¥á¥ó¥Ð¡¼¾Ò²ð/¿û¸¶ Âç²ð

¿û¸¶ Âç²ð bookmark

¥×¥í¥Õ¥£¡¼¥ë bookmark

  • »á̾¡§ ¿û¸¶ Âç²ð¡¡¡Ê¤¹¤¬¤Ï¤é ¤À¤¤¤¹¤±¡Ë
  • ¿¦°Ì¡§ ½õ¶µ
  • ÀìÌçʬÌÁÈ¿¥ºÙ˦²½³Ø¡¢Åüº¿À¸Êª³Ø¡¢¥°¥é¥¤¥³¥×¥í¥Æ¥ª¥ß¥¯¥¹
  • Ï¢ÍíÀ衧
  • ¶µ°÷¾Ò²ð¥Ú¡¼¥¸¡Ê°ÉÎÓÂç³Ø¡Ë

¢¨

¸½ºß¤Î¸¦µæ¥Æ¡¼¥Þ bookmark

Åüº¿´ØϢʬ»Ò¤ÎÁÈ¿¥ºÙ˦²½³ØŪ²òÀÏ bookmark

¥¿¥ó¥Ñ¥¯¼Á¤ÏËÝÌõ¸å½¤¾þ¤È¤·¤ÆÅüº¿Éղäò¼õ¤±¤ë¤¬¡¤Æ±¤¸¥¿¥ó¥Ñ¥¯¼Á¤Ç¤¢¤Ã¤Æ¤âÉղ䵤ì¤ëÅüº¿¹½Â¤¤ÏºÙ˦¼ïµÚ¤ÓºÙ˦¤Î¾õÂ֤ˤè¤êÊѲ½¤·¡¤Åüº¿¤Î°Û¾ï¤ÏÍÍ¡¹¤ÊÉÂÂ֤Ȥâ´ØÏ¢¤¹¤ë¡£

Àè¤Ë¶¦Æ±¸¦µæ¼Ô¤é¤ÈÊó¹ð¤·¤¿Åü¥¿¥ó¥Ñ¥¯¼Á¤Î¥×¥í¥Æ¥ª¥ß¥¯¥¹²òÀϵ»½Ñ¡ÊSugahara D et. al., Scientific Reports, 2, 680-687, 2012; Sugahara D et. al., Proteomics, 15, 2921-2933, 2015¤Ê¤É¡Ë¤Ë²Ã¤¨¡¤¥ì¥¯¥Á¥ó¤ä¹³Åüº¿¹³ÂΤòÍøÍѤ·¤¿ in situ Proximity Ligation Assay¡ÊSigma Aldrich¼Ò¡Ë¤âÍøÍѤ¹¤ë¤³¤È¤Ç¡¤ÆÃÄê¤ÎÅüº¿¤¬Éղ䵤줿¥¿¥ó¥Ñ¥¯¼Á¤¬ÁÈ¿¥Ãæ¤Ë¤É¤Î¤è¤¦¤Ëȯ¸½Ê¬ÉÛ¤¹¤ë¤«¸¡Æ¤¤·¡¤´ØÏ¢¤¹¤ë³Ø²ñ¤Ë¤ÆÊó¹ð¤·¤Æ¤¤¤ë¡£Åüº¿µÚ¤ÓÅüº¿À¸¹çÀ®´ØϢʬ»Ò¤Î²òÀÏË¡¤ò¶î»È¤·¡¤À¸Ì¿¸½¾Ý¤Ë¤ª¤±¤ëÅüº¿¤ÎÌò³äµÚ¤Ó¤½¤ÎÀ¸¹çÀ®À©¸æ¤Î¾ÜºÙ¤òÌÀ¤é¤«¤Ë¤·¤¿¤¤¤È¹Í¤¨¤Æ¤¤¤ë¡£

IJ´É¤Î¹±¾ïÀ­°Ý»ý¤Ë¤ª¤±¤ëcKitÍÛÀ­¾åÈéºÙ˦¤ÎÌò³ä¤Ë´Ø¤¹¤ë¸¦µæ bookmark

³èưŪ¤ÊÆü¾ïÀ¸³è¤Î°Ý»ý¤Ë¤Ï¡¤Ä²´É¤ò·ò¹¯¤ËÊݤĵ¡¹½¤ÎÍý²ò¤¬ÉԲķç¤Ç¤¢¤ë¡£¤½¤Îµ¡¹½¤Ë¤ª¤¤¤Æ´´ºÙ˦¤ÎÁý¿£¡¦Ê¬²½¤ÎÀ©¸æ¤Ï½ÅÍפǤ¢¤ê¡¤¤½¤ÎÃ濴Ū¤ÊÌò³ä¤ò¥Ë¥Ã¥ÁºÙ˦¤¬Ã´¤¦¡£Ä²´É¤Î±¢ãÝÄìÉô¤Ë´Ñ»¡¤µ¤ì¤ëcKit/CD117ÍÛÀ­¾åÈéºÙ˦¡ÊcKit+ºÙ˦)¤Ï¥Ë¥Ã¥ÁºÙ˦¤È¤·¤Æ¤Ï¤¿¤é¤¯¤³¤È¤¬Êó¹ð¤µ¤ì¤¿¤¬¡¤¤½¤ÎÌò³ä¤Ë¤ÏÉÔÌÀ¤ÊÅÀ¤¬Â¿¤¤¡£

¿û¸¶¤Ï¡¤¾åµ­¤Î¡ÖÅüº¿´ØϢʬ»Ò¤ÎÁÈ¿¥ºÙ˦²½³ØŪ²òÀϡפΰì´Ä¤È¤·¤Æ¡¤Burkholderia cenocepacia ͳÍè¤Î¥ì¥¯¥Á¥órBC2LCN¤òÍѤ¤¤Æ¡¤¥Þ¥¦¥¹Ä²´É¤Ë¤ª¤±¤ëH-1/H-3·¿¥Õ¥³¥·¥ë²½Åüº¿¤Îȯ¸½Ê¬ÉۤȤ½¤Î°ÕµÁ¤ò¸¡Æ¤¤·¤Æ¤­¤¿¡Ê²Ê¸¦Èñ¼ã¼êB 15K18959¡¤ÃÏ¿À˧ʸµ­Ç°¸¦µæ½õÀ®¶â¡Ê¹ÚÊìºÙ˦¸¦µæ²ñ¡Ë¤Ë¤è¤ë¸¦µæ¡¨Sugahara D et. al., Glycobiology, 27, 246-253, 2017¡Ë¡£¤½¤Î·ë²Ì¡¤¥Þ¥¦¥¹ÂçIJ¤Ë¤ª¤¤¤ÆrBC2LCN¥ì¥¯¥Á¥ó¤¬È¿±þ¤¹¤ë¤Î¤ÏcKit+ºÙ˦¤Ç¤¢¤ê¡¤¤µ¤é¤ËcKit+ºÙ˦¤ÏrBC2LCN¥ì¥¯¥Á¥ó¤ÎÈ¿±þÀ­¤Î°ã¤¤¤Ë¤è¤ê2¼ïÎà¤Ëʬ¤±¤é¤ì¤ë¤³¤È¤òÌÀ¤é¤«¤Ë¤·¤¿¡£Åüº¿¤Î°ã¤¤¤Ï¡¤¤½¤ì¤òȯ¸½¤¹¤ëºÙ˦¤Î¾õÂ֤䵡ǽ¤Î°ã¤¤¤òÈ¿±Ç¤¹¤ë¡£¤³¤Î¤³¤È¤«¤é¡¤´´ºÙ˦¤òÃæ¿´¤È¤¹¤ë¹±¾ïÀ­°Ý»ý¤Îµ¡¹½¤Ë¤ª¤¤¤ÆcKit+ºÙ˦¤¬¤½¤ì¤¾¤ì¤É¤Î¤è¤¦¤ÊÌò³ä¤ò²Ì¤¿¤¹¤Î¤«¡¤¤Þ¤¿¤É¤Î¤è¤¦¤ÊÆÃÀ­¡¦ÆÃħ¤Î°ã¤¤¤òÍ­¤¹¤ë¤Î¤«¡¤Ä²±ê¥â¥Ç¥ë¥Þ¥¦¥¹¤âÍøÍѤ·¡¤¤µ¤é¤Ë¸¡Æ¤¤ò¿Ê¤á¤Æ¤¤¤ë¡Ê²Ê¸¦Èñ´ðÈ×C 19K07275¤Ë¤è¤ë¸¦µæ¡Ë¡£

cKit+ºÙ˦¤ÏMuc2¤ò»ºÀ¸¤¹¤ë¤³¤È¤«¤éÇÕºÙ˦¤Î¥µ¥Ö¥¿¥¤¥×¤Ç¤â¤¢¤ë¡£¥à¥Á¥ó»ºÀ¸ºÙ˦¤È¤·¤Æ¤Î¤Ï¤¿¤é¤­¤Ë¤âÃíÌܤ·¡¤¤½¤ÎÆÃħ¤ÈÀ¸Íý³ØŪ°ÕµÁ¤Î¸¡Æ¤¤ò¿Ê¤á¤Æ¤¤¤ë¡£ÂçIJÆâ¹ÐɽÌ̤òʤ¤¦¥à¥Á¥ó¤Ï¡¤ÈùÀ¸Êª¤¬ÁÈ¿¥Æâ¤Ø¿¯Æþ¤¹¤ë¤³¤È¤òËɤ°¥Ð¥ê¥¢¤È¤·¤Æµ¡Ç½¤¹¤ë¡£¤Þ¤¿¡¤¥à¥Á¥ó¤Ï¤½¤ì¤ËÉղ䵤ì¤ëÅüº¿½¤¾þÉôʬ¤òÌÕIJ¡Á·ëIJ¡ÁľIJ¤È¡¤¤½¤ÎÉô°Ì¤´¤È¤ËÊѲ½¤µ¤»¤Æ¤¤¤ë¡£¤½¤ì¤Ë¤è¤êŬÀÚ¤ÊIJÆâºÙ¶ÝÁѤηÁÀ®¤È°Ý»ý¤Ë´óÍ¿¤·¡¤·ò¹¯¤ò°Ý»ý¤¹¤ë¾å¤Ç½ÅÍפʤϤ¿¤é¤­¤ò¤Ë¤Ê¤¦¡£¤½¤Î¤¿¤á, ¥à¥Á¥ó¤Î°Û¾ï¡¤Æäˤ½¤ì¤ËÉղ䵤ì¤ëÅüº¿¤Î°Û¾ï¤Ï±ê¾ÉÀ­Ä²¼À´µ¤È¿¼¤¯´ØÏ¢¤¹¤ë¤È»ØŦ¤µ¤ì¤ë¡£¤³¤Î¤³¤È¤«¤é, ¸½ºß¡¤Ä²ÆâºÙ¶ÝÀ©¸æ¤Ë¤ª¤±¤ëcKit+ºÙ˦¤Î½ÅÍ×À­¤Ë´Ø¤·¤Æ¤µ¤é¤Ë¸¦µæ¤ò¿Ê¤á¤Æ¤¤¤ë¡Ê2022 ǯÅÙ°ÉÎÓ°å³Ø²ñ¸¦µæ½õÀ®¶â¤Ë¤è¤ë¸¦µæ¡Ë¡£

cKit+ºÙ˦¤Ï´´ºÙ˦À©¸æ¤È¥à¥Á¥ó»ºÀ¸ºÙ˦¤ÎξÊý¤Ë´ØÍ¿¤·¡¤Ä²´É¤Î¹±¾ïÀ­°Ý»ý¤Ë¤ª¤¤¤Æ½ÅÍפʺÙ˦¤ÈͽÁÛ¤µ¤ì¤ë¡£¤½¤ÎÉÔ¶ñ¹ç¤Î±Æ¶Á¤ÏÂ礭¤¤¤ÈͽÁÛ¤µ¤ì¡¤¥à¥Á¥ó»ºÀ¸¤È´´ºÙ˦À©¸æ¡¤Î¾Êý¤Î°Û¾ï¤ò²ð¤·±ê¾ÉÀ­Ä²¼À´µ¤Ê¤É¤È´ØÏ¢¤¹¤ë²ÄǽÀ­¤â¤¢¤ë¡£cKit+ºÙ˦¡¤Æäˤ½¤ì¤¬È¯¸½¡¦»ºÀ¸¤¹¤ëÅüº¿¤ËÃíÌܤ·¤¿¿·¤¿¤Ê»ëÅÀ¤«¤é¸¦µæ¤ò¿Ê¤á¤ë¤³¤È¤Ë¤è¤ê¡¤Ä²´É¤Î·ò¹¯¤ËÊݤĵ¡¹½¤ÎÍý²ò¤ò¿¼¤á¡¤Â¿¤¯¤ËIJ¼À´µ¤ÎÉ°ø¡¦ÉÂÂÖ¤ÎÍý²ò¡¤¼£ÎŤع׸¥¤·¤¿¤¤¤È¹Í¤¨¤Æ¤¤¤ë¡£

Âçùõ ·É»Ò¶µ¼ø¡Ê´¶À÷¾É³Ø¶µ¼¼¡Ë¤é¤È¤Î¶¦Æ±¸¦µæ¤Ë¤è¤ê°ß´âͽËɤò¤á¤¶¤·¤¿°ßÆâºÙ¶ÝÁѤ覵æ¤â¿Ê¹ÔÃæ¤Ç¤¢¤ë¡Ê2019ǯÅÙ¶¦Æ±¸¦µæ¥×¥í¥¸¥§¥¯¥È¡ÊËܳØÉô¡Ë¤Ë¤è¤ë¸¦µæ¤Ê¤É¡Ë¡£°ß¤Î¾åÈé¤Ë¤ª¤±¤ë¹±¾ïÀ­¤ò°Ý»ý¤¹¤ëµ¡¹½¤ä¡¤´¶À÷¤«¤éÀ¸ÂΤòËɸ椹¤ëµ¡¹½¤Ë´Ø¤¹¤ë¸¦µæ¤òÊ¿¹Ô¤·¤Æ¿Ê¤á¤ë¤³¤È¤Ë¤è¤ê¡¤°ß¤ÈIJ´É¤Ë¤ª¤±¤ëµ¡¹½¤Î¶¦ÄÌÀ­¡¦°ã¤¤¤ò¸«½Ð¤·¡¤¿·¤¿¤ÊÃ諤òÆÀ¤¿¤¤¤È¹Í¤¨¤Æ¤¤¤ë¡£