![学納金サイト [在学生・保護者専用]](/assets/images/BlkFeatured_item_tuition.jpg)
Graduate School of Medicine教員紹介：柴原 純二
| 氏名 |
柴原 純二
シバハラ ジュンジ SHIBAHARA, Junji |
|---|---|
| 職位 | 教授 |
| 学内の役職・委員等 | 医学部長 |
| 所属教室 |
医学教育学教室 |
| 専攻・専門分野 （大学院） |
医学専攻 病理学分野（新課程）
|
| 担当科目（学部） | M2 病理学A M3 病理学B M4 腫瘍学 M4/M5 BSL M6 クリニカルクラークシップ |
| 担当科目（大学院） | 病理学 |
| 兼務・兼担 | 保健学部・臨床細胞診断学 |
| 専門分野 | 病理診断学 |
| 研究テーマ | 脳腫瘍の病理 肝疾患の病理 |
| 略歴 | 1997年3月 東京大学医学部医学科卒業 2001年3月 東京大学大学院医学系研究科卒業 2001年4月−2015年3月 東京大学大学医学系研究科・東京大学医学部附属病院 2011年4月−2012年3月 米国Mayo Clinic留学 2016年4月−杏林大学医学部病理学教室 教授 |
| 所有する学位 | 博士（医学） |
| 指導医・専門医・認定医、その他の資格等 | 日本病理学会専門医 日本病理学会分子病理専門医 日本病理学会病理専門医研修指導医 日本臨床細胞学会細胞診指導医 |
| 論文・著書等を含む主要研究業績 |
・Morikubo H, Miyoshi J, Hayashi A, Komatsu H, Yonezawa H, Matsuura M, Shibahara J, Hisamatsu T: Transabdominal intestinal ultrasound versus transmural histopathological findings in severe ulcerative colitis requiring colectomy. Crohns Colitis 360. 8(1):otag017,2026. ・Koba T, Hibiya T, Shibayama T, Kato K, Onizuka H, Satomi K, Nagahama K, Sunami E, Abe N, Kawakami E, Shibahara J, Hayashi A: Relative MYC downregulation and RUNX2 upregulation orchestrate partial epithelial-mesenchymal transition in colorectal cancer tumor budding and poorly differentiated clusters. J Pathol 268(3):298-310,2026. ・Bishop JA, Nakaguro M, Palsgrove D, Trzcinska A, McLean AC, Gagan J, Shibahara J, Nagao T: Novel RUNX1/2 fusions in unclassified cystic squamous salivary gland tumors: Possible expansion of the keratocystoma family. Ann Diagn Pathol. 81:152603,2026. ・Santosh V, Sarkar C, Rao S, Ng HK, Shibahara J, Al-Hussaini M, Buckland ME, Park SH, Tihan T, Wesseling P, Louis DN, Komori T: AOSNP-ADAPTR resource level-based recommendations on practical diagnostic strategies for WHO CNS5 adult-type diffuse gliomas. Brain Pathol. 36(2):e70046,2026. ・Kitahama K, Ho YJ, Satomi K, Shibayama T, Nagahama K, Ohtsuka K, Ohnishi H, Sakamoto Y, Shibahara J, Hayashi A: Epigenetic evolution and clinicopathological implications of distinct DNA methylation profiles in pancreatic ductal adenocarcinoma. Sci Rep. 15(1):28747,2025. ・Nagasaka Y, Shiraishi T, Shibayama T, Hibiya T, Shibahara J, Takushima A: Atypical Spitz Tumor Mimicking Pyogenic Granuloma: A Case Report and Literature Review. J Plast Reconstr Surg. 4(3):160-163,2024. ・Taomoto R, Aoki M, Enomoto T, Hirao N, Abe H, Shibahara J, Ichimura K, Satomi K, Hamasaki M: Difficulties of Differentiating Primary Histiocytic Sarcoma of the Central Nervous System from Glioblastoma in Older Patients: Methylation Analysis and Review of the Literature. NMJ Case Rep J. 12:275-281,2025. ・Ogihara R, Matsuura M, Ishida T, Morikubo H, Mitsui T, Saito D, Miyoshi J, Shibahara J, Sunami E, Hisamatsu T: A case of ulcerative colitis in a patient undergoing surgery due to exacerbation resulting in toxic megacolon after SARS-CoV-2 vaccination. Clin J Gastroenterol. 18(4):557-562,2025. ・Nikai Y, Satomi K, Saito K, Gomyo M, Matsushita Y, Kato K, Nagahama K, Isomura A, Hayashi A, Yamagishi Y, Sasaki N, Kobayashi K, Tsuchiya K, Nagane M, Ichimura K, Shibahara J: Glioblastoma, IDH-wildtype manifesting as intracranial hemorrhage: A case report highlighting the clinical utility of digital polymerase chain reaction in integrated diagnoses. Neuropathology. 45(4):e13025,2025. ・Satomi K, Shibayama T, Hibiya T, Hayashi A, Nagahama K, Kato K, Nikai Y, Matsushita Y, Gomyo M, Yamagishi Y, Sasaki N, Saito K, Kobayashi K, Takeda A, Fujimoto S, Matsuo T, Takai K, Komori T, Tsuchiya K, Nagane M, Ichimura K, Shibahara J: MYB::QKI fusion-positive diffuse glioma of the cerebellum: A case report. Neuropathology. 45(3):228-233,2025. ・Hiraide T, Tsuda N, Momoi M, Shinya Y, Sano M, Fukuda K, Shibahara J, Kuramoto J, Kanai Y, Kosaki K, Hakamata Y, Kataoka M: CXCL12/CXCR4 pathway as a novel therapeutic target for RNF213-associated pulmonary arterial hypertension. Sci Rep. 14(1):26604,2024. ・Kanemura A, Morisada T, Momomura M, Asano F, Shibuya H, Matsumoto H, Nagahama K, Shibahara J, Kobayashi Y: A Case of Carcinosarcoma of the Peritoneum With Serous Tubal Intraepithelial Carcinoma. Case Rep Obstet Gynecol. 2024:1907965,2024. ・Sekino Y, Sonoda Y, Shibahara I, Mizusawa J, Sasaki K, Sekita T, Ichikawa M, Igaki H, Kinoshita M, Kumabe T, Shibahara J, Ichimura K, Arakawa Y, Fukuda H; Brain Tumor Study Group (BTSG) of the Japan Clinical Oncology Group (JCOG); Narita Y: Protocol digest of a phase III randomized trial of gross total resection versus possible resection of fluid-attenuated inversion recovery-hyperintense lesion on MRI for newly diagnosed supratentorial glioblastoma: JCOG2209 (FLAMINGO). Jpn J Clin Oncol. 55(1):75-79,2025. ・Tanaka R, Tsuboshita Y, Okodo M, Settsu R, Hashimoto K, Tachibana K, Tanabe K, Kishimoto K, Fujiwara M, Shibahara J: Artificial Intelligence Recognition Model Using Liquid-Based Cytology Images to Discriminate Malignancy and Histological Types of Non-Small-Cell Lung Cancer. Pathobiology. 92(1):52-62,2025. ・Hanyu T, Ishibashi R, Kitamura K, Nishida N, Yuba Y, Honjo G, Satomi K, Ichimura K, Shibahara J, Sawada T, Ishimori T, Takebe N, Hashikata H, Toda H: Intraventricular pituicytoma: illustrative case. J Neurosurg Case Lessons. 8(9):CASE24247,2024. ・Shibayama T, Hayashi A, Toki M, Kitahama K, Ho YJ, Kato K, Yamada T, Kawamoto S, Kambayashi K, Ochiai K, Gondo K, Okano N, Melchor JP, Iacobuzio-Donahue CA, Sakamoto Y, Hisamatsu T, Shibahara J: Combination immunohistochemistry for CK5/6, p63, GATA6, and HNF4a predicts clinical outcome in treatment-naïve pancreatic ductal adenocarcinoma. Sci Rep. 14(1):15598,2024. ・Shibayama T, Hayashi A, Abe N, Ohki A, Satomi K, Shibahara J: Gastric mesenchymal tumor with gastroblastoma-like features harboring PTCH1::GLI2 fusion. Virchows Arch. 485(3):563-567,2024. ・Satomi K, Ichimura K, Shibahara J: Decoding the DNA methylome of central nervous system tumors: An emerging modality for integrated diagnosis. Pathol Int. 74(2):51-67,2024. ・Shibayama T, Hayashi A, Nagahama K, Hibiya T, Shibuya H, Kobayashi Y, Shibahara J: Ovarian Sex Cord Tumor Harboring FUS::CREM Fusion : An Ovarian Counterpart of Inflammatory and Nested Testicular Sex Cord Tumor? Am J Surg Pathol. 48(6):773-775,2024. ・Kitahama K, Shigematsu Y, Amori G, Sugawara E, Yonese J, Shibahara J, Takeuchi K, Inamura K: RAS Family Gene Mutations, Clinicopathological Features, and Spread Patterns of Inverted Urothelial Papilloma of the Bladder. Am J Surg Pathol 48(4):458-464,2024. ・Fujima T, Saito D, Shibuta H, Ogihara R, Morikubo H, Ozaki R, Tokunaga S, Minowa S, Mitsui T, Miura M, Hayashida M, Watanabe Y, Miyoshi J, Matsuura M, Shibahara J, Ukiyama E, Hisamatsu T: Endoscopic Treatment of Colo-Colonic Intussusception in a Patient with Peutz-Jeghers Syndrome. Case Rep Gastroenterol. 17(1):339-345,2023. ・Okawa Y, Sasagawa S, Kato H, Johnson TA, Nagaoka K, Kobayashi Y, Hayashi A, Shibayama T, Maejima K, Tanaka H, Miyano S, Shibahara J, Nishizuka S, Hirano S, Seto Y, Iwaya T, Kakimi K, Yasuda T, Nakagawa H: Immuno-genomic analysis reveals eosinophilic feature and favorable prognosis of female non-smoking esophageal squamous cell carcinomas. Cancer Lett. 581:216499,2024. ・Kudo S, Matsuki R, Shibahara J, Sakamoto Y: Intraductal papillary growth of metastatic colorectal cancer. Jpn J Clin Oncol. 54(2):225-226,2024. ・Hada Y, Ohno A, Miyoshi J, Kaji R, Fujikawa Y, Horikoshi T, Hiratsuka T, Miyamoto N, Kusuhara M, Jinbo Y, Fujiwara M, Shibahara J, Hisamatsu T: Surgical resection identified pseudo-invasion with submucosal dense fibrosis in early colorectal cancer existing beyond the planned endoscopic submucosal dissection line: A case report. DEN Open. 14(1):2298,2023. ・Shibayama T, Satomi K, Tanaka R, Yoshida A, Nagahama K, Hayashi A, Hibiya T, Suda K, Fujiwara M, Shibahara J: Pulmonary inflammatory leiomyosarcoma represents a potential diagnostic pitfall of DNA methylation-based classification of sarcomas: a case report. BMC Pulm Med. 23(1):324,2023. ・Nagahama K, Isomura A, Hayashi A, Momomura M, Kobayashi Y, Shibahara J: A case of low-grade intestinal-type mucinous neoplasm of the fallopian tube with KRAS exon 2 mutation. Gynecol Oncol Rep. 49:101252,2023. ・Satomi K, Saito K, Shimoyamada H, Onizuka H, Shibayama T, Hibiya T, Hayashi A, Nagahama K, Yamagishi Y, Sasaki N, Kobayashi K, Gomyo M, Nagane M, Shibahara J: The role of nonlinear dimension reduction of genome-wide DNA methylome in integrated diagnosis: A case study of glioblastoma, IDH-wildtype. Pathol Int. 73(10):523-526,2023. ・Saito Y, Kusuhara M, Ohno A, Miyamoto N, Hada Y, Shibahara J, Hisamatsu T: Endoscopic submucosal dissection for adenoma in gastric adenocarcinoma and proximal polyposis of the stomach. Endoscopy. 55(S01):E928-E929,2023. ・Hibiya T, Nagahama K, Matsumoto Y, Saito K, Sasaki N, Kobayashi K, Otsu A, Shimasaki T, Takeuchi K, Shiokawa Y, Nagane M, Shibahara J: Epstein-Barr virus-positive monoclonal lymphoplasmacytic proliferation associated with neurosyphilis in an immunocompetent patient: A case report. Neuropathology. 44(2):104-108,2024. ・Matsuki R, Okano N, Hasui N, Kawaguchi S, Momose H, Kitahama K, Nagahama K, Kogure M, Suzuki Y, Nagashima F, Shibahara J, Mori H, Sakamoto Y: Atezolizumab and Bevacizumab Combination Therapy and Sequential Conversion Hepatectomy for Advanced Fibrolamellar Hepatocellular Carcinoma Presenting Pseudoprogression. Liver Cancer. 12(2):180-183,2022. ・Shima Y, Sasagawa S, Ota N, Oyama R, Tanaka M, Kubota-Sakashita M, Kawakami H, Kobayashi M, Takubo N, Ozeki AN, Sun X, Kim YJ, Kamatani Y, Matsuda K, Maejima K, Fujita M, Noda K, Kamiyama H, Tanikawa R, Nagane M, Shibahara J, Tanaka T, Rikitake Y, Mataga N, Takahashi S, Kosaki K, Okano H, Furihata T, Nakaki R, Akimitsu N, Wada Y, Ohtsuka T, Kurihara H, Kamiguchi H, Okabe S, Nakafuku M, Kato T, Nakagawa H, Saito N, Nakatomi H: Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms. Sci Transl Med. 15(700):eabq7721,2023. ・Tanaka R, Fujiwara M, Sakamoto N, Kanno H, Arai N, Tachibana K, Kishimoto K, Anraku M, Shibahara J, Kondo H: Cytological characteristics of histological types of lung cancer by cytomorphometric and flow cytometric analyses using liquid-based cytology materials. Diagn Cytopathol. 51(6):356-364,2023. ・Tobai H, Endo M, Ishimura M, Moriya K, Yano J, Kanamori K, Sato N, Amanuma F, Maruyama H, Muramatsu H, Shibahara J, Narita M, Fumoto S, Peltier D, Ohga S: Neonatal intestinal obstruction in Hoyeraal-Hreidarsson syndrome with novel RTEL1 variants. Pediatr Blood Cancer. 70(6):e30250,2023. ・Sakata K, Goda A, Furuya M, Ito J, Endo H, Kubota H, Nagahama K, Shibahara J, Soejima K: Right Atrial Appendage Thrombus in a Patient Undergoing Thoracoscopic Left Atrial Appendectomy for Atrial Fibrillation. JACC Case Rep. 5:101635,2022. ・Takami H, Mukasa A, Takayanagi S, Koike T, Matsuura R, Ikemura M, Ushiku T, Yoshikawa G, Shibahara J, Tanaka S, Saito N. Morphologically, genetically and spatially mixed astrocytoma and oligodendroglioma; chronological acquisition of 1p/19q codeletion and CDKN2A deletion: a case report. Brain Tumor Pathol. 40(1):26-34,2023. ・Izumi K, Inami T, Takeuchi K, Kikuchi H, Goda A, Hatano M, Kohno T, Sakata K, Shibahara J, Soejima K, Satoh T: Reversible Cardiac Hypertrophy in Pulmonary Arterial Hypertension Treated With High-Dose Epoprostenol. CJC Open. 24(9):816-819,2022. ・Satomi K, Yoshida A, Matsushita Y, Sugino H, Fujimoto K, Honda-Kitahara M, Takahashi M, Ohno M, Miyakita Y, Narita Y, Yatabe Y, Shibahara J, Ichimura K: Clinical application of a highly sensitive digital PCR assay to detect a small fraction of IDH1 R132H-mutant alleles in diffuse gliomas. Brain Tumor Pathol. 39(4):210-217,2022. ・Watanabe S, Toki M, Kambayashi K, Kitada S, Nosaka T, Ochiai K, Gondo K, Shibahara J, Hisamatsu T: Successful treatment of mediastinal pancreatic pseudocyst and pancreatic pleural effusion with endoscopic pancreatic duct drainage: A case report. DEN Open. 3(1):e133,2022. ・Aso N, Ohtsuka K, Shibahara J, Koda H, Morikawa T, Abe N, Watanabe T, Ohnishi H: Microsatellite instability in the high-grade dysplasia component of duodenal adenoma is associated with progression to adenocarcinoma. Surg Today. 53(2):252-260,2023. ・Todo T, Ito H, Ino Y, Ohtsu H, Ota Y, Shibahara J, Tanaka M: Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial. Nat Med. 28(8):1630-1639,2022. ・Todo T, Ino Y, Ohtsu H, Shibahara J, Tanaka M: A phase I/II study of triple-mutated oncolytic herpes virus G47∆ in patients with progressive glioblastoma. Nat Commun. 13(1):4119,2022. |
| 所属学会 |
日本病理学会（評議員） 日本臨床細胞学会 日本脳腫瘍病理学会（理事・評議員） 日本脳腫瘍学会（理事） |