大学ホーム医学研究科教育・研究指導教員紹介:横井 秀格

教員紹介:横井 秀格


項目名 内容
氏名 横井 秀格
フリガナ ヨコイ ヒデノリ
職位 准教授
所属教室
専攻・専門分野
 (大学院)
担当科目(学部) 耳鼻咽喉科学、鼻科学、免疫アレルギー
担当科目(大学院) 耳鼻咽喉科学
兼務・兼担 保健学部(救急救命学科)
専門分野 耳鼻咽喉科学、鼻科学、免疫アレルギー
研究テーマ 内視鏡下鼻副鼻腔手術、内視鏡下頭蓋底手術、アレルギー性鼻炎や慢性副鼻腔炎の病態と治療に関する基礎的検討(マスト細胞、好酸球、神経増殖・反発因子)他
略歴 1993年 順天堂大学医学部卒
1993年 順天堂大学医学部耳鼻咽喉科学教室
臨床研修医
1995年 順天堂大学医学部大学院 入学
1999年 順天堂大学医学部大学院 卒業
1999年 順天堂浦安病院 耳鼻咽喉科 助手
2000年 順天堂静岡病院 耳鼻咽喉科 助手
2001年 順天堂医院 耳鼻咽喉科 講師
2004年 Johns Hopkins University, Division of Allergy and Clinical Immunology留学(Post-doctoral fellow, Prof. Bruce S. Bochner)
2006年 順天堂医院 耳鼻咽喉科 講師
2007年 順天堂医院 耳鼻咽喉科 准教授
2008年 順天堂浦安医院 耳鼻咽喉科 准教授
2011年 杏林大学医学部耳鼻咽喉科学教室 准教授
現在に至る
所有する学位 博士(医学)
指導医・専門医・認定医、その他の資格等 日本耳鼻咽喉科学会専門医、補聴器相談医
論文・著書等を含む主要研究業績 1. Yokoi H, Yoshitake H, Matsumoto Y, Kawada M, Takato Y, Shinagawa K, Sakurai H, Saito K. Involvement of cross-reactive carbohydrate determinants-specific IgE in pollen allergy testing. Asia Pac Allergy. 2017, 7(1):29-36.
2. Kawada M, Yokoi H*, Maruyama K, Matsumoto Y, Yamanaka H, Ikeda T, Shiokawa Y, Saito K. Rhinogenic intracranial complication with postoperative frontal sinus pyocele and inverted papilloma in the nasal cavity: A case report and literature review. SAGE Open Med Case Rep. 2016 23; 4: 2050313X16629828. * correspondence author
3. Yokoi H, Yazawa T, Matsumoto Y, Ikeda T, Fujiwara M, Ohkura Y, Kohno N. An Inflammatory Pseudotumor Arising from Pterygopalatine Fossa with Invasion to the Maxillary Sinus and Orbital Cavity. Case Rep Otolaryngol. 2015; 2015: 950823.
4. Matsumoto Y, Yokoi H*, Ikeda T, Fujiwara M, Kamma H, Kohno K. Intra-adenoid cyst-A case report with an immunohistochemical study and review of literature-. Clinical Medicine Insights: Case Reports. 2015, 21; 8: 41-5. * correspondence author
5. Pichler U, Hauser M, Wolf M, Gadermaier G, Weiss R, Mari A, Ebner C, Yokoi H, Takai T, Didierlaurent A, Briza P, Behrendt H, Wallner M, Ferreira F. Pectate lyase pollen allergens: Sensitization profiles and cross-reactivity pattern. PLoS One. 2015; 10(5): e0120038.
6. Yokoi H, Tsutsumi S, Kohno N. Schwannoma of the nasal septum presenting as multicentric neuronal tumor. B-ENT. 2015; 11(2): 141-5.
7. Matsumoto Y, Ikeda T, Yokoi H*, Kohno N. Association between Odontogenic Infection and Unilateral Sinus Opacification. Auris Nasus Larynx. 2015, 42(4): 288-93.
* correspondence author
8. Yokoi H, Kodama S, Kogashiwa Y, Matsumoto M, Ohkura Y, Nakagawa T, Kohno N. An Endoscopic Endonasal Approach for Early-Stage Olfactory Neuroblastoma: An Evaluation of 2 Cases with Minireview of Literature. Case reports in otolaryngology. 2015; 2015: 541026.
9. Ikeda T, Kuraguchi J, Kogashiwa Y, Yokoi H, Satomi T, Kohno N. Successful Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) Patients with Sitafloxacin: New Strategies for the Treatment of BRONJ. Bone. 2015; 73: 217-22.
10. Yokoi H, Arakawa A, Matsumoto F, Yokoi N, Ikeda K, Kohno N. Organized hematoma of the maxillary sinus: A clinicopathologic study of 5 cases. ENT Journal. 2014; 93: e23-e26.
11. Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H, Araki Y. Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma. Cancer Biomark. 2012; 12(3):141-8.
12. Yokoi H, Arakawa A, Inoshita A, Ikeda K. Novel use of a Weerda laryngoscope for transoral excision of a cervical ganglioneuroma: a case report. Journal of Medical Case Reports 2012, 6:88
13. Kawano K, Kusunoki T, Ono N, Yao T, Saito T, Yokoi H, Ikeda K. Heme oxygenase-1 expression in chronic rhinosinusitis with eosinophilic infiltration. Auris Nasus Larynx. 2012; 39(4): 387-92.
14. Sato D, Suzuki Y, Kano T, Suzuki H, Matsuoka J, Yokoi H, Horikoshi S, Ikeda K, Tomino Y. Tonsillar TLR9 expression and efficacy of tonsillectomy with steroid pulse therapy in IgA nephropathy patients. Nephrol Dial Transplant. 2012; 27(3): 1090-7.
15. Yokoi H, Arakawa A, Kuribayashi K, Inoshita A, Haruyama T, Ikeda K. An immunohistochemical study of sinonasal hemangiopericytoma. Auris Nasus Larynx. 2011; 38: 743-6.
16. Yokoi H, Yoshikawa H, Matsumoto T, Kawano K, Ikeda K. An inflammatory calcified nodule in the buccal subcutis-A case report. B-ENT. 2011; 7(3): 215-8.
17. Ikeda K, Yokoi H, Kusunoki T, Saitoh T, Yao T, Kase K, Minekawa A, Inoshita A, Kawano K. Bacteriology of recurrent exacerbation of postoperative course in chronic rhinosinusitis in relation to asthma. Auris Nasus Larynx. 2011; 38: 469-73.
18. Ikeda K, Yokoi H, Kusunoki T, Saito T, Yao T, Kase K, Minekawa A, Inoshita A, Kawano K. Relationship between olfactory acuity and peak expiratory flow during postoperative follow-up in chronic rhinosinusitis associated with asthma. Ann Oto Rhinol Laryngol. 2010; 119:749-754.
19. Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K. Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. J Immunol. 2010; 184: 3526-34.
20. Inoshita A, Yokoi H, Matsumoto F, Yao T, Kawano K, Furukawa M, Ikeda K. A randomized prospective study of oral levofloxacin vs intravenous flomoxef prophylaxis in postoperative infection after endoscopic sinus surgery. Am J Otolaryngol. 2009; 31: 360-363.
21. Ikeda K, Sakai Y, Haruyama T, Misawa N, Misawa N, Hori S, Kusunoki T,
Furukawa M, Yokoi H, Yokoi N, Ichihari Y, Kawano K, Matsumoto F, Hayashi C, Narui Y, Iizuka T, Ito S, Inoshita A, Kasai M, Saito T, Minekawa A, Oba S, Cho Y. Bacterial contamination of Multiple-use atomizers commonly used in Japan. Indian J Otolaryngol Head Neck Surg. 2009; 61: 193-6.
22. Saitoh T, Kusunoki T, Yao T, Kawano K, Kojima Y, Miyahara K, Onoda J, Yokoi H, Ikeda K. Relationship between epithelial damage or basement membrane thickness and eosinophilic infiltration in nasal polyps with chronic rhinosinusitis. Rhinology. 2009; 47: 275-9.
23. Saitoh T, Kusunoki T, Yao T, Kawano K, Kojima Y, Miyahara K, Onoda J, Yokoi H, Ikeda K. Role of interleukin-17A in the eosinophil accumulation and mucosal remodeling in chronic rhinosinusitis. with nasal polyps associated with asthma. Int Arch Allergy Immunol. 2010; 151: 8-16.
24. Ikeda K, Yokoi H, Saito T, Kawano K, Yao T, Furukawa M, Kusunoki T:Prevention of ultrasonic coagulator-mediated mucoperiosteal flap injury and defects by using a clip manipulation in the resection of the posterior nasal nerve. Rhinology. 2009; 47: 45-7.
25. Yao T, Kojima Y, Koyanagi A, Yokoi H, Saito T, Kawano K, Furukawa M, Kusunoki T, Ikeda K:Eotaxin-1,-2 and -3 immunoreactivity and protein concentration in the nasal polyps of eosinophilic chronic rhinosinusitis patients. Laryngoscope. 2009; 119: 1053-1059.
26. Kase K, Hua J, Yokoi H, Ikeda K, Nagaoka I: Inhibitory action of roxithromycin on histamine release. and prostaglandin D2 production from beta-defensin 2-stimulated mast cells. Int J Mol Med. 2009. 23: 337-40.
27. Ikeda K, Yokoi H, Saito T, Kawano K, Yao T, Furukawa M: Effect of resection of the posterior nasal nerve on functional and morphological changes in the inferior turbinate mucosa. Acta Otolaryngol. 2008. 128: 1337-41.
28. Matsumoto F, Itoh S, Ohba S, Yokoi H, Furukawa M, Ikeda K: Biopsy of cervical lymph node. Auris Nasus Larynx. 2009; 36: 71-74.
29. Yokoi, H. , Choi, O H., Hubbard, W., Lee H-S., Canning, BJ., Lee, HH., Ryu, SD., Bickel, CA., Hudson, SA., MacGlashan, Jr., DW., Vonakis, BM., Bochner, BS:Inhibition of FceRI-dependent mediator release from human mast cells by Siglec-8 engagement. JACI, 2008 121(2): 499-505.
30. Guo JP, Nutku E, Yokoi H, Schnaar RL, Zimmermann N, Bochner BS: Siglec-8 and Siglec-F: Org inhibitory receptors on eosinophils, basophils and mast cells. Allergy Clin Immunol Int -J World Allergy. 2007; 19:54-59.
31. Yokoi, H. , Hudson, S.A., Bovin, N., Schnaar, R.L., and Bochner, B.S: Surface expression, inhibitory function and candidate ligand for Siglec-8 on human mast cells. Allergy Clin. Immunol. Int.: J. World Allergy Org., Supplement 2, pp. 23-26, 2008.
32. Chen X, Niyonsaba F, Ushio H, Hara M, Yokoi H, Matsumot K, Saito H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Endogenous antimicrobial peptides human β-defensin (hBD)-3 and hBD-4 activate mast cells and increase the skin vascular permeability dependent on the presence of mast cells. Eur J Immunol, 2007; 37(2):434-44
33. Yokoi H, Myers A, Matsumoto K, Crocker PR, Saito H, Bochner BS: Alteration and acquisition of Siglecs during in vitro maturation of CD34+ progenitors into human mast cells. Allergy. 2006; 61(6): 769-76.
34. Saito H, Matsumoto K, Okumura S, Kashiwakura JI, Oboki K, Yokoi H, Kambe N, Ohta K, Okayama Y: Gene expression profiling of human mast cell subtypes: an in silico study. Allergol Int. 2006; 55: 173-179.
35. Yokoi, H. , Okayama Y., Niyonsaba, F., Fujimori, M., Enomoto, F., Yoshikawa, H., Ikeda, K. Saito, H: Comparison of human tonsillar mast cell localization and ultrastructural observations between IgE-mediated allergic and non-allergic donors. Allergy and Asthma Proceedings. 2006; 27 (5): 415-421.
36. Kashiwakura, J., Yokoi, H. , Saito, H., and Okayama, Y: T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells. J Immunology, 2004, 173(8):5247-57.
37. Kataoka, T., Enomoto, F., Kim, R., Yokoi, H. , Fujimori, M., Sakai, Y., Ando, I., Ichikawa G., Ikeda, K: The effect of surgical treatment of obstructive sleep apnea syndrome on the plasma TNF-alpha levels. Tohoku J Exp Med. 2004; 204(4):267-72.
38. Enomoto, F., Kim, R., Kataoka, T., Yamazaki, Y., Yokoi, H. , Fujimori, M., Nagaoka I. and Ichikawa, G: Modulation of neutrophil adhesion to vascular endothelial cells in rat experimental otitis media treated with a macrolide. Auris Nasus Larynx. 2003 Aug; 30 (3): 247-51.
39. Yokoi, H. , Wada, R., Enomoto, F., Fujimori, M. and Ichikawa, G: Polymorphous low-grade adenocarcinoma of the parotid gland. AUST. J. OTOLARYNG. 2003, 6: 42-44.
40. Yokoi, H. , Seki, M., Okazoe, S., Okumura, K. and Yoshikawa, H. The role and expression of CD27/CD70 in the human tonsil. Lymphology, 2003, 36: 74-83.
41. Yokoi, H. , Wada, R. and Ichikawa, G. Endoscopic treatment of so-called intranasal glioma. Rhinology, 2002, 40: 217-219.
所属学会 日本耳鼻咽喉科学会、日本鼻科学会、日本耳鼻咽喉科臨床学会、日本気管支食道科学会、日本耳鼻咽喉科免疫アレルギー学会、日本頭頸外科学会、日本アレルギー学会、AAAAI
公的な委員会等の役員・委員歴 日本耳鼻咽喉科学会評議員:2008年~2009年, 2011
千葉地方部会保険医療委員:2008年~2011年
The Laryngoscope reviewer 2005年~
Case Reports in Otolaryngology-Editorial Board Member 2013年~
Austin Journal of Otolaryngology-Editorial Board Member 2014年~
ひとことメッセージ 臨床では鼻科学を中心に患者さんにしっかり説明し、低侵襲で最新の治療を行うことを目指しています。研究は将来的に臨床応用される可能性の高いものを目指します。
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