大学ホーム医学研究科教育・研究指導教員紹介:長瀬 美樹

教員紹介:長瀬 美樹


氏名
 
長瀬 美樹
ナガセ ミキ NAGASE, Miki
職位 教授
所属教室
専攻・専門分野
 (大学院)
担当科目(学部) 肉眼解剖学I(医学部)
肉眼解剖学II(医学部)
専門分野 解剖学、細胞生物学、腎臓病学
研究テーマ 1) 高血圧、腎臓病とメカノバイオロジー
2) 肉眼解剖学研究(自律神経など)
3) 形態解析イメージング
4) 生活習慣病とRhoファミリー、核内受容体
5) 遺伝子改変動物を用いた機能解析
略歴 1990年 東京大学医学部医学科卒業
1992年 東京大学第四内科入局
1996年 オークランド大学医学部解剖学研究員
1998年 東京大学大学院医学系研究科博士課程修了
1998年 東京大学医学部附属病院分院教務職員
2004年 東京大学医学部附属病院22世紀医療センター特任助手
2009年 東京大学大学院医学系研究科慢性腎臓病学特任准教授
2014年 順天堂大学医学部解剖学・生体構造科学准教授
2017年4月より現職
受賞歴:
2009年 日本腎臓学会大島賞
2010年 日本心血管内分泌代謝学会高峰譲吉研究奨励賞
所有する学位 博士(医学)
指導医・専門医・認定医、その他の資格等 日本内科学会認定医
日本高血圧学会高血圧専門医
論文・著書等を含む主要研究業績 1) Nagase M, Kimoto Y, Sunami E, Matsumura G. A new human cadaver model for laparoscopic training using N-vinyl-2-pyrrolidone: a feasibility study. Anat Sci Int(in press)
2) Maruyama K, Yokoi H, Nagase M, Yoshida H, Noguchi A, Matsumura G, Saito K, Shiokawa Y. Usefulness of n-vinyl-2-pyrrolidone embalming for endoscopic transnasal skull base approach in cadaver dissection. Neurol Med Chir (in press)
3) Nishimoto M, Nagase M, et al. Hypertens Res 42:514-521, 2019
4) Haizuka Y, Nagase M (1st coauthor), Takashino S, Kobayashi Y, Fujikura Y, Matsumura G. A new substitute for formalin: Application to embalming cadavers. Clin Anat 31:90-98, 2018
5) Nagase M, et al. Deletion of Rac1GTPase in the myeloid lineage protects against inflammation-mediated kidney injury in mice. PLoS One 11:e0150886, 2016
6) Ayuzawa N, Nagase M, et al. Rac1-mediated activation of mineralocorticoid receptor in pressure overload-induced cardiac injury. Hypertension 67:99-106, 2016
7) Yoshida S, Nagase M, et al. Local mineralocorticoid receptor activation and the role of Rac1 in obesity-related diabetic kidney disease. Nephron Exp Nephrol 126:16-24, 2014
8) Ueda K, Nagase M, et al. Genome-wide analysis of murine renal distal convoluted tubular cells for the target genes of mineralocorticoid receptor. Biochem Biophys Res Commun 445:132-137, 2014
9) Nagase M, et al. Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease. Nat Rev Nephrol 9:86-98, 2013
10) Yamamoto T, Nagase M, Gotoda T, et al. A novel link between Slc22a18 and fat accumulation revealed by a mutation in the spontaneously hypertensive rat. Biochem Biophys Res Commun 440:521-526, 2013
11) Nagase T, Sanada H, Nagase M, et al. Aging-like skin changes in metabolic syndrome model mice are mediated by mineralocorticoid receptor signaling. Aging Cell 12: 50-57, 2013
12) Nagase M, et al. Oxidative stress causes mineralocorticoid receptor activation in rat cardiomyocytes: role of small GTPase Rac1. Hypertension 59: 500-506, 2012
13) Kawarazaki W, Nagase M, et al. Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation. J Am Soc Nephrol 23: 997-1007, 2012 14) Shibata S, Nagase M, et al. Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. J Clin Invest 121: 3233-3243, 2011
15) Shibata S, Nagase M (1st coauthor), et al. Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat Med 14: 1370-1376, 2008
16) Matsui H, Nagase M, et al. Salt excess causes left ventricular diastolic dysfunction in rats with metabolic disorder. Hypertension 52: 287-294, 2008
17) Yoshida S, Nagase M, et al. Podocyte injury induced by albumin overload in vivo and in vitro: involvement of TGF-beta and p38 MAPK. Nephron Exp Nephrol 108: e57-68, 2008
18) Nagase M, et al. Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress. Hypertension 50: 877-883, 2007
19) Shibata S, Nagase M, et al. Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension 49: 355-364, 2007
20) Nagase T, Nagase M, et al. Neurospheres from human adipose tissue transplanted into cultured mouse embryos can contribute to craniofacial morphogenesis: a preliminary report. J Craniofac Surg 18: 49-53, 2007
21) Nagase T, Nagase M, et al. Hedgehog signaling: a biophysical or biomechanical modulator in embryonic development? Ann N Y Acad Sci 1101: 412-438, 2007
22) Nagase M, Nagase T, et al. Critical time window of hedgehog-dependent angiogenesis in murine yolk sac. Microvasc Res 71: 85-90, 2006
23) Nagase M, et al. Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker. Hypertension 47: 1084-1093, 2006
24) Nagase M, et al. Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors. J Am Soc Nephrol 17: 3438-3446, 2006
25) Shibata S, Nagase M, et al. Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling. J Am Soc Nephrol 17: 754-764, 2006
26) Dominguez JH, Nagase M, et al. Renal injury: similarities and differences in male and female rats with the metabolic syndrome. Kidney Int 69: 1969-1976, 2006
27) Nagase T, Nagase M, et al. Defects in aortic fusion and craniofacial vasculature in the holoprosencephalic mouse embryo under inhibition of sonic hedgehog signaling. J Craniofac Surg 17: 736-744, 2006
28) Hino M, Nagase M, et al. Expression and regulation of adrenomedullin in renal glomerular podocytes. Biochem Biophys Res Commun 330: 178-185, 2005
29) Nagase T, Nagase M, et al. Craniofacial anomalies of the cultured mouse embryo induced by inhibition of sonic hedgehog signaling: an animal model of holoprosencephaly. J Craniofac Surg 16: 80-88, 2005
30) Nagase T, Nagase M (1st coauthor), et al. Angiogenesis within the developing mouse neural tube is dependent on sonic hedgehog signaling: possible roles of motor neurons. Genes Cells 10: 595-604, 2005
31) Nagase M, et al. Redox-sensitive regulation of LOX-1 gene expression in vascular endothelium. Biochem Biophys Res Commun 281: 720-725, 2001
32) Nagase M, et al. Expression of LOX-1, an oxidized low-density lipoprotein receptor, in experimental hypertensive glomerulosclerosis. J Am Soc Nephrol 11: 1826-1836, 2000
33) Nagase M, et al. Retrotransposons transcribed preferentially in proximal tubules of salt-hypertensive rats. Kidney Int 55: 995-1004, 1999
34) Nagase M, et al. Unique repetitive sequence and unexpected regulation of expression of rat endothelial receptor for oxidized low-density lipoprotein (LOX-1). Biochem J 330: 1417-1422, 1998
35) Nagase M, et al. Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene. J Biol Chem 273: 33702-33707, 1998
36) Nagase M, et al. Role of natriuretic peptide receptor type C in Dahl salt-sensitive hypertensive rats. Hypertension 30: 177-183, 1997
37) Nagase M, et al. Tissue distribution and localization of natriuretic peptide receptor subtypes in stroke-prone spontaneously hypertensive rats. J Hypertens 15: 1235-1243, 1997
38) Nagase M, et al. Enhanced expression of endothelial oxidized low-density lipoprotein receptor (LOX-1) in hypertensive rats. Biochem Biophys Res Commun 237: 496-498, 1997
39) Nagase M, et al. Local renin-angiotensin system in sympathetic overactivity of spontaneously hypertensive rats. Hypertens Res 19: 171-177, 1996
40) Nagase M, et al. Salt sensitivity of blood pressure in patients with 17 alpha-hydroxylase deficiency. Am J Hypertens 7: 1005-1011, 1994
所属学会 日本解剖学会(代議員、解剖学用語委員会委員、若手育成委員会委員、選挙管理委員会委員)、日本内科学会、日本腎臓学会(評議員、男女共同参画委員会委員)、日本高血圧学会(評議員)、日本内分泌学会(評議員)、日本心血管内分泌代謝学会(評議員、監事)、米国腎臓学会、国際腎臓学会
公的な委員会等の役員・委員歴 AMED-CREST「生体恒常性維持・変容・破綻機構のネットワーク的理解に基づく最適医療実現のための技術創出」領域アドバイザー(国立研究開発法人日本医療研究開発機構)
学外活動 順天堂大学非常勤講師
東京工業大学非常勤講師
公益財団法人日本腎臓財団「腎臓」編集委員
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