大学ホーム保健学部 教員紹介


項 目 内 容
教員名 石井 さなえ
フリガナ イシイサナエ
NAME Sanae Ishii
職 位 准教授
所属研究室 実験病理学
研究テーマ・分野 鼻腔炎症と精神神経疾患
担当科目(学部) 生化学
略 歴 平成 7年 筑波大学附属高等学校 卒業
平成12年 東京大学理学部生物学科人類学 卒業
平成14年 東京大学大学院医学系研究科医科学専攻修士課程修了
平成18年 東京大学大学院医学系研究科機能生物学専攻博士課程修了
平成18年 名古屋大学大学院医学系研究科老年科学  技術補佐員
平成19年 愛知県心身障害者コロニー発達障害研究所 病理学部  
平成24年 日本学術振興会特別研究員 (RPD)
平成27年 中部大学現代教育学部 非常勤講師 静岡県立大学薬理学部 客員共同研究員
平成27年 ペンシルバニア州立大学医学校薬理学 リサーチアソシエイト
平成29年10月〜 杏林大学保健学部准教授
所有する学位 博士(医学)
主要研究業績 原著
1. Imamura, F., Cooper, TK., Hasegawa-Ishii, S., Sonobe, T., Haouzi, P. (2017) Hydrogen Sulfide Specifically Alters Nad(P)H Quinone Dehydrogenase 1 (Nqo1) Olfactory Neurons in the Rat. Neuroscience (in press)
2. Hasegawa-Ishii, S., Shimada, A., Imamura, F. (2017) Lipopolysaccharide-initiated persistent rhinitis causes gliosis and synaptic loss in the olfactory bulb. Sci Rep. 14;7(1):11605. doi: 10.1038/s41598-017-10229-w.
3. Hasegawa-Ishii, S., Inaba, M., Umegaki, H., Unno, K., Wakabayashi, K., and Shimada, A. (2016) Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain-immune interface. Sci. Rep. 5;6:25457.
4. Hasegawa-Ishii, S., Inaba, M., Li, M., Shi, M., Umegaki, H., Ikehara, S. and Shimada, A. (2016) Increased recruitment of bone marrow-derived cells into the brain associated with altered brain cytokine profile in senescence-accelerated mice. Brain Struct. Funct. 221(3):1513-1531
5. Unno, K., Yamamoto, H., Toda, M., Hagiwara, S., Iguchi, K., Hoshino, M., Takabayashi, F., Hasegawa-Ishii, S., Shimada, A., Hosokawa, M., Higuchi, K. and Mori, M. (2014) Novel flame-shift mutation in Slc5a2 encoding SGLT2 in a strain of senescence-accelerated mouse SAMP10. Biochem. Biophys. Res. Commun. 454(1):89-94
6. Chiba, Y., Komori, H., Takei, S., Hasegawa-Ishii, S., Kawamura, N., Adachi, K., Nanba, E., Hosokawa, M., Enokido, Y., Kouchi, Z., Yoshida, F., Shimada, A. (2014) Niemann-Pick disease type C1 predominantly involving the frontotemporal region, with cortical and brainstem Lewy bodies: An autopsy case. Neuropathology. 34(1):49-57. doi: 10.1038/srep25457.
7. Tanisawa, K., Mikami, E., Fuku, N., Honda, Y., Honda, S., Ohsawa, I., Ito, M., Endo, S., Ihara, K., Ohno, K., Kishimoto, Y., Ishigami, A., Maruyama, N., Sawabe, M., Iseki, H., Okazaki, Y., Hasegawa-Ishii, S., Takei, S., Shimada, A., Hosokawa, M., Mori, M., Higuchi, K., Takeda, T., Higuchi, M., Tanaka, M. (2013) Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes. BMC Genomics. Apr 15;14(1):248.
8. Yoshikawa, K., Kita, Y., Furukawa, A., Kawamura, N., Hasegawa-Ishii, S., Chiba, Y., Takei, S., Maruyama, K., Shimizu, T., Shimada, A. (2013) Excitotoxicity-induced immediate surge in hippocampal prostanoid production has latent effects that promote chronic progressive neuronal death. Prostaglandins Leukot. Essent. Fatty Acids. May;88(5):373-81.
9. Hasegawa-Ishii, S., Shimada, A., Inaba, M., Li, M., Shi, M., Kawamura, N., Takei, S., Chiba, Y., Hosokawa, M., Ikehara, S. (2013) Selective localization of bone marrow-derived ramified cells in the brain adjacent to the attachments of choroid plexus. Brain Behav. Immun. 29:82-97.
10. Takei, S., Hasegawa-Ishii, S., Uekawa, A., Chiba, Y., Umegaki, H., Hosokawa, M., Woodward, D.F., Watanabe, K., Shimada, A. (2012) Immunohistochemical demonstration of increased prostaglandin F(2α) levels in the rat hippocampus following kainic acid-induced seizures. Neuroscience. 218:295-304.
11. Chiba, Y., Takei, S., Kawamura, N., Kawaguchi, Y., Sasaki, K., Hasegawa-Ishii, S., Furukawa, A., Hosokawa, M., Shimada, A. (2012) Immunohistochemical localization of aggresomal proteins in glial cytoplasmic inclusions in multiple system atrophy. Neuropathol. Appl. Neurobiol. 38(6):559-71.
12. Hoshino, S., Kurishima, A., Inaba, M., Ando, Y., Fukui, T., Uchida, K., Nishio, A., Iwai, H., Yokoi, T., Ito, T., Hasegawa-Ishii, S., Shimada, A., Li, M., Okazaki, K., Ikehara, S. (2011) Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells. J. Gastroenterol. 46(12): 1368-1381
13. Furukawa, A., Kawamoto, Y., Chiba, Y., Takei, S., Hasegawa-Ishii, S., Kawamura, N., Yoshikawa, K., Hosokawa, M., Oikawa, S., Kato, M., and Shimada, A. (2011) Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury. Neurobiol. Dis. 43(3):706-714
14. Yoshikawa, K., Takei, S., Hasegawa-Ishii, S., Chiba, Y., Furukawa, A., Kawamura, N., Hosokawa, M., Woodward, D.F., Watanabe, K., and Shimada, A. (2011) Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system. Brain Res. 1367: 22-32
15. Hasegawa-Ishii, S., Takei, S., Chiba, Y., Furukawa, A., Umegaki, H., Iguchi, A., Kawamura, N., Yoshikawa, K., Hosokawa, M., and Shimada, A. (2011) Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice. Neuropathology 31: 20-28
16. Hasegawa-Ishii, S., Takei, S., Inaba, M., Umegaki, H., Chiba, Y., Furukawa, A., Kawamura, N., Hosokawa, M., and Shimada, A. (2011) Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse. Brain Behav. Immun. 25 (1):83-100.
17. Furukawa, A., Oikawa, S., Hasegawa-Ishii, S., Chiba, Y., Kawamura, N., Takei, S., Yoshikawa, K., Hosokawa, M., Kawanishi, S., and Shimada, A. (2010) Proteomic analysis of aging brain in SAMP10 mouse: a model of age-related cerebral degeneration. Mech. Ageing Dev. 131:379-388.
18. Saitoh, Y., Matsui, F., Chiba, Y., Kawamura, N., Keino, H., Satoh, M., Kumagai, N., Ishii, S., Yoshikawa, K., Shimada, A., Maeda, N., Oohira, A., and Hosokawa, M. (2008) Reduced expression of MAb6B4 epitopes on chondroitin sulfate proteoglycan aggrecan in perineuronal nets from the cerebral cortices of SAMP10 mice: A model for age-dependent neurodegeneration. J. Neurosci. Res. 86: 1316-1323.
19. Satoh, M., Shimada, A., Kawamura, N., Chiba, Y., Yoshikawa, K., Ishii, S., Furukawa, A., Kumagai, N., and Hosokawa, M. (2008) Neuronal toxicity of expanded polyglutamine depends on intracellular distribution in addition to the expression level. Neuropathology 28:485-496.
20. Ishii, S., Chiba, Y., Umegaki, H., Iguchi, A., Kawamura, N., Yoshikawa, K.,Furukawa, A., Takei, S., Hosokawa, M., Shimada, A. (2008) Involvement of microglia in age-related neuronal degeneration (Japanese) Biomedical Gerontology 32(4): 21-24
21. Kumagai, N., Chiba, Y., Hosono, M., Fujii, M., Kawamura, N., Keino, H., Yoshikawa, K., Ishii, S., Saitoh, Y., Satoh, M., Shimada, A., and Hosokawa, M. (2007) Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse. Brain Res. 1185:75-85.
22. Hasegawa, S., Yamaguchi, M., Nagao, H., Mishina, M., Mori, K. (2007) Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus. J. Neuroimmunol. 186, 75-85.
23. Hasegawa, S., Yamaguchi, M., Nagao, H., Yoshihara, Y., Mori, K. (2004) Activated natural killer cells adhere to cultured hippocampal neurons and affect the dendritic morphology. J. Neuroimmunol. 151 (1-2) 126-136.

1. Shimada, A. and Hasegawa-Ishii, S. (2017) Histological architecture underlying brain-immune cell-cell interactions and the cerebral response to systemic inflammation. Front. Immunol. 19;8:17. doi: 10.3389/fimmu.2017.00017
2. Imamura, F. and Hasegawa-Ishii, S. (2016) Environmental toxicans-induced immune responses in the olfactory mucosa. Front. Immunol. 7:475.
3. Hasegawa-Ishii, S., Inaba, M., Li, M., Umegaki, H., Ikehara, S. and Shimada, A. (2014) Dynamics of bone marrow-derived cells relevant to the brain-immune cell-cell interactions under non-inflammatory conditions. Curr. Trends Neurol. 8:39-52
4. Shimada, A. and Hasegawa-Ishii, S. (2011) Senescence-accelerated mice (SAMs) as a model for brain aging and immunosenescence. Aging Dis. 2(5) 414-435
doi: 10.3389/fimmu.2016.00475
5. Chiba, Y., Shimada, A., Kumagai, N., Yoshikawa, K., Ishii, S., Furukawa, A., Takei, S., Sakura M., Kawamura, N., Hosokawa, M. (2009) The Senescence-accelerated Mouse (SAM): a higher oxidative stress and age-dependent degenerative diseases model. Neurochem. Res. 34: 679-687.

1. Zouiker, I., Hasegawa-Ishii, S. and Shimada, A. (2017) Neuroimmune interface in health and diseases. Frontiers eBooks. (in press)
2. Shimada, A., Hasegawa-Ishii, S., Furukawa, A. (2011) SAMP10 strain as a model for the study of brain aging. In: The senescence-accelerated mouse (SAM): Achievements and Future Directions. (Takeda T, Akiguchi I, Higuchi K, Hosokawa M, Hosokawa T and Nomura Y, eds.) , Elsevier, Amsterdam, pp 157-174
所属学会 PsychoNeuroImmunology Research Society, Society for Neuroscience, 日本神経科学学会、日本神経病理学会
居室・研究室 A棟506、A棟523
オフィスアワー 水曜日13:00-17:00
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