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School of Medicine教員紹介：大塚　弘毅

氏名 大塚　弘毅
オオツカ　コウキ OHTSUKA, Kouki
職位講師
学内の役職・委員等杏林大学医学部付属杉並病院臨床検査適正化委員会委員長、臨床検査部品質管理委員会委員長、輸血療法委員会委員長、文書管理ワーキング委員長、医療内容事前審査委員会委員、医療安全＆感染対策推進者メンバー
所属教室

臨床検査医学（付属杉並病院）教室

専攻・コース（大学院）

医学専攻 臨床検査医学コース（新課程）

病理系専攻 臨床検査医学分野（旧課程）

担当科目（学部）遺伝子関連検査
担当科目（大学院）遺伝子関連検査
専門分野がん分子診断
研究テーマがん分子診断、がんの先制医療、発がんメカニズム解明、がん予防および早期発見、進行がん診療のバイオマーカー探索
略歴1994年　鹿児島大学医学部卒業
1994年　杏林大学医学部第2外科入局
1996年　茨城県立地域がんセンター外科
1998年　国立がんセンター中央病院外科
2001年　杏林大学医学部第2外科助手
2001年　新潟県厚生連長岡中央綜合病院呼吸器外科医長
2006年　杏林大学医学部外科大学院医学博士課程修了
2006年　杏林大学臨床検査医学助教
2016年　杏林大学臨床検査医学講師、現在に至る
所有する学位博士（医学）
指導医・専門医・認定医、その他の資格等日本臨床検査医学会専門医、日本外科学会認定登録医、日本呼吸器外科学会認定登録医、日本胸部外科学会認定医
論文・著書等を含む主要研究業績 1. Hirayama K, Hanatsuka K, Ikeuchi T, Shida D, Ohtsuka K, Yoshimi F, Hori M, Itabashi M, Koyama A : Famotidine-induced acute interstitial nephritis.
Nephrol Dial Transplant 13 : 2636-8, 1998.

2. Ohnishi H, Ohtsuka K, Ooide A, Matsushima S, Goya T, Watanabe T : A simple and sensitive method for detecting major mutations within the tyrosine kinase domain of the epidermal growth factor receptor gene in non-small-cell lung carcinoma.
Diagn Mol Pathol 15 : 101-8, 2006.

3. Ohtsuka K, Ohnishi H, Furuyashiki G, Nogami H, Koshiishi Y, Ooide A, Matsushima S, Watanabe T, Goya T : Clinico-pathological and biological significance of tyrosine kinase domain gene mutations and overexpression of epidermal growth factor receptor for lung adenocarcinoma.
J Thorac Oncol 1 : 787-95, 2006.

4. Ohtsuka K, Ohnishi H, Fujiwara M, Kishino T, Matsushima S, Furuyashiki G, Takei H, Koshiishi Y, Goya T, Watanabe T : Abnormalities of epidermal growth factor receptor in lung squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas: tyrosine kinase domain mutations are not rare in tumors with an adenocarcinoma component.
Cancer 109 : 741-50, 2007.

5. Kishino T, Watanabe K, Urata T, Takano M, Uemura T, Nishikawa K, Mine Y, Matsumoto M, Ohtsuka K, Ohnishi H, Mori H, Takahashi S, Ishida H, Watanabe T : Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition.
Clin Chim Acta 398 : 57-62, 2008.

6. Kishino T, Morii T, Mochizuki K, Sudo E, Hirano K, Okazaki M, Ohtsuka K, Ohnishi H, Kurihara S, Tsuneyoshi M, Fujioka Y, Watanabe T : Unusual sonographic appearance of synovial sarcoma of the anterior abdominal wall.
J Clin Ultrasound 37 : 233-5, 2009.

7. Morii T, Ohtsuka K, Ohnishi H, Mochizuki K, Satomi K : Inhibition of heat-shock protein 27 expression eliminates drug resistance of osteosarcoma to zoledronic acid.
Anticancer Res 30 : 3565-71, 2010.

8. Ohtsuka K, Ohnishi H, Morii T, Fujiwara M, Kishino T, Ogura W, Chiba M, Matsushima S, Goya T, Watanabe T : Downregulated ABCG2 enhances sensitivity to topoisomerase I inhibitor in epidermal growth factor receptor tyrosine kinase inhibitor-resistant non-small cell lung cancer.
J Thorac Oncol 5 : 1726-33, 2010.

9. Sakata S, Fujiwara M, Ohtsuka K, Kamma H, Nagane M, Sakamoto A, Fujioka Y : ATP-binding cassette transporters in primary central nervous system lymphoma: decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells.
Oncol Rep 25 : 333-9, 2011.

10. Kita H, Shiraishi Y, Watanabe K, Suda K, Ohtsuka K, Koshiishi Y, Goya T : Does postoperative serum interleukin-6 influence early recurrence after curative pulmonary resection of lung cancer?
Ann Thorac Cardiovasc Surg 17 : 454-60, 2011.


11. Ohtsuka K, Ohnishi H, Kurai D, Matsushima S, Morishita Y, Shinonaga M, Goto H, Watanabe T : Familial lung adenocarcinoma caused by the EGFR V843I germ-line mutation.
J Clin Oncol 29 : e191-2, 2011.

12. Kishino T, Ohnishi H, Ohtsuka K, Matsushima S, Urata T, Watanebe K, Honda Y, Mine Y, Matsumoto M, Nishikawa K, Mori H, Takahashi S, Ishida H, Watanabe T : Low concentrations of serum n-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease patients with liver injury.
Clin Chem Lab Med 49 : 159-62, 2011.

13. Kishino T, Ohnishi H, Ohtsuka K, Matsushima S, Watanebe K, Urata T, Honda Y, Matsumoto M, Mine Y, Nishikawa K, Mori H, Takahashi S, Ishida H, Watanabe T : Subcutaneous rather than visceral adipose tissue thickness of the abdomen correlates with alterations in serum fatty acid profile in Japanese women.
Clin Chim Acta 412 : 1893-4, 2011.

14. Fukugawa Y, Ohnishi H, Ishii T, Tanouchi A, Sano J, Miyawaki H, Kishino T, Ohtsuka K, Yoshino H, Watanabe T : Effect of carryover of clot activators on coagulation tests during phlebotomy.
Am J Clin Pathol 137 : 900-3, 2012.

15. Campos CE, Caldas PC, Ohnishi H, Watanabe T, Ohtsuka K, Matsushima S, Ferreira NV, da Silva MV, Redner P, de Carvalho LD, Medeiros RF, Abbud Filho JA, Montes FC, Galvao TC, Ramos JP : First isolation of Mycobacterium kyorinense from clinical specimens in Brazil.
J Clin Microbiol 50 : 2477-8, 2012.

16. Aoyagi T, Morii T, Ohtsuka K, Ohnishi H, Tajima T, Yoshiyama A, Mochizuki K, Satomi K, Ichimura S : Lung cancer cell line sensitivity to Zoledronic acid is BAX-dependent.
Anticancer Res 33 : 5357-63, 2013.

17. Kishiki T, Ohnishi H, Masaki T, Ohtsuka K, Ohkura Y, Furuse J, Watanabe T, Sugiyama M : Overexpression of MET is a new predictive marker for anti-EGFR therapy in metastatic colorectal cancer with wild-type KRAS.
Cancer Chemother Pharmacol 73 : 749-57, 2014.

18. Kishiki T, Ohnishi H, Masaki T, Ohtsuka K, Ohkura Y, Furuse J, Sugiyama M, Watanabe T : Impact of genetic profiles on the efficacy of anti-EGFR antibodies in metastatic colorectal cancer with KRAS mutation.
Oncol Rep 32 : 57-64, 2014.

19. Matsushima S, Ohtsuka K, Ohnishi H, Fujiwara M, Nakamura H, Morii T, Kishino T, Goto H, Watanabe T : V843I, a lung cancer predisposing EGFR mutation, is responsible for resistance to EGFR tyrosine kinase inhibitors.
J Thorac Oncol 9 : 1377-84, 2014.

20. Ohtsuka K, Ohnishi H, Nozaki E, Pais Ramos J, Tortoli E, Yonetani S, Matsushima S, Tateishi Y, Matsumoto S, Watanabe T : Whole-Genome Sequence of Mycobacterium kyorinense.
Genome Announc 2 : e01062-14, 2014.

21. Kishino T, Mori T, Kawai S, Mori H, Nishikawa K, Hirano K, Matsushima S, Ohtsuka K, Ohnishi H, Watanabe T : Carcinosarcoma, an atypical subset of gallbladder malignancies.
J Med Ultrason (2001) 41 : 487-490, 2014.

22. Morii T, Ohtsuka K, Ohnishi H, Mochizuki K, Yoshiyama A, Aoyagi T, Hornicek FJ, Ichimura S : BH3 Mimetics Inhibit Growth of Chondrosarcoma―A Novel Targeted Therapy for Candidate Models.
Anticancer Res 34 : 6423-30, 2014.

23. Ohnishi H, Tortoli E, Ramos JP, Kazumi Y, Yonetani S, Matsushima S, Ohtsuka K, Watanabe T : Proposal of reclassification of Mycobacterium celatum type 2 as Mycobacterium kyorinense.
Ann Microbiol 64 : 1879-82, 2014.

24. Yoshiyama A, Morii T, Ohtsuka K, Ohnishi H, Tajima T, Aoyagi T, Mochizuki K, Satomi K, Ichimura S : Development of Stemness in Cancer Cell Lines Resistant to the Anticancer Effects of Zoledronic Acid.
Anticancer Res 36 : 625-31, 2016.

25. Watanabe K, Kishino T, Sano J, Ariga T, Okuyama S, Mori H, Matsushima S, Ohtsuka K, Ohnishi H, Watanabe T : Relationship between epicardial adipose tissue thickness and early impairment of left ventricular systolic function in patients with preserved ejection fraction.
Heart Vessels 31 : 1010-5, 2016.

26. Fujino A, Kishino T, Watanabe K, Sekiguchi K, Takagi Y, Matsushima S, Ohtsuka K, Yotsukura M, Ohnishi H, Watanabe T : Relationship between Pericardial Adipose Tissue Thickness and Early Impairment of Left Ventricular Function, Both Evaluated on Echocardiography.
Rinsho Byori 64 : 1134-1138, 2016.

27. Yokoyama M, Ohnishi H, Ohtsuka K, Matsushima S, Ohkura Y, Furuse J, Watanabe T, Mori T, Sugiyama M : KRAS Mutation as a Potential Prognostic Biomarker of Biliary Tract Cancers.
Jpn Clin Med 7 : 33-39, 2016.

28. Kojima Y, Ohtsuka K, Ohnishi H, Abe N, Furuse J, Watanabe T, Sugiyama M : APC:T1556fs and STK11 mutations in duodenal adenomas and adenocarcinomas.
Surg Today 48 : 765-772, 2018.

29. Aiso T, Ohtsuka K, Ueda M, Karita S, Yokoyama T, Takata S, Matsuki N, Kondo H, Takizawa H, Okada AA, Watanabe T, Ohnishi H : Serum levels of candidate microRNA diagnostic markers differ among the stages of non-small-cell lung cancer.
Oncol Lett 16 : 6643-6651, 2018.

30. Tanaka R, Sakamoto N, Suzuki H, Tachibana K, Ohtsuka K, Kishimoto K, Fujiwara M, Kamma H, Shibahara J, Kondo H : Genotyping and cytomorphological subtyping of lung adenocarcinoma based on liquid-based cytology.
Diagn Cytopathol 47 : 564-570, 2019.

31. Shimamori N, Kishino T, Morii T, Okabe N, Motohashi M, Matsushima S, Yamasaki S, Ohtsuka K, Shibahara J, Ichimura S, Ohnishi H, Watanabe T : Sonographic Appearances of Liposarcoma: Correlations with Pathologic Subtypes.
Ultrasound Med Biol 45 : 2568-2574, 2019.

32. Ohtsuka K, Ohnishi H, Fujiwara M, Morii T, Matsushima S, Ogura W, Yamasaki S, Kishino T, Tanaka R, Watanabe T : Predisposition to lung adenocarcinoma in a family harboring the germline EGFR V843I mutation.
JCO Precision Oncology 3 : PO.19.00104, 2019.

33. Okabe N, Fujiwara M, Mochizuki M, Ohtsuka K, Nishigaya Y, Kobayashi Y, Kamma H : CD34-positive uterine lipoleiomyoma in a postmenopausal woman with chronic glomerulonephritis.
Eur J Gynaecol Oncol 40 : 1060-1063, 2019.

34. Ogura W, Ohtsuka K, Fujiwara M, Tanaka R, Sekiguchi K, Ohnishi H, Watanabe T : Use of a plasma test for verifying epidermal growth factor receptor gene EGFR mutations in fluid samples from non-small cell lung cancer patients.
Respir Med Case Rep 29 : 101007, 2020.

35. Nozaki E, Kobayashi T, Ohnishi H, Ohtsuka K, Masaki T, Watanabe T, Sugiyama M : C-X-C motif receptor 3A enhances proliferation and invasiveness of colorectal cancer cells, and is mediated by C-X-C motif ligand 10.
Oncol Lett 19 : 2495-2501, 2020.

36. Tanaka R, Ohtsuka K, Ogura W, Arai N, Yoshida T, Nakazato Y, Tachibana K, Takata S, Fujiwara M, Kamma H, Shibahara J, Kondo H : Subtyping and EGFR mutation testing from blocks of cytological materials, based on liquid-based cytology for lung cancer at bronchoscopic examinations.
Diagn Cytopathol 48 : 516-523, 2020.

37. Kojima Y, Ohtsuka K, Ishii S, Aso N, Ohki A, Hashimoto Y, Takeuchi H, Ohnishi H, Abe N : STK11 p.F354L Germline Mutation in a Case of Multiple Gastrointestinal Tumors.
Case Rep Gastroenterol 14 : 547-553, 2020.

38. Shimamori N, Kishino T, Okabe N, Morii T, Matsushima S, Yamasaki S, Ohtsuka K, Shibahara J, Ohnishi H, Watanabe T : Discrimination of well-differentiated liposarcoma from benign lipoma on sonography: an uncontrolled retrospective study.
J Med Ultrason (2001) 47 : 617-623, 2020.

39. Yoshida T, Kojima Y, Shimada R, Tanabe H, Tabei K, Yanagida O, Nikaido T, Ohtsuka K, Ohnishi H, Abe N, Hisamatsu T, Takahashi S : Next-Generation Sequencing for Non-Ampullary Duodenal Carcinoma Suggesting the Existence of an Adenoma-Carcinoma Sequence.
Case Rep Gastroenterol 15 : 62-69, 2021.

40. Okuyama T, Ohtsuka K, Ogura W, Yonetani S, Yamasaki S, Miyagi H, Sekiguchi K, Ohnishi H, Watanabe T : Establishing an internal quality control method for the stable extraction of nucleic acids of severe acute respiratory syndrome coronavirus 2 and RT-PCR-based detection.
J Clin Lab Anal 35 : e23998, 2021.
(co-first author)

41. Urata T, Kishino T, Watanabe K, Shibasaki S, Yotsukura M, Mori H, Kawamura N, Tanaka T, Osaka M, Matsushima S, Yamasaki S, Ohtsuka K, Ohnishi H, Watanabe T : Sonographically Measured Adipose Tissue Thickness Correlates with Laboratory Test Abnormalities Reflecting Metabolic State in Elderly Women.
Metab Syndr Relat Disord 20 : 148-155, 2022.

42. Ogura W, Ohtsuka K, Matsuura S, Okuyama T, Matsushima S, Yamasaki S, Miyagi H, Sekiguchi K, Ohnishi H, Watanabe T : Can Individuals with Suboptimal Antibody Responses to Conventional Antiviral Vaccines Acquire Adequate Antibodies from SARS-CoV-2 mRNA Vaccination?
Viruses 14 : 956, 2022.
(co-first author)

43. Tanaka R, Fujiwara M, Sakamoto N, Suzuki H, Tachibana K, Ohtsuka K, Kishimoto K, Kamma H, Shibahara J, Kondo H : Cytomorphometric and flow cytometric analyses using liquid-based cytology materials in subtypes of lung adenocarcinoma.
Diagn Cytopathol 50 : 394-403, 2022.

44. Aso N, Ohtsuka K, Shibahara J, Koda H, Morikawa T, Abe N, Watanabe T, Ohnishi H : Microsatellite instability in the high-grade dysplasia component of duodenal adenoma is associated with progression to adenocarcinoma.
Surg Today 53(2) : 252-260, 2023.

45. Chisada S, Ohtsuka K, Fujiwara M, Yoshida M, Matsushima S, Watanabe T, Karita K, Ohnishi H : A rad50 germline mutation induces tumorigenesis and ataxia-telangiectasia phenotype in a transparent medaka model.
PLoS One 18(4) : e0282277, 2023.
(co-first author)

46. Kitahama K, Ho YJ, Satomi K, Shibayama T, Nagahama K, Ohtsuka K, Ohnishi H, Sakamoto Y, Shibahara J, Hayashi A : Epigenetic evolution and clinicopathological implications of distinct DNA methylation profiles in pancreatic ductal adenocarcinoma.
Sci Rep 15(1) : 28747, 2025.

47. Ohtsuka K, Fujiwara M, Michishita M, Matsushima S, Watanabe T, Ohnishi H：Analysis of spontaneous tumors in C57BL/6JJcl mice with frequent malignant lymphomas and a Braf-mutant lung adenocarcinoma.
J Toxicol Pathol，2026．Advance online publication．doi:10.1293/tox.2026-0021．

48. Ohtsuka K, Kojima Y, Aso N, Matsushima S, Chisada S, Abe N, Watanabe T, Ohnishi H：Synchronous gastrointestinal adenocarcinomas with microsatellite instability-high, high tumor mutation burden, and a germline RAD50 frameshift variant in the absence of detectable pathogenic germline mismatch repair gene variants: a case report．
Case Rep Oncol，2026．Published online August 21, 2026．doi:10.1159/000abzag024．
所属学会 日本臨床検査医学会、日本外科学会、日本呼吸器外科学会、日本遺伝子診療学会
学外活動Eminent Scientist of the Year 2008 International Award
学生のみなさんへがん分子診断を通してがん診療に貢献したいと思います。