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Faculty of Medicine教員紹介：市村 幸一
| 氏名 |
市村 幸一
イチムラ コウイチ ICHIMURA, Koichi 
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|---|---|
| 職位 | 教授（特任） |
| 所属教室 | |
| 担当科目（学部） | 病理学 |
| 専門分野 | 神経腫瘍学・腫瘍遺伝学・分子診断学 |
| 研究テーマ | 中枢神経系腫瘍（脳腫瘍）の病態解析および新規治療標的・診断マーカー探索を目的とした遺伝子解析と分子診断への応用 |
| 略歴 | 1985年 東京医科歯科大学医学部 卒業 1985年 東京医科歯科大学医学部付属病院脳神経外科 研修医 1989年 東京医科歯科大学医学部脳神経外科 助手 1991年 スウェーデン ヨテボリ大学大学院病理研究科 研究員 1994年 スウェーデン カロリンスカ研究所大学院 腫瘍病理研究科入学 1996年 スウェーデン カロリンスカ研究所大学院 腫瘍病理研究科修了（医学博士） 1996年 スウェーデン ルードヴィク癌研究所ストックホルム支部 Postdoctoral fellow 1998年 英国ケンブリッジ大学病理学部 上級研究員 2006年 英国ケンブリッジ大学病理学部分子病理科 主任研究員 2011年 国立がん研究センター研究所 脳腫瘍連携研究分野 分野長 2019年 神戸大学客員教授（兼任、現在に至る） 2020年 順天堂大学客員教授（兼任） 2021年 順天堂大学医学部 脳疾患連携分野研究講座 特任教授 2024年 杏林大学医学部 病理学教室 特任教授 |
| 所有する学位 | 博士（医学） |
| 論文・著書等を含む主要研究業績 |
詳細な業績は researchmap 研究者総覧 をご覧ください
1. Nikai Y, Satomi K, Saito K, Gomyo M, Matsushita Y, Kato K, Nagahama K, Isomura A, Hayashi A, Yamagishi Y, Sasaki N, Kobayashi K, Tsuchiya K, Nagane M, Ichimura K, Shibahara J. “Glioblastoma, IDH-wildtype manifesting as intracranial hemorrhage: A case report highlighting the clinical utility of digital polymerase chain reaction in integrated diagnoses.” Neuropathology. 2025 Jan 3. Online ahead of print. 2. Hattori K, Makishima K, Suma S, Abe Y, Suehara Y, Sakamoto T, Kurita N, Ishii R, Matsuoka R, Matsuda M, Tsurubuchi T, Nishikawa R, Tanaka S, Mukasa A, Narita Y, Ichimura K, Nagane M, Takano S, Mathis BJ, Ishikawa E, Matsubara D, Chiba S, Sakata-Yanagimoto M. “Association between microenvironment-related genes and prognosis of primary central nervous system lymphoma.” EJHaem. 2024 Nov 14;5(6):1201-1214. eCollection 2024 Dec. 3. Ozeki Y, Honda-Kitahara M, Yanagisawa S, Takahashi M, Ohno M, Miyakita Y, Kikuchi M, Nakano T, Hosoya T, Sugino H, Satomi K, Yoshida A, Igaki H, Kubo Y, Ichimura K, Suzuki H, Masutomi K, Kondo A, Narita Y. “Early progressive disease within 2 years in isocitrate dehydrogenase (IDH)-mutant astrocytoma may indicate radiation necrosis.” Jpn J Clin Oncol. 2024 Dec 11:hyae151. Online ahead of print. 4. Satomi K, Shibayama T, Hibiya T, Hayashi A, Nagahama K, Kato K, Nikai Y, Matsushita Y, Gomyo M, Yamagishi Y, Sasaki N, Saito K, Kobayashi K, Takeda A, Fujimoto S, Matsuo T, Takai K, Komori T, Tsuchiya K, Nagane M, Ichimura K, Shibahara J. “MYB::QKI fusion-positive diffuse glioma of the cerebellum: A case report.” Neuropathology. 2024 Nov 21. Online ahead of print. 5. Honma H, Tateishi K, Iwashita H, Miyake Y, Tsujimoto S, Hayashi H, Ohgaki F, Nakano Y, Ichimura K, Yamanaka S, Kato M, Fujii S, Ito S, Yokoo H, Yamamoto T. “Primary intracranial sarcoma associated with DICER1 mutant: a case report and preclinical investigation.” Brain Tumor Pathol. 2024 Nov 10. Online ahead of print. 6. Nakano Y, Nobusawa S, Sato-Otsubo A, Nakashima T, Suzuki H, Yamasaki K, Shirakura T, Inoue T, Okuno T, Kato M, Ichimura K, Sakamoto H. “TCF3::BEND2 in paediatric supratentorial tumour with carcinoma-like epithelial features classifying as MN1-altered astroblastoma by DNA methylation profiling.” Neuropathol Appl Neurobiol. 2024 Oct;50(5):e13011. 7. Imoto R, Otani Y, Fujii K, Ishida J, Hirano S, Kemmotsu N, Suruga Y, Mizuta R, Kegoya Y, Inoue Y, Umeda T, Hokama M, Washio K, Yanai H, Tanaka S, Satomi K, Ichimura K, Date I. “Tectal glioma: clinical, radiological, and pathological features, and the importance of molecular analysis.” Brain Tumor Pathol. 2024 Oct 21. Online ahead of print. 8. Niwa H, Kato T, Hasegawa T, Kuwabara K, Ohka F, Hirato J, Sasaki S, Ichimura K, Yoshioka T, Naito T, Mizuno A, Kageyama A, Oishi H, Saito R. “Recurrent symptomatic intracranial hemorrhage in high-grade astrocytoma with piloid features: illustrative case.” J Neurosurg Case Lessons. 2024 Oct 7;8(15):CASE24395. 9. Inoue S, Takami H, Tanaka S, Nomura M, Takayanagi S, Saito Y, Kikuta S, Kondo K, Matsuura R, Ikemura M, Yamazawa S, Matsutani M, Nishikawa R, Matsushita Y, Ichimura K, Saito N. “Nasal immature teratoma in an elderly patient: Clinicopathological and epigenetic analogies with central nervous system counterparts, alongside genomic divergences.” Neuropathology. 2024 Oct 2. Online ahead of print. 10. Sekino Y, Sonoda Y, Shibahara I, Mizusawa J, Sasaki K, Sekita T, Ichikawa M, Igaki H, Kinoshita M, Kumabe T, Shibahara J, Ichimura K, Arakawa Y, Fukuda H; Brain Tumor Study Group (BTSG) of the Japan Clinical Oncology Group (JCOG); Narita Y. “Protocol digest of a phase III randomized trial of gross total resection versus possible resection of fluid-attenuated inversion recovery-hyperintense lesion on MRI for newly diagnosed supratentorial glioblastoma: JCOG2209 (FLAMINGO).” Jpn J Clin Oncol. 2024 Sep 17:hyae130. Online ahead of print. 11. Hanyu T, Ishibashi R, Kitamura K, Nishida N, Yuba Y, Honjo G, Satomi K, Ichimura K, Shibahara J, Sawada T, Ishimori T, Takebe N, Hashikata H, Toda H. “Intraventricular pituicytoma: illustrative case.” J Neurosurg Case Lessons. 2024 Aug 26;8(9):CASE24247. Print 2024 Aug 26. 12. Abe E, Suzuki M, Ichimura K, Arakawa A, Satomi K, Ikuko Ogino BP, Hara T, Iwamuro H, Ohara Y, Kondo A. “Implications of DNA methylation classification in diagnosing ependymoma.” World Neurosurg. 2024 May;185:e1019-e1029. 13. Shirai Y, Ueno T, Kojima S, Ikeuchi H, Kitada R, Koyama T, Takahashi F, Takahashi K, Ichimura K, Yoshida A, Sugino H, Mano H, Narita Y, Takahashi M, Kohsaka S. “The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma.” J Neurooncol. 2024 Feb 16. Online ahead of print. 14. Sheriff A, Takami H, Takayanagi S, Kitagawa Y, Tanaka S, Ikemura M, Matsuura R, Matsushita Y, Ichimura K, Saito N. “Embryonal tumor with multilayered rosettes arising from the internal auditory canal of an adult: Illustrative case with molecular investigations.” Neuropathology. 2023 Nov 2. Online ahead of print. 15. Yamada S, Tanikawa M, Matsushita Y, Fujinami R, Yamada H, Sakomi K, Sakata T, Inagaki H, Yokoo H, Ichimura K, Mase M. “SEGA-like circumscribed astrocytoma in a non-NF1 patient, harboring molecular profile of GBM. A case report.” Neuropathology. 2023 Nov 2. Online ahead of print. 16. Odate T, Satomi K, Kubo T, Matsushita Y, Ueno T, Kurose A, Shomori K, Nakai T, Watanabe R, Segawa K, Ohshika S, Miyake N, Kudo S, Shimoi T, Kobayashi E, Komiyama M, Yoshimoto S, Nakatani F, Kawai A, Yatabe Y, Kohsaka S, Ichimura K, Ichikawa H, Yoshida A. “Inflammatory Rhabdomyoblastic Tumor: Clinicopathological and Molecular Analysis of 13 Cases.” Mod Pathol. 2023 Oct 21:100359. 17. Satake D, Natsumeda M, Satomi K, Tada M, Sato T, Okubo N, Kawabe K, Takahashi H, Tsukamoto Y, Okada M, Sano M, Iwabuchi H, Shibata N, Imamura M, Imai C, Takami H, Ichimura K, Nishikawa R, Umezu H, Kakita A, Oishi M. “Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features.” Curr Oncol. 2024 Mar 29;31(4):1831-1838. 18. Pohl LC, Leitheiser M, Obrecht D, Schweizer L, Wefers AK, Eckhardt A, Raffeld M, Sturm D, Pajtler KW, Rutkowski S, Fukuoka K, Ichimura K, Bockmayr M, Schüller U. “Molecular characteristics and improved survival prediction in a cohort of 2023 ependymomas.” Acta Neuropathol. 2024 Jan 24;147(1):24. 19. Neyazi S, Yamazawa E, Hack K, Tanaka S, Nagae G, Kresbach C, Umeda T, Eckhardt A, Tatsuno K, Pohl L, Hana T, Bockmayr M, Kim P, Dorostkar MM, Takami T, Obrecht D, Takai K, Suwala AK, Komori T, Godbole S, Wefers AK, Otani R, Neumann JE, Higuchi F, Schweizer L, Nakanishi Y, Monoranu CM, Takami H, Engertsberger L, Yamada K, Ruf V, Nomura M, Mohme T, Mukasa A, Herms J, Takayanagi S, Mynarek M, Matsuura R, Lamszus K, Ishii K, Kluwe L, Imai H, von Deimling A, Koike T, Benesch M, Kushihara Y, Snuderl M, Nambu S, Frank S, Omura T, Hagel C, Kugasawa K, Mautner VF, Ichimura K, Rutkowski S, Aburatani H, Saito N, Schüller U. “Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation.” Acta Neuropathol. 2024 Jan 24;147(1):22. 20. Fujii T, Nakano Y, Hagita D, Onishi N, Endo A, Nakagawa M, Yoshiura T, Otsuka Y, Takeuchi S, Suzuki M, Shimizu Y, Toyooka T, Matsushita Y, Hibiya Y, Tomura S, Kondo A, Wada K, Ichimura K, Tomiyama A. “KLC1-ROS1 Fusion Exerts Oncogenic Properties of Glioma Cells via Specific Activation of JAK-STAT Pathway.” Cancers (Basel). 2023 Dec 19;16(1):9. 21. Hayashi T, Tateishi K, Matsuyama S, Iwashita H, Miyake Y, Oshima A, Homma H, Sasame J, Takabayashi K, Sugino K, Hirata E, Udaka N, Matsushita Y, Kato I, Hayashi H, Nakamura T, Ikegaya N, Takayama Y, Sonoda M, Oka C, Sato M, Isoda M, Kato M, Uchiyama K, Tanaka T, Muramatsu T, Miyake S, Suzuki R, Takadera M, Tatezuki J, Ayabe J, Suenaga J, Matsunaga S, Miyahara K, Manaka H, Murata H, Yokoyama T, Tanaka Y, Shuto T, Ichimura K, Kato S, Yamanaka S, Cahill DP, Fujii S, Shankar GM, Yamamoto T. “Intraoperative integrated diagnostic system for malignant central nervous system tumors.” Clin Cancer Res. 2024 Jan 5;30(1):116-126. 22. Fukuoka K, Kurihara J, Shofuda T, Kagawa N, Yamasaki K, Ando R, Ishida J, Kanamori M, Kawamura A, Park YS, Kiyotani C, Akai T, Keino D, Miyairi Y, Sasaki A, Hirato J, Inoue T, Nakazawa A, Koh K, Nishikawa R, Date I, Nagane M, Ichimura K, Kanemura Y. “Subtyping of Group 3/4 medulloblastoma as a potential prognostic biomarker among patients treated with reduced dose of craniospinal irradiation: a Japanese Pediatric Molecular Neuro-Oncology Group study.” Acta Neuropathol Commun. 2023 Sep 25;11(1):153. 23. Takami H, Satomi K, Fukuoka K, Nakamura T, Tanaka S, Mukasa A, Saito N, Suzuki T, Yanagisawa T, Sugiyama K, Kanamori M, Kumabe T, Tominaga T, Tamura K, Maehara T, Nonaka M, Asai A, Yokogami K, Takeshima H, Iuchi T, Kobayashi K, Yoshimoto K, Sakai K, Nakazato Y, Matsutani M, Nagane M, Nishikawa R, Ichimura K. “Distinct patterns of copy number alterations may predict poor outcome in central nervous system germ cell tumors.” Sci Rep. 2023 Sep 21;13(1):15760. 24. Kojima N, Kubo T, Mori T, Satomi K, Matsushita Y, Iwata S, Yatabe Y, Ichimura K, Kawai A, Ichikawa H, Yoshida A. “Myxoid liposarcoma with nuclear pleomorphism: a clinicopathological and molecular study.” Virchows Arch. 2024 Jan;484(1):71-81 25. Motoi T, Hirata M, Kukita Y, Satomi K, Tamura H, Adachi S, Matsushita Y, Horiguchi SI, Hishima T, Ikegami M, Okuma T, Tao K, Arakawa A, Ogawa C, Matsuda K, Ichimura K, Nakamura H, Mori T, Yoshida A. “KDM2B-Rearranged Soft-Tissue Sarcomas Expand the Concept of BCOR-Associated Sarcoma.” Mod Pathol. 2023 Nov;36(11):100317 26. Kawauchi D, Ohno M, Miyakita Y, Takahashi M, Yanagisawa S, Omura T, Yoshida A, Kubo Y, Igaki H, Ichimura K, Narita Y. “Consulting a neurosurgeon upon initial medical assessment reduces the time to the first surgery and potentially contributes to improved prognosis for glioblastoma patients.” Jpn J Clin Oncol. 2023 Nov 5;53(11):1027-1033. doi: 10.1093/jjco/hyad093. 27. Tao K, Yamazaki F, Kubo T, Sunami K, Kumamoto T, Arakawa A, Sugiyama M, Watanabe Y, Nakajima M, Shirakawa N, Tanimura K, Koyama T, Hirata M, Sudo K, Tanabe N, Watanabe T, Yoshida T, Kitami M, Yoshida A, Yatabe Y, Nakano Y, Ohira M, Kamijo T, Nakazawa A, Kato M, Ichimura K, Kohno T, Yamamoto N, Hishiki T, Ichikawa H, Ogawa C. “Pediatric Precision Medicine at the National Cancer Center Japan: Prospective Genomic Study of Pediatric Patients with Cancer as Part of the TOP-GEAR Project.” JCO Precis Oncol. 2023 Jul;7:e2200266. 28. Miyake Y, Tateishi K, Oshima A, Hongo T, Satomi K, Ichimura K, Kato A, Iwashita H, Utsunomiya D, Yamamoto T. “A case of midbrain germinoma: A literature review for radiographic and clinical features.” Neurooncol Adv. 2023 Apr 19;5(1):vdad043. doi: 10.1093/noajnl/vdad043. eCollection 2023 Jan-Dec. 29. Irikura T, Fukuoka K, Nakazawa A, Ichimura K, Kurihara J, Koh K. “Molecular characterization of long-term survivors of metastatic medulloblastoma treated with reduced-dose craniospinal irradiation.” Childs Nerv Syst. 2023 Sep;39(9):2505-2507. doi: 10.1007/s00381-023-05971-8. 30. Fukuoka K, Nakazawa A, Hirato J, Nobusawa S, Itabashi T, Arakawa Y, Mori M, Matsushita Y, Honda S, Tanami Y, Ichimura K, Kurihara J, Koh K. “An infantile pineal embryonal tumor showing pathological features of a CNS ganglioneuroblastoma and the methylation profiling of an atypical teratoid/rhabdoid tumor and SMARCA4 mutation.” J Neuropathol Exp Neurol. 2023 Jun 20;82(7):664-667 31. Takami H, Graffeo CS, Perry A, Giannini C, Nakazato Y, Saito N, Matsutani M, Nishikawa R, Daniels DJ, Ichimura K. “Impact of tumor markers on diagnosis, treatment and prognosis in CNS germ cell tumors: correlations with clinical practice and histopathology.” Brain Tumor Pathol. 2023 Apr;40(2):124-132. doi: 10.1007/s10014-023-00460-x. Online ahead of print. 32. Masui K, Nitta M, Muragaki Y, Kawamata T, Satomi K, Matsushita Y, Yoshida A, Ichimura K, Tsuda M, Tanaka S, Komori T. “A case of "genetically defined" radiation-induced glioma: 29 years after surgery and radiation for pilocytic astrocytoma.” Neuropathology. 2023 Oct;43(5):425-428. 33. Sugino H, Satomi K, Mori T, Mukai Y, Honda-Kitahara M, Matsushita Y, Ichimura K, Narita Y, Yoshida A. “High-grade neuroepithelial tumor with EP300::BCOR fusion and negative BCOR immunohistochemical expression: a case report.” Brain Tumor Pathol. 2023 Apr;40(2):133-141. 34. Sugino H, Iwata S, Satomi K, Mori T, Nobusawa S, Nagashima T, Matsushita Y, Yatabe Y, Ichimura K, Kawai A, Yoshida A. “Keratin-positive fibrotic extraskeletal myxoid chondrosarcoma: a close mimic of myoepithelial tumour.” Histopathology. 2023 May;82(6):937-945. 35. Shimizu Y, Suzuki M, Akiyama O, Ogino I, Matsushita Y, Satomi K, Yanagisawa S, Ohno M, Takahashi M, Miyakita Y, Narita Y, Ichimura K, Kondo A. “Utility of real-time polymerase chain reaction for the assessment of CDKN2A homozygous deletion in adult-type IDH-mutant astrocytoma.” Brain Tumor Pathol. 2023 Apr;40(2):93-100. 36. Natsume A, Arakawa Y, Narita Y, Sugiyama K, Hata N, Muragaki Y, Shinojima N, Kumabe T, Saito R, Motomura K, Mineharu Y, Miyakita Y, Yamasaki F, Matsushita Y, Ichimura K, Ito K, Tachibana M, Kakurai Y, Okamoto N, Asahi T, Nishijima S, Yamaguchi T, Tsubouchi H, Nakamura H, Nishikawa R. “The first-in-human phase I study of a brain-penetrant mutant IDH1 inhibitor DS-1001 in patients with recurrent or progressive IDH1-mutant gliomas.” Neuro Oncol. 2023 Feb 14;25(2):326-336. 37. Träger M, Schweizer L, Eilís P, Schmid S, Hain EG, Dittmayer C, Onken J, Fukuoka K, Ichimura K, Schüller U, Dührsen L, Müther M, Paulus W, Thomas C, Gutt-Will M, Schucht P, Maragkou T, Schittenhelm J, Eckert F, Niyazi M, Fleischmann D, Dorostkar M, Feyer P, May SA, Moskopp D, Badakhshi H, Radke C, Walter J, Ehret F, Capper D, Kaul D. “Adult intracranial ependymoma - relevance of DNA methylation profiling for diagnosis, prognosis and treatment.” Neuro Oncol. 2023 Jul 6;25(7):1286-1298. 38. Okazawa Y, Sugimoto K, Ii Y, Irie T, Kawaguchi M, Kobari A, Momose H, Tsuchiya Y, Amemiya K, Motegi S, Tsukamoto R, Kure K, Honjo K, Ro H, Takahashi R, Kawano S, Kawai M, Ishiyama S, Takahashi M, Kojima Y, Tomiki Y, Arakawa A, Yao T, Satomi K, Matsushita Y, Ichimura K, Sakamoto K. “Local recurrence of submucosal invasive colorectal cancer after endoscopic submucosal dissection revealed by copy number variation.” DEN Open. 2023 Jan 31;3(1):e208. 39. Kawauchi D, Ohno M, Honda-Kitahara M, Miyakita Y, Takahashi M, Yanagisawa S, Tamura Y, Kikuchi M, Ichimura K, Narita Y. “Clinical characteristics and prognosis of Glioblastoma patients with infratentorial recurrence.” BMC Neurol. 2023 Jan 7;23(1):9. 40. Watakabe M, Fukuoka K, Ihara Y, Hara T, Kudo K, Tamura M, Ichimura K, Tanami Y, Kawashima H, Iwama I, Nakazawa A, Mizuta K, Koh K. “Optimal timing of liver transplantation for liver cirrhosis caused by sclerosing cholangitis in a patient with Langerhans cell histiocytosis: a case report.” Int J Hematol 2023 May;117(5):759-764. 41. Nagane M, Ichimura K, Onuki R, Narushima D, Honda-Kitahara M, Satomi K, Tomiyama A, Arai Y, Shibata T, Narita Y, Uzuka T, Nakamura H, Nakada M, Arakawa Y, Ohnishi T, Mukasa A, Tanaka S, Wakabayashi T, Aoki T, Aoki S, Shibui S, Matsutani M, Ishizawa K, Yokoo H, Suzuki H, Morita S, Kato M, Nishikawa R. “Bevacizumab beyond Progression for Newly Diagnosed Glioblastoma (BIOMARK): Phase II Safety, Efficacy and Biomarker Study.” Cancers (Basel). 2022 Nov 10;14(22):5522. 42. Hosoya T, Takahashi M, Davey C, Sese J, Honda-Kitahara M, Miyakita Y, Ohno M, Yanagisawa S, Omura T, Kawauchi D, Ozeki Y, Kikuchi M, Nakano T, Yoshida A, Igaki H, Matsushita Y, Ichimura K, Narita Y. “Volumetric Analysis of Glioblastoma for Determining Which CpG Sites Should Be Tested by Pyrosequencing to Predict Temozolomide Efficacy.” Biomolecules. 2022 Sep 26;12(10):1379 43. Ohno M, Kitano S, Satomi K, Yoshida A, Miyakita Y, Takahashi M, Yanagisawa S, Tamura Y, Ichimura K, Narita Y. “Assessment of radiographic and prognostic characteristics of programmed death-ligand 1 expression in high-grade gliomas.” J Neurooncol. 2022 Nov;160(2):463-472. 44. Maehara T, Yamazaki A, Nakano Y, Nakata S, Fukuoka K, Deguchi S, Mitsuya K, Hayashi N, Oishi T, Kakuda Y, Sugino T, Ichimura K, Yokoo H, Nobusawa S. “Exophytic cerebellopontine angle tumor showing mostly an embryonal appearance with H3-3A K27M.” Neuropathology. 2022 Oct 11 45. Sumida S, Toki SI, Mori T, Satomi K, Takao S, Nobusawa S, Kakimoto T, Nakagawa S, Ryo E, Matsushita Y, Ichimura K, Nishisho T, Bando Y, Yoshida A. “ZFTA::RELA fusion in a distinct liposarcoma morphologically overlapping with chondroid lipoma.” Genes Chromosomes Cancer. 2023 Feb;62(2):101-106. 46. Suruga Y, Satomi K, Otani Y, Fujii K, Ishida J, Uneda A, Tsuboi N, Makino K, Hirano S, Kemmotsu N, Imoto R, Mizuta R, Tomita Y, Yasuhara T, Washio K, Yanai H, Matsushita Y, Hibiya Y, Yoshida A, Capper D, Ichimura K, Date I. “The utility of DNA methylation analysis in elderly patients with pilocytic astrocytoma morphology.” J Neurooncol. 2022 Oct;160(1):179-189. 47. Yamada S, Tanikawa M, Shibata H, Honda-Kitahara M, Nakano Y, Satomi K, Sakata T, Hirose T, Ichimura K, Mase M. “DNA methylation array analysis for diffuse leptomeningeal glioneuronal tumor with conspicuous hypothalamic mass. A case report.” Neuropathology. 2022 Dec;42(6):512-518. 48. Tomita Y, Hibler EA, Suruga Y, Ishida J, Fujii K, Satomi K, Ichimura K, Hirotsune N, Date I, Tanaka Y, Otani Y. “Age is a major determinant for poor prognosis in patients with pilocytic astrocytoma: a SEER population study” Clin Exp Med. 2022 Sep 5. 49. Kawauchi D, Ohno M, Miyakita Y, Takahashi M, Yanagisawa S, Omura T, Yoshida A, Kubo Y, Igaki H, Ichimura K, Narita Y. “Early Diagnosis and Surgical Intervention Within 3 Weeks From Symptom Onset Are Associated With Prolonged Survival of Patients With Glioblastoma.” Neurosurgery. 2022 Nov 1;91(5):741-748. 50. Sonehara K, Kimura Y, Nakano Y, Ozawa T, Takahashi M, Suzuki K, Fujii T, Matsushita Y, Tomiyama A, Kishikawa T, Yamamoto K, Naito T, Suzuki T, Yamaguchi S, Miwa T, Sasaki H, Kitagawa M, Ohe N, Fukai J, Ogiwara H, Kawamura A, Miyawaki S, Matsuda F, Kiyokawa N, Ichimura K, Nishikawa R, Okada Y, Terashima K. “A common deletion at BAK1 reduces enhancer activity and confers risk of intracranial germ cell tumors.” Nat Commun. 2022 Aug 2;13(1):4478. 51. Satomi K, Yoshida A, Matsushita Y, Sugino H, Fujimoto K, Honda-Kitahara M, Takahashi M, Ohno M, Miyakita Y, Narita Y, Yatabe Y, Shibahara J, Ichimura K. “Clinical application of a highly sensitive digital PCR assay to detect a small fraction of IDH1 R132H-mutant alleles in diffuse gliomas.” Brain Tumor Pathol. 2022 Oct;39(4):210-217. 52. Kurozumi K, Fujii K, Washio K, Ishida J, Otani Y, Sudo T, Tahara M, Ichimura K, Ennishi D, Date I. “Response to entrectinib in a malignant glioneuronal tumor with ARHGEF2-NTRK fusion.” Neurooncol Adv. 2022 Jun 13;4(1):vdac094. 53. Satomi K, Ohno M, Kubo T, Honda-Kitahara M, Matsushita Y, Ichimura K, Narita Y, Ichikawa H, Yoshida A. “Central nervous system sarcoma with ATXN1::DUX4 fusion expands the concept of CIC-rearranged sarcoma.” Genes Chromosomes Cancer. 2022 Nov;61(11):683-688. 54. Handa H, Shibahara I, Nakano Y, Inukai M, Sato S, Hide T, Hirato J, Yoshioka T, Ichimura K, Kumabe T. “Molecular analyses of rosette-forming glioneuronal tumor of the midbrain tegmentum: A report of two cases and a review of the FGFR1 status in unusual tumor locations.” Surg Neurol Int. 2022 May 20;13:213. 55. Omura T, Takahashi M, Ohno M, Miyakita Y, Yanagisawa S, Tamura Y, Kikuchi M, Kawauchi D, Nakano T, Hosoya T, Igaki H, Satomi K, Yoshida A, Sunami K, Hirata M, Shimoi T, Sudo K, Okuma HS, Yonemori K, Suzuki H, Ichimura K, Narita Y. “Clinical Application of Comprehensive Genomic Profiling Tests for Diffuse Gliomas.” Cancers (Basel). 2022 May 16;14(10):2454. 56. Takami H, Nakamura H, Ichimura K, Nishikawa R. “Still divergent but on the way to convergence: clinical practice of CNS germ cell tumors in Europe and North America from the perspectives of the East.” Neurooncol Adv. 2022 Apr 22;4(1):vdac061. 57. Yamazaki A, Arai Y, Fukuoka K, Nakano Y, Hama N, Nakata S, Makino K, Kuroda JI, Shinojima N, Mukasa A, Mikami Y, Ichimura K, Shibata T, Yokoo H, Nobusawa S. “Diffusely infiltrating glioma with CREBBP-BCORL1 fusion showing overexpression of not only BCORL1 but BCOR: A case report.” Brain Tumor Pathol. 2022 Jul;39(3):171-178. 58. Ohno M, Miyakita Y, Takahashi M, Yanagisawa S, Tamura Y, Kawauchi D, Kikuchi M, Igaki H, Yoshida A, Satomi K, Matsushita Y, Ichimura K, Narita Y. “Assessment of therapeutic outcome and role of reirradiation in patients with radiation-induced glioma.” Radiat Oncol. 2022 May 3;17(1):85. 59. Kojima N, Arai Y, Satomi K, Kubo T, Matsushita Y, Mori T, Matsushita H, Ushijima T, Yatabe Y, Shibata T, Yonemori K, Ichimura K, Ichikawa H, Kawai A, Yoshida A. “Co-expression of ERG and CD31 in a subset of CIC-rearranged sarcoma: a potential diagnostic pitfall.” Mod Pathol. 2022 Oct;35(10):1439-1448. 60. Hosoya T, Takahashi M, Honda-Kitahara M, Miyakita Y, Ohno M, Yanagisawa S, Omura T, Kawauchi D, Tamura Y, Kikuchi M, Nakano T, Yoshida A, Igaki H, Matsushita Y, Ichimura K, Narita Y. “MGMT gene promoter methylation by pyrosequencing method correlates volumetric response and neurological status in IDH wild-type glioblastomas.” J Neurooncol. 2022 May;157(3):561-571. 61. Sasame J, Ikegaya N, Kawazu M, Natsumeda M, Hayashi T, Isoda M, Satomi K, Tomiyama A, Oshima A, Honma H, Miyake Y, Takabayashi K, Nakamura T, Ueno T, Matsushita Y, Iwashita H, Kanemaru Y, Murata H, Ryo A, Terashima K, Yamanaka S, Fujii Y, Mano H, Komori T, Ichimura K, Cahill DP, Wakimoto H, Yamamoto T, Tateishi K. “HSP90 inhibition overcomes resistance to molecular targeted therapy in BRAFV600E mutant high-grade glioma.” Clin Cancer Res. 2022 Jun 1;28(11):2425-2439. 62. Takami H, Graffeo CS, Perry A, Giannini C, Nakazato Y, Saito N, Matsutani M, Nishikawa R, Ichimura K, Daniels DJ. “Roles of Tumor Markers in Central Nervous System Germ Cell Tumors Revisited with Histopathology-Proven Cases in a Large International Cohort.” Cancers (Basel). 2022 Feb 15;14(4):979. 63. Yanagi M, Fukuoka K, Mori M, Arakawa Y, Matsushita Y, Hibiya Y, Tanami Y, Ichimura K, Hirato J, Nakazawa A, Kurihara J, Koh K. “Prognostic Implication of DNA Methylation Signature in Atypical Choroid Plexus Papilloma With Intracranial Dissemination.” J Pediatr Hematol Oncol. 2022 May 1;44(4):e844-e848. 64. Takami H, Elzawahry A, Mamatjan Y, Fukushima S, Fukuoka K, Suzuki T, Yanagisawa T, Matsushita Y, Nakamura T, Satomi K, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Tamura K, Maehara T, Sugiyama K, Yoshimoto K, Sakai K, Nonaka M, Asai A, Yokogami K, Takeshima H, Narita Y, Shibui S, Nakazato Y, Hama N, Totoki Y, Kato M, Shibata T, Nishikawa R, Matsutani M, Ichimura K; Intracranial Germ Cell Tumor Genome Analysis Consortium (the iGCT Consortium). “Transcriptome and Methylome Analysis of CNS Germ Cell Tumor Finds its Cell-of-Origin in Embryogenesis and Reveals Shared Similarities with Testicular Counterparts.” Neuro Oncol. 2022 Aug 1;24(8):1246-1258. 65. Yoshida A, Satomi K, Kobayashi E, Ryo E, Matsushita Y, Narita Y, Ichimura K, Kawai A, Mori T. “Soft tissue sarcoma with MN1-BEND2 fusion: a case report and comparison with astroblastoma.” Genes Chromosomes Cancer. 2022 Jul;61(7):427-431 66. Uchida E, Sasaki A, Shirahata M, Suzuki T, Adachi JI, Mishima K, Yasuda M, Fujimaki T, Ichimura K, Nishikawa R. “Role of proliferative marker index and KBTBD4 mutation in the pathological diagnosis of pineal parenchymal tumors.” Brain Tumor Pathol. 2022 Jul;39(3):130-138. 67. Kawauchi D, Ohno M, Honda-Kitahara M, Miyakita Y, Takahashi M, Yanagisawa S, Tamura Y, Kikuchi M, Ichimura K, Narita Y. “The clinical characteristics and outcomes of incidentally discovered glioblastoma.” J Neurooncol. 2022 Feb;156(3):551-557. 68. Nakano T, Fujimoto K, Tomiyama A, Takahashi M, Achiha T, Arita H, Kawauchi D, Yasukawa M, Masutomi K, Kondo A, Narita Y, Maehara T, Ichimura K. “Eribulin prolongs survival in an orthotopic xenograft mouse model of malignant meningioma.” Cancer Sci. 2022 Feb;113(2):697-708. 69. Yoshida A, Arai Y, Satomi K, Kubo T, Ryo E, Matsushita Y, Hama N, Sudo K, Komiyama M, Yatabe Y, Shibata T, Ichikawa H, Ichimura K, Kawai A, Mori T. “Identification of novel SSX1 fusions in synovial sarcoma.” Mod Pathol. 2022 Feb;35(2):228-239. 70. Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K. “12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.” Neuro Oncol. 2022 May 4;24(5):834-846. 71. Arakawa A, Sasaki K, Mineharu Y, Uto M, Mizowaki T, Mizusawa J, Sekino Y, Ono T, Aoyama H, Satomi K, Ichimura K, Kinoshita M, Ohno M, Ito Y, Nishikawa R, Fukuda H, Nishimura Y, Narita Y and Brain Tumor Study Group and Radiation Therapy Study Group of the Japan Clinical Oncology Group. “A randomized phase III study of short-course radiotherapy combined with Temozolomide in elderly patients with newly diagnosed glioblastoma; Japan clinical oncology group study JCOG1910 (AgedGlio-PIII).” BMC Cancer (2021) 21:1105 72. Ohno M, Hayashi Y, Aikawa H, Hayashi M, Miyakita Y, Takahashi M, Matsushita Y, Yoshida A, Satomi K, Ichimura K, Hamada A, Narita Y. “Tissue 2-Hydroxyglutarate and Preoperative Seizures in Patients with Diffuse Gliomas.” Neurology. 2021 Nov 23;97(21):e2114-e2123. 73. Yamamuro S, Takahashi M, Satomi K, Sasaki N, Kobayashi T, Uchida E, Kawauchi D, Nakano T, Fujii T, Narita Y, Kondo A, Wada K, Yoshino A, Ichimura K, Tomiyama A. “CCNU and ACNU exert efficient antitumor effects against glioblastoma models with acquired temozolomide resistance.” Cancer Sci. 2021 112(11):4736-4747. 74. Takami H, Satomi K, Fukuoka K, Fukushima S, Matsushita Y, Yamasaki K, Nakamura T, Tanaka S, Mukasa A, Saito N, Suzuki T, Yanagisawa T, Nakamura H, Sugiyama K, Tamura K, Maehara T, Nakada M, Nonaka M, Asai A, Yokogami K, Takeshima H, Iuchi T, Kanemura Y, Kobayashi K, Nagane M, Kurozumi K, Yoshimoto K, Matsuda M, Matsumura A, Hirose Y, Tokuyama T, Kumabe T, Narita Y, Shibui S, Nakazato Y, Nishikawa R, Matsutani M, Ichimura K. “Low tumor cell content predicts favorable prognosis in germinoma patients.” Neurooncol Adv. 2021 Aug 10;3(1):vdab110. 75. Yamagishi Y, Sasaki N, Nakano Y, Matushita Y, Omura T, Shimizu S, Saito K, Kobayashi K, Narita Y, Kondo A, Shiokawa Y, Nagane M, Ichimura K. “Liquid biopsy of cerebrospinal fluid for MYD88 L265P mutation is useful for diagnosis of central nervous system lymphoma.” Cancer Sci. 2021 112(11):4702-4710. 76. Sievers P, Henneken SC, Blume C, Sill M, Schrimpf D, Stichel D, Okonechnikov K, Reuss DE, Benzel J, Maaß KK, Kool M, Sturm D, Zheng T, Ghasemi DR, Kohlhof-Meinecke P, Cruz O, Suñol M, Lavarino C, Ruf V, Boldt HB, Pagès M, Pouget C, Schweizer L, Kranendonk MEG, Akhtar N, Bunkowski S, Stadelmann C, Schüller U, Mueller WC, Dohmen H, Acker T, Harter PN, Mawrin C, Beschorner R, Brandner S, Snuderl M, Abdullaev Z, Aldape K, Gilbert MR, Armstrong TS, Ellison DW, Capper D, Ichimura K, Reifenberger G, Grundy RG, Jabado N, Krskova L, Zapotocky M, Vicha A, Varlet P, Wesseling P, Rutkowski S, Korshunov A, Wick W, Pfister SM, Jones DTW, von Deimling A, Pajtler KW, Sahm F. “Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors.” Acta Neuropathol. 2021 Nov;142(5):827-839. 77. Kanamori M, Takami H, Suzuki T, Tominaga T, Kurihara J, Tanaka S, Hatazaki S, Nagane M, Matsuda M, Yoshino A, Natsumeda M, Yamaoka M, Kagawa N, Akiyama Y, Fukai J, Negoto T, Shibahara I, Tanaka K, Inoue A, Mase M, Tomita T, Kuga D, Kijima N, Fukami T, Nakahara Y, Natsume A, Yoshimoto K, Keino D, Tokuyama T, Asano K, Ujifuku K, Abe H, Nakada M, Matsuda KI, Arakawa Y, Ikeda N, Narita Y, Shinojima N, Kambe A, Nonaka M, Izumoto S, Kawanishi Y, Kanaya K, Nomura S, Nakajima K, Yamamoto S, Terashima K, Ichimura K, Nishikawa R. “Necessity for craniospinal irradiation of germinoma with positive cytology without spinal lesion on MR imaging-A controversy.” Neurooncol Adv. 2021 Jun 25;3(1):vdab086. 78. Tsutsui T, Arakawa Y, Makino Y, Kataoka H, Mineharu Y, Naito K, Minamiguchi S, Hirose T, Nobusawa S, Nakano Y, Ichimura K, Haga H, Miyamoto S. “Spinal cord astroblastoma with EWSR1-BEND2 fusion classified as HGNET-MN1 by methylation classification: a case report.” Brain Tumor Pathol. 2021 Oct;38(4):283-289. 79. Kawaguchi RK, Takahashi M, Miyake M, Kinoshita M, Takahashi S, Ichimura K, Hamamoto R, Narita Y, Sese J. “Assessing Versatile Machine Learning Models for Glioma Radiogenomic Studies across Hospitals.” Cancers (Basel). 2021 Jul 19;13(14):3611. 80. Takami H, Graffeo CS, Perry A, Ohno M, Ishida J, Giannini C, Narita Y, Nakazato Y, Saito N, Nishikawa R, Matsutani M, Ichimura K, Daniels DJ. “Histopathology and prognosis of germ cell tumors metastatic to brain: cohort study.” J Neurooncol. 2021 Aug;154(1):121-130. 81. Nakano Y, Satomi K, Okada K, Gotoh M, Ushiama M, Sakamoto H, Yoshida T, Kunihiro N, Hira K, Fukushima H, Inoue T, Hirato J, Ichimura K, Hara J. “Malignant brain tumor in an infant showing histopathological features of yolk sac tumor but genetic and epigenetic features of AT/RT.” Pediatr Blood Cancer. 2021 Sep;68(9):e29192. 82. Fujimoto K, Arita H, Satomi K, Yamasaki K, Matsushita Y, Nakamura T, Miyakita Y, Umehara T, Kobayashi K, Tamura K, Tanaka S, Higuchi F, Okita Y, Kanemura Y, Fukai J, Sakamoto D, Uda T, Machida R, Kuchiba A, Maehara T, Nagane M, Nishikawa R, Suzuki H, Shibuya M, Komori T, Narita Y, Ichimura K. “TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma.” Acta Neuropathol. 2021 Aug;142(2):323-338. 83. Hiraki T, Fukuoka K, Mori M, Arakawa Y, Matsushita Y, Hibiya Y, Honda S, Kobayashi M, Tanami Y, Ichimura K, Hirato J, Kurihara J, Nakazawa A, Koh K. “Application of Genome-Wide DNA Methylation Analysis to Differentiate a Case of Radiation-Induced Glioblastoma From Late-Relapsed Medulloblastoma.” J Neuropathol Exp Neurol. 2021 Jun 4;80(6):552-557. 84. Yonezawa H, Ohno M, Igaki H, Miyakita Y, Takahashi M, Tamura Y, Shima S, Matsushita Y, Ichimura K, Narita Y. “Outcomes of salvage fractionated re-irradiation combined with bevacizumab for recurrent high-grade gliomas that progressed after bevacizumab treatment.” Jpn J Clin Oncol. 2021 Jul 1;51(7):1028-1035. 85. Takahashi S, Takahashi M, Kinoshita M, Miyake M, Kawaguchi R, Shinojima N, Mukasa A, Saito K, Nagane M, Otani R, Higuchi F, Tanaka S, Hata N, Tamura K, Tateishi K, Nishikawa R, Arita H, Nonaka M, Uda T, Fukai J, Okita Y, Tsuyuguchi N, Kanemura Y, Kobayashi K, Sese J, Ichimura K, Narita Y, Hamamoto R. “Fine-Tuning Approach for Segmentation of Gliomas in Brain Magnetic Resonance Images with a Machine Learning Method to Normalize Image Differences among Facilities.” Cancers (Basel). 2021 Mar 19;13(6):1415. 86. Kawauchi D, Takahashi M, Satomi K, Yamamuro S, Kobayashi T, Uchida E, Honda-Kitahara M, Narita Y, Iwadate Y, Ichimura K, Tomiyama A. “The ALK inhibitors, alectinib and ceritinib, induce ALK-independent and STAT3-dependent glioblastoma cell death.” Cancer Sci. 2021 Jun;112(6):2442-2453 87. Ozawa T, Kaneko S, Szulzewsky F, Qiao Z, Takadera M, Narita Y, Kondo T, Holland EC, Hamamoto R, Ichimura K. “C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation.” Acta Neuropathol Commun. 2021 Mar 8;9(1):36. 88. Tomomasa R, Arai Y, Kawabata-Iwakawa R, Fukuoka K, Nakano Y, Hama N, Nakata S, Suzuki N, Ishi Y, Tanaka S, Takahashi JA, Yuba Y, Shiota M, Natsume A, Kurimoto M, Shiba Y, Aoki M, Nabeshima K, Enomoto T, Inoue T, Fujimura J, Kondo A, Yao T, Okura N, Hirose T, Sasaki A, Nishiyama M, Ichimura K, Shibata T, Hirato J, Yokoo H, Nobusawa S. “Ependymoma-like tumor with mesenchymal differentiation harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor related to ependymoma.” Brain Pathol. 2021 Feb 12 31:e12943. Review articles 89. Westphal M, Levin VA, Berger MS, Pieper R, Nishikawa R, Bjerkvig R, Ashley DM, Bigner D, Sampson JH, Ichimura K, Rutka JT. “Advances in neuro-oncology: contributions of the Asilomar Conference on brain tumor research and therapy.” J Neurosurg. 2024 Dec 20:1-7. 90. Satomi K, Ichimura K, Shibahara J. “Decoding the DNA methylome of central nervous system tumors: An emerging modality for integrated diagnosis.” Pathol Int. 2024 Feb;74(2):51-67. 91. Otani Y, Satomi K, Suruga Y, Ishida J, Fujii K, Ichimura K, Date I. “Utility of genome-wide DNA methylation profiling for pediatric-type diffuse gliomas.” Brain Tumor Pathol. 2023 Apr;40(2):56-65. 92. Takami H, Ichimura K. “Biomarkers for risk-based treatment modifications for CNS germ cell tumors: Updates on biological underpinnings, clinical trials, and future directions.” Front Oncol. 2022 Sep 5;12:982608. 93. Arita H, Ichimura K. “Prognostic significance of TERT promoter mutations in adult-type diffuse gliomas.” Brain Tumor Pathol. 2022 Jan 31. |
| 所属学会 |
The 24th International Conference on Brain Tumor Research and Therapy (ICBTRT 2025) 会長 第19回国際小児脳腫瘍シンポジウム (ISPNO2020) 会長 日本脳腫瘍学会理事 日本癌学会評議員 アメリカ癌学会正会員／アメリカ脳腫瘍学会 (Society for Neuro-Oncology) 会員 関東小児脳腫瘍カンファレンス世話人 日本脳神経外科学会会員／日本脳腫瘍病理学会会員／日本小児血液・がん学会会員 Neuro-Oncology Executive Editor Acta Neuropathologica Editorial Board Cancer Science Associate Editor |
| 学外活動 | 神戸大学 客員教授 |
| 学生のみなさんへ | 私は大学卒業後脳神経外科医としての研修を行ったのち基礎研究の道に進み、縁あって1991年から2011年まで20年間スウェーデンとイギリスで研究生活を送りました。研究を始めてから今までの経歴を医学部メールマガジン「Kyorin Heartbeat」に連載しております。私の専門は脳腫瘍の診断と治療開発で、特に帰国してここ10年余りは脳腫瘍の分子診断技術の開発と臨床応用を進めてきました。最近は脳腫瘍以外のがん種にもさまざまな遺伝子解析のお手伝いをさせていただいております。研究に興味のある方、分子診断に興味のある方、海外留学に興味のある方など、どうぞお気軽にお声をおかけください。 |