Faculty of Health Sciences教員紹介

項目名 内容
教員名 島田 厚良
フリガナ シマダ アツヨシ
NAME Shimada, Atsuyoshi
所属学科 臨床検査技術学科
職 位 教授
役職・委員(大学) 研究推進委員会委員(全学)
委員(保健学部) 研究委員会委員長(保健学部)
実習用顕微鏡整備委員会委員長(保健学部)
細胞検査士養成課程副委員長
所属研究室 病理学
研究テーマ・分野 脳と免疫系の細胞間相互作用とその脳病態への関与
担当科目(学部) 「病理学各論」、「病理検査学実習」、「病理組織検査技術」など
担当科目(大学院) 「臨床検査・生命科学特別講義1、2」など
兼務・兼担 医学部「人文・生命科学特論」の1コマ
略 歴 1988年 京都大学医学部 医学科 卒業
1992年 京都大学大学院医学研究科 脳統御医科学系博士課程 修了(脳実験病理学)
1992年 日本学術振興会特別研究員(PD)
1993年 米国NIH Visiting Fellow
1995年 米国コロンビア大学病院 レジデント医師(病理学)
1997年 米国コロンビア大学医学校 Research Scientist
1998年 長崎大学 医学部 助手 (病理学)
1998年 愛知県心身障害者コロニー 発達障害研究所 室長(神経病理学)
2012年 愛知県心身障害者コロニー 中央病院 中央検査部 部長
2017年 杏林大学保健学部臨床検査技術学科 教授
所有する学位 博士(医学)、京都大学
所有する資格 1988年 医師免許
1995年 米国医師免許(ECFMG)
2002年 死体解剖資格
主要研究業績 A.英文原著論文
1. Katsuki H, Ishihara K, Shimada A, Takeda T and *Satoh M : Age-related deterioration of long-term potentiation in the CA3 and CA1 regions of hippocampal slices from the senescence-accelerated mouse. Archives of Gerontology and Geriatrics 11: 77-83, 1990
2. Naiki H, Higuchi K, Matsushima K, Shimada A, Chen WH, Hosokawa M and *Takeda T : Fluorometric examination of tissue amyloid fibrils in murine senile amyloidosis: Use of the fluorescent indicator, Thioflavine T. Laboratory Investigation 62: 768-773, 1990
3. Shimada A, Ohta A, Akiguchi I and *Takeda T : Inbred SAM-P/10 as a mouse model of spontaneous, inherited brain atrophy. Journal of Neuropathology and Experimental Neurology 51: 440-450, 1992  
4. *Naiki H, Higuchi K, Shimada A, Takeda T and Nakakuki K : Genetic analysis of murine senile amyloidosis. Laboratory Investigation 68: 332-337, 1993
5. *Shimada A, Ohta A, Akiguchi I and Takeda T : Age-related deterioration in conditional avoidance task in the SAM-P/10 mouse, an animal model of spontaneous brain atrophy. Brain Research 608: 266-272, 1993
6. Takemura M, Nakamura S, Akiguchi I, Ueno M, Oka N, Ishikawa S, Shimada A, Kimura J. and *Takeda T : /A4 protein like immunoreactive granular structures in the brain of senescence-accelerated mouse. American Journal of Pathology 142: 1887-1897, 1993
7. Saitoh Y, Hosokawa M, Shimada A, Watanabe Y, Yasuda N, *Takeda T and Murakami Y : Age-related hearing impairment in senescence-accelerated mouse (SAM). Hearing Research 75: 27-37, 1994
8. *Shimada A, Hosokawa M, Ohta A, Akiguchi I and Takeda T: Localization of atrophy-prone areas in the aging mouse brain: Comparison between the brain atrophy model SAM-P/10 and the normal control SAM-R/1. Neuroscience 59: 859-869, 1994
9. Shimada A, Spangler EL, London ED and *Ingram DK : Spermidine potentiates dizocilpine- induced impairment of learning performance by rats in a 14-unit T-maze. European Journal of Pharmacology 263: 293-300, 1994
10. Saitoh Y, Hosokawa M, Shimada A, Watanabe Y, Yasuda N, Murakami Y and *Takeda T : Age-related cochlear degeneration in senescence-accelerated mouse. Neurobiology of Aging 16: 129-136, 1995
11. *Ingram DK, Shimada A, Spangler EL, Ikari H, Hengemihle J, Kuo H and Greig N. Cognitive enhancement: New strategies for stimulating cholinergic, glutamatergic, and nitric oxide systems. Annals of the New York Academy of Sciences 786: 348-361, 1996
12. Shimada A, Mukhin A, *Ingram DK and London ED : N-methyl-D-aspartate receptor binding in brains of rats at different ages. Neurobiology of Aging 18: 329-333, 1997
13. *Kawamata T, Akiguchi I, Yagi H, Irino M, Sugiyama H, Akiyama H, Shimada A, Takemura M, Ueno, M, Kitabayashi T, Ohnishi K, Seriu N, Higuchi K, Hosokawa M and Takeda T : Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory. Experimental Gerontology 32: 161-169, 1997
14. Shimada A, Mason CA and *Morrison ME : TrkB signaling modulates spine density and morphology independent of dendrite structure in cultured neonatal Purkinje cells. Journal of Neuroscience 18: 8559-8570, 1998
15. Shimada A, Lange DJ and *Hays AP : Amyotrophic lateral sclerosis in an adult following acute paralytic poliomyelitis in early childhood. Acta Neuropathologica 97: 317-321, 1999
16. *Shimada A, Keino H, Satoh M, Kishikawa M, Seriu N and Hosokawa M : Age-related progressive neuronal DNA damage associated with cerebral degeneration in a mouse model of accelerated senescence. Journals of Gerontology Series A: Biologic Sciences and Medical Sciences 57: B415-421, 2002
17. Yoneda M, Fujita T, Yamada Y, Yamada K, Fujii A, Inagaki T, Nakagawa H, Shimada A, Kishikawa M, Nagaya M, Azuma T, Kuriyama M and *Wakamatsu N : Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B. Neurology 59: 1637-1640, 2002
18. Keino H, Kishikawa M, Satoh M and *Shimada A : Expression of presenilin 1 and synapse-related proteins during postnatal development is not different between accelerated senescence-prone and -resistant mice. Neuropathology 23: 16-24, 2003
19. *Shimada A, Keino H, Satoh M, Kishikawa M and Hosokawa M : Age-related loss of synapses in the frontal cortex of SAMP10 mouse: A model of cerebral degeneration. Synapse 48: 198-204, 2003.
20. Tokuoka SM, Ishii S, Kawamura N, Satoh M, Shimada A, Sasaki S, Hirotsune S, Wynshaw-Boris A and *Shimizu T : Involvement of platelet-activating factor and LIS1 in neuronal migration. European Journal of Neuroscience 18:563-570, 2003.
21. Ito H, Kamei K, Iwamoto I, Inaguma Y, Tsuzuki M, Kishikawa M, Shimada A, Hosokawa M and *Kato K : Hsp27 suppresses the formation of inclusion bodies induced by expression of R120G B-crystallin, a cause of desmin-related myopathy. Cellular and Molecular Life Sciences 60: 1217-1223, 2003
22. *Shimada A, Satoh M, Chiba Y, Saitoh Y, Kawamura N, Keino H, Hosokawa M and Shimizu T : Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain. Neuroscience 131: 683-689, 2005
23. Ishihara N, *Shimada A, Kato J, Niimi N, Tanaka S, Miura K, Suzuki T, Wakamatsu N and Nagaya M : Variations in aganglionic segment length of the enteric neural plexus in Mowat-Wilson syndrome. Journal of Pediatric Surgery 40: 1411-1419, 2005
24. Yamashita Y, Chiba Y, Xia C, Hirayoshi K, Satoh M, Saitoh Y, Shimada A, Nakamura E and *Hosokawa M : Different adaptive traits to cold exposure in young senescence-accelerated mice. Biogerontology 6: 133-139, 2005
25. Chiba Y, Yamashita Y, Ueno M, Fujisawa H, Hirayoshi K, Hohmura K, Tomimoto H, Akiguchi I, Satoh M, Shimada A and *Hosokawa M : Cultured murine dermal fibroblast-like cells from senescence-accelerated mice as in vitro models for higher oxidative stress due to mitochondrial alterations. Journals of Gerontology Series A: Biologic Sciences and Medical Sciences 60: 1087-1098, 2005
26. Satoh M, *Shimada A, Kashiwai A, Saga S and Hosokawa M : Differential cooperative enzymatic activities of protein disulfide isomerase family in protein folding. Cell Stress and Chaperones 10: 211-220, 2005
27. Satoh M, *Shimada A, Keino H, Kashiwai A, Nagai N, Saga S and Hosokawa M : Functional characterization of 3 thioredoxin homology domains of ERp72. Cell Stress and Chaperones 10: 278-284, 2005
28. Kihara Y, Ishii S, Kita Y, Toda A, Shimada A and *Shimizu T. Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. Journal of Experimental Medicine 202: 853-863, 2005
29. *Shimada A, Tsuzuki M, Keino H, Satoh M, Chiba Y, Saitoh Y and Hosokawa M : Apical vulnerability to dendritic retraction in prefrontal neurones of ageing SAMP10 mouse: a model of cerebral degeneration. Neuropathology and Applied Neurobiology 32: 1-14, 2006
30. *Aono S, Tokita Y, Yasuda Y, Hirano K, Yamauchi S, Shuo T, Matsui F, Keino H, Kashiwai A, Kawamura N, Shimada A, Kishikawa M, Asai M and Oohira A : Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain. Journal of Neuroscience Research 83: 110-118, 2006
31. *Ueno M, Tomita S, Nakagawa T, Ueki M, Iwanaga Y, Ono J, Onodera M, Huang CL, Kanenishi K, Shimada A, Maekawa N and Sakamoto H. Effects of aging and HIF-1 deficiency on permeability of hippocampal vessels. Microscopy Research and Technique 69: 29-35, 2006
32. Chiba Y, *Shimada A, Satoh M, Saitoh Y, Kawamura N, Hanai A, Keino H, Ide Y, Shimizu T and Hosokawa, M : Sensory system-predominant distribution of leukotriene A4 hydrolase and its colocalization with calretinin in the mouse nervous system. Neuroscience 141: 917-927, 2006  
33. Kumagai N, Chiba Y, Hosono M, Fujii M, Kawamura N, Keino H, Yoshikawa K, Ishii S, Saitoh Y, Satoh M, Shimada A and *Hosokawa M : Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse. Brain Research 1185: 75-85, 2007
34. *Shimada A, Keino H, Kawamura N, Chiba Y and Hosokawa M : Limbic structures are prone to age-related impairments in proteasome activity and neuronal ubiquitinated inclusions in SAMP10 mouse: A model of cerebral degeneration. Neuropathology and Applied Neurobiology 34: 33-51, 2008
35. Komatsu T, *Chiba T, Yamaza H, Yamashita K, Shimada A, Hoshiyama Y, Henmi T, Ohtani H, Higami Y, de Cabo R, Ingram DK and Shimokawa I : Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8. Experimental Gerontology 43: 339-346, 2008
36. Satoh M, *Shimada A, Kawamura N, Chiba Y, Yoshikawa K, Ishii S, Furukawa A, Kumagai N and Hosokawa M. Neuronal toxicity of expanded polyglutamine depends on intracellular distribution in addition to the expression level. Neuropathology 28: 485-496, 2008
37. Saitoh Y, Matsui F, Chiba Y, Kawamura N, Keino H, Satoh M, Kumagai N, Ishii S, Yoshikawa K, Shimada A, Maeda N, Oohira A and *Hosokawa M : Reduced expression of MAb6B4 epitopes on chondroitin sulfate proteoglycan aggrecan in perineuronal nets from cerebral cortices of SAMP10 mice: A model for age-dependent neurodegeneration. Journal of Neuroscience Research 86: 1316-1323, 2008
38. *Sasaki T, Unno K, Tahara S, Shimada A, Chiba Y, Hoshino M and Kaneko T : Age-related increase of superoxide generation in the brains of mammals and birds. Aging Cell 7: 459-469, 2008
39. Chiba Y, *Shimada A, Yoshida F, Keino H, Hasegawa M, Ikari H, Miyake S and Hosokawa M : Risk of fall for individuals with intellectual disability. American Journal of Intellectual and Developmental Disabilities 114: 225-236, 2009
40. Ohgami N, Ida-Eto M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, *Kato M : c-Ret-mediated hearing loss in mice with Hirschsprung disease. Proceedings of the National Academy of Sciences of the United States of America 107: 13051-13056, 2010
41. Furukawa A, Oikawa S, Hasegawa-Ishii S, Chiba Y, Kawamura N, Takei S, Yoshikawa K, Hosokawa M, Kawanishi S and *Shimada A : Proteomic analysis of aging brain in SAMP10 mouse: a model of age-related cerebral degeneration. Mechanisms of Ageing and Development 131: 379-388, 2010
42. Furukawa A, *Oikawa S, Harada K, Sugiyama H, Hiraku Y, Murata M, Shimada A and Kawanishi S : Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1,2,4-triazole, a metabolite of carcinogenic amitrole. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 694: 7-12, 2010
43. Takei S, Tokuhira Y, Shimada A, Hosokawa M and *Fukuoka S : The eosin-shadow method: a selective enhancement of light microscopic visualization of pancreatic zymogen granules on hematoxylin-eosin sections. Anatomical Science International 85: 245-250, 2010
44. Hasegawa-Ishii S, Takei S, Inaba M, Umegaki H, Chiba Y, Furukawa A, Kawamura N, Hosokawa M and *Shimada A : Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse. Brain, Behavior, and Immunity 25: 83-100, 2011
45. Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Woodward DF, Watanabe K and *Shimada A : Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system. Brain Research 1367: 22-32, 2011
46. Hasegawa-Ishii S, Takei S, Chiba Y, Furukawa A, Umegaki H, Iguchi A, Kawamura N, Yoshikawa K, Hosokawa M and *Shimada A : Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice. Neuropathology 31: 20-28, 2011
47. Furukawa A, Kawamoto Y, Chiba Y, Takei S, Hasegawa-Ishii S, Kawamura N, Yoshikawa K, Hosokawa M, Oikawa S, Kato M and *Shimada A : Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury. Neurobiology of Disease 43: 706-714, 2011
48. Hoshino S, Kurishima A, Inaba M, Ando Y, Fukui T, Uchida K, Nishio A, Iwai H, Yokoi T, Ito T, Hasegawa-Ishii S, Shimada A, Li M, Okazaki K and *Ikehara S : Amelioration of 2,4,6- trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells. Journal of Gastroenterology 46: 1368-1381, 2011
49. Ohgami N, Ida-Eto M, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M and *Kato M : Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice. Neurobiology of Aging 33: 626.e25-34, 2012
50. Chiba Y, Takei S, Kawamura N, Kawaguchi Y, Sasaki K, Hasegawa-Ishii S, Furukawa A, HosokawaM and *Shimada A : Immunohistochemical localization of aggresomal proteins in glial cytoplasmic inclusions in multiple system atrophy. Neuropathology and Applied Neurobiology 38: 559-571, 2012
51. Takei S, Hasegawa-Ishii S, Uekawa A, Chiba Y, Umegaki H, Hosokawa M, Woodward DF, Watanabe K and *Shimada A : Immunohistochemical demonstration of increased prostaglandin F2α levels in the rat hippocampus following kainic acid-induced seizures. Neuroscience 218: 295-304, 2012
52. Hasegawa-Ishii S, *Shimada A, Inaba M, Li M, Shi M, Kawamura N, Takei S, Chiba Y, Hosokawa M and Ikehara S : Selective localization of bone marrow-derived ramified cells in the brain adjacent to the attachments of choroid plexus. Brain, Behavior, and Immunity 29: 82-97, 2013
53. Yoshikawa K, Kita Y, Furukawa A, Kawamura N, Hasegawa-Ishii S, Chiba Y, Takei S, Maruyama K, Shimizu T and *Shimada A : Excitotoxicity-induced immediate surge in hippocampal prostanoid production has latent effects that promote chronic progressive neuronal death. Prostaglandins, Leukotrienes and Essential Fatty Acids 88: 373–381, 2013
54. Tanisawa K, Mikami E, Fuku N, Honda Y, Honda S, Ohsawa I, Ito M, Endo S, Ihara K, Ohno K, Kishimoto Y, Ishigami A, Maruyama N, Sawabe M, Iseki H, Okazaki Y, Hasegawa-Ishii S, Takei S, Shimada A, Hosokawa M, Mori M, Higuchi K, Takeda T, Higuchi M and *Tanaka M : Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes. BMC Genomics 14: 248, 2013 (DOI: 10.1186/1471-2164-14-248)
55. Chiba Y, Komori H, Takei S, Hasegawa-Ishii S, Kawamura N, Adachi K, Nanba E, Hosokawa M, Enokido Y, Kouchi Z, Yoshida F and *Shimada A : Niemann-Pick disease type C1 predominantly involving the frontotemporal region, with cortical and brainstem Lewy bodies: An autopsy case. Neuropathology 34:49-57, 2014 (DOI: 10.1111/neup.12047)
56. *Unno K, Yamamoto H, Toda M, Hagiwara S, Iguchi K, Hoshino M, Takabayashi F, Hasegawa-Ishii S, Shimada A, Hosokawa M, Higuchi K and Mori M : Novel flame-shift mutation in Slc5a2 encoding SGLT2 in a strain of senescence-accelerated mouse SAMP10. Biochemical and Biophysical Research Communications 454:89-94, 2014 (DOI: 10.1016/j.bbrc.2014.10.039)
57. Hasegawa-Ishii S, Inaba M, Li M, Shi M, Umegaki H, Ikehara S and *Shimada A : Increased recruitment of bone marrow-derived cells into the brain associated with altered brain cytokine profile in senescence-accelerated mice. Brain Structure and Function 221:1513-1531, 2016 (Epub in Jan, 2015; DOI 10.1007/s00429-014-0987-2)
58. Hasegawa-Ishii S, Inaba M, , Umegaki H, Unno K, Wakabayashi K and *Shimada A : Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain–immune interface. Scientific Reports 6:25457, 2016 (DOI: 10.1038/srep25457) (http://www.nature.com/articles/srep25457)
59. Hasegawa-Ishii S, Shimada A and *Imamura F : Lipopolysaccharide-initiated persistent rhinitis causes gliosis and synaptic loss in the olfactory bulb. Scientific Reports 7:11605, 2017 (DOI: 10.1038/s41598-017-10229-w)
60. Hasegawa-Ishii S, Shimada A and *Imamura F : Neuroplastic changes in the olfactory bulb associated with nasal inflammation in mice. Journal of Allergy and Clinical Immunology 143(3):978-989.e3., 2019 (Epub in 2018 Oct 10, 2018; DOI: 10.1016/j.jaci.2018.09.028)

B.英文総説
1. *Shimada A and Takeda T : Inherited brain atrophy in the mouse. Comparative Pathology Bulletin XXV(4): 4-5, 1993 (published by The Registry of Comparative Pathology, Armed Forces Institute of Pathology)
2. *Higuchi K, Shimada A, Hosokawa M and Takeda T : The first international conference on senescence: The SAM model Kyoto, Japan 1994. Amyloid 2: 134-138, 1995
3. *Ingram DK, Shimada A, Mukhin A and London ED : Evaluating the glutamate hypothesis of geriatric memory impairment: focus on hippocampal NMDA receptors. Perspectives in Brain Aging Research 30-35, 1996 (published by the Italian Association on Brain Aging Research)
4. *Shimada A : Age-dependent cerebral atrophy and cognitive dysfunction in SAMP10 mice. Neurobiology of Aging. 20: 125-136, 1999
5. *Chiba Y, Shimada A, Kumagai N, Yoshikawa K, Ishii S, Furukawa A, Takei S, Sakura M, Kawamura N and Hosokawa M : The Senescence-accelerated Mouse (SAM): a higher oxidative stress and age-dependent degenerative diseases model. Neurochemical Research 34:679-687, 2009
6. *Shimada A and Hasegawa-Ishii S : Senescence-accelerated mice (SAMs) as a model for brain aging and immunosenescence. Aging and Disease 2: 414-436, 2011
7. Hasegawa-Ishii S, Inaba M, Li M, Umegaki H, Ikehara S and *Shimada A : Dynamics of bone marrow-derived cells relevant to the brain-immune cell-cell interactions under non-inflammatory conditions. Current Trends in Neurology 8:39-52, 2014
8. *Shimada A and Hasegawa-Ishii S : Histological architecture underlying brain–immune cell–cell interactions and the cerebral response to systemic inflammation. Frontiers in Immunology 8: 17, 2017 (DOI: 10.3389/fimmu.2017.00017)
9. *Zouikr I, Hasegawa-Ishii S and Shimada A : Neuroimmune interface in health and diseases [Editorial]. Frontiers in Immunology 8: 1315, 2017 (DOI: 10.3389/fimmu.2017.01315)

C.英文著書
1. Naiki H, Higuchi K, Kitagawa K, Shimada A, Chen W-H, Hosokawa M, Nakakuki K and Takeda T : Fluorometric examination of tissue amyloid fibrils in murine senile amyloidosis: Use of the fluorescent indicator, Thioflavine-T. In “Amyloid and Amyloidosis 1990” (Eds.) Natvig JB, et al., pp 393-396, Kluwer Academic Publishers, Dordrecht, 1991
2. *Shimada A, Ohta A, Akiguchi I and Takeda T : The search for an animal model of the aging brain. In “Development and Involution of Neurons” (Eds.) Fujisawa K and Morimatsu Y, pp 269-271, Japan Scientific Societies Press, Tokyo, 1992
3. *Shimada A and Takeda T : Inbred SAM-P/10 as a mouse model of spontaneous, inherited brain atrophy. In “Studies in Alzheimer's Disease: Animal Model”, pp 1-5, National Center of Neurology and Psychiatry, Tokyo, 1992
4. Naiki H, Higuchi K, Shimada A, Takeda T, Nakakuki K : Genetics of murine senile amyloidosis. In “Amyloid and Amyloidosis 1993” (Eds.) Kisilevsky, R., et al., pp 566-568, Perthenon Publishing, New York, 1994
5. *Akiguchi I, Yagi H, Ueno M, Takemura M, Kitabayashi T, Seriu N, Kawamata T, Nakamura S, Shimada A and Takeda T : Age related morphological changes in the brain of senescence-accerelated mouse (SAMP8). In “The SAM Model of Senescence” (Ed.) Takeda T, pp 67-72, Excerpta Medica/Elsevier, Amsterdam, 1994
6. *Ingram DK, Kuo H, Hengemihle J, Shimada A, Tian M and Jucker M : Motor and memory performance of SAM P8, R1, and C57BL/6 mice: Assessing the relationship to PAS-positive granules in Brain. In “The SAM Model of Senescence” (Ed.) Takeda T, pp 73-82, Excerpta Medica/Elsevier, Amsterdam, 1994
7. *Shimada A, Ohta A, Akiguchi I and Takeda T : Inbred SAMP10 as a mouse model of spontaneous, inherited brain atrophy. In “The SAM Model of Senescence” (Ed.) Takeda T, pp 95-99, Excerpta Medica/Elsevier, Amsterdam, 1994
8. *Saitoh Y, Hosokawa M, Shimada A, Watanabe Y, Yasuda N, Murakami Y and Takeda T : Age-related hearing impairment in senescence-acclerated mouse (SAM). In “The SAM Model of Senescence” (Ed.) Takeda T, pp 255-258, Excerpta Medica/Elsevier, Amsterdam, 1994
9. *Takemura M, Nakamura S, Akiguchi I, Ueno M, Oka N, Ishikawa S, Shimada A, Kimura J and Takeda, T : /A4 protein-like immunoreactive granular structures in the brain of senescence-accelerated mouse (SAM). In “The SAM Model of Senescence” (Ed.) Takeda T, pp 355-358, Excerpta Medica/Elsevier, Amsterdam, 1994
10. *Akiguchi I, Yagi H, Shimada A, Ueno M, Takemura M, Kitabayashi T, Seryu N, Kawamata T, Nakamura S and Takeda T : Neuropathological studies on strains of Senescence Accelerated Mouse with Age-related deficits in Learning and Memory. In “Alzheimer’s and Parkinson’s Diseases: Recent Developments” (Eds.) Hanin I, Yoshida M and Fisher A, pp 395-400, Plenum Press, New York, 1995
11. *Shimada A : SAMP10 strain of mouse and inherited brain atrophy. In “Pathobiology of the
Aging Mouse Vol. 2” (Eds.) Mohr U, Dungworth DL, Capen CC, Carlton WW, Ward JM, pp 53-67, ILSI Press, Washington, DC, 1996
12. *Shimada A, Chiba Y, Kawamura N, Keino H and Hosokawa M : Pathological studies of neurodegeneration in SAMP10 mice. In “The Senescence-Accelerated Mouse (SAM): An Animal Model of Senescence” (International Congress Series 1260) (Eds.) Nomura Y, Takeda T and Okuma Y, pp 77-83, Elsevier BV, Amsterdam, 2004
13. Chiba Y, Yamashita Y, Hirayoshi K, Ueno M, Fujisawa H, Matsushita T, Kogishi K, Akiguchi
I, Satoh M, Shimada A and *Hosokawa M : Mitochondrial alterations and a higher oxidative status in cultured fibroblast-like cells from senescence-accelerated mice. In “The Senescence-Accelerated Mouse (SAM): An Animal Model of Senescence” (International Congress Series 1260) (Eds.) Nomura Y, Takeda T and Okuma Y, pp 255-258, Elsevier BV, Amsterdam, 2004
14. Yamashita Y, Chiba Y, Nakamura E, Hanai A, Matsuda S, Watanabe T, Deguchi E, Satoh M, Shimada A and *Hosokawa M : Accelerated senescence and adaptation to cold exposure. In “The Senescence-Accelerated Mouse (SAM): An Animal Model of Senescence” (International Congress Series 1260) (Eds.) Nomura Y, Takeda T and Okuma Y, pp 299-302, Elsevier BV, Amsterdam, 2004.
15. Kikumori M, Furukawa S, Araki S, Nishimura T, Nishimori T, Shimada A and *Takeda T : Effects of rearing conditions on aging characteristics and pathobiological phenotypes in SAMP10 mice. In “The Senescence-Accelerated Mouse (SAM): An Animal Model of Senescence” (International Congress Series 1260) (Eds.) Nomura Y, Takeda T and Okuma Y, pp 315-319, Elsevier BV, Amsterdam, 2004
16. Keino H, *Shimada A, Tsuzuki M, Satoh M, Kitajima S, Chiba Y and Hosokawa M : Centripetal retraction of dendrites with apical vulnerability in the prefrontal neurons of aged SAMP10 mice. In “The Senescence-Accelerated Mouse (SAM): An Animal Model of Senescence” (International Congress Series 1260) (Eds.) Nomura Y, Takeda T and Okuma Y, pp 335-339, Elsevier BV, Amsterdam, 2004
17. *Saitoh Y, Chiba Y and Shimada A : Aging and proteoglycans. In “Neural proteoglycans” (Ed.) Maeda N, pp 183-199, Research Signpost, Kerala, India, 2007
18. *Chiba Y, Shimada A and Hosokawa M : The SAM strain of mice, a higher oxidative stress, age-dependent degenerative disease, and senescence acceleration model. In “Aging and Age-related Disorders, Oxidative Stress in Applied Basic Research and Clinical Practice 3” (Eds.) Bondy SC and Maiese K, pp 359-380, Humana Press, New York, 2010
19. *Shimada A, Hasegawa-Ishii S and Furukawa A : SAMP10 strain as a model for the study of brain aging, In “The senescence-accelerated mouse (SAM): Achievements and Future Directions” (Eds.) Takeda T, Akiguchi I, Higuchi K, Hosokawa M, Hosokawa T and Nomura Y, pp 157-174, Elsevier, Amsterdam, 2013
20. Zouikr I, Hasegawa-Ishii S and Shimada A eds. : Neuroimmune interface in Health and Diseases, Frontiers Media, Lausanne, 2017 (DOI: 10.3389/978-2-88945-378-8; ISBN: 978-2-88945-378-8) [E-book]

D.海外・国際学会等 招待講演
1. Shimada A : The search for an animal model of the ageing brain. The 6th Tokyo Metropolitan Institute for Neuroscience International Symposium “Development and involution of neurons”, Tokyo, Sept, 1990
2. Shimada A : Inbred SAM-P/10 as a mouse model of spontaneous, inherited brain atrophy. 4th International Symposium on Dementia, Tokyo, Mar, 1992
3. Shimada A and Takeda T : Aging of the brain in the Senescence Accelerated Mouse (SAM). Research Seminar at the Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA, May, 1992
4. Shimada A and Takeda T: Aging of the brain in the Senescence Accelerated Mouse (SAM). Annual Meeting of Biology of Aging Program, National Institute on Aging “Development of Biomarkers of Aging”, Alexandria, Virginia, USA, Jun, 1992
5. Shimada A : The senescence accelerated mouse (SAM) - Its potential as a model of accelerated brain aging. 46th Annual Scientific Meeting of the Gerontological Society of America, Basic Sciences Symposium “An overview of the development of SAM strains and their unique neurobiological characteristics”, New Orleans, USA, Nov, 1993
6. Shimada A : Inbred SAMP10 as a mouse model of spontaneous, inherited brain atrophy. The 1st International Conference on Senescence - The SAM Model, Kyoto, Mar, 1994
7. Shimada A : Clinicopathological Conference. Columbia University Medical Center Department of Neurology Grand Rounds, New York, USA, Oct, 1996
8. Shimada A : Age-dependent neuronal damages in SAMP10 strain of mouse, a model of cerebral atrophy with cognitive impairments. Japan-USA Workshop on Mouse and Monkey Models for Studying Aging, Cardiovascular Diseases and Other Age-Related Chronic Disorders, Kyoto, Jul, 2000
9. Shimada A : Pathological studies of neurodegeneration in SAMP10 mice. The 2nd International Conference on Senescence - The SAM Model, Sapporo, Jul, 2003
10. Shimada A : The distribution of prostamide/ prostaglandin F synthase in mouse brain: Developmental changes and localization to the myelin sheath. 4th International Conference on Phospholipase A2 and Lipid Mediators (PLM2009), Poster Workshop, Tokyo, May, 2009
11. Shimada A : (1) Distribution of prostamide/ prostaglandin F synthase in the central nervous system. (2) Pursuit of experimental neuropathology - Lessons from rodent models of acute brain injury and brain aging. Allergan Inc. Academic Seminar, Irvine, California, USA, Dec, 2009
12. Shimada A and Watanabe K : A novel type of PGF synthase belonging to the thioredoxin-like superfamily. Keystone Symposium “Bioactive Lipids: Biochemistry and Diseases”, Biochemistry of Lipid Metabolism I, Kyoto, Jun, 2010
13. Hasegawa-Ishii S and Shimada A : Enhanced recruitment of bone marrow-derived cells into the brain parenchyma in senescence-accelerated mice. Asian Association of Aging Research–2013 Seoul Symposium, Seoul, Korea, Nov, 2013
14. Shimada A : Microglia and neuronal degeneration in senescence-accelerated mice. 19th International Congress of Neuropathology, Symposium 1 “Microglia and Synapses”, Tokyo, Sept, 2018
15. Shimada A : Histological Architecture Underlying Brain-Immune Cell-Cell Interactions. In: The 42nd Annual Meeting of the JNS Symposium 3S02a ”Neuroinflammation and the Blood Brain Interface: New findings in brain pathology” Niigata, July, 2019
所属学会 PsychoNeuroImmunology Research Society、日本神経科学学会、Society for Neuroscience、日本神経病理学会、、New York Academy of Sciences、American Society for Investigative Pathology、日本病理学会
公的な委員会等の役員・委員歴 平成24年度 科学研究費委員会専門委員(第一段審査 実験病理学)
平成25年度 科学研究費委員会専門委員(第一段審査 実験病理学)
平成28年度 科学研究費委員会専門委員(第二段審査 第一部会 医歯薬学I小委員会)
学外活動 神経病理学領域での研究成果がMarquis Who's Whoに認めれました。
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居室・研究室 井の頭キャンパスA棟5階: A510(居室、内線1510), A523(実験室、内線1523)
メールアドレス ats7@ks.kyorin-u.ac.jp
オフィスアワー 月、火、木、金 16時〜18時
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