, Akiguchi I, Higuchi K, Hosokawa M, Hosokawa T and Nomura Y, eds., Elsevier, Amsterdam, pp 157-174. 2011

4. 招待講演
10th Mind Body Interface Symposium: Taiwan. 2020.10.30
Hasegawa-Ishii S. Changes in the brain morphology and microenvironment caused by nasal inflammation.

Special lecture, Nara Medical University: Nara, Japan. 2015.9.14
Hasegawa-Ishii S. Endotoxemia-induced brain cytokine reactions mediated by the cells in the brain-immune interface.

Neural & Behavioral Sciences Seminar Series, Pennsylvania State University College of Medicine: Pennsylvania. 2014.5.27
Hasegawa-Ishii S. Enhanced recruitment of bone marrow-derived cells into the brain parenchyma in senescence-accelerated mice.

Asia Association of Aging Research –AAAR-: Seoul. 2013.11.9
Hasegawa-Ishii S and Shimada A. Enhanced recruitment of bone marrow-derived cells into the brain parenchyma in senescence-accelerated mice.

5. 受賞歴
第48回 杏林大学医学会総会 優秀発表賞 2019
The 20th PsychoNeuroImmunology Trainee scholar Award 2013
平成24年度日本神経病理学会 日本神経病理学会賞 2012
第52回 日本神経病理学会 優秀ポスター賞 2011
第31回 日本基礎老化学会 若手奨励賞 2008
第31回 日本基礎老化学会 ポスター賞 2008
所属学会 PsychoNeuroImmunology Research Society, Society for Neuroscience, 日本神経科学学会、日本味と匂学会、日本無菌生物ノートバイオロジー学会
公的な委員会等の役員・委員歴 無菌生物ノートバイオロジー学会評議員
居室・研究室 A棟506、A棟523
オフィスアワー 水曜日15:00-17:00、木曜日15:00-17:00
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