大学ホーム医学研究科教育・研究指導教員紹介:三好 潤

教員紹介:三好 潤


氏名
 
三好 潤
ミヨシ ジュン MIYOSHI, Jun
職位 講師
所属教室
専攻・専門分野
 (大学院)
専門分野 消化管疾患、炎症性腸疾患、腸内微生物叢
研究テーマ 炎症性腸疾患の病態生理、宿主免疫機構の発達における腸内微生物叢の役割、炎症性腸疾患の疾患活動性モニタリングおよび治療効果予測
略歴 2006年 慶應義塾大学医学部卒業
2012年 慶應義塾大学大学院医学研究科博士課程修了
2012年 東京歯科大学市川総合病院消化器内科助教
2014年 米国シカゴ大学消化器科博士研究員
2019年 杏林大学医学部消化器内科学学内講師 
所有する学位 博士(医学)
論文・著書等を含む主要研究業績 (原著論文)
1. Miyoshi J, Sofia MA, Pierre JF. The evidence for fungus in Crohn's disease pathogenesis. Clin J Gastroenterol. 2018; 11:449-456.
2. Miyoshi J, Matsuoka K, Yoshida A, Naganuma M, Hisamatsu T, Yajima T, Inoue N, Okamoto S, Iwao Y, Ogata H, Ueno F, Hibi T, Kanai T. 5-aminosalicylic acid aggravates colitis mimicking exacerbation of ulcerative colitis. Intest Res. 2018; 16:635-640.
3. Miyoshi J, Leone V, Nobutani K, Musch MW, Martinez-Guryn K, Wang Y, Miyoshi S, Bobe AM, Eren AM, Chang EB. Minimizing confounders and increasing data quality in murine models for studies of the gut microbiome. PeerJ. 2018;6:e5166.
4. Martinez-Guryn K, Hubert N, Frazier K, Urlass S, Musch MW, Ojeda P, Pierre JF, Miyoshi J, Sontag TJ, Cham CM, Reardon CA, Leone V, Chang EB. Small intestine microbiota regulate host digestive and absorptive adaptive responses to dietary lipids. Cell Host Microbe. 2018; 23: 458-469.e5.
5. Pierre JF, Hinterleitner R, Bouziat R, Hubert NA, Leone V, Miyoshi J, Jabri B, Chang EB. Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility. J Nutr Biochem. 2018; 54: 95-104.
6. Miyoshi J, Qiao Y, Chang EB. The role of the intestinal microbiota in the pathogenesis and treatment of inflammatory bowel diseases. Semin Colon Rectal Surg 2018; 29: 21-27.
7. Miyoshi J, Nobutani K, Musch MW, Ringus DL, Hubert NA, Yamamoto M, Kase Y, Nishiyama M, Chang EB. Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100). Evid Based Complement Alternat Med. 2018; 2018: 7415975.
8. Nobutani K, Miyoshi J, Musch MW, Nishiyama M, Watanabe J, Kaneko A, Yamamoto M, Yoshida M, Kono T, Jeong H, Chang EB. Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal. Pharmacol Res Perspect. 2017; 5: e00361.
9. Miyoshi J, Bobe AM, Miyoshi S, Huang Y, Hubert N, Delmont TO, Eren AM, Leone V, Chang EB. Peripartum antibiotics promote gut dysbiosis, loss of immune tolerance, and inflammatory bowel disease in genetically prone offspring. Cell Rep. 2017; 20: 491-504.
10. Hasebe T, Matsukawa J, Ringus D, Miyoshi J, Hart J, Kaneko A, Yamamoto M, Kono T, Fujiya M, Kohgo Y, Wang CZ, Yuan CS, Bissonnette M, Musch MW, Chang EB. Daikenchuto (TU-100) suppresses tumor development in the azoxymethane and APCmin/+ mouse models of experimental colon cancer. Phytother Res. 2017; 31: 90-99.
11. Miyoshi J, Chang EB. The gut microbiota and inflammatory bowel diseases. Transl Res. 2017; 179: 38-48.
12. Miyoshi J, Hisamatsu T, Matsuoka K, Naganuma M, Maruyama Y, Yoneno K, Mori K, Kiyohara H, Nanki K, Okamoto S, Yajima T, Iwao Y, Ogata H, Hibi T, Kanai T. Early intervention with adalimumab may contribute to favorable clinical efficacy in patients with Crohn's disease. Digestion. 2014; 90: 130-136.
13. Yoneno K, Hisamatsu T, Matsuoka K, Okamoto S, Takayama T, Ichikawa R, Sujino T, Miyoshi J, Takabayashi K, Mikami Y, Mizuno S, Wada Y, Yajima T, Naganuma M, Inoue N, Iwao Y, Ogata H, Hasegawa H, Kitagawa Y, Hibi T, Kanai T. Risk and management of intra-abdominal abscess in Crohn’s disease treated with infliximab. Digestion. 2014; 89: 201-208.
14. Kishikawa H, Kaida S, Takarabe S, Miyoshi J, Matsukubo T, Miyauchi J, Tanaka Y, Miura S, Nishida J. Fundic gland polyps accurately predict a low risk of future gastric carcinogenesis. Clin Res Hepatol Gastroenterol. 2014; 38: 505-512.
(研究費)
2019年 杏林大学医学部若手支援研究費
2017年 Gastrointestinal Research Foundation Research Funding
所属学会 日本内科学会
日本消化器病学会
日本消化器内視鏡学会
日本大腸肛門病学会
日本臨床腫瘍学会
日本炎症性腸疾患学会
Asian Organization for Crohn’s & Colitis
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