Faculty of Medicine泌尿器科学教室

教室専任教員

教授
准教授
講師
助教

教室概要

泌尿器科診療では、常に新しい質の高い医療を取り入れ、最高の治療が出来るように努力しています。スタッフによるチーム医療を心がけ、入院患者さんはもとより外来患者さんの治療方針なども検討会で議論をし、安心して治療を受けられる診療科を目指して努力しています。

  • ロボット(ダ・ヴィンチ):前立腺全摘除術、腎部分切除術、膀胱全摘術、腎盂形成術、仙骨膣固定術
  • がんに対する薬物療法:抗がん剤、分子標的薬、免疫チェックポイント阻害剤、前立腺癌に対するホルモン療法

先進的医療としてゲノム医療を導入し、がん治療用ウイルスを用いたウイルス療法の臨床応用も行います。

教育の特色

教育においては、まず、患者の立場に立った医療を実践できる人材を輩出したいと考えております。一医療人である前に、一社会人であることが社会的にも求められてきております。最適な治療を行うには、それぞれの疾患を科学的によく理解した上で、その疾患に対する正しい治療哲学を必要とします。

泌尿器科学が扱う疾患は、癌・排尿・結石・腎不全など多岐に渡り、癌についても腎・膀胱・尿道・前立腺・精巣と臓器毎に特性がかなり異なっております。また、手技としては外科学的素養が核となります。

泌尿器科学の研鑽を通して、人としても良き医療人となるべく、情熱を持って教育にあたります。

社会的活動

  1. 多摩泌尿器科医会
    年に3回主催し、地域泌尿器科医と勉強会を通し、連携を深めています。
  2. 三鷹・武蔵野・小金井排尿障害勉強会
    上記地区にて医療・介護従事者を対象とした排尿障害の勉強会を主催しています。
  3. 前立腺癌・前立腺肥大症に関する市民公開講座
    多摩泌尿器科医会を通し、多摩地区にて市民公開講座を援助しています。
  4. 女性骨盤底勉強会
    主に多摩地区の泌尿器科医、産婦人科医を対象に女性骨盤底疾患に関する勉強会を主催しています。
  5. 多摩地区結節性硬化症診療連携セミナー
    多摩地区における結節性硬化症診療の連携構築を目的とし、診療連携セミナーを主催しています。

研究テーマ

がん治療用ウイルスを用いたウイルス療法

「ウイルス療法」とは、遺伝子組み換え技術によって、正常細胞は障害せずにがん細胞のみを破壊するウイルス(がん治療用ウイルス)を作製して治療に用いるものです。すでに欧米では第2世代がん治療用ヘルペスウイルス1型のT-VECが認可され、一般臨床で用いられています。我々は、第3世代がん治療用ヘルペスウイルス1型であるG47Δ(じー・よんじゅうなな・でるた)を用いたウイルス療法の研究をおこなっております。当科主任教授の福原が研究代表者となり、前立腺癌に対する世界初の第I相臨床試験が東京大学でおこなわれ、安全性が確認されました。ウイルスの効果をさらに検証すべく、現在杏林大学において第II相臨床試験を行っております。

末梢血循環癌細胞の遺伝子型と臨床的応用

前立腺の末梢血循環癌細胞(CTC)の検出を行い、遺伝子解析にて病期および予後との関係を検討し報告してきました。癌治療の複雑化、さらには医療費の高騰が大きな問題となっており、いわゆる”Precision Medicine”実現 に向けたバイオマーカーの開発が大きな課題となっています。このような状況で2017年Liquid Biopsy研究会を立ち上げました。科の枠を超えてより幅広い領域の専門家が多数参加いただいています。

多発性嚢胞腎に関連した研究

杏林大学泌尿器科では1994年から厚労省の多発性嚢胞腎研究班会議の中心メンバーとして臨床研究を行なってきました。2014年3月、世界に先駆けて日本で、引き続いてカナダ,EU、米国等で多発性嚢胞腎に対する治療薬としてサムスカが承認されました。それまで、多発性嚢胞腎の治療は疼痛、感染、高血圧等に対する対症療法しかなく、病気の進行を抑制する治療薬が開発されたのは画期的な進歩でした。この開発研究に杏林大学泌尿器科は積極的に取り組んできました。

近年の主な業績

  1. Fukuhara H, Takeshima Y, Todo T. Triple-mutated oncolytic herpes virus for treating both fast- and slow-growing tumor. Cancer Sci, 112, 3293-3301, 2021.
  2. Kinjo M, Tanba M, Masuda K, Nakamura Y, Tanbo M, Fukuhara H. Comparison of effectiveness between modified transvaginal mesh surgery and vaginal pessary treatment in patients with symptomatic pelvic organ prolapse. Low Urin Tract Symptoms. 14, 64-71, 2022.
  3. Taguchi S, Tambo M, Watanabe M, Machida H, Kariyasu T, Fukushima K, Shimizu Y, Okegawa T, Yokoyama K, Fukuhara H. Prospective validation of Vesical Imaging-Reporting and Data System (VI-RADS) using a next-generation magnetic resonance imaging scanner: Is denoising deep learning reconstruction useful J Urol, 205. 686-692, 2021.
  4. Higashihara E, Fukuhara H, Ouyang J, Lee J, Nutahara K, Tanbo M, Yamaguchi T, Taguchi S, Muto S, Kanayama S, Miyazaki I, Horie S. Estimation of changes in kidney volume growth rate in autosomal dominant polycystic kidney disease. Kidney Int Rep., 5, 1459-1471, 2020.
  5. Masuda K, Aizawa N, Watanabe D, Okegawa T, Kume H, Igawa Y, Fukuhara H. Pathophysiological changes of the lower urinary tract behind voiding dysfunction in streptozotocin-induced long-term diabetic rats. Scientific Reports. 10, 4182, 2020.
  6. Kinjo M, Masuda K, Nakamura Y, Taguchi S, Tambo M, Fukuhara H. Does metabolic syndrome influence the efficacy of mirabegron treatment in female patients with overactive bladder Int Urogynecol J. 2022, in press.
  7. Taguchi S, Watanabe M, Tambo M, Machida H, Yokoyama K, Fukuhara H. Proposal for a New Vesical Imaging-Reporting and Data System (VI-RADS)-Based Algorithm for the Management of Bladder Cancer: A Paradigm Shift From the Current Transurethral Resection of Bladder Tumor (TURBT)-Dependent Practice. Clin Genitourin Cancer. 2022, in press.
  8. Nakamura Y, Taguchi S, Kinjo M, Tanbo M, Okegawa T, Fukuhara H. Adrenal metastasis in nivolumab-treated renal cell carcinoma: A unique entity as a sanctuary site. Int. J Urol. 29, 597-599, 2022.
  9. Shishido T, Okegawa T, Hayashi K, Masuda K, Taguchi S, Nakamura Y, Tambo M, Fukuhara H. Laparoscopic retroperitoneal lymph node dissection versus open retroperitoneal lymph node dissection for testicular cancer: A comparison of clinical and perioperative outcomes. Asian J Urol, 9, 119-124, 2022.
  10. Kitahama K, Yoshiike S, Nagahama K, Ninomiya N, Okegawa T, Fukuhara H, Nabeshima K, Oka T, Shibahara J. Well-differentiated papillary mesothelial tumor presenting as an encysted hydrocele of the spermatic cord. Pathol Int. 2022, in press.
  11. Watanabe M, Taguchi S, Machida H, Tambo M, Takeshita Y, Kariyasu T, Fukushima K, Shimizu Y, Okegawa T, Fukuhara H, Yokoyama K. Clinical validity of non-contrast-enhanced VI-RADS: prospective study using 3-T MRI with high-gradient magnetic field. Eur Radiol. 2022, in press
  12. Mochida Y, Ochiai K, Nagase T, Nonomura K, Akimoto Y, Fukuhara H, Sakai T, Matsumura G, Yamaguchi Y, Nagase M. Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells. Sci Rep. 12, 4197, 2022.
  13. Kawai T, Taguchi S, Nakagawa T, Kamei J, Nakamura Y, Obinata D, Yamaguchi K, Kaneko T, Kakutani S, Tokunaga M, Uemura Y, Sato Y, Enomoto Y, Nishimatsu H, Fujimura T, Fukuhara H, Takahashi S, Kume H. Impact of immune-related adverse events on the therapeutic efficacy of pembrolizumab in urothelial carcinoma: a multicenter retrospective study using time-dependent analysis. J Immunother Cancer. 10, e003965, 2022.
  14. Tohi Y, Kato T, Miyakawa J, Matsumoto R, Sasaki H, Mitsuzuka K, Inokuchi J, Matsumura M, Yokomizo A, Kinoshita H, Hara I, Kawamura N, Hashimoto K, Inoue M, Teishima J, Kanno H, Fukuhara H, Maruyama S, Sakamoto S, Saito T, Kakehi Y, Sugimoto M. Impact of adherence to criteria on oncological outcomes of radical prostatectomy in patients opting for active surveillance: data from the PRIAS-JAPAN study. Jpn J Clin Oncol. 2022, in pressYokomizo A, Yonese J, Egawa S, Fukuhara H, Uemura H, Nishimura K, Nagata M, Saito A, Lee T, Yamaguchi S, Nonomura N. Real-world use of enzalutamide in men with nonmetastatic castration-resistant prostate cancer in Japan. Int J Clin Oncol. 27, 418-426, 2022.
  15. Tohi Y, Kato T, Nakamura M, Matsumoto R, Sasaki H, Mitsuzuka K, Inokuchi J, Hashine K, Yokomizo A, Naito H, Hara I, Kawamura N, Inoue M, Fukuhara H, Maruyama S, Sakamoto S, Saito T, Egawa S, Kakehi Y, Sugimoto M. Deferred radical prostatectomy in patients who initially elected for active surveillance: a multi-institutional, prospective, observational cohort of the PRIAS-JAPAN study. Int J Clin Oncol. 27, 194-201, 2022.
  16. Oshina T, Taguchi S, Miyakawa J, Akiyama Y, Sato Y, Kawai T, Fukuhara H, Nakagawa T, Kume H. Clinicopathological features and oncological outcomes of urothelial carcinoma involving the ureterovesical junction. Jpn J Clin Oncol. 52, 65-72, 2022.
  17. Tohi Y, Kato T, Yokomizo A, Mitsuzuka K, Tomida R, Inokuchi J, Matsumoto R, Saito T, Sasaki H, Inoue K, Kinoshita H, Fukuhara H, Maruyama S, Sakamoto S, Tanikawa T, Egawa S, Ichikura H, Abe T, Nakamura M, Kakehi Y, Sugimoto M. Impact of health-related quality of life on repeat protocol biopsy compliance on active surveillance for favorable prostate cancer; results from a prospective cohort in the Prostate Cancer Research International: Active Surveillance (PRIAS)-JAPAN study. Urol Oncol. 40, 56.e.9-e15, 2022.
  18. Higashihara E, Nutahara K, Itoh M, Okegawa T, Tambo M, Yamaguchi T, Nakamura Y, Taguchi S, Kaname S, Yokoyama K, Yoshioka T, Fukuhara H. Long-Term Outcomes of Longitudinal Efficacy Study With Tolvaptan in ADPKD. Kidney Int Rep. 7, 270-281, 2021.
  19. Kitamura J, Taguchi S, Okegawa T, Honda K, Kii T, Tomida Y, Matsumoto R, Ninomiya N, Masuda K, Nakamura Y, Yamaguchi T, Kinjo M, Tambo M, Isomura A, Hayashi A, Kamma H, Higashihara E, Shibahara J, Fukuhara H. Genomic analysis of circulating tumor cells in adenosquamous carcinoma of the prostate: a case report. BMC Med Genomics. 14, 217, 2021
  20. Taguchi S, Kawai T, Nakagawa T, Nakamura Y, Kamei J, Obinata D, Yamaguchi K, Kaneko T, Kakutani S, Tokunaga M, Uemura Y, Sato Y, Fujimura T, Fukuhara H, Enomoto Y, Nishimatsu H, Takahashi S, Kume H. Prognostic significance of the albumin-to-globulin ratio for advanced urothelial carcinoma treated with pembrolizumab: a multicenter retrospective study. Sci Rep. 11, 15623, 2021.
  21. Shigemori K, Higashihara E, Itoh M, Yoshida H, Yamamoto K, Nutahara K, Shiokawa Y, Kaname S, Tambo M, Yamaguchi T, Taguchi S, Yoshioka T, Yokoyama K, Fukuhara H. PKD1- associated Arachnoid Cysts in Autosomal Dominant Polycystic Kidney Disease. J Stroke Cerebrovasc Dis. 30, 105943, 2021.
  22. Kii T, Taguchi S, Nagahama K, Shimoyamada H, Honda K, Tomida Y, Matsumoto R, Kitamura J, Ninomiya N, Masuda K, Nakamura Y, Yamaguchi T, Kinjo M, Tambo M, Okegawa T, Higashihara E, Shibahara J, Fukuhara H. Pigmented median raphe cyst of the penis that developed after middle age without infection or trauma history. IJU Case Reports, 4, 172-175, 2021.
  23. Taguchi S, Morikawa T, Shibahara J, Fukuhara H. Prognostic significance of tertiary Gleason pattern in the contemporary era of Gleason grade grouping: A narrative review. Int J Urol. 28, 614-621, 2021.
  24. Taguchi S, Nakagawa T, Uemura Y, Akamatsu N, Gonoi W, Naito A, Kawai T, Kume H, Fukuhara H. Comparison of Major Definitions of Sarcopenia Based on the Skeletal Muscle Index in Patients with Urothelial Carcinoma. Future Oncology, 17, 197-203, 2021.
  25. Kinjo M, Nakamura Y, Taguchi S, Yamaguchi T, Tambo M, Okegawa T, Fukuhara H. Sex differences in prevalence and patient behavior regarding lower urinary tract symptoms among Japanese medical checkup examinees. Urology, 151, 24-30, 2021.
  26. Uchihashi T, Nakahara H, Fukuhara H, Iwai M, Ito H, Sugauchi A, Tanaka M, Kogo M, Todo T. Oncolytic herpes virus G47 injected into tongue cancer swiftly traffics in lymphatics and suppresses metastasis, Mol Ther Oncolytics. 22, 388-398, 2021.
  27. Kato T, Hirama H, Mitsuzuka K, Maruyama S, Sasaki H, Saito T, Matsumoto R, Sakamoto S, Sakai Y, Fukuhara H, Naya Y, Tsukino H, Hara I, Ogawa O, Hashine K, Fumimasa F, Yokomizo A, Tohi Y, Kakehi Y, Sugimoto M. Reclassification prediction of first-year protocol biopsy on active surveillance of prostate cancer by p2PSA-related parameters: from PRIAS-JAPAN. Prostate Cancer Prostatic Dis. 2021, in press.
  28. Matsumura S, Nakamori M, Tsuji T, Kato T, Nakamura M, Ojima T, Fukuhara H, Ino Y, Todo T, Yamaue H. Oncolytic virotherapy with SOCS3 enhances viral replicative potency and oncolysis for gastric cancer. Oncotarget, 12, 344-354, 2021.
  29. Inoue T, Okada S, Hamamoto S, Miura H, Matsuzaki J, Tambo M, Fukuhara H, Fujisawa M, Matsuda T, Nutahara K. Evaluation of flexible ureteroscope with an omni-directional bending tip, using a JOYSTICK unit (URF-Y0016); an ex-vivo study. World Journal of Urology, 39, 209-215, 2021.
  30. Mizuno K, Sumiyoshi T, Okegawa T, Terada N, Ishitoya S, Miyazaki Y, Kojima T, Katayama H, Fujimoto N, Hatakeyama S, Shiota M, Yoshimura K, Matsui Y, Narita S, Matsumoto H, Kurahashi R, Kanno H, Ito K, Kimura H, Kamiyama Y, Sunada T, Goto T, Kobayashi T, Yamada H, Tsuchiya N, Kamba T, Matsuyama H, Habuchi T, Eto M, Ohyama C, Ito A, Nishiyama H, Okuno H, Kamoto T, Fujimoto A, Ogawa O, Akamatsu S. Clinical Impact of Detecting Low-Frequency Variants in Cell-Free DNA on Treatment of Castration-Resistant Prostate Cancer. Clin Cancer Res. 27, 6164-6173, 2021.
  31. Higashihara E, Horie S, Muto S, Kawano H, Tanbo M, Yamaguchi T, Taguchi S, Kaname S, Yokoyama K, Yoshioka T, Fukukawa T, Fukuhara H. Imaging Identification of Rapidly Progressing Autosomal Dominant Polycystic Kidney Disease: Simple Eligibility Criterion for Tolvaptan. American Journal of Nephrology, 51, 891-890, 2020.
  32. Kinjo M, Masuda K, Nakamura Y, Taguchi S, Tambo M, Okegawa T, Fukuhara H. Effects on depression and anxiety after mid-urethral sling surgery for female stress urinary incontinence. Research and Reports in Urology, 12, 495-501, 2020.
  33. Omura S, Taguchi S, Miyagawa S, Matsumoto R, Samejima M, Ninomiya N, Masuda K, Nakamura Y, Yamaguchi T, Kinjo M, Tambo M, Okegawa T, Higashihara E, Fukuhara H. Prognostic significance of the albumin-to-globulin ratio for upper tract urothelial carcinoma. BMC Urology, 20, 133, 2020.
  34. Naito A, Taguchi S, Suzuki M, Kawai T, Uchida K, Fujimura T, Fukuhara H, Kume H. Transient acute kidney injury observed immediately after robot-assisted radical prostatectomy but not after open radical prostatectomy. Molecular and Clinical Oncology, 13, 18, 2020.
  35. Taguchi S, Shiraishi K, Fukuhara H. Updated evidence on oncological outcomes of surgery versus external beam radiotherapy for localized prostate cancer. Jpn J Clin Oncol. 50, 963-969, 2020.
  36. Taguchi S, Uemura Y, Fujimura T, Morikawa T, Naito A, Kawai T, Suzuki M, Kume H, Fukuhara H. Quantification of the individual risk of each Gleason pattern, including tertiary Gleason pattern 5, after radical prostatectomy: development of the modified Gleason grade grouping (mGGG) model. BMC Cancer, 20, 371, 2020.
  37. Okegawa T, Omura S, Samejima M, Ninomiya N, Taguchi S, Nakamura Y, Yamaguchi T, Tambo M, Fukuhara H. Laparoscopic radical prostatectomy versus robot-assisted radical prostatectomy: comparison of oncological outcomes at a single center. Prostate Int. 8, 16-21, 2020.
  38. Tambo M, Taguchi S, Nakamura Y, Okegawa T, Fukuhara H. Presepsin and procalcitonin as predictors of sepsis based on the new Sepsis-3 definition in obstructive pyelonephritis. BMC Urol. 20, 23, 2020.
  39. Kakutani S, Asamoto M, Araki F, Chen YN, Shinokawa M, Okagami Y, Ohata T, Taguchi S, Yamada Y, Takeshima Y, Kume H, Yamada Y, Aihara M, Ito N, Fukuhara H. Prospective evaluation of visual function in patients with ocular diseases after robotic-assisted laparoscopic prostatectomy. Int J Urol. 27, 307-313, 2020.
  40. Tambo M, Inoue T, Miura H, Matsuzaki J, Nutahara K, Hamamoto S, Okada S, Fukuhara H, Fujisawa M, Matsuda T. A novel flexible ureteroscope with omnidirectional bending tip using joystick-type control unit (URF-Y0016): initial validation study in bench models. J Endourol. 34, 676-681, 2020.
  41. Shimizu T, Yamaguchi K, Yamamoto M, Kurioka R, Kino Y, Matsunaga W, Nakao S, Fukuhara H, Tanaka A, Gotoh A, Mabuchi M. Identification of HUHS190, a human naftopidil metabolite, as a novel anti-bladder cancer drug. Bioorganic & Medicinal Chemistry Letter 30, 126744, 2020.
  42. Yoshida A, Arai Y, Hama N, Chikuta H, Bando Y, Nakano S, Kobayashi E, Shibahara J, Fukuhara H, Komiyama M, Watanabe SI, Tamura K, Kawai A, Shibata T, Expanding the clinicopathologic and molecular spectrum of BCOR-associated sarcomas in adults. Histopathology 76, 509-520, 2020.
  43. Taguchi S, Nakagawa T, Fukuhara H. Inconsistencies in currently used definitions of sarcopenia in oncology. Annals of Oncology 31, 318-319, 2020.
  44. Nakato R, Wada Y, Nakaki R, Nagae G, Katou Y, Tsutsumi S, Nakajima N, Fukuhara H, Iguchi A, Kohro T, Kanki Y, Saito Y, Kobayashi M, Izumi-Taguchi A, Osato N, Tatsuno K, Kamio A, Hayashi-Takanaka Y, Wada H, Ohta S, Aikawa M, Nakajima H, Nakamura M, McGee RC, Heppner KW, Kawakatsu T, Genno M, Yanase H, Kume H, Senbonmatsu T, Homma Y, Nishimura S, Mitsuyama T, Aburatani H, Kimura H, Shirahige K. Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells. Epigenetics Chromatin. 12, 77, 2019.
  45. Taguchi S, Shiraishi K, Fujimura T, Naito A, Kawai T, Nakagawa K, Abe O, Kume H, Fukuhara H*. Robot-assisted radical prostatectomy versus volumetric modulated arc therapy: Comparison of front-line therapies for localized prostate cancer. Radiother Oncol. 140, 62-66, 2019.
  46. Watanabe S, Hayashi K, Toh K, Kim HJ, Liu X, Chaya H, Fukushima S, Katsushima K, Kondo Y, Uchida S, Ogura S, Nomoto T, Takemoto H, Cabral H, Kinoh H, Tanaka HY, Kano MR, Matsumoto Y, Fukuhara H, Uchida S, Nangaku M, Osada K, Nishiyama N, Miyata K, Kataoka K. In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers. Nat Commun. 10, 1894, 2019.
  47. Fujimura T, Igawa Y, Aizawa N, Niimi A, Yamada Y, Sugihara T, Kamei J, Sato Y, Matsunaga A, Yoshida M, Shinoda Y, Fukuhara H, Nakagawa T, Homma Y, Kume H. Longitudinal change of comprehensive lower urinary tract symptoms and various types of urinary incontinence during robot-assisted radical prostatectomy. Neurourol Urodyn 38, 1067-1075, 2019.
  48. Akiyama Y, Daichi M, Katoh H, Morikawa T, Niimi A, Nomiya A, Sato Y, Kawai T, Goto A, Fujimura T, Fukuhara H, Nakagawa T, Igawa Y, Ishikawa S, Fukayama M, Kume H, Homma Y. Molecular Taxonomy of Interstitial Cystitis/Bladder Pain Syndrome Based on Whole Transcriptome Profiling by Next-Generation RNA Sequencing of Bladder Mucosal Biopsies. J Urol. 202, 290-300, 2019.
  49. Kinjo M, Yamaguchi T, Tambo M, Okegawa T, Fukuhara H. Effects of Mirabegron on Anxiety and Depression in Female Patients with Overactive Bladder. Urol Int. 102, 331-335, 2019.
  50. Taguchi S, Fukuhara H*, Todo T. Oncolytic virus therapy in Japan: progress in clinical trials and future perspectives.Jpn J Clin Oncol. 49, 201-209, 2019.
  51. Samejima M, Taguchi S, Miyagawa S, Matsumoto R, Omura S, Ninomiya N, Nakamura Y, Yamaguchi T, Kinjo M, Tambo M, Okegawa T, Koba T, Matsuki R, Jimbo I, Motoyasu A, Tsumura T, Shimoyamada H, Shibahara J, Sakamoto Y, Fukuhara H. Acute hypotension induced by suction of cystic fluid containing extremely high concentrations of catecholamines during resection of giant pheochromocytoma. IJU Case Rep, 2, 218-220, 2019.
  52. Taguchi S, Nakagawa T, Fukuhara H. Re: Jurgen E. Gschwend, Matthias M. Heck, Jan Lehmann, et al. Extended Versus Limited Lymph Node Dissection in Bladder Cancer Patients Undergoing Radical Cystectomy: Survival Results from a Prospective, Randomized Trial. Eur Urol 2019. Eur Urol, S0302-2838, 30345-30348, 2019.
  53. Gansevoort RT, van Gastel MDA, Chapman AB, Blais JD, Czerwiec FS, Higashihara E, Lee J, Ouyang J, Perrone RD, Stade K, Torres VE, Devuyst O; TEMPO 3:4 Investigators. Plasma copeptin levels predict disease progression and tolvaptan efficacy in autosomal dominant polycystic kidney disease. Kidney Int. 96: 159-169. 2019
  54. Higashihara E,Yamamoto K,Kaname S,Okegawa T,Tanbo M,Yamaguchi T,Shigemori K,Miyazaki I,Yokoyama K,Nutahara K:Age- and height-adjusted total kidney volume growth rate in autosomal dominant polycystic kidney diseases. Clin Exp Nephrol. 23, 100-111, 2019.
  55. Buti S,Karakiewicz PI,Bersanelli M,Capitanio U,Tian Z,Cortellini A,Taguchi S, Briganti A,Montorsi F,Leonardi F,Bandini M. Validation of the Grade, Age, Nodes and Tumor (GRANT) score within the Surveillance Epidemiology and End Results (SEER) database: A new tool to predict survival in surgically treated renal cell carcinoma patients. Sci Rep. 9, 13218, 2019.
  56. Fujisaki A, Kinjo M, Shimoinaba M, Honda S, Yoshimura Y. An evaluation of the impact of post-hysterectomy vesicovaginal fistula repair on the mental health of patients in a developed country. Int Urogynecol J. 2019, in press.
  57. Gansevoort RT, van Gastel MDA, Chapman AB, Blais JD, Czerwiec FS, Higashihara E, Lee J, Ouyang J, Perrone RD, Stade K, Torres VE, Devuyst O; TEMPO 3:4 Investigators. Plasma copeptin levels predict disease progression and tolvaptan efficacy in autosomal dominant polycystic kidney disease. Kidney Int. 96, 159-169, 2019.
  58. Gonda K, Akama T, Nakamura T, Hashimoto E, Kyoya N, Rokkaku Y, Maejima Y, Horita S, Tachibana K, Abe N, Ohtake T, Shimomura K, Kono K, Saji S, Takenoshita S, Higashihara E. Cluster of differentiation 8 and programmed cell death ligand 1 expression in triple-negative breast cancer combined with autosomal dominant polycystic kidney disease and tuberous sclerosis complex: a case report. J Med Case Rep. 13, 381, 2019.
  59. Fujimura T, Fukuhara H, Yamada Y, Taguchi S, Sugihara T, Niimi A, Nakamura M, Nakagawa T, Igawa Y, Homma Y, Kume H. Aggressive Cancer Behavior of Latent Gleason Pattern 5 in Prostatectomy Specimens. Anticancer Res. 38: 6529-6535, 2018.
  60. Kinoshita Y, Sugihara T, Yasunaga H, Matsui H, Ishikawa A, Fujimura T, Fukuhara H, Ishibashi Y, Fushimi K, Homma Y. Hospital-volume effects on perioperative outcomes in peritoneal dialysis catheter implantation: analysis of 2,505 cases. Perit Dial Int. 38, 419-423, 2018.
  61. Taguchi S, Fukuhara H*, Miyakawa J, Morikawa T, Naito A, Kawai T, Fujimura T, Kume H. Prognostic significance of neutrophil-to-lymphocyte ratio in collecting duct carcinoma. Jpn J Clin Oncol. 48, 692-694, 2018.
  62. Otsuka M, Taguchi S, Nakagawa T, Morikawa T, Maekawa S, Miyakawa J, Matsumoto A, Miyazaki H, Fujimura T, Fukuhara H, Kume H, Igawa Y, Homma Y. Clinical significance of random bladder biopsy in primary T1 bladder cancer. Mol Clin Oncol. 8, 665-670, 2018.
  63. Makino K, Nakagawa T, Ito E, Kasahara I, Murata T, Fujimura T, Fukuhara H, Homma Y. Oncological and peri-surgical outcomes of radical prostatectomy for non-metastatic prostate cancer with prostate-specific antigen level of 50 ng/ml or greater. Jpn J Clin Oncol. 48, 485-49, 2018.
  64. Aizawa N, Watanabe D, Fukuhara H, Fujimura T, Kume H, Homma Y, Igawa Y. Inhibitory effects of silodosin on the bladder mechanosensitive afferent activities and their relaxation with bladder myogenic contractions in male rats with bladder outlet obstruction. Neurourol Urodyn. 37, 1897-1903, 2018.
  65. Akiyama Y, Niimi A, Nomiya A, Yamada Y, Nakagawa T, Fujimura T, Fukuhara H, Kume H, Igawa Y and Homma Y. Extent of Hunner lesions: the relationships with symptom severity and clinical parameters in patients with Hunner-type interstitial cystitis. Neurourol Urodyn. 37, 1441-1447, 2018.
  66. Niimi A, Igawa Y, Aizawa N, Honma T, Nomiya A, Akiyama Y, Kamei J, Fujimura T, Fukuhara H and Homma Y. Diagnostic value of urinary CXCL10 as a biomarker for predicting Hunner type interstitial cystitis. Neurourol Urodyn. 37, 1113-1119, 2018.
  67. Yamada Y, Fujimura T, Fukuhara H, Sugihara T, Nakagawa T, Kume H, Igawa Y, Homma Y. Predictors of Early Continence after Robot-assisted Radical Prostatectomy. Low Urin Tract Symptoms. 10, 287-291, 2018.
  68. Matsumoto A, Nakagawa T, Kanatani A, Ikeda M, Kawai T, Miyakawa J, Taguchi S, Naito A, Otsuka M, Nakanishi Y, Suzuki M, Koga F, Nagase Y, Kondo Y, Okaneya T, Tanaka Y, Miyazaki H, Fujimura T, Fukuhara H, Kume H, Igawa Y, Homma Y. Preoperative chronic kidney disease is predictive of oncological outcome of radical cystectomy for bladder cancer. World J Urol. 36, 249-256, 2018.
  69. Arakawa K, Hata K, Yamamoto Y, Nishikawa T, Tanaka T, Kiyomatsu T, Kawai K, Nozawa H, Yoshida M, Fukuhara H, Fujishiro M, Morikawa T, Yamasoba T, Koike K, Fukayama M, Watanabe T. Nine primary malignant neoplasms-involving the esophagus, stomach, colon, rectum, prostate, and external ear canal-without microsatellite instability: a case report. BMC Cancer 18, 24, 2018.
  70. Sato M, Taguchi A, Fukui Y, Kawata A, Taguchi S, Kashiyama T, Eguchi S, Inoue T, Tomio K, Tanikawa M, Sone K, Mori M, Nagasaka K, Adachi K, Ikemura M, Domoto Y, Arimoto T, Oda K, Fukayama M, Osuga Y, Fujii T. Blood Vessel Invasion Is a Strong Predictor of Postoperative Recurrence in Endometrial Cancer. Int J Gynecol Cancer 28, 875-881, 2018.
  71. Higashihara E, Horie S, Kinoshita M, Harris PC, Okegawa T, Tanbo M, Hara H, Yamaguchi T, Shigemori K, Kawano H, Miyazaki I, Kaname S, Nutahara K. A potentially crucial role of the PKD1 C-terminal tail in renal prognosis. Clin Exp Nephrol. 22(2):395-404, 2018.
  72. Okegawa T, Ninomiya N, Masuda K, Nakamura Y, Tambo M, Nutahara K. AR-V7 in circulating tumor cells cluster as a predictive biomarker of abiraterone acetate and enzalutamide treatment in castration-resistant prostate cancer patients.Prostate. 78(8):576-582, 2018
  73. Fujita N, Tambo M, Terado Y, Fujita M, Okegawa T, Nutahara K. Vesicoenteric Fistula Arising from an Adenocarcinoma of Ectopic Pancreatic Tissue in a Meckel Diverticulum. Case Rep Oncol. 4;11(1):6-10, 2018.
  74. Kinjo M, Yoshimura Y, Kitagawa Y, Okegawa T, Nutahara K. Sexual activity and quality of life in Japanese pelvic organ prolapse patients after transvaginal mesh surgery. J Obstet Gynaecol Res. 44(7):1302-1307, 2018
  75. Yamaguchi T, Higashihara E, Okegawa T, Miyazaki I, Nutahara K. Optimal equation for estimation of glomerular filtration rate in autosomal dominant polycystic kidney disease: influence of tolvaptan. Clin Exp Nephrol. 22(5):1213-1223, 2018.
  76. Kinjo M, Sekiguchi Y, Yoshimura Y, Nutahara K. Long-term Persistence with Mirabegron versus Solifenacin in Women with Overactive Bladder: Prospective, Randomized Trial. Low Urin Tract Symptoms. 10, 148-151, 2018.