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School of Medicine教員紹介：水川　良子

氏名 水川　良子
ミズカワ　ヨシコ MIZUKAWA, Yoshiko
職位教授（特任）
所属教室

皮膚科学（付属杉並病院）教室

担当科目（学部）皮膚科学
専門分野皮膚免疫アレルギー
研究テーマアレルギー性疾患、薬疹、アトピー性皮膚炎、発汗異常、ウイルス感染症、膠原病、皮膚科一般
略歴1985年　杏林大卒
所有する学位博士（医学）
指導医・専門医・認定医、その他の資格等日本皮膚科学会認定専門医
論文・著書等を含む主要研究業績 Mizukawa Y, Shiohara T. Cytokine profile-guided management of Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN): A management algorithm useful for guiding the selection of treatment options. Allergol Int. 2025 Nov 10:S1323-8930(25)00111-X. doi: 10.1016/j.alit.2025.09.005. Epub ahead of print. PMID: 41219066.

Mizukawa Y, Shiohara T. Recent advances in the diagnosis and treatment of DIHS/DRESS in 2025. Allergol Int. 2025 Jul;74(3):372-379.

Mizukawa Y, Hama N, Niihara H, Miyagawa F, Hashizume H, Tohyama M, Takahashi H, Watanabe H, Ohyama M, Yamaguchi Y, Kawamura T, Nomura T, Kabashima K, Sueki H, Morita E, Abe R, Asada H: Guidelines for the management of drug-induced hypersensitivity syndrome 2023. J Dermatol. 52(3). e189-e209. 2025.

Mizukawa Y, Hama N, Miyagawa F, Takahashi H, Ogawa Y, Kurata M, Asada H, Abe R, Shiohara T: Drug-Induced Hypersensitivity Syndrome/Drug Reaction With Eosinophilia and Systemic Symptoms: Predictive Score and Outcomes. J Allergy Clin Immunol Pract. 11(10). 3169-3178. 2023.

Mizukawa Y, Aoyama Y, Takahashi H, Takahashi R, Shiohara T: Risk of Progression to Autoimmune Disease in Severe Drug Eruption: Risk Factors and the Factor-Guided Stratification. J Invest Dermatol 142(3 Pt B): 960-968. e9, 2022.

Mizukawa Y, Kimishima M, Aoyama Y, Shiohara T. Predictive biomarkers for cytomegalovirus reactivation before and after immunosuppressive therapy: A single institution retrospective long-term analysis of patients with drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS). Int J Infect Dis 100: 239-246, 2020.

Mizukawa Y, Sato Y, Ohyama M, Shiohara T. Restoration of sweating disturbance in atopic dermatitis treated with dupilulmab. J Dermatol Sci 100: 79-81, 2020

Mizukawa Y, Yamazaki Y, Shiohara T: Leakage of sweat into the dermo-epidermal junction as a possible trigger for lichen planus lesion development. Arch Dermatol Res 311(1): 71-82, 2019.

Mizukawa Y, Hirahara K, Kano Y, Shiohara T. Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic syndrome (DRESS) severity score: a useful tool for assessing disease severity and predicting fatal cytomegalovirus disease. J Am Acad Dermatol 80(3): 670-678, 2018.

Sueki H, Mizukawa Y, Aoyama Y. Immune reconstitution inflammatory syndrome in non-HIV immunosuppressed patients. J Dermatol 45: 3-9, 2018.

Narita YM, Horie C, Hirahara K, Kano Y, Shiohara T, Mizukawa Y. Bullous pemphigoid complicated by cytomegalovirus disease as a manifestation of immune reconstitution inflammatory syndrome: retrospective analyses of our institutional cases and literature review. Int J Dermatol 57; 202-208, 2018.

Doi T, Mizukawa Y, Shimoda Y, Shiohara T: Importance of water content of the stratum corneum in mouse models for contact hypersensitivity. J Invest Dermatol 137: 151-158, 2017.

Mizukawa Y, Doi T, Yamazaki Y, Kudo A, Shiohara T: Epidermal neuromedin U attenuates IgE-mediated allergic skin inflammation. PLoS One Jul 27: 11 (7): e0160122, 2016.

Kurata M, Mizukawa Y, Aoyama Y, Shiohara T: Herpes simplex virus reactivation as a trigger of mucous lesions in pemphigus vulgaris. Br J Dermatol 171: 554-560, 2014.

Mizukawa Y, Horie C, Yamazaki Y and Shiohara T: Detection of varicella-zoster virus antigens in lesional skin of zosterifrom lichen planus but not in that of linear lichen planus. Dermatology 225(1); 22-26, 2012.

Mizukawa Y, Shiohara T : Nonpigmenting fixed drug eruption as a possible abortive variant of toxic epidermal necrolysis: immunohistochemical and serum cytokine analyses. Clin Exp Dermatol 35: 493-497, 2010.

Mizukawa Y, Yamazaki Y, Shiohara T: In vivo dynamics of intraepidermal CD8+ T cells and CD4+ T cells during the evolution of fixed drug eruption. Br J Dermatol 158: 1230-1238, 2008.

Mizukawa Y, Yamazaki Y, Teraki Y, Hayakawa J, Hayakawa K, Nuriya H, Kohara M & Shiohara T: Direct evidence for IFN-γ production by effector-memory type intraepidermal T cells residing at an effector site of immunopathology in fixed drug eruption. Am J Pathol 161: 1337-1347, 2002.
所属学会 日本皮膚科学会 、日本研究皮膚科学会 、日本皮膚免疫アレルギー学会 、日本発汗学会、日本アレルギー学会
公的な委員会等の役員・委員歴薬事・食品衛生審議会（副作用・感染等被害判定部会（厚労省））
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