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Faculty of Medicine教員紹介:大塚 弘毅

氏名 大塚 弘毅
オオツカ コウキ
職位講師
学内の役職・委員等杏林大学医学部附属病院CPC運営委員会委員、治験審査委員会委員
所属教室

臨床検査医学教室

専攻・専門分野(大学院)

医学専攻 臨床検査医学分野(新課程)

病理系専攻 臨床検査医学分野(旧課程)

担当科目(学部)がん分子診断
担当科目(大学院)がん分子診断
専門分野がん分子診断
研究テーマがん分子診断、がんの先制医療、発がんメカニズム解明、がん予防および早期発見、進行がん診療のバイオマーカー探索
略歴1994年 鹿児島大学医学部卒業
1994年 杏林大学医学部第2外科入局
1996年 茨城県立地域がんセンター外科
1998年 国立がんセンター中央病院外科
2001年 杏林大学医学部第2外科助手
2001年 新潟県厚生連長岡中央綜合病院呼吸器外科医長
2006年 杏林大学医学部外科大学院医学博士課程修了
2006年 杏林大学臨床検査医学助教
2016年 杏林大学臨床検査医学講師、現在に至る
所有する学位博士(医学)
指導医・専門医・認定医、その他の資格等日本臨床検査医学会専門医、日本外科学会認定登録医、日本呼吸器外科学会認定登録医、日本胸部外科学会認定医
論文・著書等を含む主要研究業績 (原著論文)
1. Ohnishi H, Ohtsuka K, Ooide A, Matsushima S, Goya T, Watanabe T
A simple and sensitive method for detecting major mutations within the tyrosine kinase domain of the epidermal growth factor receptor gene in non-small-cell lung carcinoma.
Diagn Mol Pathol,15:101-8,2006(IF:1.474)

2. Ohtsuka K*, Ohnishi H, Furuyashiki G, Nogami H, Koshiishi Y, Ooide A, Matsushima S, Watanabe T, Goya T
Clinico-pathological and biological significance of tyrosine kinase domain gene mutations and overexpression of epidermal growth factor receptor for lung adenocarcinoma.
J Thorac Oncol,1:787-95,2006(IF:20.121)

3. Ohtsuka K*, Ohnishi H, Fujiwara M, Kishino T, Matsushima S, Furuyashiki G, Takei H, Koshiishi Y, Goya T, Watanabe T
Abnormalities of epidermal growth factor receptor in lung squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas: tyrosine kinase domain mutations are not rare in tumors with an adenocarcinoma component.
Cancer,109:741-50,2007(IF:6.921)

4. Kishino T, Watanabe K, Urata T, Takano M, Uemura T, Nishikawa K, Mine Y, Matsumoto M, Ohtsuka K, Ohnishi H, Mori H, Takahashi S, Ishida H, Watanabe T Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition.
Clin Chim Acta,398:57-62,2008(IF:6.315)

5. Kishino T, Morii T, Mochizuki K, Sudo E, Hirano K, Okazaki M, Ohtsuka K, Ohnishi H, Kurihara S, Tsuneyoshi M, Fujioka Y, Watanabe T
Unusual sonographic appearance of synovial sarcoma of the anterior abdominal wall.
J Clin Ultrasound,37:233-5,2009(IF:0.869)

6. Morii T, Ohtsuka K, Ohnishi H, Mochizuki K, Satomi K
Inhibition of heat-shock protein 27 expression eliminates drug resistance of osteosarcoma to zoledronic acid.
Anticancer Res,30:3565-71,2010(IF:2.435)

7. Ohtsuka K*, Ohnishi H, Morii T, Fujiwara M, Kishino T, Ogura W, Chiba M, Matsushima S, Goya T, Watanabe T
Downregulated ABCG2 enhances sensitivity to topoisomerase I inhibitor in epidermal growth factor receptor tyrosine kinase inhibitor-resistant non-small cell lung cancer.
J Thorac Oncol,5:1726-33,2010(IF:20.121)

8. Kishino T, Ohnishi H, Ohtsuka K, Matsushima S, Urata T, Watanebe K, Honda Y, Mine Y, Matsumoto M, Nishikawa K, Mori H, Takahashi S, Ishida H, Watanabe T
Low concentrations of serum n-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease patients with liver injury.
Clin Chem Lab Med,49:159-62,2011(IF:8.490)

9. Sakata S, Fujiwara M, Ohtsuka K, Kamma H, Nagane M, Sakamoto A, Fujioka Y
ATP-binding cassette transporters in primary central nervous system lymphoma: decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells.
Oncol Rep,25:333-9,2011(IF:4.136)

10. Kita H, Shiraishi Y, Watanabe K, Suda K, Ohtsuka K, Koshiishi Y, Goya T
Does postoperative serum interleukin-6 influence early recurrence after curative pulmonary resection of lung cancer?.
Ann Thorac Cardiovasc Surg,17:454-60,2011(IF:1.889)

11. Kishino T, Ohnishi H, Ohtsuka K, Matsushima S, Watanebe K, Urata T, Honda Y, Matsumoto M, Mine Y, Nishikawa K, Mori H, Takahashi S, Ishida H, Watanabe T Subcutaneous rather than visceral adipose tissue thickness of the abdomen correlates with alterations in serum fatty acid profile in Japanese women.
Clin Chim Acta,412:1893-4,2011(IF:6.315)

12. Campos CE, Caldas PC, Ohnishi H, Watanabe T, Ohtsuka K, Matsushima S, Ferreira NV, da Silva MV, Redner P, de Carvalho LD, Medeiros RF, Abbud Filho JA, Montes FC, Galvao TC, Ramos JP
First isolation of Mycobacterium kyorinense from clinical specimens in Brazil. 
J Clin Microbiol,50:2477-8,2012(IF:11.677)

13. Fukugawa Y, Ohnishi H, Ishii T, Tanouchi A, Sano J, Miyawaki H, Kishino T, Ohtsuka K, Yoshino H, Watanabe T
Effect of carryover of clot activators on coagulation tests during phlebotomy.
Am J Clin Pathol,137:900-3,2012(IF:5.400)

14. Aoyagi T, Morii T, Ohtsuka K, Ohnishi H, Tajima T, Yoshiyama A, Mochizuki K,Satomi K, Ichimura S
Lung cancer cell line sensitivity to Zoledronic acid is BAX-dependent.
Anticancer Res,33:5357-63,2013(IF:2.435)

15. Kishiki T, Ohnishi H, Masaki T, Ohtsuka K, Ohkura Y, Furuse J, Watanabe T,Sugiyama M
Overexpression of MET is a new predictive marker for anti-EGFR therapy in metastatic colorectal cancer with wild-type KRAS.
Cancer Chemother Pharmacol,73:749-57,2014(IF:3.288)

16. Kishiki T, Ohnishi H, Masaki T, Ohtsuka K, Ohkura Y, Furuse J, Sugiyama M, Watanabe T
Impact of genetic profiles on the efficacy of anti-EGFR antibodies in metastatic colorectal cancer with KRAS mutation.
Oncol Rep,32:57-64,2014(IF:4.136)

17. Matsushima S, Ohtsuka K, Ohnishi H, Fujiwara M, Nakamura H, Morii T, Kishino T, Goto H, Watanabe T
V843I, a lung cancer predisposing EGFR mutation, is responsible for resistance to EGFR tyrosine kinase inhibitors.
J Thorac Oncol,9:1377-84,2014(IF:20.121)

18. Ohtsuka K, Ohnishi H, Nozaki E, Pais Ramos J, Tortoli E, Yonetani S, Matsushima S, Tateishi Y, Matsumoto S, Watanabe T
Whole-Genome Sequence of Mycobacterium kyorinense.
Genome Announc,2:e01062-14.doi:10.1128/genomeA.01062-14,2014(IF:0)

19. Morii T, Ohtsuka K, Ohnishi H, Mochizuki K, Yoshiyama A, Aoyagi T, Hornicek FJ, Ichimura S
BH3 Mimetics Inhibit Growth of Chondrosarcoma―A Novel Targeted Therapy for Candidate Models.
Anticancer Res,34:6423-30,2014(IF:2.435)

20. Ohnishi H, Tortoli E, Ramos JP, Kazumi Y, Yonetani S, Matsushima S, Ohtsuka K, Watanabe T
Proposal of reclassification of Mycobacterium celatum type 2 as Mycobacterium kyorinense.
Ann Microbiol,64:1879-82,2014(IF:3.168)

21. Kishino T, Mori T, Kawai S, Mori H, Nishikawa K, Hirano K, Matsushima S, Ohtsuka K, Ohnishi H, Watanabe T
Carcinosarcoma, an atypical subset of gallbladder malignancies.
J Med Ultrason (2001),41:487-490,2014(IF:1.878)

22. Watanabe K, Kishino T, Sano J, Ariga T, Okuyama S, Mori H, Matsushima S, Ohtsuka K, Ohnishi H, Watanabe T
Relationship between epicardial adipose tissue thickness and early impairment of left ventricular systolic function in patients with preserved ejection fraction.
Heart Vessels,31:1010-5,2016(IF:1.814)

23. Yoshiyama A, Morii T, Ohtsuka K, Ohnishi H, Tajima T, Aoyagi T, Mochizuki K, Satomi K, Ichimura S
Development of Stemness in Cancer Cell Lines Resistant to the Anticancer Effects of Zoledronic Acid.
Anticancer Res,36:625-31,2016(IF:2.435)

24. Fujino A, Kishino T, Watanabe K, Sekiguchi K, Takagi Y, Matsushima S,
Ohtsuka K, Yotsukura M, Ohnishi H, Watanabe T
Relationship between Pericardial Adipose Tissue Thickness and Early
Impairment of Left Ventricular Function, Both Evaluated on Echocardiography.
Rinsho Byori,64:1134-1138,2016(IF:0)

25. Yokoyama M, Ohnishi H, Ohtsuka K, Matsushima S, Ohkura Y, Furuse J, Watanabe T, Mori T, Sugiyama M
KRAS Mutation as a Potential Prognostic Biomarker of Biliary Tract Cancers.
Jpn Clin Med,7:33-39,2016(IF:0)

26. Kojima Y, Ohtsuka K, Ohnishi H, Abe N, Furuse J, Watanabe T, Sugiyama M APC:T1556fs and STK11 mutations in duodenal adenomas and adenocarcinomas.
Surg Today,48:765-772,2018(IF:2.540)

27. Aiso T, Ohtsuka K, Ueda M, Karita S, Yokoyama T, Takata S, Matsuki N, Kondo H, Takizawa H, Okada AA, Watanabe T, Ohnishi H
Serum levels of candidate microRNA diagnostic markers differ among the stages of non-small-cell lung cancer.
Oncol Lett,16:6643-6651,2018(IF:3.111)

28. Tanaka R, Sakamoto N, Suzuki H, Tachibana K, Ohtsuka K, Kishimoto K, Fujiwara M, Kamma H, Shibahara J, Kondo H
Genotyping and cytomorphological subtyping of lung adenocarcinoma based on liquid-based cytology.
Diagn Cytopathol,47:564-570,2019(IF:1.390)

29. Shimamori N, Kishino T, Morii T, Okabe N, Motohashi M, Matsushima S, Yamasaki S, Ohtsuka K, Shibahara J, Ichimura S, Ohnishi H, Watanabe T
Sonographic Appearances of Liposarcoma: Correlations with Pathologic Subtypes.
Ultrasound Med Biol,45:2568-2574,2019(IF:3.694)

30. Nozaki E, Kobayashi T, Ohnishi H, Ohtsuka K, Masaki T, Watanabe T, Sugiyama M C-X-C motif receptor 3A enhances proliferation and invasiveness of colorectal cancer cells, and is mediated by C-X-C motif ligand 10.
Oncol Lett,19:2495-2501,2020(IF:3.111)

31. Tanaka R, Ohtsuka K, Ogura W, Arai N, Yoshida T, Nakazato Y, Tachibana K, Takata S, Fujiwara M, Kamma H, Shibahara J, Kondo H
Subtyping and EGFR mutation testing from blocks of cytological materials, based on liquid-based cytology for lung cancer at bronchoscopic examinations.
Diagn Cytopathol,4:516-523,2020(IF:1.390)

32. Shimamori N, Kishino T, Okabe N, Morii T, Matsushima S, Yamasaki S, Ohtsuka
K, Shibahara J, Ohnishi H, Watanabe T
Discrimination of well-differentiated liposarcoma from benign lipoma on sonography: an uncontrolled retrospective study.
J Med Ultrason (2001),47:617-623,2020(IF:1.878)

33. Okuyama T, Ohtsuka K*(co-first author), Ogura W, Yonetani S, Yamasaki S, Miyagi H, Sekiguchi K, Ohnishi H, Watanabe T
Establishing an internal quality control method for the stable extraction of nucleic acids of severe acute respiratory syndrome coronavirus 2 and RT-PCR-based detection.
J Clin Lab Anal, 35:e23998.doi:10.1002/jcla.23998,2021(IF:3.124)

34. Urata T, Kishino T, Watanabe K, Shibasaki S, Yotsukura M, Mori H, Kawamura N,
Tanaka T, Osaka M, Matsushima S, Yamasaki S, Ohtsuka K, Ohnishi H, Watanabe T
Sonographically Measured Adipose Tissue Thickness Correlates with Laboratory
Test Abnormalities Reflecting Metabolic State in Elderly Women.
Metab Syndr Relat Disord,20:148-155,2022(IF:2.363)

35. Ogura W , Ohtsuka K*(co-first author), Matsuura S, Okuyama T, Matsushima S, Yamasaki S, Miyagi H, Sekiguchi K, Ohnishi H, Watanabe T
Can Individuals with Suboptimal Antibody Responses to Conventional Antiviral Vaccines Acquire Adequate Antibodies from SARS-CoV-2 mRNA Vaccination?.
Viruses,14:956.doi:10.3390/v14050956,2022(IF:5.818)

36. Aso N, Ohtsuka K, Shibahara J, Koda H, Morikawa T, Abe N, Watanabe T, Ohnishi
H
Microsatellite instability in the high-grade dysplasia component of duodenal
adenoma is associated with progression to adenocarcinoma.
Surg Today,doi:10.1007/s00595-022-02558-9,2022 (IF:2.540)

37. Tanaka R, Fujiwara M, Sakamoto N, Suzuki H, Tachibana K, Ohtsuka K, Kishimoto
K, Kamma H, Shibahara J, Kondo H
Cytomorphometric and flow cytometric analyses using liquid-based cytology materials in subtypes of lung adenocarcinoma.
Diagn Cytopathol,50:394-403,2022(IF:1.390)

(症例報告)
1. Hirayama K, Hanatsuka K, Ikeuchi T, Shida D, Ohtsuka K, Yoshimi F, Hori M, Itabashi M, Koyama A
Famotidine-induced acute interstitial nephritis.
Nephrol Dial Transplant,13:2636-8,1998(IF:7.186)

2. Ohtsuka K, Ohnishi H, Kurai D, Matsushima S, Morishita Y, Shinonaga M, Goto H, Watanabe T
Familial lung adenocarcinoma caused by the EGFR V843I germ-line mutation.
J Clin Oncol,29:e191-2.doi:10.1200/JCO.2010.31.4492,2011(IF:50.739)

3. Ohtsuka K*, Ohnishi H, Fujiwara M, Morii T, Matsushima S, Ogura W, Yamasaki S, Kishino T, Tanaka R, Watanabe T
Predisposition to lung adenocarcinoma in a family harboring the germline EGFR V843I mutation.
JCO Precision Oncology,3:PO.19.00104.doi:10.1200/PO.19.00104,2019(IF:5.479)

4. Okabe N, Fujiwara M, Mochizuki M, Ohtsuka K, Nishigaya Y, Kobayashi Y, Kamma H
CD34-positive uterine lipoleiomyoma in a postmenopausal woman with chronic glomerulonephritis.
Eur J Gynaecol Oncol,40:1060-1063,2019(IF:0)

5. Ogura W, Ohtsuka K*, Fujiwara M, Tanaka R, Sekiguchi K, Ohnishi H, Watanabe T Use of a plasma test for verifying epidermal growth factor receptor gene EGFR mutations in fluid samples from non-small cell lung cancer patients.
Respir Med Case Rep,29:101007.doi:10.1016/j.rmcr.2020.101007,2020(IF:0)

6. Kojima Y, Ohtsuka K, Ishii S, Aso N, Ohki A, Hashimoto Y, Takeuchi H, Ohnishi
H, Abe N
STK11 p.F354L Germline Mutation in a Case of Multiple Gastrointestinal Tumors.
Case Rep Gastroenterol,14:547-553.doi:10.1159/000508929,2020(IF:0)

7. Yoshida T, Kojima Y, Shimada R, Tanabe H, Tabei K, Yanagida O, Nikaido T,
Ohtsuka K, Ohnishi H, Abe N, Hisamatsu T, Takahashi S
Next-Generation Sequencing for Non-Ampullary Duodenal Carcinoma Suggesting the Existence of an Adenoma-Carcinoma Sequence.
Case Rep Gastroenterol.15:62-69.doi:10.1159/000510919,2021(IF:0)

所属学会 日本臨床検査医学会、日本外科学会、日本呼吸器外科学会
学外活動Eminent Scientist of the Year 2008 International Award
ひとことメッセージがん分子診断を通してがん診療に貢献したいと思います。